메뉴 건너뛰기




Volumn 9, Issue 2, 2017, Pages 247-260

Subcutaneous liraglutide ameliorates methylglyoxal-induced alzheimer-like tau pathology and cognitive impairment by modulating tau hyperphosphorylation and glycogen synthase kinase-3β

Author keywords

Alzheimer s disease; Glucagon like peptide 1; Glycogen synthase kinase 3 ; Methylglyoxal; Tau protein

Indexed keywords

AMYLOID; CASPASE 3; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; LIPOFUSCIN; LIRAGLUTIDE; METHYLGLYOXAL; PROTEIN KINASE B; TAU PROTEIN;

EID: 85014401370     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (30)

References (62)
  • 2
    • 70350075694 scopus 로고    scopus 로고
    • Alzheimer’s disease
    • Mucke L. Alzheimer’s disease. Nature 2009; 461: 895-897.
    • (2009) Nature , vol.461 , pp. 895-897
    • Mucke, L.1
  • 3
    • 84939506533 scopus 로고    scopus 로고
    • Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Abeta, tau, and alpha-synuclein
    • Goedert M. Alzheimer’s and Parkinson’s diseases: the prion concept in relation to assembled Abeta, tau, and alpha-synuclein. Science 2015; 349: 1255555.
    • (2015) Science , vol.349
    • Goedert, M.1
  • 4
    • 47749147258 scopus 로고    scopus 로고
    • Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase
    • Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J Biol Chem 2008; 283: 17721-17730.
    • (2008) J Biol Chem , vol.283 , pp. 17721-17730
    • Shen, C.1    Chen, Y.2    Liu, H.3    Zhang, K.4    Zhang, T.5    Lin, A.6    Jing, N.7
  • 6
    • 0035934268 scopus 로고    scopus 로고
    • Amyloid beta-protein fragment 31-35 forms ion channels in membrane patches excised from rat hippocampal neurons
    • Qi JS, Qiao JT. Amyloid beta-protein fragment 31-35 forms ion channels in membrane patches excised from rat hippocampal neurons. Neuroscience 2001; 105: 845-852.
    • (2001) Neuroscience , vol.105 , pp. 845-852
    • Qi, J.S.1    Qiao, J.T.2
  • 7
    • 0003374626 scopus 로고    scopus 로고
    • Tau protein pathology in neurodegenerative diseases
    • Spillantini MG, Michel Goedert M. Tau protein pathology in neurodegenerative diseases. Trends Neurosci 1998; 21: 428-433.
    • (1998) Trends Neurosci , vol.21 , pp. 428-433
    • Spillantini, M.G.1    Michel Goedert, M.2
  • 9
    • 84947248386 scopus 로고    scopus 로고
    • Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer’s disease
    • Barage SH, Sonawane KD. Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer’s disease. Neuropep-tides 2015; 52: 1-18.
    • (2015) Neuropep-Tides , vol.52 , pp. 1-18
    • Barage, S.H.1    Sonawane, K.D.2
  • 10
    • 67049134478 scopus 로고    scopus 로고
    • Oxidative stress in Alzheimer disease
    • Gella A, Durany N. Oxidative stress in Alzheimer disease. Cell Adh Migr 2009; 3: 88-93.
    • (2009) Cell Adh Migr , vol.3 , pp. 88-93
    • Gella, A.1    Durany, N.2
  • 11
    • 84877873718 scopus 로고    scopus 로고
    • Methylglyoxal, obesity, and diabetes
    • Matafome P, Sena C, Seica R. Methylglyoxal, obesity, and diabetes. Endocrine 2013; 43: 472-484.
    • (2013) Endocrine , vol.43 , pp. 472-484
    • Matafome, P.1    Sena, C.2    Seica, R.3
  • 12
    • 56349145099 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer’s disease: A reappraisal
    • Pratico D. Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal. Trends Pharmacol Sci 2008; 29: 609-615.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 609-615
    • Pratico, D.1
  • 14
    • 0033571012 scopus 로고    scopus 로고
    • Formation of glyoxal, methylglyoxal and 3-deoxygluco-sone in the glycation of proteins by glucose
    • Thornalley PJ, Langborg A, Minhas HS. Formation of glyoxal, methylglyoxal and 3-deoxygluco-sone in the glycation of proteins by glucose. Biochem J 1999; 344: 109-116.
