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Volumn 14, Issue 6, 2017, Pages 356-365

Gut microbiota modulation of chemotherapy efficacy and toxicity

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; PREBIOTIC AGENT; PROBIOTIC AGENT; SYNBIOTIC AGENT; ANTIINFECTIVE AGENT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 85014509216     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2017.20     Document Type: Review
Times cited : (680)

References (106)
  • 2
    • 84994539749 scopus 로고    scopus 로고
    • 30-day mortality after systemic anticancer treatment for breast and lung cancer in England: A population-based, observational study
    • Wallington, M. et al. 30-day mortality after systemic anticancer treatment for breast and lung cancer in England: a population-based, observational study. Lancet Oncol. 17, 1203-1216 (2016).
    • (2016) Lancet Oncol. , vol.17 , pp. 1203-1216
    • Wallington, M.1
  • 4
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: Causes and consequences
    • Marusyk, A. & Polyak, K. Tumor heterogeneity: causes and consequences. Biochim. Biophys. Acta 1805, 105-117 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 5
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: A looking glass for cancer?
    • Marusyk, A., Almendro, V. & Polyak, K. Intra-tumour heterogeneity: a looking glass for cancer? Nat. Rev. Cancer 12, 323-334 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 6
    • 84886719809 scopus 로고    scopus 로고
    • Cancer drugs in the United States: Justum Pretium-the just price
    • Kantarjian, H. M., Fojo, T., Mathisen, M. & Zwelling, L. A. Cancer drugs in the United States: Justum Pretium-the just price. J. Clin. Oncol. 31, 3600-3604 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3600-3604
    • Kantarjian, H.M.1    Fojo, T.2    Mathisen, M.3    Zwelling, L.A.4
  • 7
    • 84876678621 scopus 로고    scopus 로고
    • Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: Detailed safety analysis from a phase 3 trial in patients with advanced melanoma
    • Weber, J. S. et al. Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: detailed safety analysis from a phase 3 trial in patients with advanced melanoma. Cancer 119, 1675-1682 (2013).
    • (2013) Cancer , vol.119 , pp. 1675-1682
    • Weber, J.S.1
  • 8
    • 84971231413 scopus 로고    scopus 로고
    • Resistance to combination BRAF and MEK inhibition in metastatic melanoma: Where to next?
    • Welsh, S. J., Rizos, H., Scolyer, R. A. & Long, G. V. Resistance to combination BRAF and MEK inhibition in metastatic melanoma: where to next? Eur. J. Cancer 62, 76-85 (2016).
    • (2016) Eur. J. Cancer , vol.62 , pp. 76-85
    • Welsh, S.J.1    Rizos, H.2    Scolyer, R.A.3    Long, G.V.4
  • 9
    • 33750719994 scopus 로고    scopus 로고
    • Global systems biology, personalized medicine and molecular epidemiology
    • Nicholson, J. K. Global systems biology, personalized medicine and molecular epidemiology. Mol. Syst. Biol. 2, 52 (2006).
    • (2006) Mol. Syst. Biol. , vol.2 , pp. 52
    • Nicholson, J.K.1
  • 10
    • 84958841613 scopus 로고    scopus 로고
    • The gut microbiota and host health: A new clinical frontier
    • Marchesi, J. R. et al. The gut microbiota and host health: a new clinical frontier. Gut 65, 330-339 (2016).
    • (2016) Gut , vol.65 , pp. 330-339
    • Marchesi, J.R.1
  • 11
    • 84871454511 scopus 로고    scopus 로고
    • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
    • Holmes, E., Li, J. V., Marchesi, J. R. & Nicholson, J. K. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metab. 16, 559-564 (2012).
    • (2012) Cell Metab. , vol.16 , pp. 559-564
    • Holmes, E.1    Li, J.V.2    Marchesi, J.R.3    Nicholson, J.K.4
  • 12
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson, J. K. et al. Host-gut microbiota metabolic interactions. Science 336, 1262-1267 (2012).
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1
  • 13
    • 17844404232 scopus 로고    scopus 로고
    • Gut microorganisms, mammalian metabolism and personalized health care
    • Nicholson, J. K., Holmes, E. & Wilson, I. D. Gut microorganisms, mammalian metabolism and personalized health care. Nat. Rev. Microbiol. 3, 431-438 (2005).
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 431-438
    • Nicholson, J.K.1    Holmes, E.2    Wilson, I.D.3
  • 14
    • 84954379199 scopus 로고    scopus 로고
    • The influence of gut microbiota on drug metabolism and toxicity
    • Li, H., He, J. & Jia, W. The influence of gut microbiota on drug metabolism and toxicity. Expert Opin. Drug Metab. Toxicol. 12, 31-40 (2016).
