-
1
-
-
33744804299
-
Metagenomic analysis of the human distal gut microbiome
-
Gill SR, Pop M, Deboy RT, et al. Metagenomic analysis of the human distal gut microbiome. Science. 2006;312 (5778):1355-1359.
-
(2006)
Science
, vol.312
, Issue.5778
, pp. 1355-1359
-
-
Gill, S.R.1
Pop, M.2
Deboy, R.T.3
-
2
-
-
77950251400
-
A human gut microbial gene catalogue established by metagenomic sequencing
-
Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59-65.
-
(2010)
Nature
, vol.464
, Issue.7285
, pp. 59-65
-
-
Qin, J.1
Li, R.2
Raes, J.3
-
3
-
-
38849190556
-
Gut microbiota: A potential new territory for drug targeting
-
Jia W, Li H, Zhao L, et al. Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov. 2008;7(2):123-129.
-
(2008)
Nat Rev Drug Discov
, vol.7
, Issue.2
, pp. 123-129
-
-
Jia, W.1
Li, H.2
Zhao, L.3
-
5
-
-
34547683600
-
Diversity of the human gastrointestinal tract microbiota revisited
-
Rajilic-Stojanovic M, Smidt H, De Vos WM. Diversity of the human gastrointestinal tract microbiota revisited. Environ Microbiol. 2007;9(9):2125-2136.
-
(2007)
Environ Microbiol
, vol.9
, Issue.9
, pp. 2125-2136
-
-
Rajilic-Stojanovic, M.1
Smidt, H.2
De Vos, W.M.3
-
6
-
-
84871538443
-
Gut Pharmacomicrobiomics: The tip of an iceberg of complex interactions between drugs and gut-associated microbes
-
Saad R, Rizkallah MR, Aziz RK. Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes. Gut Pathog. 2012;4(1):16.
-
(2012)
Gut Pathog
, vol.4
, Issue.1
, pp. 16
-
-
Saad, R.1
Rizkallah, M.R.2
Aziz, R.K.3
-
7
-
-
84873728735
-
Developing a metagenomic view of xenobiotic metabolism
-
Haiser HJ, Turnbaugh PJ. Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013;69(1): 21-31.
-
(2013)
Pharmacol Res
, vol.69
, Issue.1
, pp. 21-31
-
-
Haiser, H.J.1
Turnbaugh, P.J.2
-
8
-
-
70149096873
-
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
-
Clayton TA, Baker D, Lindon JC, et al. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci USA. 2009;106 (34):14728-14733.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.34
, pp. 14728-14733
-
-
Clayton, T.A.1
Baker, D.2
Lindon, J.C.3
-
9
-
-
84880439384
-
Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
-
Haiser HJ, Gootenberg DB, Chatman K, et al. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science. 2013;341(6143):295-298.
-
(2013)
Science
, vol.341
, Issue.6143
, pp. 295-298
-
-
Haiser, H.J.1
Gootenberg, D.B.2
Chatman, K.3
-
10
-
-
84868025090
-
Bacterial inactivation of the anticancer drug doxorubicin
-
Westman EL, Canova MJ, Radhi IJ, et al. Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012;19 (10):1255-1264.
-
(2012)
Chem Biol
, vol.19
, Issue.10
, pp. 1255-1264
-
-
Westman, E.L.1
Canova, M.J.2
Radhi, I.J.3
-
11
-
-
0019442903
-
Inactivation of digoxin by the gut flora: Reversal by antibiotic therapy
-
Lindenbaum J, Rund DG, Butler VP Jr., et al. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. N Engl J Med. 1981;305(14):789-794.
-
(1981)
N Engl J Med
, vol.305
, Issue.14
, pp. 789-794
-
-
Lindenbaum, J.1
Rund, D.G.2
Butler, V.P.3
-
12
-
-
0015745640
-
Contributions of host and intestinal microflora in the metabolism of L-dopa by the rat
-
Goldin BR, Peppercorn MA, Goldman P. Contributions of host and intestinal microflora in the metabolism of L-dopa by the rat. J Pharmacol Exp Ther. 1973;186 (1):160-166.
