-
1
-
-
84856796565
-
Preparing for precision medicine
-
Mirnezami, R., Nicholson, J. & Darzi, A. Preparing for precision medicine. N. Engl. J. Med. 366, 489-491 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 489-491
-
-
Mirnezami, R.1
Nicholson, J.2
Darzi, A.3
-
2
-
-
0034634448
-
An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: Application to the C57BL10J and Alpk: ApfCD mouse
-
Gavaghan, C. L., Holmes, E., Lenz, E., Wilson, I. D. & Nicholson, J. K. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett. 484, 169-174 (2000).
-
(2000)
FEBS Lett.
, vol.484
, pp. 169-174
-
-
Gavaghan, C.L.1
Holmes, E.2
Lenz, E.3
Wilson, I.D.4
Nicholson, J.K.5
-
3
-
-
43749087841
-
Human metabolic phenotype diversity and its association with diet and blood pressure
-
Holmes, E. et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453, 396-400 (2008).
-
(2008)
Nature
, vol.453
, pp. 396-400
-
-
Holmes, E.1
-
4
-
-
50249099816
-
Metabolic phenotyping in health and disease
-
Holmes, E., Wilson, I. D. & Nicholson, J. K. Metabolic phenotyping in health and disease. Cell 134, 714-717 (2008).
-
(2008)
Cell
, vol.134
, pp. 714-717
-
-
Holmes, E.1
Wilson, I.D.2
Nicholson, J.K.3
-
5
-
-
54549091125
-
Systems biology: Metabonomics
-
Nicholson, J. K. & Lindon, J. C. Systems biology: metabonomics. Nature 455, 1054-1056 (2008).
-
(2008)
Nature
, vol.455
, pp. 1054-1056
-
-
Nicholson, J.K.1
Lindon, J.C.2
-
6
-
-
0036007687
-
Metabolomics-the link between genotypes and phenotypes
-
Fiehn, O. Metabolomics-the link between genotypes and phenotypes. Plant Mol. Biol. 48, 155-171 (2002).
-
(2002)
Plant Mol. Biol.
, vol.48
, pp. 155-171
-
-
Fiehn, O.1
-
7
-
-
0032694577
-
'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
-
Nicholson, J. K., Lindon, J. C. & Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29, 1181-1189 (1999).
-
(1999)
Xenobiotica
, vol.29
, pp. 1181-1189
-
-
Nicholson, J.K.1
Lindon, J.C.2
Holmes, E.3
-
8
-
-
0043069547
-
Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
-
Nicholson, J. K. & Wilson, I. D. Understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nature Rev. Drug Discov. 2, 668-676 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 668-676
-
-
Nicholson, J.K.1
Wilson, I.D.2
-
9
-
-
0027052705
-
Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(ii) chloride and 2-bromoethanamine
-
Holmes, E. et al. Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(ii) chloride and 2-bromoethanamine. Mol. Pharmacol. 42, 922-930 (1992).
-
(1992)
Mol. Pharmacol.
, vol.42
, pp. 922-930
-
-
Holmes, E.1
-
10
-
-
34447521460
-
Human disease classification in the postgenomic era: A complex systems approach to human pathobiology
-
Loscalzo, J., Kohane, I. & Barabasi, A. L. Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol. Syst. Biol. 3, 124 (2007).
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 124
-
-
Loscalzo, J.1
Kohane, I.2
Barabasi, A.L.3
-
11
-
-
0032473005
-
High resolution 1H NMR spectroscopic studies on dynamic biochemical processes in incubated human seminal fluid samples
-
Tomlins, A. M. et al. High resolution 1H NMR spectroscopic studies on dynamic biochemical processes in incubated human seminal fluid samples. Biochim. Biophys. Acta 1379, 367-380 (1998).
-
(1998)
Biochim. Biophys. Acta
, vol.1379
, pp. 367-380
-
-
Tomlins, A.M.1
-
12
-
-
79957581759
-
Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus
-
Patterson, A. D. et al. Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J. Biol. Chem. 286, 19511-19522 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 19511-19522
-
-
Patterson, A.D.1
-
13
-
-
33847388440
-
Metabonomics in pharmaceutical discovery and development
-
Robertson, D. G., Reily, M. D. & Baker, J. D. Metabonomics in pharmaceutical discovery and development. J. Proteome Res. 6, 526-539 (2007).