    • (2016) Expert Opin. Drug Metab. Toxicol. , vol.12 , pp. 31-40
    • Li, H.1    He, J.2    Jia, W.3
  • 15
    • 0014387321 scopus 로고
    • Drug metabolism by intestinal microorganisms
    • Scheline, R. R. Drug metabolism by intestinal microorganisms. J. Pharm. Sci. 57, 2021-2037 (1968).
    • (1968) J. Pharm. Sci. , vol.57 , pp. 2021-2037
    • Scheline, R.R.1
  • 16
    • 0019825594 scopus 로고
    • Urinary excretion of reduced metabolites of digoxin
    • Lindenbaum, J., Tse-Eng, D., Butler, V. P. Jr & Rund, D. G. Urinary excretion of reduced metabolites of digoxin. Am. J. Med. 71, 67-74 (1981).
    • (1981) Am. J. Med. , vol.71 , pp. 67-74
    • Lindenbaum, J.1    Tse-Eng, D.2    Butler, V.P.3    Rund, D.G.4
  • 17
    • 84898016390 scopus 로고    scopus 로고
    • The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
    • Lin, X. B. et al. The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats. PLoS ONE 9, e83644 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e83644
    • Lin, X.B.1
  • 18
    • 38849190556 scopus 로고    scopus 로고
    • Gut microbiota: A potential new territory for drug targeting
    • Jia, W., Li, H., Zhao, L. & Nicholson, J. K. Gut microbiota: a potential new territory for drug targeting. Nat. Rev. Drug Discov. 7, 123-129 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 123-129
    • Jia, W.1    Li, H.2    Zhao, L.3    Nicholson, J.K.4
  • 19
    • 79952757721 scopus 로고    scopus 로고
    • Composition, variability, and temporal stability of the intestinal microbiota of the elderly
    • Claesson, M. J. et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4586-4591 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4586-4591
    • Claesson, M.J.1
  • 20
    • 84953336403 scopus 로고    scopus 로고
    • Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: A literature review and modelling study
    • Teillant, A., Gandra, S., Barter, D., Morgan, D. J. & Laxminarayan, R. Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: a literature review and modelling study. Lancet Infect. Dis. 15, 1429-1437 (2015).
    • (2015) Lancet Infect. Dis. , vol.15 , pp. 1429-1437
    • Teillant, A.1    Gandra, S.2    Barter, D.3    Morgan, D.J.4    Laxminarayan, R.5
  • 21
    • 84886584256 scopus 로고    scopus 로고
    • Leukemia and risk of recurrent Escherichia coli bacteremia: Genotyping implicates E. Coli translocation from the colon to the bloodstream
    • Samet, A. et al. Leukemia and risk of recurrent Escherichia coli bacteremia: genotyping implicates E. coli translocation from the colon to the bloodstream. Eur. J. Clin. Microbiol. Infect. Dis. 32, 1393-1400 (2013).
    • (2013) Eur. J. Clin. Microbiol. Infect. Dis. , vol.32 , pp. 1393-1400
    • Samet, A.1
  • 22
    • 0013954812 scopus 로고
    • Translocation of microorganisms across the intestinal wall of the rat: Effect of microbial size and concentration
    • Wolochow, H., Hildebrand, G. J. & Lamanna, C. Translocation of microorganisms across the intestinal wall of the rat: effect of microbial size and concentration. J. Infect. Dis. 116, 523-528 (1966).
    • (1966) J. Infect. Dis. , vol.116 , pp. 523-528
    • Wolochow, H.1    Hildebrand, G.J.2    Lamanna, C.3
  • 24
    • 79551523389 scopus 로고    scopus 로고
    • Cyclophosphamide synergizes with type i interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis
    • Schiavoni, G. et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res. 71, 768-778 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 768-778
    • Schiavoni, G.1
  • 25
    • 79551514818 scopus 로고    scopus 로고
    • Cyclophosphamide induces differentiation of Th17 cells in cancer patients
    • Viaud, S. et al. Cyclophosphamide induces differentiation of Th17 cells in cancer patients. Cancer Res. 71, 661-665 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 661-665
    • Viaud, S.1
  • 26
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • This paper demonstrates that translocation of bacteria and stimulation of type 17 and type 1 T-helper cell responses is necessary for cyclophosphamide efficacy in tumour-bearing mice
    • Viaud, S. et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971-976 (2013). This paper demonstrates that translocation of bacteria and stimulation of type 17 and type 1 T-helper cell responses is necessary for cyclophosphamide efficacy in tumour-bearing mice.
