메뉴 건너뛰기




Volumn 79, Issue , 2017, Pages 401-423

Three Pillars for the Neural Control of Appetite

Author keywords

Appetite; Brain; Eating; Feeding behavior; Hypothalamus; Motivation; Reward; Satiety

Indexed keywords

AGOUTI RELATED PROTEIN; CALCITONIN GENE RELATED PEPTIDE;

EID: 85013046045     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-021115-104948     Document Type: Review
Times cited : (205)

References (154)
  • 1
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States, 2011-2012
    • Ogden CL, Carroll MD, Kit BK, Flegal KM. 2014. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 311:806-14
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 2
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, et al. 2015. Genetic studies of body mass index yield new insights for obesity biology. Nature 518:197-206
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1    Kahali, B.2    Berndt, S.I.3    Justice, A.E.4    Pers, T.H.5
  • 3
    • 84922406638 scopus 로고    scopus 로고
    • Agouti-related protein neuron circuits that regulate appetite
    • Sternson SM, Atasoy D. 2014. Agouti-related protein neuron circuits that regulate appetite. Neuroendocrinology 100:95-102
    • (2014) Neuroendocrinology , vol.100 , pp. 95-102
    • Sternson, S.M.1    Atasoy, D.2
  • 4
    • 84961311666 scopus 로고    scopus 로고
    • Lateral hypothalamic circuits for feeding and reward
    • Stuber GD, Wise RA. 2016. Lateral hypothalamic circuits for feeding and reward. Nat. Neurosci. 19:198-205
    • (2016) Nat. Neurosci , vol.19 , pp. 198-205
    • Stuber, G.D.1    Wise, R.A.2
  • 5
    • 0034672327 scopus 로고    scopus 로고
    • Cerebral hemisphere regulation of motivated behavior
    • Swanson LW. 2000. Cerebral hemisphere regulation of motivated behavior. Brain Res. 886:113-64
    • (2000) Brain Res. , vol.886 , pp. 113-164
    • Swanson, L.W.1
  • 7
    • 0043250430 scopus 로고    scopus 로고
    • The role of learning in the operation of motivational systems
    • ed. R Gallistel, . New York: John Wiley &Sons
    • Dickinson A, Balleine B. 2002. The role of learning in the operation of motivational systems. In Stevens' Handbook of Experimental Psychology, ed. R Gallistel, pp. 497-533. New York: John Wiley &Sons
    • (2002) Stevens' Handbook of Experimental Psychology , pp. 497-533
    • Dickinson, A.1    Balleine, B.2
  • 8
    • 2442701355 scopus 로고    scopus 로고
    • Motivation concepts in behavioral neuroscience
    • Berridge KC. 2004. Motivation concepts in behavioral neuroscience. Physiol. Behav. 81:179-209
    • (2004) Physiol. Behav , vol.81 , pp. 179-209
    • Berridge, K.C.1
  • 9
    • 0037057802 scopus 로고    scopus 로고
    • The need to feed: Homeostatic and hedonic control of eating
    • Saper CB, Chou TC, Elmquist JK. 2002. The need to feed: homeostatic and hedonic control of eating. Neuron 36:199-211
    • (2002) Neuron , vol.36 , pp. 199-211
    • Saper, C.B.1    Chou, T.C.2    Elmquist, J.K.3
  • 10
    • 34547701951 scopus 로고    scopus 로고
    • Neurobiology of feeding and energy expenditure
    • Gao Q, Horvath TL. 2007. Neurobiology of feeding and energy expenditure. Annu. Rev. Neurosci. 30:367-98
    • (2007) Annu. Rev. Neurosci , vol.30 , pp. 367-398
    • Gao, Q.1    Horvath, T.L.2
  • 11
  • 12
    • 84952877263 scopus 로고    scopus 로고
    • Hunger: The carrot and the stick
    • Sternson SM. 2016. Hunger: the carrot and the stick. Mol. Metab. 5:1-2
    • (2016) Mol. Metab , vol.5 , pp. 1-2
    • Sternson, S.M.1
  • 13
    • 0014993183 scopus 로고
    • Positive feedbacks at work during feeding
    • Wiepkema PR. 1971. Positive feedbacks at work during feeding. Behaviour 39:266-73
    • (1971) Behaviour , vol.39 , pp. 266-273
    • Wiepkema, P.R.1
  • 14
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA. 2003. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-61
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1
  • 15
    • 2142758640 scopus 로고    scopus 로고
    • Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • van den TopM, Lee K, Whyment AD, Blanks AM, Spanswick D. 2004. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci. 7:493-94
    • (2004) Nat. Neurosci , vol.7 , pp. 493-494
    • Vanden Top, M.1    Lee, K.2    Whyment, A.D.3    Blanks, A.M.4    Spanswick, D.5
  • 16
    • 80052922112 scopus 로고    scopus 로고
    • Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
    • Yang Y, Atasoy D, Su HH, Sternson SM. 2011. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell 146:992-1003
    • (2011) Cell , vol.146 , pp. 992-1003
    • Yang, Y.1    Atasoy, D.2    Su, H.H.3    Sternson, S.M.4
  • 17
    • 84896317618 scopus 로고    scopus 로고
    • An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger
    • Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, et al. 2014. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature 507:238-42
    • (2014) Nature , vol.507 , pp. 238-242
    • Krashes, M.J.1    Shah, B.P.2    Madara, J.C.3    Olson, D.P.4    Strochlic, D.E.5
  • 18
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, et al. 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-84
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5
  • 19
    • 49049099862 scopus 로고    scopus 로고
    • A FLEX switch targets channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping
    • Atasoy D, Aponte Y, Su HH, Sternson SM. 2008. A FLEX switch targets channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J. Neurosci. 28:7025-30
    • (2008) J. Neurosci , vol.28 , pp. 7025-7030
    • Atasoy, D.1    Aponte, Y.2    Su, H.H.3    Sternson, S.M.4
  • 20
    • 0021248888 scopus 로고
    • Neuropeptide y and human pancreatic polypeptide stimulate feeding behavior in rats
    • Clark JT, Kalra PS, CrowleyWR, Kalra SP. 1984. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115:427-29
    • (1984) Endocrinology , vol.115 , pp. 427-429
    • Clark, J.T.1    Kalra, P.S.2    Crowley, W.R.3    Kalra, S.P.4
  • 21
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of centralmelanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, et al. 1997. Antagonism of centralmelanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-38
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5
  • 22
    • 79951992387 scopus 로고    scopus 로고
    • AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
