메뉴 건너뛰기




Volumn 68, Issue 2, 2005, Pages 383-392

Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; DNA; FLAVIN CONTAINING MONOOXYGENASE 3; FLAVINE ADENINE NUCLEOTIDE; GUANINE NUCLEOTIDE; LUCIFERASE; PYRIMIDINE NUCLEOTIDE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

EID: 23044469807     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.012062     Document Type: Article
Times cited : (67)

References (40)
  • 1
    • 0033008190 scopus 로고    scopus 로고
    • Sequence variations in the flavin-containing monooxygenase 3 gene (FMO3) in fish odour syndrome
    • Basarab T, Ashton GHS, Menage HD, and McGrath JA (1999) Sequence variations in the flavin-containing monooxygenase 3 gene (FMO3) in fish odour syndrome. Br J Dermatol 140:164-167.
    • (1999) Br J Dermatol , vol.140 , pp. 164-167
    • Basarab, T.1    Ashton, G.H.S.2    Menage, H.D.3    McGrath, J.A.4
  • 2
    • 0027171481 scopus 로고
    • Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene
    • Boucher PD, Ruch RJ, and Hines RN (1993) Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene. J Biol Chem 268:17384-17391.
    • (1993) J Biol Chem , vol.268 , pp. 17384-17391
    • Boucher, P.D.1    Ruch, R.J.2    Hines, R.N.3
  • 3
    • 0036265797 scopus 로고    scopus 로고
    • Human flavin-containing monooxygenase (form 3): Polymorphisms and variations in chemical metabolism
    • Cashman JR (2002) Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism. Pharmacogenomics 3:325-339.
    • (2002) Pharmacogenomics , vol.3 , pp. 325-339
    • Cashman, J.R.1
  • 4
    • 2942530688 scopus 로고    scopus 로고
    • The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development
    • Cashman JR (2004) The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development. Drug Discov Today 9:574-581.
    • (2004) Drug Discov Today , vol.9 , pp. 574-581
    • Cashman, J.R.1
  • 5
    • 0030791881 scopus 로고    scopus 로고
    • Human flavin-containing monooxygenase form 3: CDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria
    • Cashman JR, Bi YA, Lin J, Youil R, Knight M, Forrest S, and Treacy E (1997) Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria. Chem Res Toxicol 10:837-841.
    • (1997) Chem Res Toxicol , vol.10 , pp. 837-841
    • Cashman, J.R.1    Bi, Y.A.2    Lin, J.3    Youil, R.4    Knight, M.5    Forrest, S.6    Treacy, E.7
  • 6
    • 0032429154 scopus 로고    scopus 로고
    • A DNA polymorphism discovery resource for research on human genetic variation
    • Collins FS, Brooks LD, and Chakravarti A (1998) A DNA polymorphism discovery resource for research on human genetic variation. Genome Res 8:1229-1231.
    • (1998) Genome Res , vol.8 , pp. 1229-1231
    • Collins, F.S.1    Brooks, L.D.2    Chakravarti, A.3
  • 7
    • 0034523352 scopus 로고    scopus 로고
    • Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FMO3) gene in patients with fish-odour syndrome
    • Dolphin CT, Janmohamed A, Smith RL, Shephard EA, and Phillips IR (2000) Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FMO3) gene in patients with fish-odour syndrome. Pharmacogenetics 10:799-807.
    • (2000) Pharmacogenetics , vol.10 , pp. 799-807
    • Dolphin, C.T.1    Janmohamed, A.2    Smith, R.L.3    Shephard, E.A.4    Phillips, I.R.5
  • 8
    • 0037047644 scopus 로고    scopus 로고
    • Predictive identification of exonic splicing enhancers in human genes
    • Fairbrother WG, Yeh R-F, Sharp PA, and Burge CB (2002) Predictive identification of exonic splicing enhancers in human genes. Science (Wash DC) 297:1007-1013.
    • (2002) Science (Wash DC) , vol.297 , pp. 1007-1013
    • Fairbrother, W.G.1    Yeh, R.-F.2    Sharp, P.A.3    Burge, C.B.4
  • 9
    • 0035104259 scopus 로고    scopus 로고
    • A novel deletion in the flavin-containing monooxygenase gene (FMO3) in a Greek patient with trimethylaminuria
    • Forrest SM, Knight M, Akerman BR, Cashman JR, and Treacy EP (2001) A novel deletion in the flavin-containing monooxygenase gene (FMO3) in a Greek patient with trimethylaminuria. Pharmacogenetics 11:169-174.
