메뉴 건너뛰기




Volumn 9, Issue 3, 2017, Pages

Fructose and NAFLD: The multifaceted aspects of fructose metabolism

Author keywords

Fructose; Gut; Liver; Muscle; Nonalcoholic fatty liver disease

Indexed keywords

1 PHOSPHOFRUCTOKINASE; ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID SYNTHASE; FRUCTOSE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE; GLUCOSE TRANSPORTER 2; GLYCEROL 3 PHOSPHATE DEHYDROGENASE (NAD); INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; REACTIVE OXYGEN METABOLITE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUCROSE; TOLL LIKE RECEPTOR 4; VERY LOW DENSITY LIPOPROTEIN; CARBOHYDRATE DIET;

EID: 85014528207     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9030230     Document Type: Review
Times cited : (223)

References (95)
  • 1
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen, J.C.; Horton, J.D.; Hobbs, H.H. Human fatty liver disease: Old questions and new insights. Science 2011, 332, 1519-1523.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 2
    • 84941259304 scopus 로고    scopus 로고
    • Prevalence and severity of nonalcoholic fatty liver disease in non-obese patients: A population study using proton-magnetic resonance spectroscopy
    • Wei, J.L.; Leung, J.C.-F.; Loong, T.C.-W.; Wong, G.L.-H.; Yeung, D.K.-W.; Chan, R.S.-M.; Chan, H.L.; Chim, A.M.; Woo, J.; Chu, W.C.; et al. Prevalence and severity of nonalcoholic fatty liver disease in non-obese patients: A population study using proton-magnetic resonance spectroscopy. Am. J. Gastroenterol. 2015, 110, 1306-1314.
    • (2015) Am. J. Gastroenterol , vol.110 , pp. 1306-1314
    • Wei, J.L.1    Leung, J.C.-F.2    Loong, T.C.-W.3    Wong, G.L.-H.4    Yeung, D.K.-W.5    Chan, R.S.-M.6    Chan, H.L.7    Chim, A.M.8    Woo, J.9    Chu, W.C.10
  • 5
    • 84950149794 scopus 로고    scopus 로고
    • Carbohydrate intake and nonalcoholic fatty liver disease:Fructose as a weapon of mass destruction
    • Basaranoglu, M.; Basaranoglu, G.; Bugianesi, E. Carbohydrate intake and nonalcoholic fatty liver disease:Fructose as a weapon of mass destruction. Hepatobiliary Surg. Nutr. 2015, 4, 109-116.
    • (2015) Hepatobiliary Surg. Nutr , vol.4 , pp. 109-116
    • Basaranoglu, M.1    Basaranoglu, G.2    Bugianesi, E.3
  • 6
    • 84897836624 scopus 로고    scopus 로고
    • Dietary sugar and body weight: Have we reached a crisis in the epidemic of obesity and diabetes?: Health be damned! Pour on the sugar
    • Bray, G.A.; Popkin, B.M. Dietary sugar and body weight: Have we reached a crisis in the epidemic of obesity and diabetes?: Health be damned! Pour on the sugar. Diabetes Care 2014, 37, 950-956.
    • (2014) Diabetes Care , vol.37 , pp. 950-956
    • Bray, G.A.1    Popkin, B.M.2
  • 7
    • 77952692915 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis Clinical Research Network. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    • Abdelmalek, M.F.; Suzuki, A.; Guy, C.; Unalp-Arida, A.; Colvin, R.; Johnson, R.J.; Diehl, A.M. Nonalcoholic Steatohepatitis Clinical Research Network. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 2010, 51, 1961-1971.
    • (2010) Hepatology , vol.51 , pp. 1961-1971
    • Abdelmalek, M.F.1    Suzuki, A.2    Guy, C.3    Unalp-Arida, A.4    Colvin, R.5    Johnson, R.J.6    Diehl, A.M.7
  • 9
    • 84946486687 scopus 로고    scopus 로고
    • Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time
    • Sellmann, C.; Priebs, J.; Landmann, M.; Degen, C.; Engstler, A.J.; Jin, C.J.; Gärttner, S.; Spruss, A.; Huber, O.; Bergheim, I. Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time. J. Nutr. Biochem. 2015, 26, 1183-1192.