-
(2007)
J. Proteome Res.
, vol.6
, pp. 526-539
-
-
Robertson, D.G.1
Reily, M.D.2
Baker, J.D.3
-
14
-
-
33847369007
-
Chemometrics in metabonomics
-
Trygg, J., Holmes, E. & Lundstedt, T. Chemometrics in metabonomics. J. Proteome Res. 6, 469-479 (2007).
-
(2007)
J. Proteome Res.
, vol.6
, pp. 469-479
-
-
Trygg, J.1
Holmes, E.2
Lundstedt, T.3
-
15
-
-
80755125363
-
Cross-platform analysis of longitudinal data in metabolomics
-
Nevedomskaya, E., Mayboroda, O. A. & Deelder, A. M. Cross-platform analysis of longitudinal data in metabolomics. Mol. Biosyst. 7, 3214-3222 (2011).
-
(2011)
Mol. Biosyst.
, vol.7
, pp. 3214-3222
-
-
Nevedomskaya, E.1
Mayboroda, O.A.2
Deelder, A.M.3
-
16
-
-
0021321993
-
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects
-
Nicholson, J. K. et al. Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem. J. 217, 365-375 (1984).
-
(1984)
Biochem. J.
, vol.217
, pp. 365-375
-
-
Nicholson, J.K.1
-
17
-
-
0021678284
-
Rapid screening of metabolic diseases by proton NMR
-
Iles, R. A., Snodgrass, G. J., Chalmers, R. A. & Stacey, T. E. Rapid screening of metabolic diseases by proton NMR. Lancet 2, 1221-1222 (1984).
-
(1984)
Lancet
, vol.2
, pp. 1221-1222
-
-
Iles, R.A.1
Snodgrass, G.J.2
Chalmers, R.A.3
Stacey, T.E.4
-
18
-
-
78649735772
-
Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting
-
Suhre, K. et al. Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS ONE 5, e13953 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Suhre, K.1
-
19
-
-
39149126959
-
1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death
-
Makinen, V. P. et al. 1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death. Mol. Syst. Biol. 4, 167 (2008).
-
(2008)
Mol. Syst. Biol.
, vol.4
, pp. 167
-
-
Makinen, V.P.1
-
20
-
-
34247842731
-
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human
-
Salek, R. M. et al. A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiol Genomics 29, 99-108 (2007).
-
(2007)
Physiol Genomics
, vol.29
, pp. 99-108
-
-
Salek, R.M.1
-
21
-
-
59649105735
-
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
-
Oresic, M. et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J. Exp. Med. 205, 2975-2984 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2975-2984
-
-
Oresic, M.1
-
22
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
Wang, T. J. et al. Metabolite profiles and the risk of developing diabetes. Nature Med. 17, 448-453 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 448-453
-
-
Wang, T.J.1
-
23
-
-
84869031541
-
Metabolomics in diabetes research
-
Friedrich, N. Metabolomics in diabetes research. J. Endocrinol. 215, 29-42 (2012).
-
(2012)
J. Endocrinol.
, vol.215
, pp. 29-42
-
-
Friedrich, N.1
-
24
-
-
0026830713
-
Classification of tumour 1H NMR spectra by pattern recognition
-
Howells, S. L. Maxwell, R. J. Griffiths, J. R. Classification of tumour 1H NMR spectra by pattern recognition. NMR Biomed. 5, 59-64 (1992).
-
(1992)
NMR Biomed.
, vol.5
, pp. 59-64
-
-
Howells, S.L.1
Maxwell, R.J.2
Griffiths, J.R.3
-
25
-
-
84859783281
-
Identification of metabolic biomarkers to diagnose epithelial ovarian cancer using a UPLC/QTOF/MS platform
-
Fan, L. et al. Identification of metabolic biomarkers to diagnose epithelial ovarian cancer using a UPLC/QTOF/MS platform. Acta Oncol. 51, 473-479 (2012).
-
(2012)
Acta Oncol.
, vol.51
, pp. 473-479
-
-
Fan, L.1
-
26
-
-
79953708853
-
Diagnosis of early stage ovarian cancer by 1H NMR metabonomics of serum explored by use of a microflow NMR probe
-
Garcia, E. et al. Diagnosis of early stage ovarian cancer by 1H NMR metabonomics of serum explored by use of a microflow NMR probe. J. Proteome Res. 10, 1765-1771 (2011).
