Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory

Journal of Neurochemistry

Volumn 87, Issue 6, 2003, Pages 1333-1344

  Liu, Shi Jie ^a   Zhang, Ai Hong ^a   Li, Hong Lian ^a   Wang, Qun ^a   Deng, Heng Mei ^a   Netzer, William J ^b   Xu, Huaxi ^c,d   Wang, Jian Zhi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b ROCKEFELLER UNIVERSITY   (United States)

^c BURNHAM INSTITUTE   (United States)

^d XIAMEN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Glycogen synthase kinase 3; Phosphoinositol 3 kinase; Protein kinase C; Spatial memory; Tau

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; TAU PROTEIN; WORTMANNIN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE DISRUPTION; GENETIC TRANSFECTION; MALE; NEUROFIBRILLARY TANGLE; NONHUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RAT; RECEPTOR DOWN REGULATION; SPATIAL MEMORY;

ANIMALIA;

EID: 0346434153     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02070.x     Document Type: Article

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