-
1
-
-
0033588184
-
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
-
1 Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999), 437–451.
-
(1999)
Cell
, vol.98
, pp. 437-451
-
-
Chemelli, R.M.1
Willie, J.T.2
Sinton, C.M.3
Elmquist, J.K.4
Scammell, T.5
Lee, C.6
Richardson, J.A.7
Williams, S.C.8
Xiong, Y.9
Kisanuki, Y.10
-
2
-
-
0034992322
-
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
-
2 Hara, J., Beuckmann, C.T., Nambu, T., Willie, J.T., Chemelli, R.M., Sinton, C.M., Sugiyama, F., Yagami, K., Goto, K., Yanagisawa, M., Sakurai, T., Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30 (2001), 345–354.
-
(2001)
Neuron
, vol.30
, pp. 345-354
-
-
Hara, J.1
Beuckmann, C.T.2
Nambu, T.3
Willie, J.T.4
Chemelli, R.M.5
Sinton, C.M.6
Sugiyama, F.7
Yagami, K.8
Goto, K.9
Yanagisawa, M.10
Sakurai, T.11
-
3
-
-
0033710848
-
Reduced number of hypocretin neurons in human narcolepsy
-
3 Thannickal, T.C., Moore, R.Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., Siegel, J.M., Reduced number of hypocretin neurons in human narcolepsy. Neuron 27 (2000), 469–474.
-
(2000)
Neuron
, vol.27
, pp. 469-474
-
-
Thannickal, T.C.1
Moore, R.Y.2
Nienhuis, R.3
Ramanathan, L.4
Gulyani, S.5
Aldrich, M.6
Cornford, M.7
Siegel, J.M.8
-
4
-
-
0033971611
-
Hypocretin (orexin) deficiency in human narcolepsy
-
4 Nishino, S., Ripley, B., Overeem, S., Lammers, G.J., Mignot, E., Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355 (2000), 39–40.
-
(2000)
Lancet
, vol.355
, pp. 39-40
-
-
Nishino, S.1
Ripley, B.2
Overeem, S.3
Lammers, G.J.4
Mignot, E.5
-
5
-
-
73849143579
-
A key role for orexin in panic anxiety
-
5 Johnson, P.L., Truitt, W., Fitz, S.D., Minick, P.E., Dietrich, A., Sanghani, S., Träskman-Bendz, L., Goddard, A.W., Brundin, L., Shekhar, A., A key role for orexin in panic anxiety. Nat. Med. 16 (2010), 111–115.
-
(2010)
Nat. Med.
, vol.16
, pp. 111-115
-
-
Johnson, P.L.1
Truitt, W.2
Fitz, S.D.3
Minick, P.E.4
Dietrich, A.5
Sanghani, S.6
Träskman-Bendz, L.7
Goddard, A.W.8
Brundin, L.9
Shekhar, A.10
-
6
-
-
18144389456
-
Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior
-
6 Suzuki, M., Beuckmann, C.T., Shikata, K., Ogura, H., Sawai, T., Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior. Brain Res. 1044 (2005), 116–121.
-
(2005)
Brain Res.
, vol.1044
, pp. 116-121
-
-
Suzuki, M.1
Beuckmann, C.T.2
Shikata, K.3
Ogura, H.4
Sawai, T.5
-
7
-
-
77957359098
-
Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats
-
7 Li, Y., Li, S., Wei, C., Wang, H., Sui, N., Kirouac, G.J., Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats. Psychopharmacology (Berl.) 212 (2010), 251–265.
-
(2010)
Psychopharmacology (Berl.)
, vol.212
, pp. 251-265
-
-
Li, Y.1
Li, S.2
Wei, C.3
Wang, H.4
Sui, N.5
Kirouac, G.J.6
-
8
-
-
84863883736
-
Orexin, stress, and anxiety/panic states
-
8 Johnson, P.L., Molosh, A., Fitz, S.D., Truitt, W.A., Shekhar, A., Orexin, stress, and anxiety/panic states. Prog. Brain Res. 198 (2012), 133–161.
-
(2012)
Prog. Brain Res.