    • (2015) J. Nutr. Biochem , vol.26 , pp. 1183-1192
    • Sellmann, C.1    Priebs, J.2    Landmann, M.3    Degen, C.4    Engstler, A.J.5    Jin, C.J.6    Gärttner, S.7    Spruss, A.8    Huber, O.9    Bergheim, I.10
  • 10
    • 84946544026 scopus 로고    scopus 로고
    • Nutritional modulation of non-alcoholic fatty liver disease and insulin resistance
    • Yki-Järvinen, H. Nutritional modulation of non-alcoholic fatty liver disease and insulin resistance. Nutrients 2015, 7, 9127-9138.
    • (2015) Nutrients , vol.7 , pp. 9127-9138
    • Yki-Järvinen, H.1
  • 11
    • 84991032538 scopus 로고    scopus 로고
    • Exercise-based interventions for nonalcoholic fatty liver disease: A meta-analysis and meta-regression
    • Orci, L.A.; Gariani, K.; Oldani, G.; Delaune, V.; Morel, P.; Toso, C. Exercise-based interventions for nonalcoholic fatty liver disease: A meta-analysis and meta-regression. Clin. Gastroenterol. Hepatol. 2016, 14, 1398-1411.
    • (2016) Clin. Gastroenterol. Hepatol , vol.14 , pp. 1398-1411
    • Orci, L.A.1    Gariani, K.2    Oldani, G.3    Delaune, V.4    Morel, P.5    Toso, C.6
  • 12
    • 84957706228 scopus 로고    scopus 로고
    • Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease
    • Softic, S.; Cohen, D.E.; Kahn, C.R. Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Dig. Dis. Sci. 2016, 61, 1282-1293.
    • (2016) Dig. Dis. Sci , vol.61 , pp. 1282-1293
    • Softic, S.1    Cohen, D.E.2    Kahn, C.R.3
  • 14
    • 77953292372 scopus 로고    scopus 로고
    • Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men
    • Sobrecases, H.; Lê, K.-A.; Bortolotti, M.; Schneiter, P.; Ith, M.; Kreis, R.; Boesch, C.; Tappy, L. Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men. Diabetes Metab. 2010, 36, 244-246.
    • (2010) Diabetes Metab , vol.36 , pp. 244-246
    • Sobrecases, H.1    Lê, K.-A.2    Bortolotti, M.3    Schneiter, P.4    Ith, M.5    Kreis, R.6    Boesch, C.7    Tappy, L.8
  • 16
    • 75149166672 scopus 로고    scopus 로고
    • Metabolic effects of fructose and the worldwide increase in obesity
    • Tappy, L.; Lê, K.-A. Metabolic effects of fructose and the worldwide increase in obesity. Physiol. Rev. 2010, 90, 23-46.
    • (2010) Physiol. Rev , vol.90 , pp. 23-46
    • Tappy, L.1    Lê, K.-A.2
  • 17
    • 84977079006 scopus 로고    scopus 로고
    • The sweet path to metabolic demise: Fructose and lipid synthesis
    • Herman, M.A.; Samuel, V.T. The sweet path to metabolic demise: Fructose and lipid synthesis. Trends Endocrinol. Metab. 2016, 27, 719-730.
    • (2016) Trends Endocrinol. Metab. , vol.27 , pp. 719-730
    • Herman, M.A.1    Samuel, V.T.2
  • 18
    • 84945207761 scopus 로고    scopus 로고
    • Citrulline and nonessential amino acids prevent fructose-induced nonalcoholic fatty liver disease in rats
    • Jegatheesan, P.; Beutheu, S.; Ventura, G.; Nubret, E.; Sarfati, G.; Bergheim, I.; De Bandt, J.P. Citrulline and nonessential amino acids prevent fructose-induced nonalcoholic fatty liver disease in rats. J. Nutr. 2015, 145, 2273-2279.
