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Volumn 23, Issue 4, 2017, Pages 362-374

Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease

Author keywords

inflammatory bowel disease; receptor modulators; small molecules; sphingosine 1 phosphate; therapy

Indexed keywords

AMISELIMOD; ETRASIMOD; LYASE; OZANIMOD; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; INDAN DERIVATIVE; LYSOPHOSPHOLIPID; MOLECULAR LIBRARY; OXADIAZOLE DERIVATIVE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

EID: 85014671116     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2017.02.002     Document Type: Review
Times cited : (61)

References (115)
  • 1
    • 84943246777 scopus 로고    scopus 로고
    • Diagnostic and prognostic microbial biomarkers in inflammatory bowel diseases
    • 1 Dubinsky, M., Braun, J., Diagnostic and prognostic microbial biomarkers in inflammatory bowel diseases. Gastroenterology 149 (2015), 1265–1274.
    • (2015) Gastroenterology , vol.149 , pp. 1265-1274
    • Dubinsky, M.1    Braun, J.2
  • 2
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel disease: current status and the future ahead
    • 2 Kostic, A.D., et al. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146 (2014), 1489–1499.
    • (2014) Gastroenterology , vol.146 , pp. 1489-1499
    • Kostic, A.D.1
  • 3
    • 80455140368 scopus 로고    scopus 로고
    • Ulcerative colitis
    • 3 Danese, S., Fiocchi, C., Ulcerative colitis. N. Engl. J. Med. 365 (2011), 1713–1725.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1713-1725
    • Danese, S.1    Fiocchi, C.2
  • 4
    • 84868212109 scopus 로고    scopus 로고
    • Crohn's disease
    • 4 Baumgart, D.C., Sandborn, W.J., Crohn's disease. Lancet 380 (2012), 1590–1605.
    • (2012) Lancet , vol.380 , pp. 1590-1605
    • Baumgart, D.C.1    Sandborn, W.J.2
  • 5
    • 84952700582 scopus 로고    scopus 로고
    • The changing landscape of inflammatory bowel disease: East meets West
    • 5 Kaplan, G.G., Jess, T., The changing landscape of inflammatory bowel disease: East meets West. Gastroenterology 150 (2016), 24–26.
    • (2016) Gastroenterology , vol.150 , pp. 24-26
    • Kaplan, G.G.1    Jess, T.2
  • 6
    • 83755219473 scopus 로고    scopus 로고
    • Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    • 6 Molodecky, N.A., et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142 (2012), 46–54.
    • (2012) Gastroenterology , vol.142 , pp. 46-54
    • Molodecky, N.A.1
  • 7
    • 77953105781 scopus 로고    scopus 로고
    • Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management
    • 7 Larsen, S., et al. Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Ann. Med. 42 (2010), 97–114.
    • (2010) Ann. Med. , vol.42 , pp. 97-114
    • Larsen, S.1
  • 8
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • 8 Abraham, C., Cho, J.H., Inflammatory bowel disease. N. Engl. J. Med. 361 (2009), 2066–2078.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 10
    • 84927139183 scopus 로고    scopus 로고
    • Cancers complicating inflammatory bowel disease
    • 10 Beaugerie, L., Itzkowitz, S.H., Cancers complicating inflammatory bowel disease. N. Engl. J. Med. 372 (2015), 1441–1452.
    • (2015) N. Engl. J. Med. , vol.372 , pp. 1441-1452
    • Beaugerie, L.1    Itzkowitz, S.H.2
  • 11
    • 79953777773 scopus 로고    scopus 로고
    • Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis
    • 11 Ford, A.C., et al. Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis. Am. J. Gastroenterol. 106 (2011), 590–599.
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 590-599
    • Ford, A.C.1
  • 13
    • 84921327156 scopus 로고    scopus 로고
    • The role and advances of immunomodulator therapy for inflammatory bowel disease
    • 13 Nielsen, O.H., et al. The role and advances of immunomodulator therapy for inflammatory bowel disease. Expert. Rev. Gastroenterol. Hepatol. 9 (2015), 177–189.