    • (2001) Pharmacogenetics , vol.11 , pp. 169-174
    • Forrest, S.M.1    Knight, M.2    Akerman, B.R.3    Cashman, J.R.4    Treacy, E.P.5
  • 10
    • 0017873321 scopus 로고
    • Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins
    • Garnier J, Osguthorpe DJ, and Robson B (1978) Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol 120:97-120.
    • (1978) J Mol Biol , vol.120 , pp. 97-120
    • Garnier, J.1    Osguthorpe, D.J.2    Robson, B.3
  • 11
    • 1342309263 scopus 로고    scopus 로고
    • Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: Identification of novel gene and pseudogene clusters
    • Hernandez D, Janmohamed A, Chandan P, Phillips IR, and Shephard EA (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. Pharmacogenetics 14:117-130.
    • (2004) Pharmacogenetics , vol.14 , pp. 117-130
    • Hernandez, D.1    Janmohamed, A.2    Chandan, P.3    Phillips, I.R.4    Shephard, E.A.5
  • 12
    • 0036076899 scopus 로고    scopus 로고
    • Alternative processing of the human hepatic FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase
    • Hines RN, Hopp KA, Franco J, Saeian K, and Begun FP (2002) Alternative processing of the human hepatic FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase. Mol Pharmacol 62:320-325.
    • (2002) Mol Pharmacol , vol.62 , pp. 320-325
    • Hines, R.N.1    Hopp, K.A.2    Franco, J.3    Saeian, K.4    Begun, F.P.5
  • 15
    • 0036157094 scopus 로고    scopus 로고
    • Human hepatic flavin-containing monooxygenase 1 (FMO1) and 3 (FMO3) developmental expression
    • Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, and Hines RN (2002) Human hepatic flavin-containing monooxygenase 1 (FMO1) and 3 (FMO3) developmental expression. Pediatric Res 51:236-243.
    • (2002) Pediatric Res , vol.51 , pp. 236-243
    • Koukouritaki, S.B.1    Simpson, P.2    Yeung, C.K.3    Rettie, A.E.4    Hines, R.N.5
  • 16
    • 19444375492 scopus 로고    scopus 로고
    • Mammalian flavin-containing monooxygenases: Structure/function, genetic polymorphisms and role in drug metabolism
    • Krueger SK and Williams DE (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther 106:357-387.
    • (2005) Pharmacol Ther , vol.106 , pp. 357-387
    • Krueger, S.K.1    Williams, D.E.2
  • 17
    • 0020475449 scopus 로고
    • A simple method for displaying the hydropathic character of a protein
    • Kyte J and Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157:105-132.
    • (1982) J Mol Biol , vol.157 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2
  • 18
    • 2442642701 scopus 로고    scopus 로고
    • Alternative processing events in human FMO genes
    • Lattard V, Zhang J, and Cashman JR (2004) Alternative processing events in human FMO genes. Mol Pharmacol 65:1517-1525.
    • (2004) Mol Pharmacol , vol.65 , pp. 1517-1525
    • Lattard, V.1    Zhang, J.2    Cashman, J.R.3
  • 19
    • 0037974644 scopus 로고    scopus 로고
    • Two new polymorphisms of the fmo3 gene in Caucasian and African-American populations: Comparative genetic and functional studies
    • Lattard V, Zhang J, Tran Q, Furnes B, Schlenk D, and Cashman JR (2003) Two new polymorphisms of the fmo3 gene in Caucasian and African-American populations: comparative genetic and functional studies. Drug Metab Dispos 31:854-860.
    • (2003) Drug Metab Dispos , vol.31 , pp. 854-860
    • Lattard, V.1    Zhang, J.2    Tran, Q.3    Furnes, B.4    Schlenk, D.5    Cashman, J.R.6
  • 21
    • 0033963336 scopus 로고    scopus 로고
    • Exonic splicing enhancer motif recognized by human SC35 under splicing conditions
    • Liu H-X, Chew SL, Cartegni L, Zhang MQ, and Krainer AR (2000) Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol 20:1063-1071.
    • (2000) Mol Cell Biol , vol.20 , pp. 1063-1071
    • Liu, H.-X.1    Chew, S.L.2    Cartegni, L.3    Zhang, M.Q.4    Krainer, A.R.5
  • 22
    • 0032128255 scopus 로고    scopus 로고
    • Identification of functional exonic splicing enhancer motifs recognized by individual sr proteins
    • Liu H-X, Zhang M, and Krainer AR (1998) Identification of functional exonic splicing enhancer motifs recognized by individual sr proteins. Genes Dev 12:1998-2012.