    • (2013) Science , vol.342 , pp. 971-976
    • Viaud, S.1
  • 27
    • 84994831796 scopus 로고    scopus 로고
    • Enterococcus hirae and Barnesiella intestinihominis facilitate cyclophosphamide-induced therapeutic immunomodulatory effects
    • Daillere, R. et al. Enterococcus hirae and Barnesiella intestinihominis facilitate cyclophosphamide-induced therapeutic immunomodulatory effects. Immunity 45, 931-943 (2016).
    • (2016) Immunity , vol.45 , pp. 931-943
    • Daillere, R.1
  • 28
    • 84888049920 scopus 로고    scopus 로고
    • Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
    • Iida, N. et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 342, 967-970 (2013)
    • (2013) Science , vol.342 , pp. 967-970
    • Iida, N.1
  • 29
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
    • Vetizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
    • (2015) Science , vol.350 , pp. 1079-1084
    • Vetizou, M.1
  • 30
    • 84923335913 scopus 로고    scopus 로고
    • Cancer: Antitumour immunity gets a boost
    • Wolchok, J. D. & Chan, T. A. Cancer: antitumour immunity gets a boost. Nature 515, 496-498 (2014).
    • (2014) Nature , vol.515 , pp. 496-498
    • Wolchok, J.D.1    Chan, T.A.2
  • 31
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
    • Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350, 1084-1089 (2015).
    • (2015) Science , vol.350 , pp. 1084-1089
    • Sivan, A.1
  • 32
    • 78650428877 scopus 로고    scopus 로고
    • Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma
    • Berman, D. et al. Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun. 10, 11 (2010).
    • (2010) Cancer Immun. , vol.10 , pp. 11
    • Berman, D.1
  • 33
    • 84957565779 scopus 로고    scopus 로고
    • Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockadeinduced colitis
    • Dubin, K. et al. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockadeinduced colitis. Nat. Commun. 7, 10391 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10391
    • Dubin, K.1
  • 34
    • 0035424901 scopus 로고    scopus 로고
    • Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    • Abreu, M. T. et al. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J. Immunol. 167, 1609-1616 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 1609-1616
    • Abreu, M.T.1
  • 35
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario, E. & Podolsky, D. K. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 68, 7010-7017 (2000).
    • (2000) Infect. Immun. , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 36
    • 84922572991 scopus 로고    scopus 로고
    • TLR signaling modulates side effects of anticancer therapy in the small intestine
    • Frank, M. et al. TLR signaling modulates side effects of anticancer therapy in the small intestine. J. Immunol. 194, 1983-1995 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 1983-1995
    • Frank, M.1
  • 37
    • 84971578038 scopus 로고    scopus 로고
    • Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms
    • Wardill, H. R. et al. Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Mol. Cancer Ther. 15, 1376-1386 (2016).
    • (2016) Mol. Cancer Ther. , vol.15 , pp. 1376-1386
    • Wardill, H.R.1
  • 38
    • 84904066463 scopus 로고    scopus 로고
    • Review of therapeutic drug monitoring of anticancer drugs part 1-cytotoxics
    • Paci, A. et al. Review of therapeutic drug monitoring of anticancer drugs part 1-cytotoxics. Eur. J. Cancer 50, 2010-2019 (2014).
    • (2014) Eur. J. Cancer , vol.50 , pp. 2010-2019
    • Paci, A.1
  • 39
    • 84928496512 scopus 로고    scopus 로고
    • Mucositis: Pathobiology and management
    • Villa, A. & Sonis, S. T. Mucositis: pathobiology and management. Curr. Opin. Oncol. 27, 159-164 (2015).
    • (2015) Curr. Opin. Oncol. , vol.27 , pp. 159-164
    • Villa, A.1    Sonis, S.T.2
  • 40
    • 84905858666 scopus 로고    scopus 로고
    • Systematic review: The role of the gut microbiota in chemotherapy-or radiation-induced gastrointestinal mucositis-current evidence and potential clinical applications
    • Touchefeu, Y. et al. Systematic review: the role of the gut microbiota in chemotherapy-or radiation-induced gastrointestinal mucositis-current evidence and potential clinical applications. Aliment. Pharmacol. Ther. 40, 409-421 (2014).
    • (2014) Aliment. Pharmacol. Ther. , vol.40 , pp. 409-421
    • Touchefeu, Y.1
  • 41
    • 33847389418 scopus 로고    scopus 로고
    • Updated clinical practice guidelines for the prevention and treatment of mucositis
    • Keefe, D. M. et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109, 820-831 (2007).