    • (2015) Expert. Rev. Gastroenterol. Hepatol. , vol.9 , pp. 177-189
    • Nielsen, O.H.1
  • 14
    • 84882762733 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibitors for inflammatory bowel disease
    • 14 Nielsen, O.H., Ainsworth, M.A., Tumor necrosis factor inhibitors for inflammatory bowel disease. N. Engl. J. Med. 369 (2013), 754–762.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 754-762
    • Nielsen, O.H.1    Ainsworth, M.A.2
  • 15
    • 85007487754 scopus 로고    scopus 로고
    • Novel targeted therapies for inflammatory bowel disease
    • 15 Coskun, M., et al. Novel targeted therapies for inflammatory bowel disease. Trends Pharmacol. Sci. 38 (2017), 127–142.
    • (2017) Trends Pharmacol. Sci. , vol.38 , pp. 127-142
    • Coskun, M.1
  • 16
    • 84940890255 scopus 로고    scopus 로고
    • Biologic agents for IBD: practical insights
    • 16 Danese, S., et al. Biologic agents for IBD: practical insights. Nat. Rev. Gastroenterol. Hepatol. 12 (2015), 537–545.
    • (2015) Nat. Rev. Gastroenterol. Hepatol. , vol.12 , pp. 537-545
    • Danese, S.1
  • 17
    • 84959543785 scopus 로고    scopus 로고
    • Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases
    • 17 Olesen, C.M., et al. Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases. Pharmacol. Ther. 159 (2016), 110–119.
    • (2016) Pharmacol. Ther. , vol.159 , pp. 110-119
    • Olesen, C.M.1
  • 18
    • 84962730998 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire
    • 18 Suh, J.H., Saba, J.D., Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire. Transl. Cancer Res. 4 (2015), 469–483.
    • (2015) Transl. Cancer Res. , vol.4 , pp. 469-483
    • Suh, J.H.1    Saba, J.D.2
  • 19
    • 85016350979 scopus 로고    scopus 로고
    • Effect of a therapeutic sphingosine 1-phosphate antibody on intratumoral hypoxia and standard chemotherapy in a preclinical model of prostate cancer
    • 19 Cuvillier, O., et al. Effect of a therapeutic sphingosine 1-phosphate antibody on intratumoral hypoxia and standard chemotherapy in a preclinical model of prostate cancer. J. Clin. Oncol., 30, 2012, 223.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 223
    • Cuvillier, O.1
  • 20
    • 84927648765 scopus 로고    scopus 로고
    • Anti-S1P antibody as a novel therapeutic strategy for VEGFR TKI-resistant renal cancer
    • 20 Zhang, L., et al. Anti-S1P antibody as a novel therapeutic strategy for VEGFR TKI-resistant renal cancer. Clin. Cancer Res. 21 (2015), 1925–1934.
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1925-1934
    • Zhang, L.1
  • 21
    • 79951981180 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration
    • 21 Sabbadini, R.A., Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. Br. J. Pharmacol. 162 (2011), 1225–1238.
    • (2011) Br. J. Pharmacol. , vol.162 , pp. 1225-1238
    • Sabbadini, R.A.1
  • 22
    • 84961199748 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013–2015)
    • 22 Guerrero, M., et al. Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013–2015). Expert. Opin. Ther. Pat. 26 (2016), 455–470.
    • (2016) Expert. Opin. Ther. Pat. , vol.26 , pp. 455-470
    • Guerrero, M.1
  • 23
    • 84999280602 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate receptor: a novel therapeutic target for multiple sclerosis and other autoimmune diseases
    • 23 Mao-Draayer, Y., et al. The sphingosine-1-phosphate receptor: a novel therapeutic target for multiple sclerosis and other autoimmune diseases. Clin. Immunol. 175 (2016), 10–15.
    • (2016) Clin. Immunol. , vol.175 , pp. 10-15
    • Mao-Draayer, Y.1
  • 24
    • 84926293921 scopus 로고    scopus 로고
    • Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
    • 24 Proia, R.L., Hla, T., Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J. Clin. Invest. 125 (2015), 1379–1387.
    • (2015) J. Clin. Invest. , vol.125 , pp. 1379-1387
    • Proia, R.L.1    Hla, T.2
  • 25
    • 0032976314 scopus 로고    scopus 로고
    • Sphingolipids in food and the emerging importance of sphingolipids to nutrition
    • 25 Vesper, H., et al. Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr. 129 (1999), 1239–1250.
    • (1999) J. Nutr. , vol.129 , pp. 1239-1250
    • Vesper, H.1
  • 26
    • 84955474254 scopus 로고    scopus 로고
    • Fostering inflammatory bowel disease: sphingolipid strategies to join forces
    • 26 Abdel Hadi, L., et al. Fostering inflammatory bowel disease: sphingolipid strategies to join forces. Mediators Inflamm., 2016, 2016, 3827684.