, vol.198
, pp. 133-161
-
-
Johnson, P.L.1
Molosh, A.2
Fitz, S.D.3
Truitt, W.A.4
Shekhar, A.5
-
9
-
-
84899903449
-
Optogenetic examination identifies a context-specific role for orexins/hypocretins in anxiety-related behavior
-
9 Heydendael, W., Sengupta, A., Beck, S., Bhatnagar, S., Optogenetic examination identifies a context-specific role for orexins/hypocretins in anxiety-related behavior. Physiol. Behav. 130 (2014), 182–190.
-
(2014)
Physiol. Behav.
, vol.130
, pp. 182-190
-
-
Heydendael, W.1
Sengupta, A.2
Beck, S.3
Bhatnagar, S.4
-
10
-
-
30044447392
-
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
-
10 Boutrel, B., Kenny, P.J., Specio, S.E., Martin-Fardon, R., Markou, A., Koob, G.F., de Lecea, L., Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc. Natl. Acad. Sci. USA 102 (2005), 19168–19173.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 19168-19173
-
-
Boutrel, B.1
Kenny, P.J.2
Specio, S.E.3
Martin-Fardon, R.4
Markou, A.5
Koob, G.F.6
de Lecea, L.7
-
11
-
-
20244380014
-
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
11 Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998), 573–585.
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
Matsuzaki, I.4
Chemelli, R.M.5
Tanaka, H.6
Williams, S.C.7
Richardson, J.A.8
Kozlowski, G.P.9
Wilson, S.10
-
12
-
-
0041920735
-
Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets
-
12 Diano, S., Horvath, B., Urbanski, H.F., Sotonyi, P., Horvath, T.L., Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets. Endocrinology 144 (2003), 3774–3778.
-
(2003)
Endocrinology
, vol.144
, pp. 3774-3778
-
-
Diano, S.1
Horvath, B.2
Urbanski, H.F.3
Sotonyi, P.4
Horvath, T.L.5
-
13
-
-
84903518549
-
Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons
-
13 Inutsuka, A., Inui, A., Tabuchi, S., Tsunematsu, T., Lazarus, M., Yamanaka, A., Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology 85 (2014), 451–460.
-
(2014)
Neuropharmacology
, vol.85
, pp. 451-460
-
-
Inutsuka, A.1
Inui, A.2
Tabuchi, S.3
Tsunematsu, T.4
Lazarus, M.5
Yamanaka, A.6
-
14
-
-
19544376694
-
Behavioral correlates of activity in identified hypocretin/orexin neurons
-
14 Mileykovskiy, B.Y., Kiyashchenko, L.I., Siegel, J.M., Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46 (2005), 787–798.
-
(2005)
Neuron
, vol.46
, pp. 787-798
-
-
Mileykovskiy, B.Y.1
Kiyashchenko, L.I.2
Siegel, J.M.3
-
15
-
-
34547494916
-
Control of hypothalamic orexin neurons by acid and CO2
-
15 Williams, R.H., Jensen, L.T., Verkhratsky, A., Fugger, L., Burdakov, D., Control of hypothalamic orexin neurons by acid and CO2. Proc. Natl. Acad. Sci. USA 104 (2007), 10685–10690.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10685-10690
-
-
Williams, R.H.1
Jensen, L.T.2
Verkhratsky, A.3
Fugger, L.4
Burdakov, D.5
-
16
-
-
67349139242
-
CO2 activates orexin-containing neurons in mice
-
16 Sunanaga, J., Deng, B.S., Zhang, W., Kanmura, Y., Kuwaki, T., CO2 activates orexin-containing neurons in mice. Respir. Physiol. Neurobiol. 166 (2009), 184–186.
-
(2009)
Respir. Physiol. Neurobiol.
, vol.166
, pp. 184-186
-
-
Sunanaga, J.1
Deng, B.S.2
Zhang, W.3
Kanmura, Y.4
Kuwaki, T.5
-
17
-
-
84964430262
-
Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks
-
17 González, J.A., Iordanidou, P., Strom, M., Adamantidis, A., Burdakov, D., Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks. Nat. Commun., 7, 2016, 11395.
-
(2016)
Nat. Commun.