    • (2007) Cancer , vol.109 , pp. 820-831
    • Keefe, D.M.1
  • 42
    • 0035281522 scopus 로고    scopus 로고
    • Irinotecan in the treatment of colorectal cancer: Clinical overview
    • Vanhoefer, U. et al. Irinotecan in the treatment of colorectal cancer: clinical overview. J. Clin. Oncol. 19, 1501-1518 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1501-1518
    • Vanhoefer, U.1
  • 43
    • 84864386786 scopus 로고    scopus 로고
    • Irinotecan (CPT-11) chemotherapy alters intestinal microbiota in tumour bearing rats
    • Lin, X. B. et al. Irinotecan (CPT-11) chemotherapy alters intestinal microbiota in tumour bearing rats. PLoS ONE 7, e39764 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e39764
    • Lin, X.B.1
  • 44
    • 0028022585 scopus 로고
    • Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
    • Gupta, E. et al. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res. 54, 3723-3725 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 3723-3725
    • Gupta, E.1
  • 45
    • 78149295964 scopus 로고    scopus 로고
    • Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
    • Wallace, B. D. et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science 330, 831-835 (2010).
    • (2010) Science , vol.330 , pp. 831-835
    • Wallace, B.D.1
  • 46
    • 84962744324 scopus 로고    scopus 로고
    • The inhibitory effect of ciprofloxacin on the beta-glucuronidase-mediated deconjugation of the irinotecan metabolite SN-38-G
    • Kodawara, T. et al. The inhibitory effect of ciprofloxacin on the beta-glucuronidase-mediated deconjugation of the irinotecan metabolite SN-38-G. Basic Clin. Pharmacol. Toxicol. 118, 333-337 (2016).
    • (2016) Basic Clin. Pharmacol. Toxicol. , vol.118 , pp. 333-337
    • Kodawara, T.1
  • 47
    • 84903837906 scopus 로고    scopus 로고
    • Old drug new use-amoxapine and its metabolites as potent bacterial beta-glucuronidase inhibitors for alleviating cancer drug toxicity
    • Kong, R. et al. Old drug new use-amoxapine and its metabolites as potent bacterial beta-glucuronidase inhibitors for alleviating cancer drug toxicity. Clin. Cancer Res. 20, 3521-3530 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 3521-3530
    • Kong, R.1
  • 48
    • 84941938693 scopus 로고    scopus 로고
    • Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity
    • Wallace, B. D. et al. Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem. Biol. 22, 1238-1249 (2015).
    • (2015) Chem. Biol. , vol.22 , pp. 1238-1249
    • Wallace, B.D.1
  • 49
    • 77955898834 scopus 로고    scopus 로고
    • The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity
    • Lam, W. et al. The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Sci. Transl Med. 2, 45ra59 (2010).
    • (2010) Sci. Transl Med. , vol.2 , pp. 45ra59
    • Lam, W.1
  • 50
    • 0030985696 scopus 로고    scopus 로고
    • Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil
    • Nakayama, H. et al. Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil. Pharmacogenetics 7, 35-43 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 35-43
    • Nakayama, H.1
  • 51
    • 0031858786 scopus 로고    scopus 로고
    • Sorivudine and 5-fluorouracil; A clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase
    • Diasio, R. B. Sorivudine and 5-fluorouracil; a clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase. Br. J. Clin. Pharmacol. 46, 1-4 (1998).
    • (1998) Br. J. Clin. Pharmacol. , vol.46 , pp. 1-4
    • Diasio, R.B.1
  • 53
    • 45649084620 scopus 로고    scopus 로고
    • The cytostatic activity of pyrimidine nucleosides is strongly modulated by Mycoplasma hyorhinis infection: Implications for cancer therapy
    • Bronckaers, A., Balzarini, J. & Liekens, S. The cytostatic activity of pyrimidine nucleosides is strongly modulated by Mycoplasma hyorhinis infection: implications for cancer therapy. Biochem. Pharmacol. 76, 188-197 (2008).
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 188-197
    • Bronckaers, A.1    Balzarini, J.2    Liekens, S.3
  • 54
    • 84900439025 scopus 로고    scopus 로고
    • Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine
    • Vande Voorde, J. et al. Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine. J. Biol. Chem. 289, 13054-13065 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 13054-13065
    • Vande Voorde, J.1
  • 55
    • 84938547773 scopus 로고    scopus 로고
    • Substantial decreases in the number and diversity of microbiota during chemotherapyinduced gastrointestinal mucositis in a rat model
    • Fijlstra, M. et al. Substantial decreases in the number and diversity of microbiota during chemotherapyinduced gastrointestinal mucositis in a rat model. Support. Care Cancer 23, 1513-1522 (2015).
    • (2015) Support. Care Cancer , vol.23 , pp. 1513-1522
    • Fijlstra, M.1
  • 56
    • 84909993511 scopus 로고    scopus 로고
    • 16S rRNA gene pyrosequencing reveals shift in patient faecal microbiota during highdose chemotherapy as conditioning regimen for bone marrow transplantation
    • Montassier, E. et al. 16S rRNA gene pyrosequencing reveals shift in patient faecal microbiota during highdose chemotherapy as conditioning regimen for bone marrow transplantation. Microb. Ecol. 67, 690-699 (2014).