    • Aponte Y, Atasoy D, Sternson SM. 2011. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat. Neurosci. 14:351-55
    • (2011) Nat. Neurosci , vol.14 , pp. 351-355
    • Aponte, Y.1    Atasoy, D.2    Sternson, S.M.3
  • 23
    • 79953307878 scopus 로고    scopus 로고
    • Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
    • Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, et al. 2011. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J. Clin. Investig. 121:1424-28
    • (2011) J. Clin. Investig , vol.121 , pp. 1424-1428
    • Krashes, M.J.1    Koda, S.2    Ye, C.3    Rogan, S.C.4    Adams, A.C.5
  • 24
    • 84929359280 scopus 로고    scopus 로고
    • Neurons for hunger and thirst transmit a negative-valence teaching signal
    • Betley JN, Xu S, Cao ZF, Gong R, Magnus CJ, et al. 2015. Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature 521:180-85
    • (2015) Nature , vol.521 , pp. 180-185
    • Betley, J.N.1    Xu, S.2    Cao, Z.F.3    Gong, R.4    Magnus, C.J.5
  • 25
    • 84864711337 scopus 로고    scopus 로고
    • Deconstruction of a neural circuit for hunger
    • Atasoy D, Betley JN, Su HH, Sternson SM. 2012. Deconstruction of a neural circuit for hunger. Nature 488:172-77
    • (2012) Nature , vol.488 , pp. 172-177
    • Atasoy, D.1    Betley, J.N.2    Su, H.H.3    Sternson, S.M.4
  • 26
    • 84885089652 scopus 로고    scopus 로고
    • Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP
    • Krashes MJ, Shah BP, Koda S, Lowell BB. 2013. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab. 18:588-95
    • (2013) Cell Metab , vol.18 , pp. 588-595
    • Krashes, M.J.1    Shah, B.P.2    Koda, S.3    Lowell, B.B.4
  • 27
    • 0026749745 scopus 로고
    • Neuropeptide y paradoxically increases food intake yet causes conditioned flavor aversions
    • Sipols AJ, Brief DJ, Ginter KL, Saghafi S, Woods SC. 1992. Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions. Physiol. Behav. 51:1257-60
    • (1992) Physiol. Behav , vol.51 , pp. 1257-1260
    • Sipols, A.J.1    Brief, D.J.2    Ginter, K.L.3    Saghafi, S.4    Woods, S.C.5
  • 28
    • 0016292783 scopus 로고
    • Dieting and depression reexamined A critical review of reports of untoward responses during weight reduction for obesity
    • Stunkard AJ, Rush J. 1974. Dieting and depression reexamined. A critical review of reports of untoward responses during weight reduction for obesity. Ann. Intern. Med. 81:526-33
    • (1974) Ann. Intern. Med , vol.81 , pp. 526-533
    • Stunkard, A.J.1    Rush, J.2
  • 31
    • 84923345978 scopus 로고    scopus 로고
    • Sensory detection of food rapidly modulates arcuate feeding circuits
    • Chen Y, Lin YC, Kuo TW, Knight ZA. 2015. Sensory detection of food rapidly modulates arcuate feeding circuits. Cell 160:829-41
    • (2015) Cell , vol.160 , pp. 829-841
    • Chen, Y.1    Lin, Y.C.2    Kuo, T.W.3    Knight, Z.A.4
  • 32
    • 84937437240 scopus 로고    scopus 로고
    • Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales
    • Mandelblat-Cerf Y, Ramesh RN, Burgess CR, Patella P, Yang Z, et al. 2015. Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales. eLife 4:e07122
    • (2015) ELife , vol.4 , pp. e07122
    • Mandelblat-Cerf, Y.1    Ramesh, R.N.2    Burgess, C.R.3    Patella, P.4    Yang, Z.5
  • 33
    • 85013118440 scopus 로고    scopus 로고
    • Deep brain Ca2+ imaging of AGRP and POMC neuronal dynamics in the arcuate nucleus of freelymovingmice
    • Washington, DC
    • Xu S, Eiselt AK, Magnus C, Sternson S. 2014. Deep brain Ca2+ imaging of AGRP and POMC neuronal dynamics in the arcuate nucleus of freelymovingmice. Presented at Annu.Meet. Soc.Neurosci.,Washington, DC
    • (2014) Annu.Meet. Soc.Neurosci
    • Xu, S.1    Eiselt, A.K.2    Magnus, C.3    Sternson, S.4
  • 34
    • 0028900950 scopus 로고
    • Neuropeptide y fails to increase intraoral intake in rats
    • Seeley RJ, Payne CJ,Woods SC. 1995. Neuropeptide Y fails to increase intraoral intake in rats. Am. J. Physiol. 268:R423-27
    • (1995) Am. J. Physiol , vol.268 , pp. R423-R427
    • Seeley, R.J.1    Payne, C.J.2    Woods, S.C.3
  • 35
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet S, Perez FA, Hnasko TS, Palmiter RD. 2005. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310:683-85
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 36
    • 67549112681 scopus 로고    scopus 로고
    • Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    • Wu Q, Boyle M, Palmiter R. 2009. Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137:1225-34
    • (2009) Cell , vol.137 , pp. 1225-1234
    • Wu, Q.1    Boyle, M.2    Palmiter, R.3
  • 38
    • 0032443807 scopus 로고    scopus 로고
    • The neuropeptide Y/agouti generelated protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    • Broberger C, Johansen J, Johansson C, SchallingM,Hökfelt T. 1998. The neuropeptide Y/agouti generelated protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. PNAS 95:15043-48
    • (1998) PNAS , vol.95 , pp. 15043-15048
    • Broberger, C.1    Johansen, J.2    Johansson, C.3    Schalling, M.4    Hökfelt, T.5
  • 39
    • 84890097302 scopus 로고    scopus 로고
    • Parallel, redundant circuit organization for homeostatic control of feeding behavior
    • Betley JN, Cao ZFH, Ritola KD, Sternson SM. 2013. Parallel, redundant circuit organization for homeostatic control of feeding behavior. Cell 155:1337-50
    • (2013) Cell , vol.155 , pp. 1337-1350
    • Betley, J.N.1    Cao, Z.F.H.2    Ritola, K.D.3    Sternson, S.M.4
  • 40
    • 0018591727 scopus 로고
    • GABA and hypothalamic feeding systems i Topographic analysis of the effects of microinjections of muscimol
    • Kelly J, Rothstein J, Grossman SP. 1979. GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol. Physiol. Behav. 23:1123-34
    • (1979) Physiol. Behav , vol.23 , pp. 1123-1134
    • Kelly, J.1    Rothstein, J.2    Grossman, S.P.3
  • 41
    • 84901009992 scopus 로고    scopus 로고
    • Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior
    • Stachniak TJ, Ghosh A, Sternson SM. 2014. Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior. Neuron 82:797-808
    • (2014) Neuron , vol.82 , pp. 797-808
    • Stachniak, T.J.1    Ghosh, A.2    Sternson, S.M.3
  • 42
  • 43
    • 0033782303 scopus 로고    scopus 로고
    • The rewarding properties of neuropeptide y in perifornical hypothalamus vs nucleus accumbens