    • (1998) Genes Dev , vol.12 , pp. 1998-2012
    • Liu, H.-X.1    Zhang, M.2    Krainer, A.R.3
  • 24
    • 0031456078 scopus 로고    scopus 로고
    • Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans
    • McCarver DG, Thomasson H, Martier SS, Sokol RJ, and Li T-K (1997) Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans. J Pharmacol Exp Ther 283:1095-1101.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1095-1101
    • McCarver, D.G.1    Thomasson, H.2    Martier, S.S.3    Sokol, R.J.4    Li, T.-K.5
  • 25
    • 0030833164 scopus 로고    scopus 로고
    • Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans
    • Overby LH, Carver GC, and Philpot RM (1997) Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. Chem Biol Interact 106:29-45.
    • (1997) Chem Biol Interact , vol.106 , pp. 29-45
    • Overby, L.H.1    Carver, G.C.2    Philpot, R.M.3
  • 26
    • 0036152701 scopus 로고    scopus 로고
    • Ethnic differences in allelic frequency for two flavincontaining monooxygenase 3 (FMO3) polymorphisms: Linkage and effects on in vivo and in vitro FMO activities
    • Park C-S, Kang J-H, Chung W-G, Yi H-G, Pie J-E, Park D-K, Hines RN, McCarver DG, and Cha Y-N (2002) Ethnic differences in allelic frequency for two flavincontaining monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities. Pharmacogenetics 12:77-80.
    • (2002) Pharmacogenetics , vol.12 , pp. 77-80
    • Park, C.-S.1    Kang, J.-H.2    Chung, W.-G.3    Yi, H.-G.4    Pie, J.-E.5    Park, D.-K.6    Hines, R.N.7    McCarver, D.G.8    Cha, Y.-N.9
  • 27
    • 7444235907 scopus 로고    scopus 로고
    • cis-Acting regulatory variation in the human genome
    • Pastinen T and Hudson TJ (2004) cis-Acting regulatory variation in the human genome. Science (Wash DC) 306:647-650.
    • (2004) Science (Wash DC) , vol.306 , pp. 647-650
    • Pastinen, T.1    Hudson, T.J.2
  • 28
    • 0031880376 scopus 로고    scopus 로고
    • Information analysis of human splice site mutations
    • Rogan PK, Faux BM, and Schneider TD (1998) Information analysis of human splice site mutations. Hum Mutat 12:153-171.
    • (1998) Hum Mutat , vol.12 , pp. 153-171
    • Rogan, P.K.1    Faux, B.M.2    Schneider, T.D.3
  • 29
    • 0038070292 scopus 로고    scopus 로고
    • Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations
    • Rogan PK, Svojanovsky S, and Leeder JS (2003) Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations. Pharmacogenetics 13:1-12.
    • (2003) Pharmacogenetics , vol.13 , pp. 1-12
    • Rogan, P.K.1    Svojanovsky, S.2    Leeder, J.S.3
  • 31
    • 0242691208 scopus 로고    scopus 로고
    • A comparison of Bayesian methods for haplotype reconstruction from population genotype data
    • Stephens M and Donnelly P (2003) A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169.
    • (2003) Am J Hum Genet , vol.73 , pp. 1162-1169
    • Stephens, M.1    Donnelly, P.2
  • 32
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens M, Smith NJ, and Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989.
    • (2001) Am J Hum Genet , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 36
    • 0033844080 scopus 로고    scopus 로고
    • Immunoquantitation of FMO1 in human liver, kidney and intestine
    • Yeung CK, Lang DH, Thummel KE, and Rettie AE (2000) Immunoquantitation of FMO1 in human liver, kidney and intestine. Drug Metab Dispos 28:1107-1111.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1107-1111
    • Yeung, C.K.1    Lang, D.H.2    Thummel, K.E.3    Rettie, A.E.4
  • 37
    • 0036897469 scopus 로고    scopus 로고
    • Expression, purification, biochemical characterization and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic forms
    • Yu A, Kneller BM, Rettie AE, and Haining RL (2002) Expression, purification, biochemical characterization and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic forms. J Pharmacol Exp Ther 303:1291-1300.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1291-1300
    • Yu, A.1    Kneller, B.M.2    Rettie, A.E.3    Haining, R.L.4
  • 39
    • 0036036854 scopus 로고    scopus 로고
    • An overview of the mechanism, substrate specificities and structure of FMOs
    • Ziegler DM (2002) An overview of the mechanism, substrate specificities and structure of FMOs. Drug Metab Rev 34:503-511.
    • (2002) Drug Metab Rev , vol.34 , pp. 503-511
    • Ziegler, D.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.