    • (1999) Biochem J , vol.344 , pp. 109-116
    • Thornalley, P.J.1    Langborg, A.2    Minhas, H.S.3
  • 15
    • 84881240163 scopus 로고    scopus 로고
    • Advanced glycoxidation and li-poxidation end products (AGEs and ALEs): An overview of their mechanisms of formation
    • Vistoli G, De Maddis D, Cipak A, Zarkovic N, Ca-rini M, Aldini G. Advanced glycoxidation and li-poxidation end products (AGEs and ALEs): an overview of their mechanisms of formation. Free Radic Res 2013; 47 Suppl 1: 3-27.
    • (2013) Free Radic Res , vol.47 , pp. 3-27
    • Vistoli, G.1    De Maddis, D.2    Cipak, A.3    Zarkovic, N.4    Ca-Rini, M.5    Aldini, G.6
  • 18
    • 84861521520 scopus 로고    scopus 로고
    • Amyloid-beta metabolite sensing: Biochemical linking of glycation modification and misfolding
    • Fawver JN, Schall HE, Petrofes Chapa, RD, Zhu X, Murray IV. Amyloid-beta metabolite sensing: biochemical linking of glycation modification and misfolding. J Alzheimers Dis 2012; 30: 63-73.
    • (2012) J Alzheimers Dis , vol.30 , pp. 63-73
    • Fawver, J.N.1    Schall, H.E.2    Petrofes Chapa, R.D.3    Zhu, X.4    Murray, I.V.5
  • 19
    • 77956186680 scopus 로고    scopus 로고
    • Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity
    • Chen YJ, Huang XB, Li ZX, Yin LL, Chen WQ, Li L. Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity. Eur J Pharmacol 2010; 645: 1-8.
    • (2010) Eur J Pharmacol , vol.645 , pp. 1-8
    • Chen, Y.J.1    Huang, X.B.2    Li, Z.X.3    Yin, L.L.4    Chen, W.Q.5    Li, L.6
  • 20
    • 34147135482 scopus 로고    scopus 로고
    • Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation
    • Kuhla B, Haase C, Flach K, Luth HJ, Arendt T, Munch G. Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation. J Biol Chem 2007; 282: 6984-6991.
    • (2007) J Biol Chem , vol.282 , pp. 6984-6991
    • Kuhla, B.1    Haase, C.2    Flach, K.3    Luth, H.J.4    Arendt, T.5    Munch, G.6
  • 23
    • 0345305844 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons
    • Gilman CP, Perry T, Furukawa K, Grieg NH, Egan JM, Mattson MP. Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons. J Neurochem 2003; 87: 1137-1144.
    • (2003) J Neurochem , vol.87 , pp. 1137-1144
    • Gilman, C.P.1    Perry, T.2    Furukawa, K.3    Grieg, N.H.4    Egan, J.M.5    Mattson, M.P.6
  • 24
    • 44149122563 scopus 로고    scopus 로고
    • GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    • Gault VA, Holscher C. GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. Eur J Pharmacol 2008; 587: 112-117.
    • (2008) Eur J Pharmacol , vol.587 , pp. 112-117
    • Gault, V.A.1    Holscher, C.2
  • 25
    • 84855548096 scopus 로고    scopus 로고
    • (Val(8)) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains
    • Li L, Zhang ZF, Holscher C, Gao C, Jiang YH, Liu YZ. (Val(8)) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur J Pharmacol 2012; 674: 280-286.
    • (2012) Eur J Pharmacol , vol.674 , pp. 280-286
    • Li, L.1    Zhang, Z.F.2    Holscher, C.3    Gao, C.4    Jiang, Y.H.5    Liu, Y.Z.6
  • 26
    • 84886592674 scopus 로고    scopus 로고
    • Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer’s disease
    • McClean PL, Holscher C. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer’s disease. Neuropharma-cology 2014; 76: 57-67.
    • (2014) Neuropharma-Cology , vol.76 , pp. 57-67
    • McClean, P.L.1    Holscher, C.2
  • 27
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer’s disease
    • McClean PL, Parthsarathy V, Faivre E, Holscher C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer’s disease. J Neurosci 2011; 31: 6587-6594.