    • (2015) J. Nutr , vol.145 , pp. 2273-2279
    • Jegatheesan, P.1    Beutheu, S.2    Ventura, G.3    Nubret, E.4    Sarfati, G.5    Bergheim, I.6    De Bandt, J.P.7
  • 20
    • 84957990959 scopus 로고    scopus 로고
    • High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons
    • Mastrocola, R.; Nigro, D.; Cento, A.S.; Chiazza, F.; Collino, M.; Aragno, M. High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons. Neurobiol. Dis. 2016, 89, 65-75.
    • (2016) Neurobiol. Dis , vol.89 , pp. 65-75
    • Mastrocola, R.1    Nigro, D.2    Cento, A.S.3    Chiazza, F.4    Collino, M.5    Aragno, M.6
  • 22
  • 23
    • 84964299212 scopus 로고    scopus 로고
    • Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle
    • Madlala, H.P.; Maarman, G.J.; Ojuka, E. Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle. Nutr. Rev. 2016, 74, 259-266.
    • (2016) Nutr. Rev , vol.74 , pp. 259-266
    • Madlala, H.P.1    Maarman, G.J.2    Ojuka, E.3
  • 27
    • 85011990236 scopus 로고    scopus 로고
    • Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
    • Nigro, D.; Menotti, F.; Cento, A.S.; Serpe, L.; Chiazza, F.; dal Bello, F.; Romaniello, F.; Medana, C.; Collino, M.; Aragno, M.; et al. Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver. J. Nutr. Biochem. 2017, 42, 160-171.
    • (2017) J. Nutr. Biochem , vol.42 , pp. 160-171
    • Nigro, D.1    Menotti, F.2    Cento, A.S.3    Serpe, L.4    Chiazza, F.5    dal Bello, F.6    Romaniello, F.7    Medana, C.8    Collino, M.9    Aragno, M.10
  • 30
    • 84860483727 scopus 로고    scopus 로고
    • The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling
    • Fu, S.; Watkins, S.M.; Hotamisligil, G.S. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab. 2012, 15, 623-634.
    • (2012) Cell Metab , vol.15 , pp. 623-634
    • Fu, S.1    Watkins, S.M.2    Hotamisligil, G.S.3
  • 31
    • 33947532213 scopus 로고    scopus 로고
    • Unfolded protein response: Its role in physiology and physiopathology
    • Foufelle, F.; Ferré, P. Unfolded protein response: Its role in physiology and physiopathology. Med. Sci. (Paris) 2007, 23, 291-296.
    • (2007) Med. Sci. (Paris) , vol.23 , pp. 291-296
    • Foufelle, F.1    Ferré, P.2
  • 32
    • 84894234845 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
    • Zhang, X.-Q.; Xu, C.-F.; Yu, C.-H.; Chen, W.-X.; Li, Y.-M. Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. World J. Gastroenterol. 2014, 20, 1768-1776.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 1768-1776
    • Zhang, X.-Q.1    Xu, C.-F.2    Yu, C.-H.3    Chen, W.-X.4    Li, Y.-M.5
  • 33
    • 79952708723 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in liver disease
    • Malhi, H.; Kaufman, R.J. Endoplasmic reticulum stress in liver disease. J. Hepatol. 2011, 54, 795-809.
    • (2011) J. Hepatol. , vol.54 , pp. 795-809
    • Malhi, H.1    Kaufman, R.J.2
  • 34
    • 78349283092 scopus 로고    scopus 로고
    • Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
    • Dekker, M.J.; Su, Q.; Baker, C.; Rutledge, A.C.; Adeli, K. Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am. J. Physiol. Endocrinol. Metab. 2010, 299, E685-E694.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299 , pp. E685-E694
    • Dekker, M.J.1    Su, Q.2    Baker, C.3    Rutledge, A.C.4    Adeli, K.5
  • 36
    • 67349205002 scopus 로고    scopus 로고
    • Kupffer cells in non-alcoholic fatty liver disease: The emerging view
    • Baffy, G. Kupffer cells in non-alcoholic fatty liver disease: The emerging view. J. Hepatol. 2009, 51, 212-223.