-
(2011)
J. Proteome Res.
, vol.10
, pp. 1765-1771
-
-
Garcia, E.1
-
27
-
-
79951518482
-
Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine
-
Carrola, J. et al. Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine. J. Proteome Res. 10, 221-230 (2011).
-
(2011)
J. Proteome Res.
, vol.10
, pp. 221-230
-
-
Carrola, J.1
-
28
-
-
84866162860
-
Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study
-
Gaudet, M. M. et al. Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study. J. Clin. Endocrinol. Metab. 97, 3216-3223 (2012).
-
(2012)
J. Clin. Endocrinol. Metab.
, vol.97
, pp. 3216-3223
-
-
Gaudet, M.M.1
-
29
-
-
84858050477
-
Urinary acylcarnitines are altered in human kidney cancer
-
Ganti, S. et al. Urinary acylcarnitines are altered in human kidney cancer. Int. J. Cancer 130, 2791-2800 (2012).
-
(2012)
Int. J. Cancer
, vol.130
, pp. 2791-2800
-
-
Ganti, S.1
-
30
-
-
84863844396
-
A novel serum metabolomics-based diagnostic approach for colorectal cancer
-
Nishiumi, S. et al. A novel serum metabolomics-based diagnostic approach for colorectal cancer. PLoS ONE 7, e40459 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Nishiumi, S.1
-
31
-
-
78650375977
-
Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers
-
Slupsky, C. M. et al. Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers. Clin. Cancer Res. 16, 5835-5841 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5835-5841
-
-
Slupsky, C.M.1
-
32
-
-
79952436750
-
LC-MS based serum metabonomic analysis for renal cell carcinoma diagnosis, staging, and biomarker discovery
-
Lin, L. et al. LC-MS based serum metabonomic analysis for renal cell carcinoma diagnosis, staging, and biomarker discovery. J. Proteome Res. 10, 1396-1405 (2011).
-
(2011)
J. Proteome Res.
, vol.10
, pp. 1396-1405
-
-
Lin, L.1
-
33
-
-
79957798468
-
Identification of a serum-detectable metabolomic fingerprint potentially correlated with the presence of micrometastatic disease in early breast cancer patients at varying risks of disease relapse by traditional prognostic methods
-
Oakman, C. et al. Identification of a serum-detectable metabolomic fingerprint potentially correlated with the presence of micrometastatic disease in early breast cancer patients at varying risks of disease relapse by traditional prognostic methods. Ann. Oncol. 22, 1295-1301 (2011).
-
(2011)
Ann. Oncol.
, vol.22
, pp. 1295-1301
-
-
Oakman, C.1
-
34
-
-
84864309412
-
Exploration of serum metabolomic profiles and outcomes in women with metastatic breast cancer: A pilot study
-
Tenori, L. et al. Exploration of serum metabolomic profiles and outcomes in women with metastatic breast cancer: a pilot study. Mol. Oncol. 6, 437-444 (2012).
-
(2012)
Mol. Oncol.
, vol.6
, pp. 437-444
-
-
Tenori, L.1
-
36
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant, D. A., Durán, R. V. & Gottlieb, E. Targeting metabolic transformation for cancer therapy. Nature Rev. Cancer 10, 267-277 (2010).
-
(2010)
Nature Rev. Cancer
, vol.10
, pp. 267-277
-
-
Tennant, D.A.1
Durán, R.V.2
Gottlieb, E.3
-
37
-
-
59449097019
-
Clinical applications of metabolomics in oncology: A review
-
Spratlin, J. L., Serkova, N. J. & Eckhardt, S. G. Clinical applications of metabolomics in oncology: a review. Clin. Cancer Res. 15, 431-440 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 431-440
-
-
Spratlin, J.L.1
Serkova, N.J.2
Eckhardt, S.G.3
-
38
-
-
80055026433
-
Metabolomics as a tool for cardiac research
-
Griffin, J. L., Atherton, H., Shockcor, J. P. & Atzori, L. Metabolomics as a tool for cardiac research. Nature Rev. Cardiol. 8, 630-643 (2011).
-
(2011)
Nature Rev. Cardiol.
, vol.8
, pp. 630-643
-
-
Griffin, J.L.1
Atherton, H.2
Shockcor, J.P.3
Atzori, L.4
-
39
-
-
84861304175
-
Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease
-
Shah, S. H. et al. Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease. Am. Heart J. 163, 844-850 (2012).
-
(2012)
Am. Heart J.