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 28
    • 84897003731 scopus 로고    scopus 로고
    • Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress
    • Sharma MK, Jalewa J, Holscher C. Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress. J Neurochem 2014; 128: 459-471.
    • (2014) J Neurochem , vol.128 , pp. 459-471
    • Sharma, M.K.1    Jalewa, J.2    Holscher, C.3
  • 30
    • 84921849377 scopus 로고    scopus 로고
    • Mitochondrial protection by the mixed musca-rinic/sigma1 ligand ANAVEX2-73, a tetrahydro-furan derivative
    • Lahmy V, Long R, Morin D, Villard V, Maurice T. Mitochondrial protection by the mixed musca-rinic/sigma1 ligand ANAVEX2-73, a tetrahydro-furan derivative, in Abeta25-35 peptide-inject-ed mice, a nontransgenic Alzheimer’s disease model. Front Cell Neurosci 2014; 8: 463.
    • (2014) Front Cell Neurosci , vol.8 , pp. 463
    • Lahmy, V.1    Long, R.2    Morin, D.3    Villard, V.4    Maurice, T.5
  • 31
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: Procedures for assessing spatial and related forms of learning and memory
    • Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006; 1: 848-858.
    • (2006) Nat Protoc , vol.1 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 32
    • 84896779646 scopus 로고    scopus 로고
    • Long-term ginsenoside Rg1 supplementation improves age-related cognitive decline by promoting synaptic plasticity associated protein expression in C57BL/6J mice
    • Yang L, Zhang J, Zheng K, Shen H, Chen X. Long-term ginsenoside Rg1 supplementation improves age-related cognitive decline by promoting synaptic plasticity associated protein expression in C57BL/6J mice. J Gerontol A Biol Sci Med Sci 2014; 69: 282-294.
    • (2014) J Gerontol a Biol Sci Med Sci , vol.69 , pp. 282-294
    • Yang, L.1    Zhang, J.2    Zheng, K.3    Shen, H.4    Chen, X.5
  • 33
    • 0015730965 scopus 로고
    • The nervous system of ctenophores. III. Ultrastructure of synapses
    • Hernandez-Nicaise ML. The nervous system of ctenophores. III. Ultrastructure of synapses. J Neurocytol 1973; 2: 249-263.
    • (1973) J Neurocytol , vol.2 , pp. 249-263
    • Hernandez-Nicaise, M.L.1
  • 34
    • 77549087405 scopus 로고    scopus 로고
    • Age-related loss of phospholipid asymmetry in APP (NLh)/APP (NLh) x PS-1 (P264L)/PS-1 (P264L) human double mutant knock-in mice: Relevance to Alzheimer disease
    • Bader Lange ML, St Clair D, Markesbery WR, Studzinski CM, Murphy MP, Butterfield DA. Age-related loss of phospholipid asymmetry in APP (NLh)/APP (NLh) x PS-1 (P264L)/PS-1 (P264L) human double mutant knock-in mice: relevance to Alzheimer disease. Neurobiol Dis 2010; 38: 104-115.
    • (2010) Neurobiol Dis , vol.38 , pp. 104-115
    • Bader Lange, M.L.1    St Clair, D.2    Markesbery, W.R.3    Studzinski, C.M.4    Murphy, M.P.5    Butterfield, D.A.6
  • 35
    • 43249124363 scopus 로고    scopus 로고
    • Microtubule-associated protein tau in development, degeneration and protection of neurons
    • Wang JZ, Liu F. Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol 2008; 85: 148-175.
    • (2008) Prog Neurobiol , vol.85 , pp. 148-175
    • Wang, J.Z.1    Liu, F.2
  • 36
    • 84890808796 scopus 로고    scopus 로고
    • Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes
    • Yang Y, Zhang J, Ma D, Zhang M, Hu S, Shao S, Gong CX. Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes. J Alzheimers Dis 2013; 37: 637-648.
    • (2013) J Alzheimers Dis , vol.37 , pp. 637-648
    • Yang, Y.1    Zhang, J.2    Ma, D.3    Zhang, M.4    Hu, S.5    Shao, S.6    Gong, C.X.7
  • 38
    • 0035170842 scopus 로고    scopus 로고
    • Differential phosphoryla- tion of tau proteins during kitten brain development and Alzheimer’s disease
    • Riederer BM, Mourton-Gilles C, Frey P, Delacourte A, Probst A. Differential phosphoryla- tion of tau proteins during kitten brain development and Alzheimer’s disease. J Neurocytol 2001; 30: 145-158.