-
(1973)
J Pharmacol Exp Ther
, vol.186
, Issue.1
, pp. 160-166
-
-
Goldin, B.R.1
Peppercorn, M.A.2
Goldman, P.3
-
13
-
-
0018362216
-
The anaerobic metabolism of metronidazole forms N-(2- hydroxyethyl)-oxamic acid
-
Koch RL, Goldman P. The anaerobic metabolism of metronidazole forms N-(2- hydroxyethyl)-oxamic acid. J Pharmacol Exp Ther. 1979;208(3):406-410.
-
(1979)
J Pharmacol Exp Ther
, vol.208
, Issue.3
, pp. 406-410
-
-
Koch, R.L.1
Goldman, P.2
-
14
-
-
78751671824
-
Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro
-
Aura AM, Mattila I, Hyotylainen T, et al. Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro. Mol Biosyst. 2011;7(2):437-446.
-
(2011)
Mol Biosyst
, vol.7
, Issue.2
, pp. 437-446
-
-
Aura, A.M.1
Mattila, I.2
Hyotylainen, T.3
-
15
-
-
84906853367
-
Gut microbiota-mediated drug interactions between lovastatin and antibiotics
-
Yoo DH, Kim IS, Van Le TK, et al. Gut microbiota-mediated drug interactions between lovastatin and antibiotics. Drug Metab Dispos. 2014;42(9):1508-1513.
-
(2014)
Drug Metab Dispos
, vol.42
, Issue.9
, pp. 1508-1513
-
-
Yoo, D.H.1
Kim, I.S.2
Van Le, T.K.3
-
16
-
-
0023879753
-
The role of intestinal microflora in the formation of the methylthio adduct metabolites of paracetamol. Studies in neomycin- pretreated and germ-free mice
-
Mikov M, Caldwell J, Dolphin CT, et al. The role of intestinal microflora in the formation of the methylthio adduct metabolites of paracetamol. Studies in neomycin- pretreated and germ-free mice. Biochem Pharmacol. 1988;37(8):1445-1449.
-
(1988)
Biochem Pharmacol
, vol.37
, Issue.8
, pp. 1445-1449
-
-
Mikov, M.1
Caldwell, J.2
Dolphin, C.T.3
-
17
-
-
0025879859
-
Metabolism of levamisole, an anticolon cancer drug, by human intestinal bacteria
-
Shu YZ, Kingston DG, Van Tassell RL, et al. Metabolism of levamisole, an anticolon cancer drug, by human intestinal bacteria. Xenobiotica. 1991;21(6):737-750.
-
(1991)
Xenobiotica
, vol.21
, Issue.6
, pp. 737-750
-
-
Shu, Y.Z.1
Kingston, D.G.2
Van Tassell, R.L.3
-
18
-
-
77958157551
-
Effects of gut microflora on pharmacokinetics of hesperidin: A study on non-antibiotic and pseudo-germ-free rats
-
Jin MJ, Kim U, Kim IS, et al. Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats. J Toxicol Environ Health A. 2010;73(21-22):1441-1450.
-
(2010)
J Toxicol Environ Health A
, vol.73
, Issue.21-22
, pp. 1441-1450
-
-
Jin, M.J.1
Kim, U.2
Kim, I.S.3
-
19
-
-
4043153467
-
Antiallergic activity of hesperidin is activated by intestinal microflora
-
Lee NK, Choi SH, Park SH, et al. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology. 2004;71(4):174-180.
-
(2004)
Pharmacology
, vol.71
, Issue.4
, pp. 174-180
-
-
Lee, N.K.1
Choi, S.H.2
Park, S.H.3
-
20
-
-
0015621623
-
The demethylation of methamphetamine by intestinal microflora
-
Caldwell J, Hawksworth GM. The demethylation of methamphetamine by intestinal microflora. J Pharm Pharmacol. 1973;25(5):422-424.
-
(1973)
J Pharm Pharmacol
, vol.25
, Issue.5
, pp. 422-424
-
-
Caldwell, J.1
Hawksworth, G.M.2
-
21
-
-
0037177374
-
Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora
-
Basit AW, Newton JM, Lacey LF. Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora. Int J Pharm. 2002;237 (1-2):23-33.
-
(2002)
Int J Pharm
, vol.237
, Issue.1-2
, pp. 23-33
-
-
Basit, A.W.1
Newton, J.M.2
Lacey, L.F.3
-
22
-
-
0028914209
-
Metabolism of omeprazole by gut flora in rats
-
Watanabe K, Yamashita S, Furuno K, et al. Metabolism of omeprazole by gut flora in rats. J Pharm Sci. 1995;84(4):516-517.