    • (2009) J. Hepatol , vol.51 , pp. 212-223
    • Baffy, G.1
  • 37
    • 84919452312 scopus 로고    scopus 로고
    • Metabolic reprograming in macrophage polarization
    • Galván-Peña, S.; O’Neill, L.A.J. Metabolic reprograming in macrophage polarization. Front. Immunol. 2014, 5, 420.
    • (2014) Front. Immunol , vol.5 , pp. 420
    • Galván-Peña, S.1    O’Neill, L.A.J.2
  • 38
    • 26044451626 scopus 로고    scopus 로고
    • Pathological features of NASH
    • Brunt, E.M.; Tiniakos, D.G. Pathological features of NASH. Front. Biosci. 2005, 10, 1475-1484.
    • (2005) Front. Biosci. , vol.10 , pp. 1475-1484
    • Brunt, E.M.1    Tiniakos, D.G.2
  • 39
    • 84863103652 scopus 로고    scopus 로고
    • Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis
    • Ilan, Y. Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis. World J. Gastroenterol. 2012, 18, 2609-2618.
    • (2012) World J. Gastroenterol , vol.18 , pp. 2609-2618
    • Ilan, Y.1
  • 40
    • 84875549943 scopus 로고    scopus 로고
    • The role of hepatokines in metabolism
    • Stefan, N.; Häring, H.-U. The role of hepatokines in metabolism. Nat. Rev. Endocrinol. 2013, 9, 144-152.
    • (2013) Nat. Rev. Endocrinol , vol.9 , pp. 144-152
    • Stefan, N.1    Häring, H.-U.2
  • 41
    • 84937522427 scopus 로고    scopus 로고
    • Hepatokines: Unlocking the multi-organ network in metabolic diseases
    • Iroz, A.; Couty, J.-P.; Postic, C. Hepatokines: Unlocking the multi-organ network in metabolic diseases. Diabetologia 2015, 58, 1699-1703.
    • (2015) Diabetologia , vol.58 , pp. 1699-1703
    • Iroz, A.1    Couty, J.-P.2    Postic, C.3
  • 50
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer, M.; Roggel, F.; Gerbes, A.L. Role of Kupffer cells in host defense and liver disease. Liver Int. 2006, 26, 1175-1186.
    • (2006) Liver Int , vol.26 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 51
    • 84865297442 scopus 로고    scopus 로고
    • The inflammation highway: Metabolism accelerates inflammatory traffic in obesity
    • Johnson, A.R.; Milner, J.J.; Makowski, L. The inflammation highway: Metabolism accelerates inflammatory traffic in obesity. Immunol. Rev. 2012, 249, 218-238.
    • (2012) Immunol. Rev , vol.249 , pp. 218-238
    • Johnson, A.R.1    Milner, J.J.2    Makowski, L.3
  • 52
    • 84961792818 scopus 로고    scopus 로고
    • Physiological handling of dietary fructose-containing sugars: Implications for health
    • Campos VC, Tappy L. Physiological handling of dietary fructose-containing sugars: Implications for health. Int. J. Obes. (Lond.) 2016, 40, S6-S11.
    • (2016) Int. J. Obes. (Lond.) , vol.40 , pp. S6-S11
    • Campos, V.C.1    Tappy, L.2
  • 53
    • 66449093225 scopus 로고    scopus 로고
    • Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    • Stanhope, K.L.; Schwarz, J.M.; Keim, N.L.; Griffen, S.C.; Bremer, A.A.; Graham, J.L.; Hatcher, B.; Cox, C.L.; Dyachenko, A.; Zhang, W.; et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J. Clin. Investig. 2009, 119, 1322-1334.
