High uric acid directly inhibits insulin signalling and induces insulin resistance

Biochemical and Biophysical Research Communications

Volumn 447, Issue 4, 2014, Pages 707-714

  Zhu, Yuzhang ^a   Hu, Yaqiu ^a   Huang, Tianliang ^a   Zhang, Yongneng ^a   Li, Zhi ^a   Luo, Chaohuan ^a   Luo, Yinfeng ^a   Yuan, Huier ^a   Hisatome, Ichiro ^b   Yamamoto, Tetsuya ^c   Cheng, Jidong ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b TOTTORI UNIVERSITY   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Akt; Insulin resistance; IRS1; Reactive oxygen species; Uric acid

Indexed keywords

ACETYLCYSTEINE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME PHOSPHORYLATION; GLUCOSE TOLERANCE TEST; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYPERURICEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; URIC ACID BLOOD LEVEL; WESTERN BLOTTING;

MUS;

AKT; INSULIN RESISTANCE; IRS1; REACTIVE OXYGEN SPECIES; URIC ACID;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; GLUCOSE INTOLERANCE; HEP G2 CELLS; HUMANS; HYPERURICEMIA; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; URIC ACID;

EID: 84900430253     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.080     Document Type: Article

References (39)

1. K. Chizynski, and M. Rozycka Hyperuricemia Pol. Merkur. Lekarski 19 2005 693 696
2. D. Conen, V. Wietlisbach, and P. Bovet et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country BMC Public Health 4 2004 9
3. Y. Zhu, B.J. Pandya, and H.K. Choi Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008 Arthritis Rheum. 63 2011 3136 3141
4. T. Yang, and C.H. Chu et al. Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study Atherosclerosis 220 2012 525 531
5. A. So, and B. Thorens Uric acid transport and disease J. Clin. Invest. 120 2010 1791 1799
6. C.F. Kuo, and Luo et al. Hyperuricaemia and accelerated reduction in renal function Scand. J. Rheumatol. 40 2011 116 121
7. E. Abreu, M.J. Fonseca, and A.C. Santos Association between hyperuricemia and insulin resistance Acta Med. Port. Suppl. 2 2011 565 574
8. Z. Jiao, H.L. Gao, and H. Li et al. Pre-diabetes mellitus influenced by hyperuricemia Zhonghua Liu Xing Bing Xue Za Zhi 34 7 2013 725 727
9. E. Krishnan, B.J. Pandya, and L. Chung et al. Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study Am. J. Epidemiol. 176 2 2012 108 116
10. C.C. Kelly, H. Lyall, and J.R. Petrie et al. Low grade chronic inflammation in women with polycystic ovarian syndrome J. Clin. Endocrinol. Metab. 86 6 2001 2453 2455
11. A. Festa, R. D'Agostino Jr., and G. Howard et al. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) Circulation 102 1 2000 42 47
12. Y.Y. Sautin, T. Nakagawa, and S. Zharikov et al. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress J. Am. J. Physiol. Cell Physiol. 293 2 2007 C584 C596
13. M.A. Yu, and Sanchez-Lozada et al. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction J. Hypertens. 28 2010 1234 1242
14. D.B. Corry, and Eslami et al. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system J. Hypertens. 26 2008 269 275
15. Y. Zhang, Tetsuya Yamamoto, and Ichiro Hisatome et al. Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic b cells Mol. Cell. Endocrinol. 375 2013 89 96
16. J.L. Evans, and Goldfine et al. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes Endocr. Rev. 23 2002 599 622
17. J.L. Evans, and Maddux et al. The molecular basis for oxidative stress-induced insulin resistance Antioxid. Redox Signal. 7 2005 1040 1052
18. M.G. Myers Jr., and M.F. White Insulin signal transduction and the IRS proteins Annu. Rev. Pharmacol. Toxicol. 36 1996 615 658
19. K. Paz, H. Voliovitch, and Y.R. Hadari et al. Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis J. Biol. Chem. 271 1996 6998 7003
20. T. Yamauchi, K. Tobe, and H. Tamemoto et al. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice Mol. Cell Biol. 16 1996 3074 3084
21. X.J. Sun, and M. Miralpeix et al. Expression and function of IRS-1 in insulin signal transmission J. Biol. Chem. 267 1992 22662 22672
22. G.S. Hotamisligil, P. Peraldi, and A. Budavari et al. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance Science 271 1996 665 668
23. X.J. Sun, J.L. Goldberg, and L.Y. Qiao et al. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway Diabetes 48 1999 1359 1364
24. V. Aguirre, T. Uchida, and L. Yenush et al. The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307) J. Biol. Chem. 275 2000 9047 9054
25. V. Aguirre, E.D. Werner, and J. Giraud et al. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action J. Biol. Chem. 277 2002 1531 1537
26. G.L. Chen, W. Wei, and S.Y. Xu Effect and mechanism of total saponin of Dioscorea on animal experimental hyperuricemia Am. J. Chin. Med. 34 2006 77 85
27. C.P. Wang, Y. Wang, and X. Wang et al. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice Planta Med. 77 2011 786 794
28. A. Barbu, and Welsh et al. Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Deltapsi(m)) in pancreatic RINm5F cells: prevention by Bcl-2 Mol. Cell Endocrinol. 190 2002 75 82
29. J.M. Li, X. Zhang, and X. Wang et al. Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice Eur. J. Pharmacol. 666 2011 196 204
30. D. Su, N. Zhang, and J. He et al. Angiopoietin-1 productionin islets improves islet engraftment and protects islets from cytokine-induced apoptosis Diabetes 56 2007 2274 2283
31. Z. Zhao, C. Zhao, and X.H. Zhang et al. Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis Endocrinology 150 2009 2569 2576
32. A.R. Saltiel, and C.R. Kahn Insulin signaling and the regulation of glucose and lipid metabolism Nature 414 2001 799 806
33. M.H. Shin, and Moon et al. Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression Free Radic. Biol. Med. 44 2008 635 645
34. Y.Y. Sautin, and Nakagawa et al. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/ nitrosative stress Am. J. Physiol. Cell Physiol. 293 2007 C584 C596
35. L.G. Sanchez-Lozada, and Soto et al. Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia Am. J. Physiol. Renal. Physiol. 295 2008 F1134 F1141
36. L. Qiao, and J.L. Goldberg et al. Identification of enhanced serine kinase activity in insulin resistance J. Biol. Chem. 274 1999 10625 10632
37. J. Li, and De Fea et al. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway J. Biol. Chem. 274 1999 9351 9356
38. K. De Fea, and R.A. Roth Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase J. Biol. Chem. 272 1997 31400 31406
39. A. Virkamaki, and Ueki et al. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance J. Clin. Invest. 103 1999 931 943