    • Brown CM, Coscina DV, Fletcher PJ. 2000. The rewarding properties of neuropeptide Y in perifornical hypothalamus vs. nucleus accumbens. Peptides 21: 1279-87
    • (2000) Peptides , vol.21 , pp. 1279-1287
    • Brown, C.M.1    Coscina, D.V.2    Fletcher, P.J.3
  • 44
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. 1997. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-68
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 45
    • 84874215150 scopus 로고    scopus 로고
    • Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively
    • Zhan C, Zhou J, Feng Q, Zhang JE, Lin S, et al. 2013. Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J. Neurosci. 33:3624-32
    • (2013) J. Neurosci , vol.33 , pp. 3624-3632
    • Zhan, C.1    Zhou, J.2    Feng, Q.3    Zhang, J.E.4    Lin, S.5
  • 46
    • 78751642791 scopus 로고    scopus 로고
    • Centralmelanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat
    • Davis JF, Choi DL, Shurdak JD, Krause EG, Fitzgerald MF, et al. 2011. Centralmelanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat. Physiol. Behav. 102:491-95
    • (2011) Physiol. Behav , vol.102 , pp. 491-495
    • Davis, J.F.1    Choi, D.L.2    Shurdak, J.D.3    Krause, E.G.4    Fitzgerald, M.F.5
  • 47
    • 84987704814 scopus 로고    scopus 로고
    • Hunger neurons drive feeding through a sustained, positive reinforcement signal
    • Chen Y, Lin YC, Zimmerman CA, Essner RA, Knight ZA. 2016. Hunger neurons drive feeding through a sustained, positive reinforcement signal. Elife 5:e18640
    • (2016) Elife , vol.5 , pp. e18640
    • Chen, Y.1    Lin, Y.C.2    Zimmerman, C.A.3    Essner, R.A.4    Knight, Z.A.5
  • 48
    • 0001109622 scopus 로고
    • Increase of food intake induced by electrical stimulation of the lateral hypothalamus
    • Delgado JM, Anand BK. 1953. Increase of food intake induced by electrical stimulation of the lateral hypothalamus. Am. J. Physiol. 172:162-68
    • (1953) Am. J. Physiol , vol.172 , pp. 162-168
    • Delgado, J.M.1    Anand, B.K.2
  • 49
    • 0001079511 scopus 로고
    • Hypothalamic control of feeding and self-stimulation
    • Hoebel BG, Teitelbaum P. 1962. Hypothalamic control of feeding and self-stimulation. Science 135:375-77
    • (1962) Science , vol.135 , pp. 375-377
    • Hoebel, B.G.1    Teitelbaum, P.2
  • 50
    • 84964125510 scopus 로고
    • Localization of a "feeding center" in the hypothalamus of the rat
    • Anand BK, Brobeck JR. 1951. Localization of a "feeding center" in the hypothalamus of the rat. Proc. Soc. Exp. Biol. Med. 77:323-24
    • (1951) Proc. Soc. Exp. Biol. Med , vol.77 , pp. 323-324
    • Anand, B.K.1    Brobeck, J.R.2
  • 51
    • 0018855581 scopus 로고
    • The effect of electrical stimulation in the hypothalamus on the monosynaptic jaw closing and the disynaptic jaw opening reflexes in the cat
    • Landgren S, Olsson KA . 1980. The effect of electrical stimulation in the hypothalamus on the monosynaptic jaw closing and the disynaptic jaw opening reflexes in the cat. Exp. Brain Res. 39:389-400
    • (1980) Exp. Brain Res. , vol.39 , pp. 389-400
    • Landgren, S.1    Ka, O.2
  • 52
    • 0020694818 scopus 로고
    • Organized behavioral responses to lateral hypothalamic electrical stimulation in infant rats
    • Moran TH, Schwartz GJ, Blass EM. 1983. Organized behavioral responses to lateral hypothalamic electrical stimulation in infant rats. J. Neurosci. 3:10-19
    • (1983) J. Neurosci , vol.3 , pp. 10-19
    • Moran, T.H.1    Schwartz, G.J.2    Blass, E.M.3
  • 53
    • 0027655906 scopus 로고
    • Electromyographic activity in the masseter muscle resulting from stimulation of hypothalamic behavioral sites in the cat
    • Weiner S, Shaikh MB, Siegel A. 1993. Electromyographic activity in the masseter muscle resulting from stimulation of hypothalamic behavioral sites in the cat. J. Orofac. Pain 7:370-77
    • (1993) J. Orofac. Pain , vol.7 , pp. 370-377
    • Weiner, S.1    Shaikh, M.B.2    Siegel, A.3
  • 54
    • 0014056253 scopus 로고
    • Drinking induced by electrical stimulation of the lateral hypothalamus
    • Mogenson GJ, Stevenson JA. 1967. Drinking induced by electrical stimulation of the lateral hypothalamus. Exp. Neurol. 17:119-27
    • (1967) Exp. Neurol , vol.17 , pp. 119-127
    • Mogenson, G.J.1    Stevenson, J.A.2
  • 55
    • 0003080673 scopus 로고
    • Suggestive evidence of a primary drinking center in hypothalamus of the rat
    • Greer MA. 1955. Suggestive evidence of a primary drinking center in hypothalamus of the rat. Proc. Soc. Exp. Biol. Med. 89:59-62
    • (1955) Proc. Soc. Exp. Biol. Med , vol.89 , pp. 59-62
    • Greer, M.A.1
  • 56
    • 0015039108 scopus 로고
    • Attack elicited in rats by electrical stimulation of the lateral hypothalamus
    • Woodworth CH. 1971. Attack elicited in rats by electrical stimulation of the lateral hypothalamus. Physiol. Behav. 6:345-53
    • (1971) Physiol. Behav , vol.6 , pp. 345-353
    • Woodworth, C.H.1
  • 57
    • 0000171873 scopus 로고
    • Experiments onmotivation Studies combining psychological, physiological, and pharmacological techniques
    • MillerNE. 1957. Experiments onmotivation. Studies combining psychological, physiological, and pharmacological techniques. Science 126:1271-78
    • (1957) Science , vol.126 , pp. 1271-1278
    • Miller, N.E.1
  • 58
    • 0014406296 scopus 로고
    • Modification of motivated behavior elicited by electrical stimulation of the hypothalamus
    • Valenstein ES, Cox VC, Kakolewski JW. 1968. Modification of motivated behavior elicited by electrical stimulation of the hypothalamus. Science 159:1119-21
    • (1968) Science , vol.159 , pp. 1119-1121
    • Valenstein, E.S.1    Cox, V.C.2    Kakolewski, J.W.3
  • 59
    • 0040554386 scopus 로고
    • Male sexual behavior induced by intracranial electrical stimulation
    • Vaughan E, Fisher AE. 1962. Male sexual behavior induced by intracranial electrical stimulation. Science 137:758-60
    • (1962) Science , vol.137 , pp. 758-760
    • Vaughan, E.1    Fisher, A.E.2
  • 60
    • 0014694862 scopus 로고
    • Plasticity of hypothalamic motivational systems
    • Wise RA. 1969. Plasticity of hypothalamic motivational systems. Science 165:929-30
    • (1969) Science , vol.165 , pp. 929-930
    • Wise, R.A.1
  • 61
    • 0015972086 scopus 로고
    • Lateral hypothalamic electrical stimulation: Does it make animals 'hungry'?