    • (2014) Microb. Ecol. , vol.67 , pp. 690-699
    • Montassier, E.1
  • 57
    • 67651121491 scopus 로고    scopus 로고
    • Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut
    • van Vliet, M. J. et al. Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut. Clin. Infect. Dis. 49, 262-270 (2009).
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 262-270
    • Van Vliet, M.J.1
  • 58
    • 84938555496 scopus 로고    scopus 로고
    • Chemotherapy-driven dysbiosis in the intestinal microbiome
    • Montassier, E. et al. Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment. Pharmacol. Ther. 42, 515-528 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.42 , pp. 515-528
    • Montassier, E.1
  • 59
    • 84903376660 scopus 로고    scopus 로고
    • Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission
    • Rooks, M. G. et al. Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J. 8, 1403-1417 (2014).
    • (2014) ISME J. , vol.8 , pp. 1403-1417
    • Rooks, M.G.1
  • 60
    • 0003135066 scopus 로고
    • The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the Streptococcus erysipelas and the Bacillus prodigiosus)
    • Coley, W. B. The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). Proc. R. Soc. Med. 3, 1-48 (1910).
    • (1910) Proc. R. Soc. Med. , vol.3 , pp. 1-48
    • Coley, W.B.1
  • 61
    • 84890120075 scopus 로고    scopus 로고
    • Defining progression in nonmuscle invasive bladder cancer: It is time for a new, standard definition
    • Lamm, D. et al. Defining progression in nonmuscle invasive bladder cancer: it is time for a new, standard definition. J. Urol. 191, 20-27 (2014).
    • (2014) J. Urol. , vol.191 , pp. 20-27
    • Lamm, D.1
  • 62
    • 84869049715 scopus 로고    scopus 로고
    • Metabolic phenotyping in clinical and surgical environments
    • Nicholson, J. K. et al. Metabolic phenotyping in clinical and surgical environments. Nature 491, 384-392 (2012).
    • (2012) Nature , vol.491 , pp. 384-392
    • Nicholson, J.K.1
  • 63
    • 84940055522 scopus 로고    scopus 로고
    • Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
    • Mima, K. et al. Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut 65, 1973-1980 (2015).
    • (2015) Gut , vol.65 , pp. 1973-1980
    • Mima, K.1
  • 64
    • 84964514022 scopus 로고    scopus 로고
    • Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection
    • Montassier, E. et al. Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection. Genome Med. 8, 49 (2016).
    • (2016) Genome Med. , vol.8 , pp. 49
    • Montassier, E.1
  • 65
    • 84977566637 scopus 로고    scopus 로고
    • The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia
    • Galloway-Pena, J. R. et al. The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia. Cancer 122, 2186-2196 (2016).
    • (2016) Cancer , vol.122 , pp. 2186-2196
    • Galloway-Pena, J.R.1
  • 66
    • 84929094853 scopus 로고    scopus 로고
    • Fat, fibre and cancer risk in African Americans and rural Africans
    • OKeefe, S. J. et al. Fat, fibre and cancer risk in African Americans and rural Africans. Nat. Commun. 6, 6342 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6342
    • Okeefe, S.J.1
  • 67
    • 79960300039 scopus 로고    scopus 로고
    • Bacterial translocation is reduced by a specific nutritional combination in mice with chemotherapy-induced neutropenia
    • Faber, J. et al. Bacterial translocation is reduced by a specific nutritional combination in mice with chemotherapy-induced neutropenia. J. Nutr. 141, 1292-1298 (2011).
    • (2011) J. Nutr. , vol.141 , pp. 1292-1298
    • Faber, J.1
  • 68
    • 84984601511 scopus 로고    scopus 로고
    • Fasting and caloric restriction in cancer prevention and treatment
    • Brandhorst, S. & Longo, V. D. Fasting and caloric restriction in cancer prevention and treatment. Recent Results Cancer Res. 207, 241-266 (2016).
    • (2016) Recent Results Cancer Res. , vol.207 , pp. 241-266
    • Brandhorst, S.1    Longo, V.D.2
  • 69
    • 84863229916 scopus 로고    scopus 로고
    • Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy
    • Lee, C. et al. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci. Transl Med. 4, 124ra27 (2012).
    • (2012) Sci. Transl Med. , vol.4 , pp. 124ra27
    • Lee, C.1
  • 70
    • 84948676244 scopus 로고    scopus 로고
    • Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: The role of SIRT1
    • Lee, J. D. et al. Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. Eur. J. Cancer Prev. 25, 54-64 (2016).