    • (2016) Mediators Inflamm. , vol.2016 , pp. 3827684
    • Abdel Hadi, L.1
  • 27
    • 78049518892 scopus 로고    scopus 로고
    • An overview of sphingolipid metabolism: from synthesis to breakdown
    • 27 Gault, C.R., et al. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv. Exp. Med Biol. 688 (2010), 1–23.
    • (2010) Adv. Exp. Med Biol. , vol.688 , pp. 1-23
    • Gault, C.R.1
  • 28
    • 84980009964 scopus 로고    scopus 로고
    • Therapeutic strategies and pharmacological tools influencing S1P signaling and metabolism
    • 28 Vogt, D., Stark, H., Therapeutic strategies and pharmacological tools influencing S1P signaling and metabolism. Med. Res. Rev. 37 (2017), 3–51.
    • (2017) Med. Res. Rev. , vol.37 , pp. 3-51
    • Vogt, D.1    Stark, H.2
  • 29
    • 0034733556 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
    • 29 Liu, H., et al. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem. 275 (2000), 19513–19520.
    • (2000) J. Biol. Chem. , vol.275 , pp. 19513-19520
    • Liu, H.1
  • 30
    • 0142091073 scopus 로고    scopus 로고
    • Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
    • 30 Igarashi, N., et al. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J. Biol. Chem. 278 (2003), 46832–46839.
    • (2003) J. Biol. Chem. , vol.278 , pp. 46832-46839
    • Igarashi, N.1
  • 31
    • 0142105397 scopus 로고    scopus 로고
    • Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
    • 31 Pitson, S.M., et al. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J. 22 (2003), 5491–5500.
    • (2003) EMBO J. , vol.22 , pp. 5491-5500
    • Pitson, S.M.1
  • 32
    • 34247379074 scopus 로고    scopus 로고
    • Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    • 32 Pappu, R., et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316 (2007), 295–298.
    • (2007) Science , vol.316 , pp. 295-298
    • Pappu, R.1
  • 33
    • 0035023404 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphatases
    • 33 Mandala, S.M., Sphingosine-1-phosphate phosphatases. Prostaglandins 64 (2001), 143–156.
    • (2001) Prostaglandins , vol.64 , pp. 143-156
    • Mandala, S.M.1
  • 34
    • 84901936622 scopus 로고    scopus 로고
    • Sphingolipid metabolites in inflammatory disease
    • 34 Maceyka, M., Spiegel, S., Sphingolipid metabolites in inflammatory disease. Nature 510 (2014), 58–67.
    • (2014) Nature , vol.510 , pp. 58-67
    • Maceyka, M.1    Spiegel, S.2
  • 35
    • 78049502852 scopus 로고    scopus 로고
    • Extracellular and intracellular actions of sphingosine-1-phosphate
    • 35 Strub, G.M., et al. Extracellular and intracellular actions of sphingosine-1-phosphate. Adv. Exp. Med. Biol. 688 (2010), 141–155.
    • (2010) Adv. Exp. Med. Biol. , vol.688 , pp. 141-155
    • Strub, G.M.1
  • 36
    • 84903632868 scopus 로고    scopus 로고
    • S1pping fire: sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer
    • 36 Degagne, E., Saba, J.D., S1pping fire: sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. Clin. Exp. Gastroenterol. 7 (2014), 205–214.
    • (2014) Clin. Exp. Gastroenterol. , vol.7 , pp. 205-214
    • Degagne, E.1    Saba, J.D.2
  • 37
    • 84861003638 scopus 로고    scopus 로고
    • Truth and consequences of sphingosine-1-phosphate lyase
    • 37 Aguilar, A., Saba, J.D., Truth and consequences of sphingosine-1-phosphate lyase. Adv. Biol. Regul. 52 (2012), 17–30.
    • (2012) Adv. Biol. Regul. , vol.52 , pp. 17-30
    • Aguilar, A.1    Saba, J.D.2
  • 38
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • 38 Schwab, S.R., et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309 (2005), 1735–1739.
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1
  • 39
    • 0037256412 scopus 로고    scopus 로고
    • 6 plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants
    • 6 plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Am. J. Gastroenterol. 98 (2003), 112–117.
    • (2003) Am. J. Gastroenterol. , vol.98 , pp. 112-117
    • Saibeni, S.1
  • 40
    • 84887611937 scopus 로고    scopus 로고
    • −/− model of inflammatory bowel disease
    • −/− model of inflammatory bowel disease. J. Nutr. Biochem. 24 (2013), 2138–2143.