-
(1995)
J Pharm Sci
, vol.84
, Issue.4
, pp. 516-517
-
-
Watanabe, K.1
Yamashita, S.2
Furuno, K.3
-
23
-
-
0028147301
-
The metabolism and excretion of risperidone after oral administration in rats and dogs
-
Meuldermans W, Hendrickx J, Mannens G, et al. The metabolism and excretion of risperidone after oral administration in rats and dogs. Drug Metab Dispos. 1994; 22(1):129-138.
-
(1994)
Drug Metab Dispos
, vol.22
, Issue.1
, pp. 129-138
-
-
Meuldermans, W.1
Hendrickx, J.2
Mannens, G.3
-
24
-
-
0025903764
-
A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease
-
Wadworth AN, Olsalazine FA. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease. Drugs. 1991;41(4):647-664.
-
(1991)
Drugs
, vol.41
, Issue.4
, pp. 647-664
-
-
Wadworth, A.N.1
Olsalazine, F.A.2
-
25
-
-
0023234065
-
The reduction of sulphinpyrazone and sulindac by intestinal bacteria
-
Strong HA, Renwick AG, George CF, et al. The reduction of sulphinpyrazone and sulindac by intestinal bacteria. Xenobiotica. 1987;17(6):685-696.
-
(1987)
Xenobiotica
, vol.17
, Issue.6
, pp. 685-696
-
-
Strong, H.A.1
Renwick, A.G.2
George, C.F.3
-
26
-
-
0014198434
-
The bacterial degradation of chloramphenicol
-
Holt R. The bacterial degradation of chloramphenicol. Lancet. 1967;1 (7502):1259-1260.
-
(1967)
Lancet
, vol.1
, Issue.7502
, pp. 1259-1260
-
-
Holt, R.1
-
27
-
-
0029020691
-
Metabolism of peptide drugs by the microorganisms in rat cecal contents
-
Tozaki H, Emi Y, Horisaka E, et al. Metabolism of peptide drugs by the microorganisms in rat cecal contents. Biol Pharm Bull. 1995;18(6):929-931.
-
(1995)
Biol Pharm Bull
, vol.18
, Issue.6
, pp. 929-931
-
-
Tozaki, H.1
Emi, Y.2
Horisaka, E.3
-
28
-
-
0033974827
-
Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis
-
Shim SB, Kim NJ, Kim DH. Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis. Planta Med. 2000;66(1):40-43.
-
(2000)
Planta Med
, vol.66
, Issue.1
, pp. 40-43
-
-
Shim, S.B.1
Kim, N.J.2
Kim, D.H.3
-
29
-
-
0028262303
-
Intestinal bacterial hydrolysis is indispensable to absorption of 18-beta-glycyrrhetic acid after oral-administration of glycyrrhizin in rats
-
Akao T, Hayashi T, Kobashi K, et al. Intestinal bacterial hydrolysis is indispensable to absorption of 18-beta-glycyrrhetic acid after oral-administration of glycyrrhizin in rats. J Pharm And Pharmacol. 1994;46(2):135-137.
-
(1994)
J Pharm and Pharmacol
, vol.46
, Issue.2
, pp. 135-137
-
-
Akao, T.1
Hayashi, T.2
Kobashi, K.3
-
30
-
-
0025912777
-
Involvement of the intestinal microflora in nitrazepaminduced teratogenicity in rats and its relationship to nitroreduction
-
Takeno S, Sakai T. Involvement of the intestinal microflora in nitrazepaminduced teratogenicity in rats and its relationship to nitroreduction. Teratology. 1991;44(2):209-214.
-
(1991)
Teratology
, vol.44
, Issue.2
, pp. 209-214
-
-
Takeno, S.1
Sakai, T.2
-
31
-
-
0022649516
-
Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora
-
Harris BE, Manning BW, Federle TW, et al. Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora. Antimicrob Agents Chemother. 1986;29(1):44-48.
-
(1986)
Antimicrob Agents Chemother
, vol.29
, Issue.1
, pp. 44-48
-
-
Harris, B.E.1
Manning, B.W.2
Federle, T.W.3
-
32
-
-
0028941669
-
Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans
-
Lavrijsen K, Van Dyck D, Van Houdt J, et al. Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans. Drug Metab Dispos. 1995;23(3):354-362.