    • (2009) J. Clin. Investig , vol.119 , pp. 1322-1334
    • Stanhope, K.L.1    Schwarz, J.M.2    Keim, N.L.3    Griffen, S.C.4    Bremer, A.A.5    Graham, J.L.6    Hatcher, B.7    Cox, C.L.8    Dyachenko, A.9    Zhang, W.10
  • 54
    • 85013936229 scopus 로고    scopus 로고
    • Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome
    • Alwahsh, S.M.; Dwyer, B.J.; Forbes, S.; van Thiel, D.H.; Lewis, P.J.S.; Ramadori, G. Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome. Int. J. Mol. Sci. 2017, 18, 285.
    • (2017) Int. J. Mol. Sci , vol.18 , pp. 285
    • Alwahsh, S.M.1    Dwyer, B.J.2    Forbes, S.3    van Thiel, D.H.4    Lewis, P.J.S.5    Ramadori, G.6
  • 55
    • 0015824038 scopus 로고
    • Effect of dietary fructose on fatty acid synthesis in adipose tissue and on triglyceride concentration in blood in the rat
    • Vrána, A.; Fábry, P.; Kazdová, L. Effect of dietary fructose on fatty acid synthesis in adipose tissue and on triglyceride concentration in blood in the rat. Nutr. Metab. 1973, 15, 305-313.
    • (1973) Nutr. Metab. , vol.15 , pp. 305-313
    • Vrána, A.1    Fábry, P.2    Kazdová, L.3
  • 56
    • 84882762779 scopus 로고    scopus 로고
    • Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2
    • Masterjohn, C.; Park, Y.; Lee, J.; Noh, S.K.; Koo, S.I.; Bruno, R.S. Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2. Nutrients 2013, 5, 3311-3328.
    • (2013) Nutrients , vol.5 , pp. 3311-3328
    • Masterjohn, C.1    Park, Y.2    Lee, J.3    Noh, S.K.4    Koo, S.I.5    Bruno, R.S.6
  • 57
    • 35548952654 scopus 로고    scopus 로고
    • Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats
    • Jia, X.; Wu, L. Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats. Mol. Cell. Biochem. 2007, 306, 133-139.
    • (2007) Mol. Cell. Biochem , vol.306 , pp. 133-139
    • Jia, X.1    Wu, L.2
  • 58
    • 84867007389 scopus 로고    scopus 로고
    • Regulation of adipose differentiation by fructose and GluT5
    • Du, L.; Heaney, A.P. Regulation of adipose differentiation by fructose and GluT5. Mol. Endocrinol. 2012, 26, 1773-1782.
    • (2012) Mol. Endocrinol , vol.26 , pp. 1773-1782
    • Du, L.1    Heaney, A.P.2
  • 59
    • 84881260646 scopus 로고    scopus 로고
    • Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: What do we really know?
    • Rippe, J.M.; Angelopoulos, T.J. Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: What do we really know? Adv. Nutr. 2013, 4, 236-245.
    • (2013) Adv. Nutr , vol.4 , pp. 236-245
    • Rippe, J.M.1    Angelopoulos, T.J.2
  • 62
    • 70649098452 scopus 로고    scopus 로고
    • Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats
    • Rieu, I.; Magne, H.; Savary-Auzeloux, I.; Averous, J., Bos, C., Peyron, M.A.; Combaret, L.; Dardevet, D. Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats. J. Physiol. (Lond.). 2009, 587, 5483-5492.
    • (2009) J. Physiol. (Lond.). , vol.587 , pp. 5483-5492
    • Rieu, I.1    Magne, H.2    Savary-Auzeloux, I.3    Averous, J.4    Bos, C.5    Peyron, M.A.6    Combaret, L.7    Dardevet, D.8
  • 65
    • 84929485304 scopus 로고    scopus 로고
    • Chronic intake of sucrose accelerates sarcopenia in older male rats through alterations in insulin sensitivity and muscle protein synthesis
    • Gatineau, E.; Savary-Auzeloux, I.; Migné, C.; Polakof, S.; Dardevet, D.; Mosoni, L. Chronic intake of sucrose accelerates sarcopenia in older male rats through alterations in insulin sensitivity and muscle protein synthesis. J. Nutr. 2015, 145, 923-930.