    • (2013) J. Nutr. Biochem. , vol.24 , pp. 2138-2143
    • Selhub, J.1
  • 41
    • 33751225686 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
    • 41 Oskouian, B., et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 17384–17389.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 17384-17389
    • Oskouian, B.1
  • 42
    • 33749185077 scopus 로고    scopus 로고
    • Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
    • 42 Kohno, M., et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol. Cell. Biol. 26 (2006), 7211–7223.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 7211-7223
    • Kohno, M.1
  • 43
    • 84867096429 scopus 로고    scopus 로고
    • Sphingolipid signaling in metabolic disorders
    • 43 Hla, T., Dannenberg, A.J., Sphingolipid signaling in metabolic disorders. Cell Metab. 16 (2012), 420–434.
    • (2012) Cell Metab. , vol.16 , pp. 420-434
    • Hla, T.1    Dannenberg, A.J.2
  • 44
    • 79957610938 scopus 로고    scopus 로고
    • The outs and the ins of sphingosine-1-phosphate in immunity
    • 44 Spiegel, S., Milstien, S., The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol. 11 (2011), 403–415.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 403-415
    • Spiegel, S.1    Milstien, S.2
  • 45
    • 77953790503 scopus 로고    scopus 로고
    • An update on sphingosine-1-phosphate and other sphingolipid mediators
    • 45 Fyrst, H., Saba, J.D., An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat. Chem. Biol. 6 (2010), 489–497.
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 489-497
    • Fyrst, H.1    Saba, J.D.2
  • 46
    • 84905003546 scopus 로고    scopus 로고
    • An update on the biology of sphingosine 1-phosphate receptors
    • 46 Blaho, V.A., Hla, T., An update on the biology of sphingosine 1-phosphate receptors. J. Lipid Res. 55 (2014), 1596–1608.
    • (2014) J. Lipid Res. , vol.55 , pp. 1596-1608
    • Blaho, V.A.1    Hla, T.2
  • 47
    • 34250832664 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology
    • 47 Brinkmann, V., Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol. Ther. 115 (2007), 84–105.
    • (2007) Pharmacol. Ther. , vol.115 , pp. 84-105
    • Brinkmann, V.1
  • 48
    • 84896546877 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity
    • 48 Simmons, S., Ishii, M., Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. Arch. Immunol. Ther. Exp. (Warsz.) 62 (2014), 103–115.
    • (2014) Arch. Immunol. Ther. Exp. (Warsz.) , vol.62 , pp. 103-115
    • Simmons, S.1    Ishii, M.2
  • 49
    • 12544253058 scopus 로고    scopus 로고
    • Structural and functional characteristics of S1P receptors
    • 49 Sanchez, T., Hla, T., Structural and functional characteristics of S1P receptors. J. Cell. Biochem. 92 (2004), 913–922.
    • (2004) J. Cell. Biochem. , vol.92 , pp. 913-922
    • Sanchez, T.1    Hla, T.2
  • 50
    • 84905858913 scopus 로고    scopus 로고
    • Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues
    • 50 Wang, C., et al. Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues. Exp. Mol. Pathol. 97 (2014), 259–265.
    • (2014) Exp. Mol. Pathol. , vol.97 , pp. 259-265
    • Wang, C.1
  • 51
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • 51 Matloubian, M., et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427 (2004), 355–360.
    • (2004) Nature , vol.427 , pp. 355-360
    • Matloubian, M.1
  • 52
    • 84859385704 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
    • 52 Cyster, J.G., Schwab, S.R., Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. Annu. Rev. Immunol. 30 (2012), 69–94.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 69-94
    • Cyster, J.G.1    Schwab, S.R.2
  • 53
    • 84868539338 scopus 로고    scopus 로고
    • Shaping the landscape: metabolic regulation of S1P gradients
    • 53 Olivera, A., et al. Shaping the landscape: metabolic regulation of S1P gradients. Biochim. Biophys. Acta 1831 (2013), 193–202.
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 193-202
    • Olivera, A.1
  • 54
    • 41449112571 scopus 로고    scopus 로고
    • Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    • 54 Venkataraman, K., et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ. Res. 102 (2008), 669–676.
