An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

Nature

Volumn 507, Issue 7491, 2014, Pages 238-242

  Krashes, Michael J ^a,f,g   Shah, Bhavik P ^a,h   Madara, Joseph C ^a   Olson, David P ^a,d   Strochlic, David E ^b   Garfield, Alastair S ^a,c   Vong, Linh ^a,i   Pei, Hongjuan ^d   Watabe Uchida, Mitsuko ^e   Uchida, Naoshige ^b,e   Liberles, Stephen D ^b   Lowell, Bradford B ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e HARVARD UNIVERSITY   (United States)

^f NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^g NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^h PFIZER INC   (United States)

ⁱ NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; CLOZAPINE N OXIDE; CRE RECOMBINASE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; PROTIRELIN; VESICULAR GLUTAMATE TRANSPORTER 2;

ENZYME ACTIVITY; INHIBITION; NEUROLOGY;

ARCUATE NUCLEUS; ARTICLE; FEEDING; FOOD INTAKE; HUMAN; HUNGER; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MOTIVATION; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; SENSORY NERVE;

AGOUTI; MUS;

AGOUTI-RELATED PROTEIN; ANIMALS; APPETITE; ARCUATE NUCLEUS; BRAIN MAPPING; CELL TRACKING; CLOZAPINE; DEPENDOVIRUS; EATING; FEMALE; FOOD DEPRIVATION; HUNGER; INTEGRASES; MALE; MICE; NEURAL PATHWAYS; NEURONAL PLASTICITY; NEURONS; NEURONS, AFFERENT; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PEPTIDE FRAGMENTS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RABIES VIRUS; SATIETY RESPONSE; THYROTROPIN-RELEASING HORMONE;

EID: 84896317618     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12956     Document Type: Article

References (33)

1. Takahashi, K. A.&Cone, R. D. Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons. Endocrinology 146, 1043-1047 (2005).
2. Aponte, Y., Atasoy, D. & Sternson, S. M. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nature Neurosci. 14, 351-355 (2011).
3. Krashes, M. J. et al. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J. Clin. Invest. 121, 1424-1428 (2011).
4. Krashes, M. J., Shah, B. P., Koda, S.& Lowell, B. B. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab. 18, 588-595 (2013).
5. Atasoy, D., Betley, J. N., Su, H. H.&Sternson, S. M.Deconstruction of a neural circuit for hunger. Nature 488, 172-177 (2012).
6. Luquet, S., Perez, F. A., Hnasko, T. S. & Palmiter, R. D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310, 683-685 (2005).
7. Gropp, E. et al. Agouti-related peptide-expressing neurons are mandatory for feeding. Nature Neurosci. 8, 1289-1291 (2005).
8. Liu, T. et al. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron 73, 511-522 (2012).
9. Yang, Y., Atasoy, D., Su, H. H. & Sternson, S. M. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell 146, 992-1003 (2011).
10. Pinto, S. et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304, 110-115 (2004).
11. Wickersham, I. R., Finke, S., Conzelmann, K. K. & Callaway, E. M. Retrograde neuronal tracing with a deletion-mutant rabies virus. Nature Methods 4, 47-49 (2007).
12. Watabe-Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A. & Uchida, N. Whole-brain mapping of direct inputs to midbrain dopamine neurons. Neuron 74, 858-873 (2012).
13. Vong, L. et al. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71, 142-154 (2011).
14. Petreanu, L., Huber, D., Sobczyk, A. & Svoboda, K. Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nature Neurosci. 10, 663-668 (2007).
15. Atasoy, D., Aponte, Y., Su, H. H. & Sternson, S. M. A. FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J. Neurosci. 28, 7025-7030 (2008).
16. Hahn, T. M., Breininger, J. F., Baskin, D. G. & Schwartz, M. W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neurosci. 1, 271-272 (1998).
17. van den Pol, A. N. et al. Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J. Neurosci. 29, 4622-4639 (2009).
18. Sternson, S. M.,Shepherd, G. M.&Friedman, J. M. TopographicmappingofVMHR arcuate nucleus microcircuits and their reorganization by fasting. Nature Neurosci. 8, 1356-1363 (2005).
19. Michaud, J. L., Rosenquist, T., May, N. R. & Fan, C. M. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 12, 3264-3275 (1998).
20. Balthasar, N. et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123, 493-505 (2005).
21. Wu, Z. et al. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS ONE 7, e45167 (2012).
22. Fukushima, Y. et al. Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1562-R1567 (2001).
23. Zhan, C. et al. Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J. Neurosci. 33, 3624-3632 (2013).
24. Alexander, G. M. et al. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63, 27-39 (2009).
25. Leibowitz, S. F., Hammer, N. J. & Chang, K. Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat. Physiol. Behav. 27, 1031-1040 (1981).
26. Gold, R. M., Jones, A. P. & Sawchenko, P. E. Paraventricular area: critical focus of a longitudinal neurocircuitry mediating food intake. Physiol. Behav. 18, 1111-1119 (1977).
27. Stanley, B. G. & Leibowitz, S. F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl Acad. Sci. USA 82, 3940-3943 (1985).
28. Cowley, M. A. et al. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24, 155-163 (1999).
29. Kong, D. et al. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 151, 645-657 (2012).
30. Montmayeur, J. P., Liberles, S. D., Matsunami, H. & Buck, L. B. A candidate taste receptor gene near a sweet taste locus. Nature Neurosci. 4, 492-498 (2001).
31. Heiman, M. et al. A translational profiling approach for the molecular characterization of CNS cell types. Cell 135, 738-748 (2008).
32. Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
33. Satoh, T., Yamada, M., Monden, T., Iizuka, M. & Mori, M. Cloning of the mouse hypothalamic preprothyrotropin-releasing hormone (TRH) cDNA and tissue distribution of its mRNA. Brain Res. Mol. Brain Res. 14, 131-135 (1992).