    • (2015) J. Nutr , vol.145 , pp. 923-930
    • Gatineau, E.1    Savary-Auzeloux, I.2    Migné, C.3    Polakof, S.4    Dardevet, D.5    Mosoni, L.6
  • 66
    • 84933524261 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men
    • Stephens, F.B.; Chee, C.; Wall, B.T.; Murton, A.J.; Shannon, C.E.; van Loon, L.J.C.; Tsintzas, K. Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men. Diabetes 2015, 64, 1615-1620.
    • (2015) Diabetes , vol.64 , pp. 1615-1620
    • Stephens, F.B.1    Chee, C.2    Wall, B.T.3    Murton, A.J.4    Shannon, C.E.5    van Loon, L.J.C.6    Tsintzas, K.7
  • 67
    • 84939897718 scopus 로고    scopus 로고
    • The effect of high-fat-High-fructose diet on skeletal muscle mitochondrial energetics in adult rats
    • Crescenzo, R.; Bianco, F.; Coppola, P.; Mazzoli, A.; Cigliano, L.; Liverini, G.; Iossa, S. The effect of high-fat-High-fructose diet on skeletal muscle mitochondrial energetics in adult rats. Eur. J. Nutr. 2015, 54, 183-192.
    • (2015) Eur. J. Nutr , vol.54 , pp. 183-192
    • Crescenzo, R.1    Bianco, F.2    Coppola, P.3    Mazzoli, A.4    Cigliano, L.5    Liverini, G.6    Iossa, S.7
  • 68
    • 33745312600 scopus 로고    scopus 로고
    • Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species
    • Riboulet-Chavey, A.; Pierron, A.; Durand, I.; Murdaca, J.; Giudicelli, J.; van Obberghen, E. Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species. Diabetes 2006, 55, 1289-1299.
    • (2006) Diabetes , vol.55 , pp. 1289-1299
    • Riboulet-Chavey, A.1    Pierron, A.2    Durand, I.3    Murdaca, J.4    Giudicelli, J.5    van Obberghen, E.6
  • 70
    • 84867076729 scopus 로고    scopus 로고
    • Consumption of fructose-but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
    • Cox, C.L.; Stanhope, K.L.; Schwarz, J.M.; Graham, J.L.; Hatcher, B.; Griffen, S.C.; Berglund, L.; McGahan, J.P.; Keim, N.L.; Havel, P.J. Consumption of fructose-but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans. Nutr. Metab. (Lond.) 2012, 9, 68.
    • (2012) Nutr. Metab. (Lond.) , vol.9 , pp. 68
    • Cox, C.L.1    Stanhope, K.L.2    Schwarz, J.M.3    Graham, J.L.4    Hatcher, B.5    Griffen, S.C.6    Berglund, L.7    McGahan, J.P.8    Keim, N.L.9    Havel, P.J.10
  • 72
    • 84894444173 scopus 로고    scopus 로고
    • Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects
    • Fabbrini, E.; Serafini, M.; Colic Baric, I.; Hazen, S.L.; Klein, S. Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes 2014, 63, 976-981.
    • (2014) Diabetes , vol.63 , pp. 976-981
    • Fabbrini, E.1    Serafini, M.2    Colic Baric, I.3    Hazen, S.L.4    Klein, S.5
  • 73
    • 84862750317 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance
    • Ou, H.-Y.; Wu, H.-T.; Hung, H.-C.; Yang, Y.-C.; Wu, J.-S.; Chang, C.-J. Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance. Endocrinology 2012, 153, 2974-2984.
