Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet

Obesity

Volumn 23, Issue 12, 2015, Pages 2357-2363

  Boutagy, Nabil E ^a   Neilson, Andrew P ^a   Osterberg, Kristin L ^a   Smithson, Andrew T ^a   Englund, Tessa R ^a   Davy, Brenda M ^a   Hulver, Matthew W ^a   Davy, Kevin P ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CARNITINE; CHOLINE; PLACEBO; PROBIOTIC AGENT; STARCH; TRIMETHYLAMINE OXIDE; METHYLAMINE; TRIMETHYLOXAMINE;

ADULT; ARTICLE; BACTERIAL COUNT; BETAINE BLOOD LEVEL; BIFIDOBACTERIUM BREVE; BIFIDOBACTERIUM INFANTIS; BIFIDOBACTERIUM LONGUM; BIOSYNTHESIS; BLOOD LEVEL; CALORIC INTAKE; CARNITINE BLOOD LEVEL; CHOLINE BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; HUMAN EXPERIMENT; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS; LACTOBACILLUS PARACASEI; LACTOBACILLUS PLANTARUM; LIPID DIET; MALE; NONHUMAN; NORMAL HUMAN; OBESITY; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; STREPTOCOCCUS THERMOPHILUS; TREATMENT RESPONSE; TRIMETHYLAMINE OXIDE BLOOD LEVEL; ADOLESCENT; ADVERSE EFFECTS; BLOOD; DIETARY SUPPLEMENT; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

ADOLESCENT; ADULT; BETAINE; CARNITINE; CHOLINE; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; FASTING; HUMANS; MALE; METHYLAMINES; PROBIOTICS; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84955183057     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21212     Document Type: Article

References (39)

