Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men

Diabetes

Volumn 64, Issue 5, 2015, Pages 1615-1620

  Stephens, Francis B ^a   Chee, Carolyn ^a   Wall, Benjamin T ^b   Murton, Andrew J ^a   Shannon, Chris E ^a   Van Loon, Luc J C ^b   Tsintzas, Kostas ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCARNITINE; ACYL COENZYME A; GLUCOSE; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; INTRALIPID; MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE PROTEIN; PHENYLALANINE; PROTEIN KINASE B; SODIUM CHLORIDE; AMINO ACID; EMULSION; PHOSPHOLIPID; SOYBEAN OIL; SOYBEAN OIL, PHOSPHOLIPID EMULSION;

ADULT; AMINO ACID METABOLISM; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MUSCLE BIOPSY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; STEADY STATE; TRANSLATION INITIATION; VASTUS LATERALIS MUSCLE; YOUNG ADULT; DRUG EFFECTS; EMULSION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHARMACOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

AMINO ACIDS; EMULSIONS; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INSULIN RESISTANCE; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHOSPHOLIPIDS; SIGNAL TRANSDUCTION; SOYBEAN OIL; YOUNG ADULT;

EID: 84933524261     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0961     Document Type: Article

References (24)

1. Rennie MJ. Anabolic resistance in critically ill patients. Crit Care Med 2009; 37(Suppl.):S398-S399.
2. Wall BT, van Loon LJ. Nutritional strategies to attenuate muscle disuse atrophy. Nutr Rev 2013;71:195-208.
3. Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 2007;87:507-520.
4. Proud CG. Regulation of protein synthesis by insulin. Biochem Soc Trans 2006;34:213-216.
5. Lai YC, Liu Y, Jacobs R, Rider MH. A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle. Biochem J 2012;447:137-147.
6. Guillet C, Delcourt I, Rance M, et al. Changes in basal and insulin and amino acid response of whole body and skeletal muscle proteins in obese men. J Clin Endocrinol Metab 2009;94:3044-3050.
7. Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab 2002;87:226-234.
8. Boden G, Jadali F, White J, et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 1991;88:960-966.
9. Tsintzas K, Chokkalingam K, Jewell K, Norton L, Macdonald IA, Constantin- Teodosiu D. Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme A. J Clin Endocrinol Metab 2007;92:3967-3972.
10. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223.
11. Gallen IW, Macdonald IA. Effect of two methods of hand heating on body temperature, forearm blood flow, and deep venous oxygen saturation. Am J Physiol 1990;259:E639-E643.
12. Gorissen SH, Burd NA, Hamer HM, Gijsen AP, Groen BB, van Loon LJ. Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion. J Clin Endocrinol Metab 2014;99:2250-2258.
13. Wolfe R, Chinkes D. Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis. 2nd edition. New York, Wiley-Liss, 2005.
14. Zilversmit DB. The design and analysis of isotope experiments. Am J Med 1960;29:832-848.
15. Wall BT, Hamer HM, de Lange A, et al. Leucine co-ingestion improves postprandial muscle protein accretion in elderly men. Clin Nutr 2013;32:412-419.
16. Anderson SR, Gilge DA, Steiber AL, Previs SF. Diet-induced obesity alters protein synthesis: Tissue-specific effects in fasted versus fed mice. Metabolism 2008;57:347-354.
17. Masgrau A, Mishellany-Dutour A, Murakami H, et al. Time-course changes of muscle protein synthesis associated with obesity-induced lipotoxicity. J Physiol 2012;590:5199-5210.
18. Chevalier S, Marliss EB, Morais JA, Lamarche M, Gougeon R. Whole-body protein anabolic response is resistant to the action of insulin in obese women. Am J Clin Nutr 2005;82:355-365.
19. Wall BT, Snijders T, Senden JM, et al. Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men. J Clin Endocrinol Metab 2013;98:4872-4881.
20. Lang CH. Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle. Am J Physiol Endocrinol Metab 2006;291:E666-E674.
21. Hyde R, Hajduch E, Powell DJ, Taylor PM, Hundal HS. Ceramide downregulates System A amino acid transport and protein synthesis in rat skeletal muscle cells. FASEB J 2005;19:461-463.
22. Katsanos CS, Aarsland A, Cree MG, Wolfe RR. Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab 2009;94: 2984-2990.
23. Brechtel K, Dahl DB, Machann J, et al. Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: A dynamic 1H-MRS study. Magn Reson Med 2001;45:179-183.
24. Oakes ND, Bell KS, Furler SM, et al. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes 1997;46:2022-2028.