    • (2008) Circ. Res. , vol.102 , pp. 669-676
    • Venkataraman, K.1
  • 55
    • 76149126108 scopus 로고    scopus 로고
    • Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    • 55 Pham, T.H., et al. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J. Exp. Med. 207 (2010), 17–27.
    • (2010) J. Exp. Med. , vol.207 , pp. 17-27
    • Pham, T.H.1
  • 56
    • 82455192466 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate
    • 56 Kharel, Y., et al. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. Biochem. J. 440 (2011), 345–353.
    • (2011) Biochem. J. , vol.440 , pp. 345-353
    • Kharel, Y.1
  • 57
    • 84949669661 scopus 로고    scopus 로고
    • Exit strategies: S1P signaling and T cell migration
    • 57 Baeyens, A., et al. Exit strategies: S1P signaling and T cell migration. Trends Immunol. 36 (2015), 778–787.
    • (2015) Trends Immunol. , vol.36 , pp. 778-787
    • Baeyens, A.1
  • 58
    • 37849033437 scopus 로고    scopus 로고
    • i-coupled receptors to promote T cell egress
    • i-coupled receptors to promote T cell egress. Immunity 28 (2008), 122–133.
    • (2008) Immunity , vol.28 , pp. 122-133
    • Pham, T.H.1
  • 59
    • 33645289121 scopus 로고    scopus 로고
    • CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    • 59 Shiow, L.R., et al. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440 (2006), 540–544.
    • (2006) Nature , vol.440 , pp. 540-544
    • Shiow, L.R.1
  • 60
    • 0018814072 scopus 로고
    • Lymphocyte traffic through lymph nodes during cell shutdown
    • 60 McConnell, I., et al. Lymphocyte traffic through lymph nodes during cell shutdown. Ciba Found. Symp. 71 (1980), 167–195.
    • (1980) Ciba Found. Symp. , vol.71 , pp. 167-195
    • McConnell, I.1
  • 61
    • 3242796768 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
    • 61 Cinamon, G., et al. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat. Immunol. 5 (2004), 713–720.
    • (2004) Nat. Immunol. , vol.5 , pp. 713-720
    • Cinamon, G.1
  • 62
    • 79151486083 scopus 로고    scopus 로고
    • Metabolism, migration and memory in cytotoxic T cells
    • 62 Finlay, D., Cantrell, D.A., Metabolism, migration and memory in cytotoxic T cells. Nat. Rev. Immunol. 11 (2011), 109–117.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 109-117
    • Finlay, D.1    Cantrell, D.A.2
  • 63
    • 58249117646 scopus 로고    scopus 로고
    • A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis
    • 63 Snider, A.J., et al. A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J. 23 (2009), 143–152.
    • (2009) FASEB J. , vol.23 , pp. 143-152
    • Snider, A.J.1
  • 64
    • 40849134419 scopus 로고    scopus 로고
    • Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase
    • 64 Maines, L.W., et al. Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig. Dis. Sci. 53 (2008), 997–1012.
    • (2008) Dig. Dis. Sci. , vol.53 , pp. 997-1012
    • Maines, L.W.1
  • 65
    • 77952236198 scopus 로고    scopus 로고
    • Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease
    • 65 Maines, L.W., et al. Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease. Inflammopharmacology 18 (2010), 73–85.
    • (2010) Inflammopharmacology , vol.18 , pp. 73-85
    • Maines, L.W.1
  • 66
    • 85011045343 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor-1 (S1P) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease
    • 66 Karuppuchamy, T., et al. Sphingosine-1-phosphate receptor-1 (S1P) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease. Mucosal Immunol. 10 (2017), 161–171.
    • (2017) Mucosal Immunol. , vol.10 , pp. 161-171
    • Karuppuchamy, T.1
  • 67
    • 79952684482 scopus 로고    scopus 로고
    • Physiological functions and clinical implications of sphingolipids in the gut
    • 67 Duan, R.D., Physiological functions and clinical implications of sphingolipids in the gut. J. Dig. Dis. 12 (2011), 60–70.
    • (2011) J. Dig. Dis. , vol.12 , pp. 60-70
    • Duan, R.D.1
  • 68
    • 84874064551 scopus 로고    scopus 로고
    • 1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity
    • 1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. J. Lipid Res. 54 (2013), 843–851.
    • (2013) J. Lipid Res. , vol.54 , pp. 843-851
    • Montrose, D.C.1
  • 69
    • 78651265495 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy
    • 69 Lepine, S., et al. Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death Differ. 18 (2011), 350–361.