    • Wise RA. 1974. Lateral hypothalamic electrical stimulation: Does it make animals 'hungry'? Brain Res. 67:187-209
    • (1974) Brain Res. , vol.67 , pp. 187-209
    • Wise, R.A.1
  • 62
    • 0013842582 scopus 로고
    • Lateral hypothalamus: Learning of food-seeking response motivated by electrical stimulation
    • Coons EE, Levak M, Miller NE. 1965. Lateral hypothalamus: learning of food-seeking response motivated by electrical stimulation. Science 150:1320-21
    • (1965) Science , vol.150 , pp. 1320-1321
    • Coons, E.E.1    Levak, M.2    Miller, N.E.3
  • 64
    • 0001015875 scopus 로고
    • Identical "feeding" and "rewarding" systems in the lateral hypothalamus of rats
    • Margules DL, Olds J. 1962. Identical "feeding" and "rewarding" systems in the lateral hypothalamus of rats. Science 135:374-75
    • (1962) Science , vol.135 , pp. 374-375
    • Margules, D.L.1    Olds, J.2
  • 65
    • 79951699573 scopus 로고    scopus 로고
    • Reward mechanisms in obesity: New insights and future directions
    • Kenny PJ. 2011. Reward mechanisms in obesity: new insights and future directions. Neuron 69:664-79
    • (2011) Neuron , vol.69 , pp. 664-679
    • Kenny, P.J.1
  • 66
    • 34248174973 scopus 로고    scopus 로고
    • Sensory processing in the brain related to the control of food intake
    • Rolls ET. 2007. Sensory processing in the brain related to the control of food intake. Proc. Nutr. Soc. 66:96-112
    • (2007) Proc. Nutr. Soc , vol.66 , pp. 96-112
    • Rolls, E.T.1
  • 67
    • 84885594437 scopus 로고    scopus 로고
    • The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding
    • Jennings JH, Rizzi G, Stamatakis AM, Ung RL, Stuber GD. 2013. The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding. Science 341:1517-21
    • (2013) Science , vol.341 , pp. 1517-1521
    • Jennings, J.H.1    Rizzi, G.2    Stamatakis, A.M.3    Ung, R.L.4    Stuber, G.D.5
  • 68
    • 84922224310 scopus 로고    scopus 로고
    • Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors
    • Jennings JH, Ung RL, Resendez SL, Stamatakis AM, Taylor JG, et al. 2015. Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors. Cell 160:516-27
    • (2015) Cell , vol.160 , pp. 516-527
    • Jennings, J.H.1    Ung, R.L.2    Resendez, S.L.3    Stamatakis, A.M.4    Taylor, J.G.5
  • 69
    • 0019381238 scopus 로고
    • Monkey lateral hypothalamic neuron response to sight of food, and during bar press and ingestion
    • Ono T, Nishino H, Sasaki K, Fukuda M, Muramoto KI. 1981. Monkey lateral hypothalamic neuron response to sight of food, and during bar press and ingestion. Neurosci. Lett. 21:99-104
    • (1981) Neurosci. Lett , vol.21 , pp. 99-104
    • Ono, T.1    Nishino, H.2    Sasaki, K.3    Fukuda, M.4    Muramoto, K.I.5
  • 70
    • 0018332413 scopus 로고
    • The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey
    • Rolls ET, Sanghera MK, Roper-Hall A. 1979. The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey. Brain Res. 164:121-35
    • (1979) Brain Res. , vol.164 , pp. 121-135
    • Rolls, E.T.1    Sanghera, M.K.2    Roper-Hall, A.3
  • 71
    • 0017155571 scopus 로고
    • Effects of hunger on the responses of neurons in the lateral hypothalamus to the sight and taste of food
    • Burton MJ, Rolls ET, Mora F. 1976. Effects of hunger on the responses of neurons in the lateral hypothalamus to the sight and taste of food. Exp. Neurol. 51:668-77
    • (1976) Exp. Neurol , vol.51 , pp. 668-677
    • Burton, M.J.1    Rolls, E.T.2    Mora, F.3
  • 73
    • 0023597591 scopus 로고
    • Gustatory preference-aversion thresholds are increased by ibotenic acid lesion of the lateral hypothalamus in the rat
    • Ferssiwi A, Cardo B, Velley L. 1987. Gustatory preference-aversion thresholds are increased by ibotenic acid lesion of the lateral hypothalamus in the rat. Brain Res. 437:142-50
    • (1987) Brain Res. , vol.437 , pp. 142-150
    • Ferssiwi, A.1    Cardo, B.2    Velley, L.3
  • 74
    • 0015691428 scopus 로고
    • Failure of recovered lateral hypothalamic rats to learn specific food aversions
    • Roth SR, SchwartzM, Teitelbaum P. 1973. Failure of recovered lateral hypothalamic rats to learn specific food aversions. J. Comp. Physiol. Psychol. 83:184-97
    • (1973) J. Comp. Physiol. Psychol , vol.83 , pp. 184-197
    • Roth, S.R.1    Schwartz, M.2    Teitelbaum, P.3
  • 75
    • 0035129948 scopus 로고    scopus 로고
    • Conditioned flavor preference and aversion: Role of the lateral hypothalamus
    • Touzani K, Sclafani A. 2001. Conditioned flavor preference and aversion: role of the lateral hypothalamus. Behav. Neurosci. 115:84-93
    • (2001) Behav. Neurosci , vol.115 , pp. 84-93
    • Touzani, K.1    Sclafani, A.2
  • 76
    • 0036930152 scopus 로고    scopus 로고
    • Lateral hypothalamic lesions impair flavour-nutrient and flavour-toxin trace learning in rats
    • Touzani K, Sclafani A. 2002. Lateral hypothalamic lesions impair flavour-nutrient and flavour-toxin trace learning in rats. Eur. J. Neurosci. 16:2425-33
    • (2002) Eur. J. Neurosci , vol.16 , pp. 2425-2433
    • Touzani, K.1    Sclafani, A.2
  • 77
    • 84878280528 scopus 로고    scopus 로고
    • Lateral hypothalamus contains two types of palatabilityrelated taste responses with distinct dynamics
    • Li JX, Yoshida T, Monk KJ, Katz DB. 2013. Lateral hypothalamus contains two types of palatabilityrelated taste responses with distinct dynamics. J. Neurosci. 33:9462-73
    • (2013) J. Neurosci , vol.33 , pp. 9462-9473
    • Li, J.X.1    Yoshida, T.2    Monk, K.J.3    Katz, D.B.4
  • 78
    • 0014968236 scopus 로고