-
(1995)
Drug Metab Dispos
, vol.23
, Issue.3
, pp. 354-362
-
-
Lavrijsen, K.1
Van Dyck, D.2
Van Houdt, J.3
-
33
-
-
84922983227
-
Insights on the human microbiome and its xenobiotic metabolism: What is known about its effects on human physiology?
-
Tralau T, Sowada J, Luch A. Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology? Expert Opin Drug Metab Toxicol. 2015;11(3):411-425.
-
(2015)
Expert Opin Drug Metab Toxicol
, vol.11
, Issue.3
, pp. 411-425
-
-
Tralau, T.1
Sowada, J.2
Luch, A.3
-
34
-
-
84886727251
-
Cometabolism of microbes and host: Implications for drug metabolism and drug-induced toxicity
-
Li H, Jia W. Cometabolism of microbes and host: implications for drug metabolism and drug-induced toxicity. Clin Pharmacol Ther. 2013;94(5):574-581.
-
(2013)
Clin Pharmacol Ther
, vol.94
, Issue.5
, pp. 574-581
-
-
Li, H.1
Jia, W.2
-
35
-
-
0030985696
-
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5- fluorouracil
-
Nakayama H, Kinouchi T, Kataoka K, et al. Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5- fluorouracil. Pharmacogenetics. 1997;7 (1):35-43.
-
(1997)
Pharmacogenetics
, vol.7
, Issue.1
, pp. 35-43
-
-
Nakayama, H.1
Kinouchi, T.2
Kataoka, K.3
-
36
-
-
84910146333
-
In vitro fermentation of lactulose by human gut bacteria
-
Mao B, Li D, Zhao J, et al. In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014;62 (45):10970-10977.
-
(2014)
J Agric Food Chem
, vol.62
, Issue.45
, pp. 10970-10977
-
-
Mao, B.1
Li, D.2
Zhao, J.3
-
37
-
-
0020029786
-
The fermentation of lactulose by colonic bacteria
-
Sahota SS, Bramley PM, Menzies IS. The fermentation of lactulose by colonic bacteria. J Gen Microbiol. 1982;128(2):319-325.
-
(1982)
J Gen Microbiol
, vol.128
, Issue.2
, pp. 319-325
-
-
Sahota, S.S.1
Bramley, P.M.2
Menzies, I.S.3
-
38
-
-
77953236227
-
Antipruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice
-
Trinh HT, Joh EH, Kwak HY, et al. Antipruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice. Acta Pharmacol Sin. 2010;31(6):718-724.
-
(2010)
Acta Pharmacol Sin
, vol.31
, Issue.6
, pp. 718-724
-
-
Trinh, H.T.1
Joh, E.H.2
Kwak, H.Y.3
-
39
-
-
84896399662
-
Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin
-
Kang MJ, Ko GS, Oh Do G, et al. Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin. Arch Pharm Res. 2014;37(3):371-378.
-
(2014)
Arch Pharm Res
, vol.37
, Issue.3
, pp. 371-378
-
-
Kang, M.J.1
Ko, G.S.2
Oh Do, G.3
-
40
-
-
49449095071
-
Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine
-
Matthies A, Clavel T, Gutschow M, et al. Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine. Appl Environ Microbiol. 2008;74(15):4847-4852.
-
(2008)
Appl Environ Microbiol
, vol.74
, Issue.15
, pp. 4847-4852
-
-
Matthies, A.1
Clavel, T.2
Gutschow, M.3
-
41
-
-
79958226297
-
Bacteroides uniformis is a putative bacterial species associated with the degradation of the isoflavone genistein in human feces
-
Renouf M, Hendrich S. Bacteroides uniformis is a putative bacterial species associated with the degradation of the isoflavone genistein in human feces. J Nutr. 2011;141(6):1120-1126.
-
(2011)
J Nutr
, vol.141
, Issue.6
, pp. 1120-1126
-
-
Renouf, M.1
Hendrich, S.2
-
42
-
-
0031736410
-
Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb-1 from Panax ginseng
-
Akao T, Kida H, Kanaoka M, et al. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb-1 from Panax ginseng. J Pharm And Pharmacol. 1998;50(10):1155-1160.