    • (2012) Endocrinology , vol.153 , pp. 2974-2984
    • Ou, H.-Y.1    Wu, H.-T.2    Hung, H.-C.3    Yang, Y.-C.4    Wu, J.-S.5    Chang, C.-J.6
  • 74
    • 33745855835 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4
    • Marchand, A.; Tomkiewicz, C.; Magne, L.; Barouki, R.; Garlatti, M. Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4. J. Biol. Chem. 2006, 281, 19124-19133.
    • (2006) J. Biol. Chem , vol.281 , pp. 19124-19133
    • Marchand, A.1    Tomkiewicz, C.2    Magne, L.3    Barouki, R.4    Garlatti, M.5
  • 76
    • 0034088143 scopus 로고    scopus 로고
    • Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance
    • Crossey, P.A.; Jones, J.S.; Miell, J.P. Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance. Diabetes 2000, 49, 457-465.
    • (2000) Diabetes , vol.49 , pp. 457-465
    • Crossey, P.A.1    Jones, J.S.2    Miell, J.P.3
  • 77
    • 84908200877 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
    • Jiang, S.; Yan, C.; Fang, Q.; Shao, M.; Zhang, Y.; Liu, Y.; Deng, Y.P., Shan, B.; Liu, J.Q.; Li, H.T.; et al. Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. J. Biol. Chem. 2014, 289, 29751-29765.
    • (2014) J. Biol. Chem , vol.289 , pp. 29751-29765
    • Jiang, S.1    Yan, C.2    Fang, Q.3    Shao, M.4    Zhang, Y.5    Liu, Y.6    Deng, Y.P.7    Shan, B.8    Liu, J.Q.9    Li, H.T.10
  • 78
    • 84921771693 scopus 로고    scopus 로고
    • The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy
    • Liu, J.; Xu, Y.; Hu, Y.; Wang, G. The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. Metabolism 2015, 64, 380-390.
    • (2015) Metabolism , vol.64 , pp. 380-390
    • Liu, J.1    Xu, Y.2    Hu, Y.3    Wang, G.4
  • 80
    • 0016742907 scopus 로고
    • Effects of intravenously administered fructose and glucose on splanchnic amino acid and carbohydrate metabolism in hypertriglyceridemic men
    • Wolfe, B.M.; Ahuja, S.P.; Marliss, E.B. Effects of intravenously administered fructose and glucose on splanchnic amino acid and carbohydrate metabolism in hypertriglyceridemic men. J. Clin. Investig. 1975, 56, 970-977.
    • (1975) J. Clin. Investig. , vol.56 , pp. 970-977
    • Wolfe, B.M.1    Ahuja, S.P.2    Marliss, E.B.3
  • 82
    • 84905899270 scopus 로고    scopus 로고
    • Normal roles for dietary fructose in carbohydrate metabolism
    • Laughlin, M.R. Normal roles for dietary fructose in carbohydrate metabolism. Nutrients 2014, 6, 3117-3129.
    • (2014) Nutrients , vol.6 , pp. 3117-3129
    • Laughlin, M.R.1
  • 83
    • 0033375252 scopus 로고    scopus 로고
    • Rôle du foie dans le métabolisme des nutriments en nutrition artificielle
    • Leverve, X. Rôle du foie dans le métabolisme des nutriments en nutrition artificielle. Nutr. Clin. Métabol. 1999, 13, 225-231.
    • (1999) Nutr. Clin. Métabol. , vol.13 , pp. 225-231
    • Leverve, X.1
  • 87
    • 84905453839 scopus 로고    scopus 로고
    • Combination of alcohol and fructose exacerbates metabolic imbalance in terms of hepatic damage, dyslipidemia, and insulin resistance in rats
    • Alwahsh, S.M.; Xu, M.; Schultze, F.C.; Wilting, J.; Mihm, S.; Raddatz, D.; Ramadori, G. Combination of alcohol and fructose exacerbates metabolic imbalance in terms of hepatic damage, dyslipidemia, and insulin resistance in rats. PLoS ONE 2014, 9, e104220.