    • Gustatory responses in the hypothalamus
    • Norgren R. 1970. Gustatory responses in the hypothalamus. Brain Res. 21:63-77
    • (1970) Brain Res. , vol.21 , pp. 63-77
    • Norgren, R.1
  • 79
    • 0024233069 scopus 로고
    • Electrophysiology of taste, feeding and reward in lateral hypothalamus of rabbit
    • Schwartzbaum JS. 1988. Electrophysiology of taste, feeding and reward in lateral hypothalamus of rabbit. Physiol. Behav. 44:507-26
    • (1988) Physiol. Behav , vol.44 , pp. 507-526
    • Schwartzbaum, J.S.1
  • 80
    • 0016273682 scopus 로고
    • Gustatory afferents to ventral forebrain
    • Norgren R. 1974. Gustatory afferents to ventral forebrain. Brain Res. 81:285-95
    • (1974) Brain Res. , vol.81 , pp. 285-295
    • Norgren, R.1
  • 81
    • 84905166320 scopus 로고    scopus 로고
    • Activation of lateral hypothalamusprojecting parabrachial neurons by intraorally delivered gustatory stimuli
    • Tokita K, Armstrong WE, St John SJ, Boughter JD Jr. 2014. Activation of lateral hypothalamusprojecting parabrachial neurons by intraorally delivered gustatory stimuli. Front. Neural Circuits 8:86
    • (2014) Front. Neural Circuits , vol.8 , pp. 86
    • Tokita, K.1    Armstrong, W.E.2    St John, S.J.3    Boughter, J.D.4
  • 82
    • 0015041964 scopus 로고
    • Hypothalamic unit activity and eating behavior
    • Hamburg MD. 1971. Hypothalamic unit activity and eating behavior. Am. J. Physiol. 220:980-85
    • (1971) Am. J. Physiol , vol.220 , pp. 980-985
    • Hamburg, M.D.1
  • 83
  • 84
    • 13344279395 scopus 로고    scopus 로고
    • A role for melaninconcentrating hormone in the central regulation of feeding behaviour
    • Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, et al. 1996. A role for melaninconcentrating hormone in the central regulation of feeding behaviour. Nature 380:243-47
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3    Piper, M.4    Pelleymounter, M.A.5
  • 85
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-85
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5
  • 86
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
    • de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, et al. 1998. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. PNAS 95:322-27
    • (1998) PNAS , vol.95 , pp. 322-327
    • De Lecea, L.1    Kilduff, T.S.2    Peyron, C.3    Gao, X.4    Foye, P.E.5
  • 87
    • 19544376694 scopus 로고    scopus 로고
    • Behavioral correlates of activity in identified hypocretin/orexin neurons
    • Mileykovskiy BY, Kiyashchenko LI, Siegel JM. 2005. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46:787-98
    • (2005) Neuron , vol.46 , pp. 787-798
    • Mileykovskiy, B.Y.1    Kiyashchenko, L.I.2    Siegel, J.M.3
  • 89
    • 22244443005 scopus 로고    scopus 로고
    • Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    • Lee MG, Hassani OK, Jones BE. 2005. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J. Neurosci. 25:6716-20
    • (2005) J. Neurosci , vol.25 , pp. 6716-6720
    • Lee, M.G.1    Hassani, O.K.2    Jones, B.E.3
  • 90
    • 60549087337 scopus 로고    scopus 로고
    • Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    • Hassani OK, Lee MG, Jones BE. 2009. Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. PNAS 106:2418-22
    • (2009) PNAS , vol.106 , pp. 2418-2422
    • Hassani, O.K.1    Lee, M.G.2    Jones, B.E.3
  • 92
    • 84891822239 scopus 로고    scopus 로고
    • Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
    • Domingos AI, Sordillo A, Dietrich MO, Liu ZW, Tellez LA, et al. 2013. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. eLife 2:e01462
    • (2013) ELife , vol.2 , pp. e01462
    • Domingos, A.I.1    Sordillo, A.2    Dietrich, M.O.3    Liu, Z.W.4    Tellez, L.A.5
  • 93
    • 0031004672 scopus 로고    scopus 로고
    • GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior
    • Stratford TR, Kelley AE. 1997. GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior. J. Neurosci. 17:4434-40
    • (1997) J. Neurosci , vol.17 , pp. 4434-4440
    • Stratford, T.R.1    Kelley, A.E.2
  • 94
    • 0033573532 scopus 로고    scopus 로고
    • Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior
    • Stratford TR, Kelley AE. 1999. Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J. Neurosci. 19:11040-48
    • (1999) J. Neurosci , vol.19 , pp. 11040-11048
    • Stratford, T.R.1    Kelley, A.E.2
  • 95
    • 27744599679 scopus 로고    scopus 로고
    • A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward
    • Kelley AE, Baldo BA, PrattWE. 2005. A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward. J. Comp. Neurol. 493:72-85
    • (2005) J. Comp. Neurol , vol.493 , pp. 72-85
    • Kelley, A.E.1    Baldo, B.A.2    Pratt, W.E.3
  • 96
    • 13844256154 scopus 로고    scopus 로고
    • Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output
    • Roitman MF, Wheeler RA, Carelli RM. 2005. Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output. Neuron 45:587-97
    • (2005) Neuron , vol.45 , pp. 587-597
    • Roitman, M.F.1    Wheeler, R.A.2    Carelli, R.M.3
  • 97
    • 0017737626 scopus 로고
    • Activity of neurons in the region of the substantia nigra during feeding in the monkey
    • Mora F, Mogenson GJ, Rolls ET. 1977. Activity of neurons in the region of the substantia nigra during feeding in the monkey. Brain Res. 133:267-76
    • (1977) Brain Res. , vol.133 , pp. 267-276
    • Mora, F.1    Mogenson, G.J.2    Rolls, E.T.3
  • 98
    • 33847641489 scopus 로고    scopus 로고
    • Opiods for hedonic experience and dopamine to get ready for it