-
(1998)
J Pharm and Pharmacol
, vol.50
, Issue.10
, pp. 1155-1160
-
-
Akao, T.1
Kida, H.2
Kanaoka, M.3
-
43
-
-
84855565780
-
Daidzein and genistein are converted to equol and 5- hydroxy-equol by human intestinal Slackia isoflavoniconvertens in gnotobiotic rats
-
Matthies A, Loh G, Blaut M, et al. Daidzein and genistein are converted to equol and 5- hydroxy-equol by human intestinal Slackia isoflavoniconvertens in gnotobiotic rats. J Nutr. 2012;142(1):40-46.
-
(2012)
J Nutr
, vol.142
, Issue.1
, pp. 40-46
-
-
Matthies, A.1
Loh, G.2
Blaut, M.3
-
44
-
-
0034528031
-
Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria
-
Schneider H, Simmering R, Hartmann L, et al. Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. J Appl Microbiol. 2000;89(6):1027-1037.
-
(2000)
J Appl Microbiol
, vol.89
, Issue.6
, pp. 1027-1037
-
-
Schneider, H.1
Simmering, R.2
Hartmann, L.3
-
45
-
-
84894206729
-
The role of drug metabolizing enzymes in clearance
-
Di L. The role of drug metabolizing enzymes in clearance. Expert Opin Drug Metab Toxicol. 2014;10(3):379-393.
-
(2014)
Expert Opin Drug Metab Toxicol
, vol.10
, Issue.3
, pp. 379-393
-
-
Di, L.1
-
46
-
-
84858439578
-
The human microbiome: At the interface of health and disease
-
Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13(4):260-270.
-
(2012)
Nat Rev Genet
, vol.13
, Issue.4
, pp. 260-270
-
-
Cho, I.1
Blaser, M.J.2
-
47
-
-
0014029813
-
Acute liver necrosis following overdose of paracetamol
-
Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J. 1966;2(5512):497-499.
-
(1966)
Br Med J
, vol.2
, Issue.5512
, pp. 497-499
-
-
Davidson, D.G.1
Eastham, W.N.2
-
48
-
-
32644474169
-
Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study
-
Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42 (6):1364-1372.
-
(2005)
Hepatology
, vol.42
, Issue.6
, pp. 1364-1372
-
-
Larson, A.M.1
Polson, J.2
Fontana, R.J.3
-
49
-
-
0030888455
-
Formation of phenolic and indolic compounds by anaerobic bacteria in the human large intestine
-
Smith EA, Macfarlane GT. Formation of phenolic and indolic compounds by anaerobic bacteria in the human large intestine. Microb Ecol. 1997;33(3):180-188.
-
(1997)
Microb Ecol
, vol.33
, Issue.3
, pp. 180-188
-
-
Smith, E.A.1
Macfarlane, G.T.2
-
50
-
-
84866262534
-
Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats
-
Lee SH, An JH, Lee HJ, et al. Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats. Biopharm Drug Dispos. 2012;33(6):292-303.
-
(2012)
Biopharm Drug Dispos
, vol.33
, Issue.6
, pp. 292-303
-
-
Lee, S.H.1
An, J.H.2
Lee, H.J.3
-
51
-
-
33144464115
-
Human sulfotransferases and their role in chemical metabolism
-
Gamage N, Barnett A, Hempel N, et al. Human sulfotransferases and their role in chemical metabolism. Toxicol Sci. 2006;90(1):5-22.
-
(2006)
Toxicol Sci
, vol.90
, Issue.1
, pp. 5-22
-
-
Gamage, N.1
Barnett, A.2
Hempel, N.3
-
52
-
-
84922746074
-
The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity
-
Possamai LA, McPhail MJ, Khamri W, et al. The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity. Liver Int. 2015;35(3):764-773.
-
(2015)
Liver Int
, vol.35
, Issue.3
, pp. 764-773
-
-
Possamai, L.A.1
McPhail, M.J.2
Khamri, W.3
-
53
-
-
84899461094
-
The relationship between the structure and the biological action of the cardiac glucosides
-
Jacobs WAHA. The relationship between the structure and the biological action of the cardiac glucosides. J Biol Chem. 1927;74:787-793.
-
(1927)
J Biol Chem
, vol.74
, pp. 787-793
-
-
Jacobs, W.A.H.A.1
-
54
-
-
84899450880
-
Effects of dihydroouabain, dihydrodigoxin and dihydrodigitoxin on the heart-lung preparation of the dog
-
Vick RL KJJ, Acheson GH. Effects of dihydroouabain, dihydrodigoxin and dihydrodigitoxin on the heart-lung preparation of the dog. J Pharmacol Exp Ther. 1957;121:330-339.