    • (2011) Cell Death Differ. , vol.18 , pp. 350-361
    • Lepine, S.1
  • 70
    • 52949108813 scopus 로고    scopus 로고
    • The alliance of sphingosine-1-phosphate and its receptors in immunity
    • 70 Rivera, J., et al. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat. Rev. Immunol. 8 (2008), 753–763.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 753-763
    • Rivera, J.1
  • 71
    • 78649982367 scopus 로고    scopus 로고
    • STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
    • 71 Lee, H., et al. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat. Med. 16 (2010), 1421–1428.
    • (2010) Nat. Med. , vol.16 , pp. 1421-1428
    • Lee, H.1
  • 72
    • 84872406787 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
    • 72 Liang, J., et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 23 (2013), 107–120.
    • (2013) Cancer Cell , vol.23 , pp. 107-120
    • Liang, J.1
  • 73
    • 84856689575 scopus 로고    scopus 로고
    • Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis
    • 73 Naser, S.A., et al. Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis. World J. Gastroenterol. 18 (2012), 412–424.
    • (2012) World J. Gastroenterol. , vol.18 , pp. 412-424
    • Naser, S.A.1
  • 74
    • 77953923379 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    • 74 Alvarez, S.E., et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465 (2010), 1084–1088.
    • (2010) Nature , vol.465 , pp. 1084-1088
    • Alvarez, S.E.1
  • 75
    • 84883449877 scopus 로고    scopus 로고
    • Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond
    • 75 Salem, M., et al. Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond. Cell. Mol. Life Sci. 70 (2013), 3391–3404.
    • (2013) Cell. Mol. Life Sci. , vol.70 , pp. 3391-3404
    • Salem, M.1
  • 76
    • 84856249964 scopus 로고    scopus 로고
    • Fingolimod for multiple sclerosis
    • 76 Pelletier, D., Hafler, D.A., Fingolimod for multiple sclerosis. N. Engl. J. Med. 366 (2012), 339–347.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 339-347
    • Pelletier, D.1    Hafler, D.A.2
  • 77
    • 34247599871 scopus 로고    scopus 로고
    • FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions
    • 77 Daniel, C., et al. FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. Mol. Immunol. 44 (2007), 3305–3316.
    • (2007) Mol. Immunol. , vol.44 , pp. 3305-3316
    • Daniel, C.1
  • 78
    • 33846908988 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Immunol. 178 (2007), 2458–2468.
    • (2007) J. Immunol. , vol.178 , pp. 2458-2468
    • Daniel, C.1
  • 79
    • 35748943897 scopus 로고    scopus 로고
    • The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice
    • 79 Deguchi, Y., et al. The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice. Oncol. Rep. 16 (2006), 699–703.
    • (2006) Oncol. Rep. , vol.16 , pp. 699-703
    • Deguchi, Y.1
  • 80
    • 2442422272 scopus 로고    scopus 로고
    • Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis
    • 80 Mizushima, T., et al. Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflamm. Bowel. Dis. 10 (2004), 182–192.
    • (2004) Inflamm. Bowel. Dis. , vol.10 , pp. 182-192
    • Mizushima, T.1
  • 81
    • 70249131137 scopus 로고    scopus 로고
    • Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells
    • 81 Cucak, H., et al. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31 (2009), 491–501.
    • (2009) Immunity , vol.31 , pp. 491-501
    • Cucak, H.1
  • 82
    • 84908323531 scopus 로고    scopus 로고
    • Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications
    • 82 Camm, J., et al. Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. Am. Heart J. 168 (2014), 632–644.
    • (2014) Am. Heart J. , vol.168 , pp. 632-644
    • Camm, J.1
  • 83
    • 84872352059 scopus 로고    scopus 로고
    • Prolonged and symptomatic bradycardia following a single dose of fingolimod
    • 83 Faber, H., et al. Prolonged and symptomatic bradycardia following a single dose of fingolimod. Mult. Scler. 19 (2013), 126–128.
    • (2013) Mult. Scler. , vol.19 , pp. 126-128
    • Faber, H.1
  • 84
    • 80655128161 scopus 로고    scopus 로고
    • Delayed fingolimod-associated asystole
    • 84 Espinosa, P.S., Berger, J.R., Delayed fingolimod-associated asystole. Mult. Scler. 17 (2011), 1387–1389.