, vol.163
, pp. 844-850
-
-
Shah, S.H.1
-
40
-
-
79953733693
-
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
-
Wang, Z. et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57-63 (2011).
-
(2011)
Nature
, vol.472
, pp. 57-63
-
-
Wang, Z.1
-
41
-
-
79956268399
-
Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology
-
Caldeira, M. et al. Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology. J. Chromatogr. A 1218, 3771-3780 (2011).
-
(2011)
J. Chromatogr. A
, vol.1218
, pp. 3771-3780
-
-
Caldeira, M.1
-
42
-
-
82555189254
-
Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD
-
Fens, N. et al. Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD. Eur. Respir. J. 38, 1301-1309 (2009).
-
(2009)
Eur. Respir. J.
, vol.38
, pp. 1301-1309
-
-
Fens, N.1
-
43
-
-
79952309777
-
Metabolomic profiling of asthma: Diagnostic utility of urine nuclear magnetic resonance spectroscopy
-
Saude, E. J. et al. Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy. J. Allergy Clin. Immunol. 127, 757-764 (2011).
-
(2011)
J. Allergy Clin. Immunol.
, vol.127
, pp. 757-764
-
-
Saude, E.J.1
-
44
-
-
84864776788
-
Metabolic profiling detects biomarkers of protein degradation in COPD patients
-
Ubhi, B. K. et al. Metabolic profiling detects biomarkers of protein degradation in COPD patients. Eur. Respir. J. 40, 345-355 (2012).
-
(2012)
Eur. Respir. J.
, vol.40
, pp. 345-355
-
-
Ubhi, B.K.1
-
45
-
-
77950251400
-
A human gut microbial gene catalogue established by metagenomic sequencing
-
Qin, J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59-65 (2010).
-
(2010)
Nature
, vol.464
, pp. 59-65
-
-
Qin, J.1
-
46
-
-
84862141704
-
Human gut microbiome viewed across age and geography
-
Yatsunenko, T. et al. Human gut microbiome viewed across age and geography. Nature 486, 222-227 (2012).
-
(2012)
Nature
, vol.486
, pp. 222-227
-
-
Yatsunenko, T.1
-
47
-
-
84861978076
-
Host-gut microbiota metabolic interactions
-
Nicholson, J. K. et al. Host-gut microbiota metabolic interactions. Science. 336, 1262-1267 (2012).
-
(2012)
Science
, vol.336
, pp. 1262-1267
-
-
Nicholson, J.K.1
-
48
-
-
80052062107
-
GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis
-
Ooi, M. et al. GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis. Inflamm. Res. 60, 831-840 (2011).
-
(2011)
Inflamm. Res.
, vol.60
, pp. 831-840
-
-
Ooi, M.1
-
49
-
-
66949180452
-
Characterization of inflammatory bowel disease with urinary metabolic profiling
-
Williams, H. R. et al. Characterization of inflammatory bowel disease with urinary metabolic profiling. Am. J. Gastroenterol. 104, 1435-1444 (2009).
-
(2009)
Am. J. Gastroenterol.
, vol.104
, pp. 1435-1444
-
-
Williams, H.R.1
-
50
-
-
33847378014
-
Rapid and non-invasive metabonomic characterization of inflammatory bowel disease
-
Marchesi, J. R. et al. Rapid and non-invasive metabonomic characterization of inflammatory bowel disease. J. Proteome Res. 6, 546-551 (2007).
-
(2007)
J. Proteome Res.
, vol.6
, pp. 546-551
-
-
Marchesi, J.R.1
-
51
-
-
41149099000
-
Symbiotic gut microbes modulate human metabolic phenotypes
-
Li, M. et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc. Natl Acad. Sci. USA 105, 2117-2122 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 2117-2122
-
-
Li, M.1
-
52
-
-
84861980130
-
Interactions between the microbiota and the immune system
-
Hooper, L. V., Littman, D. R. & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268-1273 (2012).
-
(2012)
Science
, vol.336
, pp. 1268-1273
-
-
Hooper, L.V.1
Littman, D.R.2
MacPherson, A.J.3
-
53
-
-
79952749979
-
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
-
Swann, J. R. et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl Acad. Sci. USA 108, 4523-4530 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 4523-4530
-
-
Swann, J.R.1
-
54
-
-
84861992769
-
Therapeutic modulation of microbiota-host metabolic interactions
-
Holmes, E. et al. Therapeutic modulation of microbiota-host metabolic interactions. Sci. Transl. Med. 4, 137rv6 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Holmes, E.1
-
55
-
-
77955153069
-
The endocannabinoid system links gut microbiota to adipogenesis
-
Muccioli, G. G. et al. The endocannabinoid system links gut microbiota to adipogenesis. Mol. Syst. Biol. 6, 392 (2010).