-
(1957)
J Pharmacol Exp Ther
, vol.121
, pp. 330-339
-
-
Vick, R.L.K.J.J.1
Acheson, G.H.2
-
55
-
-
0020527551
-
Digoxin-inactivating bacteria: Identification in human gut flora
-
Saha JR, Butler VP Jr., Neu HC, et al. Digoxin-inactivating bacteria: identification in human gut flora. Science. 1983;220(4594):325-327.
-
(1983)
Science
, vol.220
, Issue.4594
, pp. 325-327
-
-
Saha, J.R.1
Butler, V.P.2
Neu, H.C.3
-
56
-
-
70149092771
-
Drugs, bugs, and personalized medicine: Pharmacometabonomics enters the ring
-
Wilson ID. Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring. Proc Natl Acad Sci USA. 2009;106(34):14187-14188.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.34
, pp. 14187-14188
-
-
Wilson, I.D.1
-
57
-
-
27744532144
-
Pharmacogenomics of statin responsiveness
-
discussion 34K-35K
-
Kajinami K, Akao H, Polisecki E, et al. Pharmacogenomics of statin responsiveness. Am J Cardiol. 2005;96 (9A):65K-70K. discussion 34K-35K.
-
(2005)
Am J Cardiol
, vol.96
, Issue.9 A
, pp. 65K-70K
-
-
Kajinami, K.1
Akao, H.2
Polisecki, E.3
-
58
-
-
84880380617
-
Pharmacogenomics: Historical perspective and current status
-
Charlab R, Zhang L. Pharmacogenomics: historical perspective and current status. Methods Mol Biol. 2013;1015:3-22.
-
(2013)
Methods Mol Biol
, vol.1015
, pp. 3-22
-
-
Charlab, R.1
Zhang, L.2
-
59
-
-
84946207422
-
Investigation of hostgut microbiota modulation of therapeutic outcome
-
Yip LY, Chan EC. Investigation of hostgut microbiota modulation of therapeutic outcome. Drug Metab Dispos. 2015;43 (10):1619-1631.
-
(2015)
Drug Metab Dispos
, vol.43
, Issue.10
, pp. 1619-1631
-
-
Yip, L.Y.1
Chan, E.C.2
-
60
-
-
84861980130
-
Interactions between the microbiota and the immune system
-
Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012;336 (6086):1268-1273.
-
(2012)
Science
, vol.336
, Issue.6086
, pp. 1268-1273
-
-
Hooper, L.V.1
Littman, D.R.2
Macpherson, A.J.3
-
61
-
-
85027957593
-
Immunomodulatory effects of cyclophosphamide and implementations for vaccine design
-
Sistigu A, Viaud S, Chaput N, et al. Immunomodulatory effects of cyclophosphamide and implementations for vaccine design. Semin Immunopathol. 2011;33 (4):369-383.
-
(2011)
Semin Immunopathol
, vol.33
, Issue.4
, pp. 369-383
-
-
Sistigu, A.1
Viaud, S.2
Chaput, N.3
-
62
-
-
79551523389
-
Cyclophosphamide synergizes with type i interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis
-
Schiavoni G, Sistigu A, Valentini M, et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res. 2011;71(3):768-778.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 768-778
-
-
Schiavoni, G.1
Sistigu, A.2
Valentini, M.3
-
63
-
-
1642378018
-
CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
-
Ghiringhelli F, Larmonier N, Schmitt E, et al. CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. Eur J Immunol. 2004;34(2):336-344.
-
(2004)
Eur J Immunol
, vol.34
, Issue.2
, pp. 336-344
-
-
Ghiringhelli, F.1
Larmonier, N.2
Schmitt, E.3
-
64
-
-
79551514818
-
Cyclophosphamide induces differentiation of Th17 cells in cancer patients
-
Viaud S, Flament C, Zoubir M, et al. Cyclophosphamide induces differentiation of Th17 cells in cancer patients. Cancer Res. 2011;71(3):661-665.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 661-665
-
-
Viaud, S.1
Flament, C.2
Zoubir, M.3
-
65
-
-
84888059687
-
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
-
Viaud S, Saccheri F, Mignot G, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013;342(6161):971-976.