    • (2016) Eur. J. Cancer Prev. , vol.25 , pp. 54-64
    • Lee, J.D.1
  • 71
    • 33847323097 scopus 로고    scopus 로고
    • Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia
    • Narta, U. K., Kanwar, S. S. & Azmi, W. Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia. Crit. Rev. Oncol. Hematol. 61, 208-221 (2007).
    • (2007) Crit. Rev. Oncol. Hematol. , vol.61 , pp. 208-221
    • Narta, U.K.1    Kanwar, S.S.2    Azmi, W.3
  • 72
    • 84994028116 scopus 로고    scopus 로고
    • Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo
    • Jeon, H. et al. Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo. Oncotarget 7, 67223-67234 (2016).
    • (2016) Oncotarget , vol.7 , pp. 67223-67234
    • Jeon, H.1
  • 73
    • 84872905650 scopus 로고    scopus 로고
    • Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
    • Maddocks, O. D. et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493, 542-546 (2013).
    • (2013) Nature , vol.493 , pp. 542-546
    • Maddocks, O.D.1
  • 74
    • 0031456990 scopus 로고    scopus 로고
    • Tyrosine and phenylalanine restriction induces G0/G1 cell cycle arrest in murine melanoma in vitro and in vivo
    • Fu, Y. M., Yu, Z. X., Ferrans, V. J. & Meadows, G. G. Tyrosine and phenylalanine restriction induces G0/G1 cell cycle arrest in murine melanoma in vitro and in vivo. Nutr. Cancer 29, 104-113 (1997).
    • (1997) Nutr. Cancer , vol.29 , pp. 104-113
    • Fu, Y.M.1    Yu, Z.X.2    Ferrans, V.J.3    Meadows, G.G.4
  • 75
    • 84901625233 scopus 로고    scopus 로고
    • Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme
    • Champ, C. E. et al. Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. J. Neurooncol. 117, 125-131 (2014).
    • (2014) J. Neurooncol. , vol.117 , pp. 125-131
    • Champ, C.E.1
  • 76
    • 84925851513 scopus 로고    scopus 로고
    • Fasting reduces the incidence of delayed-type vomiting associated with doxorubicin treatment in dogs with lymphoma
    • Withers, S. S. et al. Fasting reduces the incidence of delayed-type vomiting associated with doxorubicin treatment in dogs with lymphoma. Transl Oncol. 7, 377-383 (2014).
    • (2014) Transl Oncol. , vol.7 , pp. 377-383
    • Withers, S.S.1
  • 77
    • 84943789828 scopus 로고    scopus 로고
    • Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice
    • Huisman, S. A. et al. Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice. Cell Cycle 14, 2333-2339 (2015).
    • (2015) Cell Cycle , vol.14 , pp. 2333-2339
    • Huisman, S.A.1
  • 78
    • 0035240033 scopus 로고    scopus 로고
    • Panax ginseng-a non-organ-specific cancer preventive?
    • Yun, T. K. Panax ginseng-a non-organ-specific cancer preventive? Lancet Oncol. 2, 49-55 (2001).
    • (2001) Lancet Oncol. , vol.2 , pp. 49-55
    • Yun, T.K.1
  • 79
    • 84921858255 scopus 로고    scopus 로고
    • Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer
    • Wang, C. Z. et al. Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer. Nutrients 7, 799-814 (2015).
    • (2015) Nutrients , vol.7 , pp. 799-814
    • Wang, C.Z.1
  • 80
    • 34247332195 scopus 로고    scopus 로고
    • Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells
    • Wang, C. Z. et al. Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells. Cancer Chemother. Pharmacol. 60, 69-79 (2007).
    • (2007) Cancer Chemother. Pharmacol. , vol.60 , pp. 69-79
    • Wang, C.Z.1
  • 81
    • 69049106403 scopus 로고    scopus 로고
    • Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells
    • Li, X. L. et al. Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells. Cancer Chemother. Pharmacol. 64, 1097-1104 (2009).
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , pp. 1097-1104
    • Li, X.L.1
  • 82
    • 84905049318 scopus 로고    scopus 로고
    • Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species
    • Selma, M. V., Beltran, D., Garcia-Villalba, R., Espin, J. C. & Tomas-Barberan, F. A. Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. Food Funct. 5, 1779-1784 (2014).
    • (2014) Food Funct. , vol.5 , pp. 1779-1784
    • Selma, M.V.1    Beltran, D.2    Garcia-Villalba, R.3    Espin, J.C.4    Tomas-Barberan, F.A.5
  • 83
    • 84903906709 scopus 로고    scopus 로고
    • Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells
    • Gonzalez-Sarrias, A. et al. Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells. Eur. J. Nutr. 53, 853-864 (2014).