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 392
-
-
Muccioli, G.G.1
-
56
-
-
77954592502
-
Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls
-
Yap, I. K. et al. Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. J. Proteome Res. 9, 2996-3004 (2010).
-
(2010)
J. Proteome Res.
, vol.9
, pp. 2996-3004
-
-
Yap, I.K.1
-
57
-
-
45749156816
-
Altered amino acid excretion in children with autism
-
Evans, C. et al. Altered amino acid excretion in children with autism. Nutr. Neurosci. 11, 9-17 (2008).
-
(2008)
Nutr. Neurosci.
, vol.11
, pp. 9-17
-
-
Evans, C.1
-
58
-
-
80053919756
-
Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant
-
Thomas, E. L. et al. Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant. Pediatr. Res. 70, 507-512 (2011).
-
(2011)
Pediatr. Res.
, vol.70
, pp. 507-512
-
-
Thomas, E.L.1
-
59
-
-
84861982483
-
Honor thy gut symbionts: Redux
-
Gordon J. I. Honor thy gut symbionts: redux. Science 336, 1251-1253 (2012).
-
(2012)
Science
, vol.336
, pp. 1251-1253
-
-
Gordon, J.I.1
-
60
-
-
38849190556
-
Gut microbiota: A potential new territory for drug targeting
-
Jia, W., Li, H., Zhao, L. & Nicholson, J. K. Gut microbiota: a potential new territory for drug targeting. Nature Rev. Drug Discov. 7, 123-129 (2008).
-
(2008)
Nature Rev. Drug Discov.
, vol.7
, pp. 123-129
-
-
Jia, W.1
Li, H.2
Zhao, L.3
Nicholson, J.K.4
-
61
-
-
79957857701
-
Metabolic phenotyping for monitoring surgical patients
-
Kinross, J. M., Holmes, E., Darzi, A. W. & Nicholson, J. K. Metabolic phenotyping for monitoring surgical patients. Lancet 377, 1817-1819 (2011).
-
(2011)
Lancet
, vol.377
, pp. 1817-1819
-
-
Kinross, J.M.1
Holmes, E.2
Darzi, A.W.3
Nicholson, J.K.4
-
62
-
-
33646198860
-
Pharmaco-metabonomic phenotyping and personalized drug treatment
-
Clayton, T. A. et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440, 1073-1077 (2006).
-
(2006)
Nature
, vol.440
, pp. 1073-1077
-
-
Clayton, T.A.1
-
63
-
-
70149096873
-
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
-
Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R. & Nicholson, J. K. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl Acad. Sci. USA 106, 14728-14733 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 14728-14733
-
-
Clayton, T.A.1
Baker, D.2
Lindon, J.C.3
Everett, J.R.4
Nicholson, J.K.5
-
64
-
-
79955510058
-
Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine
-
Backshall, A., Sharma, R., Clarke, S. J. & Keun, H. C. Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine. Clin. Cancer Res. 17, 3019-3028 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 3019-3028
-
-
Backshall, A.1
Sharma, R.2
Clarke, S.J.3
Keun, H.C.4
-
65
-
-
84862333733
-
Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients
-
Schmerler, D. et al. Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients. J. Lipid Res. 53, 1369-1375 (2012).
-
(2012)
J. Lipid Res.
, vol.53
, pp. 1369-1375
-
-
Schmerler, D.1
-
66
-
-
77954717673
-
1H-NMR-based metabolic signatures of clinical outcomes in trauma patients-beyond lactate and base deficit
-
Cohen, M. J., Serkova, N. J., Wiener-Kronish, J., Pittet, J. F. & Niemann, C. U. 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients-beyond lactate and base deficit. J. Trauma 69, 31-40 (2010).
-
(2010)
J. Trauma
, vol.69
, pp. 31-40
-
-
Cohen, M.J.1
Serkova, N.J.2
Wiener-Kronish, J.3
Pittet, J.F.4
Niemann, C.U.5
-
67
-
-
84555178229
-
Epidemiological burden of minor, major and fatal trauma in a national injury pyramid
-
Polinder, S., Haagsma, J. A., Toet, H. & van Beeck, E. F. Epidemiological burden of minor, major and fatal trauma in a national injury pyramid. Br. J. Surg. 99, 114-121 (2012).