    • (2011) Mult. Scler. , vol.17 , pp. 1387-1389
    • Espinosa, P.S.1    Berger, J.R.2
  • 85
    • 84968903266 scopus 로고    scopus 로고
    • Ozanimod induction and maintenance treatment for ulcerative colitis
    • 85 Sandborn, W.J., et al. Ozanimod induction and maintenance treatment for ulcerative colitis. N. Engl. J. Med. 374 (2016), 1754–1762.
    • (2016) N. Engl. J. Med. , vol.374 , pp. 1754-1762
    • Sandborn, W.J.1
  • 86
    • 84960483909 scopus 로고    scopus 로고
    • Safety and efficacy of the selective sphingosine 1-phosphate receptor modulator ozanimod in relapsing multiple sclerosis (RADIANCE): a randomised, placebo-controlled, Phase 2 trial
    • 86 Cohen, J.A., et al. Safety and efficacy of the selective sphingosine 1-phosphate receptor modulator ozanimod in relapsing multiple sclerosis (RADIANCE): a randomised, placebo-controlled, Phase 2 trial. Lancet Neurol. 15 (2016), 373–381.
    • (2016) Lancet Neurol. , vol.15 , pp. 373-381
    • Cohen, J.A.1
  • 87
    • 84966429005 scopus 로고    scopus 로고
    • 5) agonist with autoimmune disease-modifying activity
    • 5) agonist with autoimmune disease-modifying activity. Br. J. Pharmacol. 173 (2016), 1778–1792.
    • (2016) Br. J. Pharmacol. , vol.173 , pp. 1778-1792
    • Scott, F.L.1
  • 88
    • 37349056751 scopus 로고    scopus 로고
    • A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice
    • 88 Song, J., et al. A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice. J. Pharmacol. Exp. Ther. 324 (2008), 276–283.
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , pp. 276-283
    • Song, J.1
  • 89
    • 84867319781 scopus 로고    scopus 로고
    • The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate
    • 89 Gergely, P., et al. The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate. Br. J. Pharmacol. 167 (2012), 1035–1047.
    • (2012) Br. J. Pharmacol. , vol.167 , pp. 1035-1047
    • Gergely, P.1
  • 90
    • 84914809927 scopus 로고    scopus 로고
    • S1P signaling: new therapies and opportunities
    • 90 Gonzalez-Cabrera, P.J., S1P signaling: new therapies and opportunities. F1000Prime Rep., 6, 2014, 109.
    • (2014) F1000Prime Rep. , vol.6 , pp. 109
    • Gonzalez-Cabrera, P.J.1
  • 91
    • 84918563892 scopus 로고    scopus 로고
    • Discovery of APD334: design of a clinical stage functional antagonist of the sphingosine-1-phosphate-1 receptor
    • 91 Buzard, D.J., et al. Discovery of APD334: design of a clinical stage functional antagonist of the sphingosine-1-phosphate-1 receptor. ACS Med. Chem. Lett. 5 (2014), 1313–1317.
    • (2014) ACS Med. Chem. Lett. , vol.5 , pp. 1313-1317
    • Buzard, D.J.1
  • 92
    • 84940606889 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor modulators in multiple sclerosis
    • 92 Subei, A.M., Cohen, J.A., Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS Drugs 29 (2015), 565–575.
    • (2015) CNS Drugs , vol.29 , pp. 565-575
    • Subei, A.M.1    Cohen, J.A.2
  • 93
    • 84959456101 scopus 로고    scopus 로고
    • Leukocyte trafficking to the small intestine and colon
    • 93 Habtezion, A., et al. Leukocyte trafficking to the small intestine and colon. Gastroenterology 150 (2016), 340–354.
    • (2016) Gastroenterology , vol.150 , pp. 340-354
    • Habtezion, A.1
  • 94
    • 78649740029 scopus 로고    scopus 로고
    • 4
    • 4. FASEB J. 24 (2010), 4701–4710.
    • (2010) FASEB J. , vol.24 , pp. 4701-4710
    • Golfier, S.1
  • 95
    • 0034799675 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    • 95 Garcia, J.G., et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J. Clin. Invest. 108 (2001), 689–701.
    • (2001) J. Clin. Invest. , vol.108 , pp. 689-701
    • Garcia, J.G.1
  • 96
    • 0033783522 scopus 로고    scopus 로고
    • Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    • 96 Liu, Y., et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106 (2000), 951–961.
    • (2000) J. Clin. Invest. , vol.106 , pp. 951-961
    • Liu, Y.1
  • 97
    • 11144353922 scopus 로고    scopus 로고
    • 3, respectively, regulate lymphocyte recirculation and heart rate
    • 3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279 (2004), 13839–13848.