    • Barbano MF, Cador M. 2007. Opiods for hedonic experience and dopamine to get ready for it. Psychopharmacology 191:497-506
    • (2007) Psychopharmacology , vol.191 , pp. 497-506
    • Barbano, M.F.1    Cador, M.2
  • 99
    • 68649118810 scopus 로고    scopus 로고
    • Liking and wanting food rewards Brain substrates and roles in eating disorders
    • Berridge KC. 2009. 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiol. Behav. 97:537-50
    • (2009) Physiol. Behav , vol.97 , pp. 537-550
    • Berridge, K.C.1
  • 101
    • 84946120273 scopus 로고    scopus 로고
    • Accumbal D1R neurons projecting to lateral hypothalamus authorize feeding
    • O'Connor EC, Kremer Y, Lefort S, Harada M, Pascoli V, et al. 2015. Accumbal D1R neurons projecting to lateral hypothalamus authorize feeding. Neuron 88:553-64
    • (2015) Neuron , vol.88 , pp. 553-564
    • O'Connor, E.C.1    Kremer, Y.2    Lefort, S.3    Harada, M.4    Pascoli, V.5
  • 102
    • 33847128442 scopus 로고    scopus 로고
    • Opioid limbic circuit for reward: Interaction between hedonic hotspots of nucleus accumbens and ventral pallidum
    • Smith KS, Berridge KC. 2007. Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. J. Neurosci. 27:1594-605
    • (2007) J. Neurosci , vol.27 , pp. 1594-1605
    • Smith, K.S.1    Berridge, K.C.2
  • 103
    • 84873991930 scopus 로고    scopus 로고
    • Lateral hypothalamic involvement in feeding elicited from the ventral pallidum
    • Stratford TR,WirtshafterD. 2013. Lateral hypothalamic involvement in feeding elicited from the ventral pallidum. Eur. J. Neurosci. 37:648-53
    • (2013) Eur. J. Neurosci , vol.37 , pp. 648-653
    • Stratford, T.R.1    Wirtshafter, D.2
  • 104
    • 66249125042 scopus 로고    scopus 로고
    • Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning
    • Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, et al. 2009. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science 324:1080-84
    • (2009) Science , vol.324 , pp. 1080-1084
    • Tsai, H.C.1    Zhang, F.2    Adamantidis, A.3    Stuber, G.D.4    Bonci, A.5
  • 105
    • 0016763232 scopus 로고
    • Disruption of brain stimulation-induced feeding by dopamine receptor blockade
    • Phillips AG, Nikaido RS. 1975. Disruption of brain stimulation-induced feeding by dopamine receptor blockade. Nature 258:750-51
    • (1975) Nature , vol.258 , pp. 750-751
    • Phillips, A.G.1    Nikaido, R.S.2
  • 106
    • 0030896968 scopus 로고    scopus 로고
    • Aneural substrate of prediction and reward
    • SchultzW,Dayan P, Montague PR. 1997.Aneural substrate of prediction and reward. Science 275:1593-9
    • (1997) Science , vol.275 , pp. 1593-1599
    • Schultz, W.1    Dayan, P.2    Montague, P.R.3
  • 107
    • 2642519680 scopus 로고    scopus 로고
    • Dopamine, learning and motivation.Nat
    • Wise R. 2004. Dopamine, learning and motivation.Nat. Rev. Neurosci. 5:483-94
    • (2004) Rev. Neurosci , vol.5 , pp. 483-494
    • Wise, R.1
  • 108
    • 84949624774 scopus 로고    scopus 로고
    • Modulation of cueinduced firing of ventral tegmental area dopamine neurons by leptin and ghrelin
    • van der Plasse G, van Zessen R, Luijendijk MC, Erkan H, Stuber GD, et al. 2015. Modulation of cueinduced firing of ventral tegmental area dopamine neurons by leptin and ghrelin. Int. J. Obes 39:1742-49
    • (2015) Int. J. Obes , vol.39 , pp. 1742-1749
    • Vander Plasse, G.1    Van Zessen, R.2    Luijendijk, M.C.3    Erkan, H.4    Stuber, G.D.5
  • 109
    • 84881124503 scopus 로고    scopus 로고
    • Bidirectional modulation of substantia nigra activity by motivational state
    • Rossi MA, Fan D, Barter JW, Yin HH. 2013. Bidirectional modulation of substantia nigra activity by motivational state. PLOS ONE 8:e71598
    • (2013) PLOS ONE , vol.8 , pp. e71598
    • Rossi, M.A.1    Fan, D.2    Barter, J.W.3    Yin, H.H.4
  • 110
    • 0020628736 scopus 로고
    • Visual and oculomotor functions of monkey substantia nigra pars reticulata i Relation of visual and auditory responses to saccades
    • Hikosaka O, Wurtz RH. 1983. Visual and oculomotor functions of monkey substantia nigra pars reticulata. I. Relation of visual and auditory responses to saccades. J. Neurophysiol. 49:1230-53
    • (1983) J. Neurophysiol , vol.49 , pp. 1230-1253
    • Hikosaka, O.1    Wurtz, R.H.2
  • 111
    • 84962077051 scopus 로고    scopus 로고
    • A GABAergic nigrotectal pathway for coordination of drinking behavior
    • Rossi MA, Li HE, Lu D, Kim IH, Bartholomew RA, et al. 2016. A GABAergic nigrotectal pathway for coordination of drinking behavior. Nat. Neurosci. 19:742-48
    • (2016) Nat. Neurosci , vol.19 , pp. 742-748
    • Rossi, M.A.1    Li, H.E.2    Lu, D.3    Kim, I.H.4    Bartholomew, R.A.5
  • 113
    • 0015699417 scopus 로고
    • Do rats terminate hypothalamic stimulation only in order to turn it on again?
    • Mendelson J, Freed WJ. 1973. Do rats terminate hypothalamic stimulation only in order to turn it on again? Behav. Biol. 8:619-28
    • (1973) Behav. Biol. , vol.8 , pp. 619-628
    • Mendelson, J.1    Freed, W.J.2
  • 114
    • 0011722364 scopus 로고
    • Rewarding and punishing effects from stimulating the same place in the rat's brain
    • Bower GH, Miller NE. 1958. Rewarding and punishing effects from stimulating the same place in the rat's brain. J. Comp. Physiol. Psychol. 51:669-74
    • (1958) J. Comp. Physiol. Psychol , vol.51 , pp. 669-674
    • Bower, G.H.1    Miller, N.E.2
  • 115
    • 0025970096 scopus 로고
    • What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?