-
(2012)
Br. J. Surg.
, vol.99
, pp. 114-121
-
-
Polinder, S.1
Haagsma, J.A.2
Toet, H.3
Van Beeck, E.F.4
-
68
-
-
0037324154
-
Influence of the critically ill state on host-pathogen interactions within the intestine: Gut-derived sepsis redefined
-
Alverdy, J. C., Laughlin, R. S. & Wu, L. Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined. Crit. Care Med. 31, 598-607 (2003).
-
(2003)
Crit. Care Med.
, vol.31
, pp. 598-607
-
-
Alverdy, J.C.1
Laughlin, R.S.2
Wu, L.3
-
69
-
-
77952680389
-
Undiagnosed malnutrition and nutrition-related problems in geriatric patients
-
Volkert, D., Saeglitz, C., Gueldenzoph, H., Sieber, C. C. & Stehle, P. Undiagnosed malnutrition and nutrition-related problems in geriatric patients. J. Nutr. Health Aging 14, 387-392 (2010).
-
(2010)
J. Nutr. Health Aging
, vol.14
, pp. 387-392
-
-
Volkert, D.1
Saeglitz, C.2
Gueldenzoph, H.3
Sieber, C.C.4
Stehle, P.5
-
70
-
-
77956266237
-
An analysis of the interactions between individual comorbidities and their treatments - Implications for guidelines and polypharmacy
-
Fitzgerald, S. P. & Bean, N. G. An analysis of the interactions between individual comorbidities and their treatments - implications for guidelines and polypharmacy. J. Am. Med. Dir. Assoc. 11, 475-484 (2010).
-
(2010)
J. Am. Med. Dir. Assoc.
, vol.11
, pp. 475-484
-
-
Fitzgerald, S.P.1
Bean, N.G.2
-
71
-
-
84858339934
-
Metabolic profiles predict adverse events after coronary artery bypass grafting
-
Shah, A. A. et al. Metabolic profiles predict adverse events after coronary artery bypass grafting. J. Thorac. Cardiovasc. Surg. 143, 873-878 (2012).
-
(2012)
J. Thorac. Cardiovasc. Surg.
, vol.143
, pp. 873-878
-
-
Shah, A.A.1
-
72
-
-
71549122282
-
Systemic metabolic changes of traumatic critically ill patients revealed by an NMR-based metabonomic approach
-
Mao, H. et al. Systemic metabolic changes of traumatic critically ill patients revealed by an NMR-based metabonomic approach. J. Proteome Res. 8, 5423-5430 (2009).
-
(2009)
J. Proteome Res.
, vol.8
, pp. 5423-5430
-
-
Mao, H.1
-
73
-
-
84863124048
-
Metabonomics study of the acute graft rejection in rat renal transplantation using reversed-phase liquid chromatography and hydrophilic interaction chromatography coupled with mass spectrometry
-
Chen, J. et al. Metabonomics study of the acute graft rejection in rat renal transplantation using reversed-phase liquid chromatography and hydrophilic interaction chromatography coupled with mass spectrometry. Mol. Biosyst. 8, 871-878 (2012).
-
(2012)
Mol. Biosyst.
, vol.8
, pp. 871-878
-
-
Chen, J.1
-
74
-
-
77957997338
-
Metabonomic analysis of serum metabolites in kidney transplant recipients with cyclosporine A- or tacrolimus-based immunosuppression
-
Kim, C. D. et al. Metabonomic analysis of serum metabolites in kidney transplant recipients with cyclosporine A- or tacrolimus-based immunosuppression. Transplantation 90, 748-756 (2010).
-
(2010)
Transplantation
, vol.90
, pp. 748-756
-
-
Kim, C.D.1
-
75
-
-
79960714351
-
Bile UPLC-MS fingerprinting and bile acid fluxes during human liver transplantation
-
Legido-Quigley, C. et al. Bile UPLC-MS fingerprinting and bile acid fluxes during human liver transplantation. Electrophoresis 32, 2063-2070 (2011).
-
(2011)
Electrophoresis
, vol.32
, pp. 2063-2070
-
-
Legido-Quigley, C.1
-
76
-
-
84879520861
-
Metabolomics of human intestinal transplant rejection
-
July
-
Girlanda, R. et al. Metabolomics of human intestinal transplant rejection. Am. J. Transplant. http://dx.doi.org/10.1111/j.1600-6143.2012.04183.x (July 2012).