1. Mozaffarian D, Benjamin EJ, Go AS, et al., Heart disease and stroke statistics-2015 update: a report from the American heart association. Circulation 2015; 131(4): e29-322.
2. Bernstein AM, Sun Q, Hu FB, Stampfer MJ, Manson JE, Willett WC., Major dietary protein sources and risk of coronary heart disease in women. Circulation 2010; 122: 876-883.
3. Tang WW, Wang Z, Levison BS, et al., Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013; 368: 1575-1584.
4. Koeth RA, Wang Z, Levison BS, et al., Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013; 19: 576-585.
5. Wang Z, Klipfell E, Bennett BJ, et al., Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011; 472: 57-63.
6. Wang Z, Tang WW, Buffa JA, et al., Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Hear J 2014; 35: 904-910
7. Al-Waiz M, Mikov M, Mitchell S, Smith R., The exogenous origin of trimethylamine in the mouse. Metabolism 1992; 41: 135-136.
8. Lang D, Yeung C, Peter R, et al., Isoform specificity of trimethylamine-N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by fmo3. Biochem Pharmacol 1998; 56: 1005-1012.
9. Martin F-PJ, Wang Y, Sprenger N, et al., Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Systems Biol 2008; 4: 1-21.
10. Shimizu M, Cashman JR, Yamazaki H., Transient trimethylaminuria related to menstruation. BMC Med Genet 2007; 8: 1-3.
11. Spanhaak S, Havenaar R, Schaafsma G., The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr 1998; 52: 899-907.
12. Brigidi P, Swennen E, Vitali B, Rossi M, Matteuzzi D., PCR detection of Bifidobacterium strains and Streptococcus thermophilus in feces of human subjects after oral bacteriotherapy and yogurt consumption. Int J Food Microbiol 2003; 81: 203-209.
13. Matsumoto K, Takada T, Shimizu K, et al., Effects of a probiotic fermented milk beverage containing Lactobacillus casei strain Shirota on defecation frequency, intestinal microbiota, and the intestinal environment of healthy individuals with soft stools. J Biosci Bioeng 2010; 110: 547-552.
14. Nagata S, Asahara T, Ohta T, et al., Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged. Br J Nutr 2011; 106: 549-556.
15. Sood A, Midha V, Makharia GK, et al., The probiotic preparation, VSL# 3 induces remission in patients with mild-to-moderately active ulcerative colitis. Clin Gastroenterol Hepatol 2009; 7: 1202.
16. Gionchetti P, Rizzello F, Helwig U, et al., Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 2003; 124: 1202-1209.
17. Gionchetti P, Rizzello F, Venturi A, et al., Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology 2000; 119: 305.
18. Brigidi P, Vitali B, Swennen E, Bazzocchi G, Matteuzzi D., Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. Res Microbiol 2001; 152: 735-741.
19. Chapman TM, Plosker GL, Figgitt DP., VSL# 3 probiotic mixture. Drugs 2006; 66: 1371-1387.
20. Institute of Medicine of the National Academies. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. National Academies Press; Washington D.C., 2005.
21. Werner TJ, Boutagy NE, Osterberg KL, Rivero JM, Davy KP., Singular and combined effects of nebivolol and lifestyle modification on large artery stiffness in hypertensive adults. Ther Adv Cardiovasc Dis 2013; 7: 285-292.
22. Demarquoy J, Georges B, Rigault C, et al., Radioisotopic determination of L-carnitine content in foods commonly eaten in Western countries. Food Chem 2004; 86: 137-142.
23. Shils ME, Shike M., Modern Nutrition in Health and Disease, 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2006.
24. Brigidi P, Vitali B, Swennen E, Altomare L, Rossi M, Matteuzzi D., Specific detection of Bifidobacterium strains in a pharmaceutical probiotic product and in human feces by polymerase chain reaction. Syst Appl Microbiol 2000; 23: 391-399.
25. Desai AS, Mitchell GF, Fang JC, Creager MA., Central aortic stiffness is increased in patients with heart failure and preserved ejection fraction. J Cardiac Failure 2009; 15: 658-664.
26. Kirsch SH, Herrmann W, Rabagny Y, Obeid R., Quantification of acetylcholine, choline, betaine, and dimethylglycine in human plasma and urine using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 2010; 878: 3338-3344.
27. Stella C, Beckwith-Hall B, Cloarec O, et al., Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res 2006; 5: 2780-2788.
28. Vinjé S, Stroes E, Nieuwdorp M, Hazen SL., The gut microbiome as novel cardio-metabolic target: the time has come! Eur Heart J 2013; 38(14): 883-887.
29. Rebouche CJ., Kinetics, Pharmacokinetics, and Regulation of l-Carnitine and Acetyl-l-Carnitine Metabolism. Ann N Y Acad Sci 2004; 1033: 30-41.
30. Chester DNGJ, Ahuja JK, Moshfegh AJ., Dietary Intakes of Choline: What We Eat in America, NHANES 2007-2008. Food Surveys Research Group Dietary Data Brief No 9. Available at: http://ars.usda.gov/Services/docs.htm?docid=19476.; 2011.
31. Sanaie S, Ebrahimi-Mameghani M, Mahmoodpoor A, Shadvar K, Golzari SE., Effect of a probiotic preparation (VSL#3) on cardiovascularrisk parameters in critically-ill patients. J Cardiovasc Thoracic Res 2013; 5: 67-70.
32. Alisi A, Bedogni G, Baviera G, et al., Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis. Aliment Pharmacol Therap 2014; 39: 1276-1285.
33. Rehman A, Heinsen FA, Koenen ME, et al., Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine. BMC Microbiol 2012; 12: 47.
34. Mencarelli A, Distrutti E, Renga B, et al., Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. PloS One 2011; 6: e22978.
35. Clarke SF, Murphy EF, O'Sullivan O, et al., Targeting the microbiota to address diet-induced obesity: a time dependent challenge. PloS One 2013; 8: e65790.
36. Wang K-L, Cheng H-M, Chuang S-Y, et al., Central or peripheral systolic or pulse pressure: which best relates to target-organs and future mortality? J Hypertension 2009; 27: 461.
37. Roman MJ, Devereux RB, Kizer JR, et al., Central pressure more strongly relates to vascular disease and outcome than does brachial pressure the strong heart study. Hypertension 2007; 50: 197-203.
38. Vlachopoulos C, Aznaouridis K, O'Rourke MF, Safar ME, Baou K, Stefanadis C., Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J 2010; 31: 1865-1871.
39. Inaba Y, Chen JA, Bergmann SR., Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging 2010; 26: 631-640.