    • (2001) J Neurocytol , vol.30 , pp. 145-158
    • Riederer, B.M.1    Mourton-Gilles, C.2    Frey, P.3    Delacourte, A.4    Probst, A.5
  • 39
    • 84901776466 scopus 로고    scopus 로고
    • Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-de-rived tau oligomeric seeds
    • Castillo-Carranza DL, Gerson JE, Sengupta U, Guerrero-Munoz MJ, Lasagna-Reeves CA, Kayed R. Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-de-rived tau oligomeric seeds. J Alzheimers Dis 2014; 40 Suppl 1: S97-S111.
    • (2014) J Alzheimers Dis , vol.40 , pp. SS97-S111
    • Castillo-Carranza, D.L.1    Gerson, J.E.2    Sengupta, U.3    Guerrero-Munoz, M.J.4    Lasagna-Reeves, C.A.5    Kayed, R.6
  • 44
    • 84875842853 scopus 로고    scopus 로고
    • Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: Recent advances and mechanistic insights
    • Distler MG, Palmer AA. Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights. Front Genet 2012; 3: 250.
    • (2012) Front Genet , vol.3 , pp. 250
    • Distler, M.G.1    Palmer, A.A.2
  • 45
    • 84885762771 scopus 로고    scopus 로고
    • The glyco-lytic metabolite methylglyoxal induces changes in vigilance by generating low-amplitude non-REM sleep
    • Jakubcakova V, Curzi ML, Flachskamm C, Hambsch B, Landgraf R, Kimura M. The glyco-lytic metabolite methylglyoxal induces changes in vigilance by generating low-amplitude non-REM sleep. J Psychopharmacol 2013; 27: 1070-1075.
    • (2013) J Psychopharmacol , vol.27 , pp. 1070-1075
    • Jakubcakova, V.1    Curzi, M.L.2    Flachskamm, C.3    Hambsch, B.4    Landgraf, R.5    Kimura, M.6
  • 46
    • 84888058168 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation
    • Chen S, An FM, Yin L, Liu AR, Yin DK, Yao WB, Gao XD. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience 2014; 256: 137-146.
    • (2014) Neuroscience , vol.256 , pp. 137-146
    • Chen, S.1    An, F.M.2    Yin, L.3    Liu, A.R.4    Yin, D.K.5    Yao, W.B.6    Gao, X.D.7
  • 47
    • 84877575636 scopus 로고    scopus 로고
    • Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice
    • Porter WD, Flatt PR, Holscher C, Gault VA. Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice. Int J Obes (Lond) 2013; 37: 678-684.
    • (2013) Int J Obes (Lond) , vol.37 , pp. 678-684
    • Porter, W.D.1    Flatt, P.R.2    Holscher, C.3    Gault, V.A.4
  • 48
    • 84866972198 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer’s disease model mice
    • Ma T, Du X, Pick JE, Sui G, Brownlee M, Klann E. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer’s disease model mice. J Neurosci 2012; 32: 13701-13708.
    • (2012) J Neurosci , vol.32 , pp. 13701-13708
    • Ma, T.1    Du, X.2    Pick, J.E.3    Sui, G.4    Brownlee, M.5    Klann, E.6
  • 49
    • 84936990507 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer’s disease
    • Hansen HH, Fabricius K, Barkholt P, Niehoff ML, Morley JE, Jelsing J, Pyke C, Bjerre Knud- sen L, Farr SA, Vrang N. The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer’s disease. J Alzheimers Dis 2015; 46: 877-888.
    • (2015) J Alzheimers Dis , vol.46 , pp. 877-888
    • Hansen, H.H.1    Fabricius, K.2    Barkholt, P.3    Niehoff, M.L.4    Morley, J.E.5    Jelsing, J.6    Pyke, C.7    Bjerre Knud-Sen, L.8    Farr, S.A.9    Vrang, N.10
  • 50
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer’s disease
    • Abbas T, Faivre E, Holscher C. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer’s disease. Behav Brain Res 2009; 205: 265-271.