    • Berridge KC, Valenstein ES. 1991. What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus? Behav. Neurosci. 105:3-14
    • (1991) Behav. Neurosci , vol.105 , pp. 3-14
    • Berridge, K.C.1    Valenstein, E.S.2
  • 116
    • 34347343926 scopus 로고    scopus 로고
    • Lateral habenula as a source of negative reward signals in dopamine neurons
    • Matsumoto M, Hikosaka O. 2007. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 447:1111-15
    • (2007) Nature , vol.447 , pp. 1111-1115
    • Matsumoto, M.1    Hikosaka, O.2
  • 117
    • 84864456653 scopus 로고    scopus 로고
    • Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
    • Stamatakis AM, Stuber GD. 2012. Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nat. Neurosci. 15:1105-7
    • (2012) Nat. Neurosci , vol.15 , pp. 1105-1107
    • Stamatakis, A.M.1    Stuber, G.D.2
  • 118
    • 84875861827 scopus 로고    scopus 로고
    • A glutamatergic projection from the lateral hypothalamus targets VTA-projecting neurons in the lateral habenula of the rat
    • PollerWC, Madai VI, Bernard R, Laube G, Veh RW. 2013. A glutamatergic projection from the lateral hypothalamus targets VTA-projecting neurons in the lateral habenula of the rat. Brain Res. 1507:45-60
    • (2013) Brain Res. , vol.1507 , pp. 45-60
    • Poller, W.C.1    Madai, V.I.2    Bernard, R.3    Laube, G.4    Veh, R.W.5
  • 119
    • 84954350379 scopus 로고    scopus 로고
    • Lateral hypothalamic area glutamatergic neurons and their projections to the lateral habenula regulate feeding and reward
    • Stamatakis AM, Van SwietenM, BasiriML, Blair GA, Kantak P, Stuber GD. 2016. Lateral hypothalamic area glutamatergic neurons and their projections to the lateral habenula regulate feeding and reward. J. Neurosci. 36:302-11
    • (2016) J. Neurosci , vol.36 , pp. 302-311
    • Stamatakis, A.M.1    Van Swieten, M.2    Basiri, M.L.3    Blair, G.A.4    Kantak, P.5    Stuber, G.D.6
  • 122
    • 0034614698 scopus 로고    scopus 로고
    • Modulation of brain reward circuitry by leptin
    • Fulton S, Woodside B, Shizgal P. 2000. Modulation of brain reward circuitry by leptin. Science 287:125-8
    • (2000) Science , vol.287 , pp. 125-128
    • Fulton, S.1    Woodside, B.2    Shizgal, P.3
  • 123
    • 33748540764 scopus 로고    scopus 로고
    • Leptin receptor signaling in midbrain dopamine neurons regulates feeding
    • Hommel JD. 2006. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51:801-10
    • (2006) Neuron , vol.51 , pp. 801-810
    • Hommel, J.D.1
  • 125
    • 0034993663 scopus 로고    scopus 로고
    • Leptin reverses sucrose-conditioned place preference in food-restricted rats
    • Figlewicz DP, Higgins MS, Ng-Evans SB, Havel PJ. 2001. Leptin reverses sucrose-conditioned place preference in food-restricted rats. Physiol. Behav. 73:229-34
    • (2001) Physiol. Behav , vol.73 , pp. 229-234
    • Figlewicz, D.P.1    Higgins, M.S.2    Ng-Evans, S.B.3    Havel, P.J.4
  • 126
    • 0036812537 scopus 로고    scopus 로고
    • Amygdalo-hypothalamic circuit allows learned cues to override satiety and promote eating
    • PetrovichGD,Setlow B, Holland PC, GallagherM. 2002. Amygdalo-hypothalamic circuit allows learned cues to override satiety and promote eating. J. Neurosci. 22:8748-53
    • (2002) J. Neurosci , vol.22 , pp. 8748-8753
    • Petrovich, G.D.1    Setlow, B.2    Holland, P.C.3    Gallagher, M.4
  • 127
    • 0014409608 scopus 로고
    • Relative effects of nutritional deficit and deprivation period on rate of electrical self-stimulation of lateral hypothalamus
    • Blundell JE, Herberg LJ. 1968. Relative effects of nutritional deficit and deprivation period on rate of electrical self-stimulation of lateral hypothalamus. Nature 219:627-28
    • (1968) Nature , vol.219 , pp. 627-628
    • Blundell, J.E.1    Herberg, L.J.2
  • 128
    • 0014677348 scopus 로고
    • Ethological and neurological aspects of the regulation of food intake
    • de Ruiter L, Wiepkema PR, Reddingius J. 1969. Ethological and neurological aspects of the regulation of food intake. Ann. N.Y. Acad. Sci. 157:1204-16
    • (1969) Ann. N.Y. Acad. Sci. , vol.157 , pp. 1204-1216
    • De Ruiter, L.1    Wiepkema, P.R.2    Reddingius, J.3
  • 129
    • 0021905218 scopus 로고
    • Cholecystokinin bioactivity in human plasma Molecular forms, responses to feeding, and relationship to gallbladder contraction
    • Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA. 1985. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J. Clin. Investig. 75:1144-52
    • (1985) J. Clin. Investig , vol.75 , pp. 1144-1152
    • Liddle, R.A.1    Goldfine, I.D.2    Rosen, M.S.3    Taplitz, R.A.4    Williams, J.A.5
  • 131
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology, physiology, andmechanisms of incretin hormone action
    • Campbell JE, Drucker DJ. 2013. Pharmacology, physiology, andmechanisms of incretin hormone action. Cell Metab. 17:819-37
    • (2013) Cell Metab , vol.17 , pp. 819-837
    • Campbell, J.E.1    Drucker, D.J.2
  • 132
    • 0032189856 scopus 로고    scopus 로고
    • Behavioral satiety sequence (BSS) for the diagnosis of drug action on food intake
    • Halford JC, Wanninayake SC, Blundell JE. 1998. Behavioral satiety sequence (BSS) for the diagnosis of drug action on food intake. Pharmacol. Biochem. Behav. 61:159-68
    • (1998) Pharmacol. Biochem. Behav , vol.61 , pp. 159-168
    • Halford, J.C.1    Wanninayake, S.C.2    Blundell, J.E.3
  • 133
    • 3242742898 scopus 로고    scopus 로고
    • Gut peptides in the control of food intake: 30 years of ideas
    • Moran TH. 2004. Gut peptides in the control of food intake: 30 years of ideas. Physiol. Behav. 82:175-80
    • (2004) Physiol. Behav , vol.82 , pp. 175-180
    • Moran, T.H.1
  • 134
    • 0032932704 scopus 로고    scopus 로고
    • The parabrachial nucleus and conditioned taste aversion
    • Reilly S. 1999. The parabrachial nucleus and conditioned taste aversion. Brain Res. Bull. 48:239-54
    • (1999) Brain Res. Bull , vol.48 , pp. 239-254
    • Reilly, S.1
  • 135
    • 84949115965 scopus 로고    scopus 로고
    • Leptin receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake
    • Alhadeff AL, Hayes MR, Grill HJ. 2014. Leptin receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307:R1338-44
    • (2014) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.307 , pp. R1338-R1344
    • Alhadeff, A.L.1    Hayes, M.R.2    Grill, H.J.3
  • 136
    • 84904468017 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake and motivation to feed