    • (2014) Eur. J. Nutr. , vol.53 , pp. 853-864
    • Gonzalez-Sarrias, A.1
  • 84
    • 84929485270 scopus 로고    scopus 로고
    • The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells
    • Gonzalez-Sarrias, A., Tome-Carneiro, J., Bellesia, A., Tomas-Barberan, F. A. & Espin, J. C. The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells. Food Funct. 6, 1460-1469 (2015).
    • (2015) Food Funct. , vol.6 , pp. 1460-1469
    • Gonzalez-Sarrias, A.1    Tome-Carneiro, J.2    Bellesia, A.3    Tomas-Barberan, F.A.4    Espin, J.C.5
  • 85
    • 84907856427 scopus 로고    scopus 로고
    • Dietary squid ink polysaccharides ameliorated the intestinal microflora dysfunction in mice undergoing chemotherapy
    • Tang, Q. et al. Dietary squid ink polysaccharides ameliorated the intestinal microflora dysfunction in mice undergoing chemotherapy. Food Funct. 5, 2529-2535 (2014).
    • (2014) Food Funct. , vol.5 , pp. 2529-2535
    • Tang, Q.1
  • 86
    • 84928590068 scopus 로고    scopus 로고
    • The efficacy and safety of probiotics in people with cancer: A systematic review
    • Redman, M. G., Ward, E. J. & Phillips, R. S. The efficacy and safety of probiotics in people with cancer: a systematic review. Ann. Oncol. 25, 1919-1929 (2014).
    • (2014) Ann. Oncol. , vol.25 , pp. 1919-1929
    • Redman, M.G.1    Ward, E.J.2    Phillips, R.S.3
  • 87
    • 42549126844 scopus 로고    scopus 로고
    • VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss
    • Bowen, J. M. et al. VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss. Cancer Biol. Ther. 6, 1449-1454 (2007).
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 1449-1454
    • Bowen, J.M.1
  • 88
    • 33847229128 scopus 로고    scopus 로고
    • Probiotic effects on 5-fluorouracilinduced mucositis assessed by the sucrose breath test in rats
    • Mauger, C. A., Butler, R. N., Geier, M. S., Tooley, K. L. & Howarth, G. S. Probiotic effects on 5-fluorouracilinduced mucositis assessed by the sucrose breath test in rats. Dig. Dis. Sci. 52, 612-619 (2007).
    • (2007) Dig. Dis. Sci. , vol.52 , pp. 612-619
    • Mauger, C.A.1    Butler, R.N.2    Geier, M.S.3    Tooley, K.L.4    Howarth, G.S.5
  • 89
    • 84947762368 scopus 로고    scopus 로고
    • Amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model
    • Yeung, C. Y. et al. Amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model. PLoS ONE 10, e0138746 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0138746
    • Yeung, C.Y.1
  • 90
    • 35348904439 scopus 로고    scopus 로고
    • Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: A randomised study
    • Osterlund, P. et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br. J. Cancer 97, 1028-1034 (2007).
    • (2007) Br. J. Cancer , vol.97 , pp. 1028-1034
    • Osterlund, P.1
  • 91
    • 84948800191 scopus 로고    scopus 로고
    • Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients
    • Motoori, M. et al. Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients. Clin. Nutr. 36, 93-99 (2017).
    • Clin. Nutr. , vol.36 , Issue.93-99 , pp. 2017
    • Motoori, M.1
  • 92
    • 77953610750 scopus 로고    scopus 로고
    • Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies
    • Wada, M. et al. Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies. Support. Care Cancer 18, 751-759 (2010).
    • (2010) Support. Care Cancer , vol.18 , pp. 751-759
    • Wada, M.1
  • 93
    • 32644459142 scopus 로고    scopus 로고
    • Prevention of febrile neutropenia in cancer patients by probiotic strain Enterococcus faecium M-74
    • Mego, M. et al. Prevention of febrile neutropenia in cancer patients by probiotic strain Enterococcus faecium M-74. Phase II study. Support. Care Cancer 14, 285-290 (2006).
    • (2006) Phase II Study. Support. Care Cancer , vol.14 , pp. 285-290
    • Mego, M.1
  • 94
    • 16244394837 scopus 로고    scopus 로고
    • Possible adjuvant cancer therapy by two prebiotics-inulin or oligofructose
    • Taper, H. S. & Roberfroid, M. B. Possible adjuvant cancer therapy by two prebiotics-inulin or oligofructose. In Vivo 19, 201-204 (2005).
    • (2005) In Vivo , vol.19 , pp. 201-204
    • Taper, H.S.1    Roberfroid, M.B.2
  • 95
    • 0034448768 scopus 로고    scopus 로고
    • Nontoxic potentiation of cancer chemotherapy by dietary oligofructose or inulin
    • Taper, H. S. & Roberfroid, M. B. Nontoxic potentiation of cancer chemotherapy by dietary oligofructose or inulin. Nutr. Cancer 38, 1-5 (2000).