-
(2013)
Science
, vol.342
, Issue.6161
, pp. 971-976
-
-
Viaud, S.1
Saccheri, F.2
Mignot, G.3
-
66
-
-
84888049920
-
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
-
Iida N, Dzutsev A, Stewart CA, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 2013;342(6161):967-970.
-
(2013)
Science
, vol.342
, Issue.6161
, pp. 967-970
-
-
Iida, N.1
Dzutsev, A.2
Stewart, C.A.3
-
67
-
-
0035281522
-
Irinotecan in the treatment of colorectal cancer: Clinical overview
-
Vanhoefer U, Harstrick A, Achterrath W, et al. Irinotecan in the treatment of colorectal cancer: clinical overview. J Clin Oncol. 2001;19(5):1501-1518.
-
(2001)
J Clin Oncol
, vol.19
, Issue.5
, pp. 1501-1518
-
-
Vanhoefer, U.1
Harstrick, A.2
Achterrath, W.3
-
68
-
-
58149114609
-
Faecal microflora and beta-glucuronidase expression are altered in an irinotecaninduced diarrhea model in rats
-
Stringer AM, Gibson RJ, Logan RM, et al. Faecal microflora and beta-glucuronidase expression are altered in an irinotecaninduced diarrhea model in rats. Cancer Biol Ther. 2008;7(12):1919-1925.
-
(2008)
Cancer Biol Ther
, vol.7
, Issue.12
, pp. 1919-1925
-
-
Stringer, A.M.1
Gibson, R.J.2
Logan, R.M.3
-
69
-
-
0029741368
-
Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats
-
Takasuna K, Hagiwara T, Hirohashi M, et al. Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996;56(16):3752-3757.
-
(1996)
Cancer Res
, vol.56
, Issue.16
, pp. 3752-3757
-
-
Takasuna, K.1
Hagiwara, T.2
Hirohashi, M.3
-
70
-
-
78149295964
-
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
-
Wallace BD, Wang H, Lane KT, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010;330(6005):831-835.
-
(2010)
Science
, vol.330
, Issue.6005
, pp. 831-835
-
-
Wallace, B.D.1
Wang, H.2
Lane, K.T.3
-
71
-
-
3142729178
-
Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
-
Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004;110(2): 227-239.
-
(2004)
Circulation
, vol.110
, Issue.2
, pp. 227-239
-
-
Grundy, S.M.1
Cleeman, J.I.2
Merz, C.N.3
-
72
-
-
77951533290
-
Genome-wide association of lipid-lowering response to statins in combined study populations
-
Barber MJ, Mangravite LM, Hyde CL, et al. Genome-wide association of lipid-lowering response to statins in combined study populations. PLoS One. 2010;5(3):e9763.
-
(2010)
PLoS One
, vol.5
, Issue.3
-
-
Barber, M.J.1
Mangravite, L.M.2
Hyde, C.L.3
-
73
-
-
80054059835
-
Enteric microbiome metabolites correlate with response to simvastatin treatment
-
Kaddurah-Daouk R, Baillie RA, Zhu H, et al. Enteric microbiome metabolites correlate with response to simvastatin treatment. PLoS One. 2011;6(10):e25482.
-
(2011)
PLoS One
, vol.6
, Issue.10
-
-
Kaddurah-Daouk, R.1
Baillie, R.A.2
Zhu, H.3
-
74
-
-
84859812538
-
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
-
Dapito DH, Mencin A, Gwak GY, et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell. 2012;21(4):504-516.
-
(2012)
Cancer Cell
, vol.21
, Issue.4
, pp. 504-516
-
-
Dapito, D.H.1
Mencin, A.2
Gwak, G.Y.3
-
75
-
-
62649151803
-
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
-
Wikoff WR, Anfora AT, Liu J, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA. 2009;106(10):3698-3703.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.10
, pp. 3698-3703
-
-
Wikoff, W.R.1
Anfora, A.T.2
Liu, J.3
-
76
-
-
84861978076
-
Host-gut microbiota metabolic interactions
-
Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science. 2012;336(6086):1262-1267.
-
(2012)
Science
, vol.336
, Issue.6086
, pp. 1262-1267
-
-
Nicholson, J.K.1
Holmes, E.2
Kinross, J.3
|