    • (2009) Behav Brain Res , vol.205 , pp. 265-271
    • Abbas, T.1    Faivre, E.2    Holscher, C.3
  • 52
    • 69549128161 scopus 로고    scopus 로고
    • Receptors for the in-cretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
    • Hamilton A, Holscher C. Receptors for the in-cretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport 2009; 20: 1161-1166.
    • (2009) Neuroreport , vol.20 , pp. 1161-1166
    • Hamilton, A.1    Holscher, C.2
  • 54
    • 0346434153 scopus 로고    scopus 로고
    • Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory
    • Liu SJ, Zhang AH, Li HL, Wang Q, Deng HM, Netzer WJ, Xu H, Wang JZ. Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem 2003; 87: 1333-1344.
    • (2003) J Neurochem , vol.87 , pp. 1333-1344
    • Liu, S.J.1    Zhang, A.H.2    Li, H.L.3    Wang, Q.4    Deng, H.M.5    Netzer, W.J.6    Xu, H.7    Wang, J.Z.8
  • 55
    • 33744818219 scopus 로고    scopus 로고
    • Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer’s brains
    • Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafu-zoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei JJ. Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer’s brains. Neurobiol Dis 2006; 22: 657-668.
    • (2006) Neurobiol Dis , vol.22 , pp. 657-668
    • Zhou, X.W.1    Li, X.2    Bjorkdahl, C.3    Sjogren, M.J.4    Alafu-Zoff, I.5    Soininen, H.6    Grundke-Iqbal, I.7    Iqbal, K.8    Winblad, B.9    Pei, J.J.10
  • 57
    • 48249087675 scopus 로고    scopus 로고
    • Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells
    • Hu M, Waring JF, Gopalakrishnan M, Li J. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem 2008; 106: 1371-1377.
    • (2008) J Neurochem , vol.106 , pp. 1371-1377
    • Hu, M.1    Waring, J.F.2    Gopalakrishnan, M.3    Li, J.4
  • 58
    • 84965162519 scopus 로고    scopus 로고
    • Subcutaneous administration of liraglutide ameliorates learaning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced Alzheimer disease mouse model
    • Qi LQ, Ke LF, Liu XH, Liao LM, Ke SJ, Liu XY, Wang YP, Lin XW, Zhou Y, Wu LJ, Chen Z, Liu LB. Subcutaneous administration of liraglutide ameliorates learaning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced Alzheimer disease mouse model. Eur J Pharmacol 2016; 783: 23-32.
    • (2016) Eur J Pharmacol , vol.783 , pp. 23-32
    • Qi, L.Q.1    Ke, L.F.2    Liu, X.H.3    Liao, L.M.4    Ke, S.J.5    Liu, X.Y.6    Wang, Y.P.7    Lin, X.W.8    Zhou, Y.9    Lj, W.10    Chen, Z.11    Liu, L.B.12
  • 60
    • 84882284105 scopus 로고    scopus 로고
    • Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer’s disease transgenic mouse
    • Zhao H, Chang R, Che H, Wang J, Yang L, Fang W, Xia Y, Li N, Ma Q, Wang X. Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer’s disease transgenic mouse. Neurosci Lett 2013; 551: 12-16.
    • (2013) Neurosci Lett , vol.551 , pp. 12-16
    • Zhao, H.1    Chang, R.2    Che, H.3    Wang, J.4    Yang, L.5    Fang, W.6    Xia, Y.7    Li, N.8    Ma, Q.9    Wang, X.10
  • 61
    • 25844458239 scopus 로고    scopus 로고
    • Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer’s disease and tauopathies
    • Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribe E, Dalfo E, Avila J. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer’s disease and tauopathies. Curr Alzheimer Res 2005; 2: 3-18.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 3-18
    • Ferrer, I.1    Gomez-Isla, T.2    Puig, B.3    Freixes, M.4    Ribe, E.5    Dalfo, E.6    Avila, J.7
  • 62
    • 34447503455 scopus 로고    scopus 로고
    • Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
    • Mazanetz MP, Fischer PM. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nat Rev Drug Discov 2007; 6: 464-479.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 464-479
    • Mazanetz, M.P.1    Fischer, P.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.