    • (2000) Nutr. Cancer , vol.38 , pp. 1-5
    • Taper, H.S.1    Roberfroid, M.B.2
  • 97
    • 84885629462 scopus 로고    scopus 로고
    • Excess risk of Clostridium difficile infection in ovarian cancer is related to exposure to broad-spectrum antibiotics
    • Kim, J. S. et al. Excess risk of Clostridium difficile infection in ovarian cancer is related to exposure to broad-spectrum antibiotics. Support. Care Cancer 21, 3103-3107 (2013).
    • (2013) Support. Care Cancer , vol.21 , pp. 3103-3107
    • Kim, J.S.1
  • 98
    • 0034682335 scopus 로고    scopus 로고
    • Lateral gene transfer and the nature of bacterial innovation
    • Ochman, H., Lawrence, J. G. & Groisman, E. A. Lateral gene transfer and the nature of bacterial innovation. Nature 405, 299-304 (2000).
    • (2000) Nature , vol.405 , pp. 299-304
    • Ochman, H.1    Lawrence, J.G.2    Groisman, E.A.3
  • 99
    • 84992070829 scopus 로고    scopus 로고
    • Enhanced TLR4 expression on colon cancer cells after chemotherapy promotes cell survival and epithelial-mesenchymal transition through phosphorylation of GSK3beta
    • Chung, Y. H. & Kim, D. Enhanced TLR4 expression on colon cancer cells after chemotherapy promotes cell survival and epithelial-mesenchymal transition through phosphorylation of GSK3beta. Anticancer Res. 36, 3383-3394 (2016).
    • (2016) Anticancer Res. , vol.36 , pp. 3383-3394
    • Chung, Y.H.1    Kim, D.2
  • 100
    • 84856969539 scopus 로고    scopus 로고
    • Fecal microbiota transplantation and emerging applications
    • Borody, T. J. & Khoruts, A. Fecal microbiota transplantation and emerging applications. Nat. Rev. Gastroenterol. Hepatol. 9, 88-96 (2011).
    • (2011) Nat. Rev. Gastroenterol. Hepatol. , vol.9 , pp. 88-96
    • Borody, T.J.1    Khoruts, A.2
  • 101
    • 84873038467 scopus 로고    scopus 로고
    • Fecal microbiota transplantation-an old therapy comes of age
    • Kelly, C. P. Fecal microbiota transplantation-an old therapy comes of age. N. Engl. J. Med. 368, 474-475 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 474-475
    • Kelly, C.P.1
  • 102
    • 85020615240 scopus 로고    scopus 로고
    • Seress pioneering microbiome drug fails midstage trial
    • Ratner, M. Seress pioneering microbiome drug fails midstage trial. Nat. Biotechnol. 34, 1004-1005 (2016).
    • (2016) Nat. Biotechnol. , vol.34 , pp. 1004-1005
    • Ratner, M.1
  • 103
    • 84894241861 scopus 로고    scopus 로고
    • Policy: How to regulate faecal transplants
    • Smith, M. B., Kelly, C. & Alm, E. J. Policy: How to regulate faecal transplants. Nature 506, 290-291 (2014).
    • (2014) Nature , vol.506 , pp. 290-291
    • Smith, M.B.1    Kelly, C.2    Alm, E.J.3
  • 104
    • 84856456056 scopus 로고    scopus 로고
    • E. Coli-produced BMP-2 as a chemopreventive strategy for colon cancer: A proof-of-concept study
    • Yuvaraj, S. et al. E. coli-produced BMP-2 as a chemopreventive strategy for colon cancer: a proof-of-concept study. Gastroenterol. Res. Pract. 2012, 895462 (2012).
    • (2012) Gastroenterol. Res. Pract. , vol.2012 , pp. 895462
    • Yuvaraj, S.1
  • 105
    • 84982836605 scopus 로고    scopus 로고
    • Synchronized cycles of bacterial lysis for in vivo delivery
    • Din, M. O. et al. Synchronized cycles of bacterial lysis for in vivo delivery. Nature 536, 81-85 (2016).
    • (2016) Nature , vol.536 , pp. 81-85
    • Din, M.O.1
  • 106
    • 78651061453 scopus 로고    scopus 로고
    • Streptomycin alleviates irinotecaninduced delayed-onset diarrhea in rats by a mechanism other than inhibition of beta-glucuronidase activity in intestinal lumen
    • Kurita, A. et al. Streptomycin alleviates irinotecaninduced delayed-onset diarrhea in rats by a mechanism other than inhibition of beta-glucuronidase activity in intestinal lumen. Cancer Chemother. Pharmacol. 67, 201-213 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.67 , pp. 201-213
    • Kurita, A.1


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