    • (2014) PLoS ONE , vol.9
    • Alwahsh, S.M.1    Xu, M.2    Schultze, F.C.3    Wilting, J.4    Mihm, S.5    Raddatz, D.6    Ramadori, G.7
  • 88
    • 84980347995 scopus 로고    scopus 로고
    • Mediterranean diet and nonalcoholic fatty liver disease:Molecular mechanisms of protection
    • Godos, J.; Federico, A.; Dallio, M.; Scazzina, F. Mediterranean diet and nonalcoholic fatty liver disease:Molecular mechanisms of protection. Int. J. Food Sci. Nutr. 2017, 68, 18-27.
    • (2017) Int. J. Food Sci. Nutr , vol.68 , pp. 18-27
    • Godos, J.1    Federico, A.2    Dallio, M.3    Scazzina, F.4
  • 90
    • 84858703583 scopus 로고    scopus 로고
    • Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • Parker, H.M.; Johnson, N.A.; Burdon, C.A.; Cohn, J.S.; O’Connor, H.T.; George, J. Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis. J. Hepatol. 2012, 56, 944-951.
    • (2012) J. Hepatol. , vol.56 , pp. 944-951
    • Parker, H.M.1    Johnson, N.A.2    Burdon, C.A.3    Cohn, J.S.4    O’Connor, H.T.5    George, J.6
  • 91
    • 85011705015 scopus 로고    scopus 로고
    • How does bariatric surgery improve Type II Diabetes? The neglected importance of the liver in clearing glucose and insulin from the portal blood
    • Alwahsh, S.M.; Ramadori, G. How does bariatric surgery improve Type II Diabetes? The neglected importance of the liver in clearing glucose and insulin from the portal blood. J. Obes. Weight Loss Ther. 2015, 5, 280.
    • (2015) J. Obes. Weight Loss Ther. , vol.5 , pp. 280
    • Alwahsh, S.M.1    Ramadori, G.2
  • 92
    • 85006482154 scopus 로고    scopus 로고
    • Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD)
    • Alwahsh, S.M.; Gebhardt, R. Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD). Arch. Toxicol. 2016, doi:10.1007/s00204-016-1892-7.
    • (2016) Arch. Toxicol
    • Alwahsh, S.M.1    Gebhardt, R.2
  • 93
    • 85011650191 scopus 로고    scopus 로고
    • Effects of natural products on fructose-induced nonalcoholic fatty liver disease (NAFLD)
    • Chen, Q.; Wang, T.; Li, J.; Wang, S.; Qiu, F.; Yu, H.; Zhang, Y.; Wang, T. Effects of natural products on fructose-induced nonalcoholic fatty liver disease (NAFLD). Nutrients 2017, 9, 96.
    • (2017) Nutrients , vol.9 , pp. 96
    • Chen, Q.1    Wang, T.2    Li, J.3    Wang, S.4    Qiu, F.5    Yu, H.6    Zhang, Y.7    Wang, T.8
  • 94
    • 84862999195 scopus 로고    scopus 로고
    • Metformin protects against the development of fructose-induced steatosis in mice: Role of the intestinal barrier function
    • Spruss, A.; Kanuri, G.; Stahl, C.; Bischoff, S.C.; Bergheim, I. Metformin protects against the development of fructose-induced steatosis in mice: Role of the intestinal barrier function. Lab. Investig. 2012, 92, 1020-1032.
    • (2012) Lab. Investig , vol.92 , pp. 1020-1032
    • Spruss, A.1    Kanuri, G.2    Stahl, C.3    Bischoff, S.C.4    Bergheim, I.5
  • 95
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani, N.; Younossi, Z.; Lavine, J.E.; Diehl, A.M.; Brunt, E.M.; Cusi, K.; Charlton, M.; Sanyal, A.J. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012, 55, 2005-2023.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6    Charlton, M.7    Sanyal, A.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.