    • Alhadeff AL, Baird JP, Swick JC,Hayes MR, Grill HJ. 2014. Glucagon-like peptide-1 receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake and motivation to feed. Neuropsychopharmacology 39:2233-43
    • (2014) Neuropsychopharmacology , vol.39 , pp. 2233-2243
    • Alhadeff, A.L.1    Baird, J.P.2    Swick, J.C.3    Hayes, M.R.4    Grill, H.J.5
  • 137
    • 0035194845 scopus 로고    scopus 로고
    • Parametric analysis of gastric distension responses in the parabrachial nucleus
    • Baird JP, Travers JB, Travers SP. 2001. Parametric analysis of gastric distension responses in the parabrachial nucleus. Am. J. Physiol. 281:R1568-80
    • (2001) Am. J. Physiol , vol.281 , pp. R1568-R1580
    • Baird, J.P.1    Travers, J.B.2    Travers, S.P.3
  • 138
    • 3843069820 scopus 로고    scopus 로고
    • The pattern of c-Fos immunoreactivity in the hindbrain of the rat following stomach distension
    • Sabbatini M, Molinari C, Grossini E, Mary DA, Vacca G, Cannas M. 2004. The pattern of c-Fos immunoreactivity in the hindbrain of the rat following stomach distension. Exp. Brain Res. 157:315-23
    • (2004) Exp. Brain Res. , vol.157 , pp. 315-323
    • Sabbatini, M.1    Molinari, C.2    Grossini, E.3    Mary, D.A.4    Vacca, G.5    Cannas, M.6
  • 139
    • 84887407770 scopus 로고    scopus 로고
    • Genetic identification of a neural circuit that suppresses appetite
    • Carter ME, Soden ME, Zweifel LS, Palmiter RD. 2013. Genetic identification of a neural circuit that suppresses appetite. Nature 503:111-14
    • (2013) Nature , vol.503 , pp. 111-114
    • Carter, M.E.1    Soden, M.E.2    Zweifel, L.S.3    Palmiter, R.D.4
  • 140
    • 84937210916 scopus 로고    scopus 로고
    • Elucidating an affective pain circuit that creates a threat memory
    • Han S, Soleiman MT, Soden ME, Zweifel LS, Palmiter RD. 2015. Elucidating an affective pain circuit that creates a threat memory. Cell 162:363-74
    • (2015) Cell , vol.162 , pp. 363-374
    • Han, S.1    Soleiman, M.T.2    Soden, M.E.3    Zweifel, L.S.4    Palmiter, R.D.5
  • 141
    • 84925070777 scopus 로고    scopus 로고
    • Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion
    • Carter ME, Han S, Palmiter RD. 2015. Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion. J. Neurosci. 35:4582-86
    • (2015) J. Neurosci , vol.35 , pp. 4582-4586
    • Carter, M.E.1    Han, S.2    Palmiter, R.D.3
  • 143
    • 84859215897 scopus 로고    scopus 로고
    • Deciphering a neuronal circuit that mediates appetite
    • Wu Q, Clark MS, Palmiter RD. 2012. Deciphering a neuronal circuit that mediates appetite. Nature 483:594-97
    • (2012) Nature , vol.483 , pp. 594-597
    • Wu, Q.1    Clark, M.S.2    Palmiter, R.D.3
  • 145
    • 84857311304 scopus 로고    scopus 로고
    • Rethinking the emotional brain
    • LeDoux J. 2012. Rethinking the emotional brain. Neuron 73:653-76
    • (2012) Neuron , vol.73 , pp. 653-676
    • LeDoux, J.1
  • 146
    • 84916608125 scopus 로고    scopus 로고
    • Optogenetic excitation of central amygdala amplifies and narrows incentive motivation to pursue one reward above another
    • Robinson MJ, Warlow SM, Berridge KC. 2014. Optogenetic excitation of central amygdala amplifies and narrows incentive motivation to pursue one reward above another. J. Neurosci. 34:16567-80
    • (2014) J. Neurosci , vol.34 , pp. 16567-16580
    • Robinson, M.J.1    Warlow, S.M.2    Berridge, K.C.3
  • 147
    • 33646136898 scopus 로고    scopus 로고
    • Parallel incentive processing: An integrated view of amygdala function
    • Balleine BW, Killcross S. 2006. Parallel incentive processing: an integrated view of amygdala function. Trends Neurosci. 29:272-79
    • (2006) Trends Neurosci , vol.29 , pp. 272-279
    • Balleine, B.W.1    Killcross, S.2
  • 148
    • 84921683974 scopus 로고    scopus 로고
    • Central amygdala PKC-δ+ neurons mediate the influence of multiple anorexigenic signals
    • Cai H, Haubensak W, Anthony TE, Anderson DJ. 2014. Central amygdala PKC-δ+ neurons mediate the influence of multiple anorexigenic signals. Nat. Neurosci. 17:1240-48
    • (2014) Nat. Neurosci , vol.17 , pp. 1240-1248
    • Cai, H.1    Haubensak, W.2    Anthony, T.E.3    Anderson, D.J.4
  • 149
    • 0001904325 scopus 로고
    • Appetites and aversions as constituents of instincts
    • Craig W. 1918. Appetites and aversions as constituents of instincts. Biol. Bull. 34:91-107
    • (1918) Biol. Bull , vol.34 , pp. 91-107
    • Craig, W.1
  • 150
    • 84864474183 scopus 로고    scopus 로고
    • AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
    • Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, et al. 2012. AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat. Neurosci. 15:1108-10
    • (2012) Nat. Neurosci , vol.15 , pp. 1108-1110
    • Dietrich, M.O.1    Bober, J.2    Ferreira, J.G.3    Tellez, L.A.4    Mineur, Y.S.5
  • 151
    • 84923322091 scopus 로고    scopus 로고
    • GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding
    • Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, et al. 2015. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J. Neurosci. 35:3312-18
    • (2015) J. Neurosci , vol.35 , pp. 3312-3318
    • Wu, Z.1    Kim, E.R.2    Sun, H.3    Xu, Y.4    Mangieri, L.R.5
  • 152
    • 14144256759 scopus 로고    scopus 로고
    • Modulation of parabrachial taste neurons by electrical and chemical stimulation of the lateral hypothalamus and amygdala
    • Li CS, Cho YK, Smith DV. 2005. Modulation of parabrachial taste neurons by electrical and chemical stimulation of the lateral hypothalamus and amygdala. J. Neurophysiol. 93:1183-96
    • (2005) J. Neurophysiol , vol.93 , pp. 1183-1196
    • Li, C.S.1    Cho, Y.K.2    Smith, D.V.3
  • 153
    • 84906979430 scopus 로고    scopus 로고
    • MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus
    • Shah BP, Vong L, OlsonDP, Koda S, KrashesMJ, et al. 2014. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. PNAS 111:13193-98
    • (2014) PNAS , vol.111 , pp. 13193-13198
    • Shah, B.P.1    Vong, L.2    Olson, D.P.3    Koda, S.4    Krashes, M.J.5
  • 154
    • 84960419106 scopus 로고    scopus 로고
    • Feeding and reward are differentially induced by activating GABAergic lateral hypothalamic projections to VTA
    • Barbano MF, Wang HL, Morales M,Wise RA. 2016. Feeding and reward are differentially induced by activating GABAergic lateral hypothalamic projections to VTA. J. Neurosci. 36:2975-85
    • (2016) J. Neurosci , vol.36 , pp. 2975-2985
    • Barbano, M.F.1    Wang, H.L.2    Morales, M.3    Wise, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.