-
(2012)
Am. J. Transplant.
-
-
Girlanda, R.1
-
77
-
-
84864522742
-
Bariatric surgery or medical therapy for obesity
-
Fornari, F., Comis, V. R. & Lisboa, H. R. Bariatric surgery or medical therapy for obesity. N. Engl J. Med. 367, 474 (2012).
-
(2012)
N. Engl J. Med.
, vol.367
, pp. 474
-
-
Fornari, F.1
Comis, V.R.2
Lisboa, H.R.3
-
78
-
-
80051545971
-
Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk
-
Li, J. V. et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut 60, 1214-1223 (2011).
-
(2011)
Gut
, vol.60
, pp. 1214-1223
-
-
Li, J.V.1
-
79
-
-
70949093312
-
Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery
-
Mutch, D. M. et al. Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery. PLoS ONE 4, e7905 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Mutch, D.M.1
-
80
-
-
60549086580
-
Human gut microbiota in obesity and after gastric bypass
-
Zhang, H. et al. Human gut microbiota in obesity and after gastric bypass. Proc. Natl Acad. Sci. USA 106, 2365-2370 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2365-2370
-
-
Zhang, H.1
-
81
-
-
84862149788
-
Aging of the human metaorganism: The microbial counterpart
-
Biagi, E., Candela, M., Fairweather-Tait, S., Franceschi, C. & Brigidi, P. Aging of the human metaorganism: the microbial counterpart. Age (Dordr.) 34, 247-267 (2012).
-
(2012)
Age (Dordr.)
, vol.34
, pp. 247-267
-
-
Biagi, E.1
Candela, M.2
Fairweather-Tait, S.3
Franceschi, C.4
Brigidi, P.5
-
82
-
-
84864722033
-
Gut microbiota composition correlates with diet and health in the elderly
-
Claesson, M. J. et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 488, 178-184 (2012).
-
(2012)
Nature
, vol.488
, pp. 178-184
-
-
Claesson, M.J.1
-
83
-
-
84864886553
-
Reoperation rates after breast conserving surgery for breast cancer among women in England: Retrospective study of hospital episode statistics
-
Jeevan, R. et al. Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics. Br. Med. J. 345, e4505 (2012).
-
(2012)
Br. Med. J.
, vol.345
-
-
Jeevan, R.1
-
84
-
-
60849139445
-
Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS)
-
Chan, E. C. et al. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J. Proteome Res. 8, 352-361 (2009).
-
(2009)
J. Proteome Res.
, vol.8
, pp. 352-361
-
-
Chan, E.C.1
-
85
-
-
50049102731
-
An investigation of human brain tumour lipids by high-resolution magic angle spinning 1H MRS and histological analysis
-
Opstad, K. S., Bell, B. A., Griffiths, J. R. & Howe, F. A. An investigation of human brain tumour lipids by high-resolution magic angle spinning 1H MRS and histological analysis. NMR Biomed. 21, 677-685 (2008).
-
(2008)
NMR Biomed.
, vol.21
, pp. 677-685
-
-
Opstad, K.S.1
Bell, B.A.2
Griffiths, J.R.3
Howe, F.A.4
-
86
-
-
77955076888
-
Ex-vivo HRMAS of adult brain tumours: Metabolite quantification and assignment of tumour biomarkers
-
Wright, A. J. et al. Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers. Mol. Cancer 9, 66 (2010).
-
(2010)
Mol. Cancer
, vol.9
, pp. 66
-
-
Wright, A.J.1
-
87
-
-
77953007681
-
Metabolomic imaging for human prostate cancer detection
-
Wu, C. L. et al. Metabolomic imaging for human prostate cancer detection. Sci. Transl. Med. 2, 16ra18 (2010).
-
(2010)
Sci. Transl. Med.
, vol.2
-
-
Wu, C.L.1
-
88
-
-
84862534252
-
Changes in gene transcription underlying the aberrant citrate and choline metabolism in human prostate cancer samples
-
Bertilsson, H. et al. Changes in gene transcription underlying the aberrant citrate and choline metabolism in human prostate cancer samples. Clin. Cancer Res. 18, 3261-3269 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 3261-3269
-
-
Bertilsson, H.1
-
90
-
-
77956234847
-
Identification of biological tissues by rapid evaporative ionization mass spectrometry
-
Balog, J. et al. Identification of biological tissues by rapid evaporative ionization mass spectrometry. Anal. Chem. 82, 7343-7350 (2010).