    • (2004) J. Biol. Chem. , vol.279 , pp. 13839-13848
    • Sanna, M.G.1
  • 98
    • 84884650824 scopus 로고    scopus 로고
    • Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation
    • 98 Zhang, G., et al. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood 122 (2013), 443–455.
    • (2013) Blood , vol.122 , pp. 443-455
    • Zhang, G.1
  • 101
    • 77950231687 scopus 로고    scopus 로고
    • 3 receptor antagonist
    • 3 receptor antagonist. Mol. Pharmacol. 77 (2010), 704–713.
    • (2010) Mol. Pharmacol. , vol.77 , pp. 704-713
    • Murakami, A.1
  • 102
  • 104
    • 85016365810 scopus 로고    scopus 로고
    • 4 receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs
    • 4 receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs. Pulm. Circ. 1 (2011), 399–404.
    • (2011) Pulm. Circ. , vol.1 , pp. 399-404
    • Ota, H.1
  • 105
    • 67649185215 scopus 로고    scopus 로고
    • 1 overrides regulatory T cell-mediated immune suppression through Akt–mTOR
    • 1 overrides regulatory T cell-mediated immune suppression through Akt–mTOR. Nat. Immunol. 10 (2009), 769–777.
    • (2009) Nat. Immunol. , vol.10 , pp. 769-777
    • Liu, G.1
  • 106
    • 77958151145 scopus 로고    scopus 로고
    • reg cells
    • reg cells. Nat. Immunol. 11 (2010), 1047–1056.
    • (2010) Nat. Immunol. , vol.11 , pp. 1047-1056
    • Liu, G.1
  • 107
    • 84886721875 scopus 로고    scopus 로고
    • H17-mediated autoimmune neuroinflammation
    • H17-mediated autoimmune neuroinflammation. Nat. Immunol. 14 (2013), 1166–1172.
    • (2013) Nat. Immunol. , vol.14 , pp. 1166-1172
    • Garris, C.S.1
  • 108
    • 79959377393 scopus 로고    scopus 로고
    • 2 maintains the homeostasis of germinal center B cells and promotes niche confinement
    • 2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat. Immunol. 12 (2011), 672–680.
    • (2011) Nat. Immunol. , vol.12 , pp. 672-680
    • Green, J.A.1
  • 109
    • 84862908273 scopus 로고    scopus 로고
    • Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers
    • 109 Wang, X., et al. Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J. Exp. Med. 208 (2011), 2497–2510.
    • (2011) J. Exp. Med. , vol.208 , pp. 2497-2510
    • Wang, X.1
  • 110
    • 80355129639 scopus 로고    scopus 로고
    • H17-cell differentiation in a murine model
    • H17-cell differentiation in a murine model. FASEB J. 25 (2011), 4024–4036.
    • (2011) FASEB J. , vol.25 , pp. 4024-4036
    • Schulze, T.1
  • 111
    • 36248966560 scopus 로고    scopus 로고
    • Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    • 111 Walzer, T., et al. Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nat. Immunol. 8 (2007), 1337–1344.
    • (2007) Nat. Immunol. , vol.8 , pp. 1337-1344
    • Walzer, T.1
  • 112
    • 34247554847 scopus 로고    scopus 로고
    • 5 inhibits oligodendrocyte progenitor migration
    • 5 inhibits oligodendrocyte progenitor migration. FASEB J. 21 (2007), 1503–1514.
    • (2007) FASEB J. , vol.21 , pp. 1503-1514
    • Novgorodov, A.S.1
  • 113
    • 23844552403 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate mediates migration of mature dendritic cells
    • 113 Czeloth, N., et al. Sphingosine-1-phosphate mediates migration of mature dendritic cells. J. Immunol. 175 (2005), 2960–2967.
    • (2005) J. Immunol. , vol.175 , pp. 2960-2967
    • Czeloth, N.1
  • 114
    • 0036551246 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses
    • 114 Idzko, M., et al. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J. 16 (2002), 625–627.
    • (2002) FASEB J. , vol.16 , pp. 625-627
    • Idzko, M.1
  • 115
    • 77955358808 scopus 로고    scopus 로고
    • Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis
    • 115 Mehling, M., et al. Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis. Neurology 75 (2010), 403–410.
    • (2010) Neurology , vol.75 , pp. 403-410
    • Mehling, M.1


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