Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase

Digestive Diseases and Sciences

Volumn 53, Issue 4, 2008, Pages 997-1012

  Maines, Lynn W ^a   Fitzpatrick, Leo R ^b   French, Kevin J ^a   Zhuang, Yan ^a   Xia, Zuping ^a   Keller, Staci N ^a   Upson, John J ^a   Smith, Charles D ^a,b  

^a APOGEE BIOTECHNOLOGY CORPORATION   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Inflammatory bowel disease; Sphingosine kinase; TNF ; Ulcerative colitis

Indexed keywords

3 (4 CHLOROPHENYL)ADAMANTANE 1 CARBOXYLIC ACID(PYRIDIN 4 YLMETHYL)AMIDE; 4 (2 [4 (4 CHLOROPHENYL)THIAZOL 2 YLCARBAMOYL]VINYL) 2 METHOXYPHENYL ESTER; ABC 294640; ABC 747080; DEXTRAN SULFATE; ENZYME INHIBITOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; OLSALAZINE; PROSTAGLANDIN E2; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; SPHINGOSINE KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULCERATIVE COLITIS;

ADMINISTRATION, ORAL; ANIMALS; COLITIS, ULCERATIVE; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); TUMOR NECROSIS FACTOR-ALPHA;

EID: 40849134419     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-0133-6     Document Type: Article

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