-
(2010)
Anal. Chem.
, vol.82
, pp. 7343-7350
-
-
Balog, J.1
-
91
-
-
80755168397
-
Electrospray post-ionization mass spectrometry of electrosurgical aerosols
-
Guenther, S. et al. Electrospray post-ionization mass spectrometry of electrosurgical aerosols. J. Am. Soc. Mass Spectrom. 22, 2082-2089 (2011).
-
(2011)
J. Am. Soc. Mass Spectrom.
, vol.22
, pp. 2082-2089
-
-
Guenther, S.1
-
92
-
-
84863723868
-
Analysis of colorectal adenocarcinoma tissue by desorption electrospray ionization mass spectrometric imaging
-
Gerbig, S. et al. Analysis of colorectal adenocarcinoma tissue by desorption electrospray ionization mass spectrometric imaging. Anal. Bioanal. Chem. 403, 2315-2325 (2012).
-
(2012)
Anal. Bioanal. Chem.
, vol.403
, pp. 2315-2325
-
-
Gerbig, S.1
-
93
-
-
80054713192
-
Real time analysis of brain tissue by direct combination of ultrasonic surgical aspiration and sonic spray mass spectrometry
-
Schafer, K. C. et al. Real time analysis of brain tissue by direct combination of ultrasonic surgical aspiration and sonic spray mass spectrometry. Anal. Chem. 83, 7729-7735 (2011).
-
(2011)
Anal. Chem.
, vol.83
, pp. 7729-7735
-
-
Schafer, K.C.1
-
94
-
-
39149126712
-
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
-
Beckonert, O. et al. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nature Protocal. 2, 2692-2703 (2007).
-
(2007)
Nature Protocal.
, vol.2
, pp. 2692-2703
-
-
Beckonert, O.1
-
95
-
-
66349087823
-
Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics
-
Lindon, J. C. & Nicholson, J. K. Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics. Annu. Rev. Anal. Chem. 1, 45-69 (2008).
-
(2008)
Annu. Rev. Anal. Chem.
, vol.1
, pp. 45-69
-
-
Lindon, J.C.1
Nicholson, J.K.2
-
96
-
-
84859915011
-
Evaluation of high resolution magic-angle coil spinning NMR spectroscopy for metabolic profiling of nanoliter tissue biopsies
-
Wong, A. et al. Evaluation of high resolution magic-angle coil spinning NMR spectroscopy for metabolic profiling of nanoliter tissue biopsies. Anal. Chem. 84, 3843-3848 (2012).
-
(2012)
Anal. Chem.
, vol.84
, pp. 3843-3848
-
-
Wong, A.1
-
97
-
-
0017297724
-
Application of glass capillary-column gas chromatography-mass spectrometry to the studies of human diseases
-
Jellum, E. et al. Application of glass capillary-column gas chromatography-mass spectrometry to the studies of human diseases. J. Chromatogr. 126, 487-493 (1976).
-
(1976)
J. Chromatogr.
, vol.126
, pp. 487-493
-
-
Jellum, E.1
-
98
-
-
78650301750
-
CE-MS for metabolomics: Developments and applications in the period 2008-2010
-
Ramautar, R., Mayboroda, O. A., Somsen, G. W. & de Jong, G. J. CE-MS for metabolomics: developments and applications in the period 2008-2010. Electrophoresis 32, 52-65 (2011).
-
(2011)
Electrophoresis
, vol.32
, pp. 52-65
-
-
Ramautar, R.1
Mayboroda, O.A.2
Somsen, G.W.3
De Jong, G.J.4
-
99
-
-
30744443014
-
Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: Application in metabonomic toxicology studies
-
Crockford, D. J. et al. Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies. Anal. Chem. 78, 363-371 (2006).
-
(2006)
Anal. Chem.
, vol.78
, pp. 363-371
-
-
Crockford, D.J.1
-
100
-
-
84856743468
-
Robust data processing and normalization strategy for MALDI mass spectrometric imaging
-
Fonville, J. M. et al. Robust data processing and normalization strategy for MALDI mass spectrometric imaging. Anal. Chem. 84, 1310-1319 (2012).
-
(2012)
Anal. Chem.
, vol.84
, pp. 1310-1319
-
-
Fonville, J.M.1
|