, vol.7
, pp. 11395
-
-
González, J.A.1
Iordanidou, P.2
Strom, M.3
Adamantidis, A.4
Burdakov, D.5
-
18
-
-
13044249865
-
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
-
18 Hagan, J.J., Leslie, R.A., Patel, S., Evans, M.L., Wattam, T.A., Holmes, S., Benham, C.D., Taylor, S.G., Routledge, C., Hemmati, P., et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl. Acad. Sci. USA 96 (1999), 10911–10916.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 10911-10916
-
-
Hagan, J.J.1
Leslie, R.A.2
Patel, S.3
Evans, M.L.4
Wattam, T.A.5
Holmes, S.6
Benham, C.D.7
Taylor, S.G.8
Routledge, C.9
Hemmati, P.10
-
19
-
-
0038521277
-
Hypothalamic orexin neurons regulate arousal according to energy balance in mice
-
19 Yamanaka, A., Beuckmann, C.T., Willie, J.T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K., Sugiyama, F., Goto, K., et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38 (2003), 701–713.
-
(2003)
Neuron
, vol.38
, pp. 701-713
-
-
Yamanaka, A.1
Beuckmann, C.T.2
Willie, J.T.3
Hara, J.4
Tsujino, N.5
Mieda, M.6
Tominaga, M.7
Yagami, K.8
Sugiyama, F.9
Goto, K.10
-
20
-
-
84861463423
-
Orexin neurons and emotional stress
-
20 Kuwaki, T., Zhang, W., Orexin neurons and emotional stress. Vitam. Horm. 89 (2012), 135–158.
-
(2012)
Vitam. Horm.
, vol.89
, pp. 135-158
-
-
Kuwaki, T.1
Zhang, W.2
-
21
-
-
0034846670
-
Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy
-
21 Nishino, S., Ripley, B., Overeem, S., Nevsimalova, S., Lammers, G.J., Vankova, J., Okun, M., Rogers, W., Brooks, S., Mignot, E., Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann. Neurol. 50 (2001), 381–388.
-
(2001)
Ann. Neurol.
, vol.50
, pp. 381-388
-
-
Nishino, S.1
Ripley, B.2
Overeem, S.3
Nevsimalova, S.4
Lammers, G.J.5
Vankova, J.6
Okun, M.7
Rogers, W.8
Brooks, S.9
Mignot, E.10
-
22
-
-
84899855138
-
Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function
-
22 Tabuchi, S., Tsunematsu, T., Black, S.W., Tominaga, M., Maruyama, M., Takagi, K., Minokoshi, Y., Sakurai, T., Kilduff, T.S., Yamanaka, A., Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function. J. Neurosci. 34 (2014), 6495–6509.
-
(2014)
J. Neurosci.
, vol.34
, pp. 6495-6509
-
-
Tabuchi, S.1
Tsunematsu, T.2
Black, S.W.3
Tominaga, M.4
Maruyama, M.5
Takagi, K.6
Minokoshi, Y.7
Sakurai, T.8
Kilduff, T.S.9
Yamanaka, A.10
-
23
-
-
12744273152
-
Hypocretin deficiency in Prader-Willi syndrome
-
23 Nevsimalova, S., Vankova, J., Stepanova, I., Seemanova, E., Mignot, E., Nishino, S., Hypocretin deficiency in Prader-Willi syndrome. Eur. J. Neurol. 12 (2005), 70–72.
-
(2005)
Eur. J. Neurol.
, vol.12
, pp. 70-72
-
-
Nevsimalova, S.1
Vankova, J.2
Stepanova, I.3
Seemanova, E.4
Mignot, E.5
Nishino, S.6
-
24
-
-
14644396121
-
Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
-
24 Burdakov, D., Gerasimenko, O., Verkhratsky, A., Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J. Neurosci. 25 (2005), 2429–2433.
-
(2005)
J. Neurosci.
, vol.25
, pp. 2429-2433
-
-
Burdakov, D.1
Gerasimenko, O.2
Verkhratsky, A.3
-
25
-
-
84873733797
-
Concurrent activation of striatal direct and indirect pathways during action initiation
-
25 Cui, G., Jun, S.B., Jin, X., Pham, M.D., Vogel, S.S., Lovinger, D.M., Costa, R.M., Concurrent activation of striatal direct and indirect pathways during action initiation. Nature 494 (2013), 238–242.
-
(2013)
Nature
, vol.494
, pp. 238-242
-
-
Cui, G.1
Jun, S.B.2
Jin, X.3
Pham, M.D.4
Vogel, S.S.5
Lovinger, D.M.6
Costa, R.M.7
-
26
-
-
84903204587
-
Natural neural projection dynamics underlying social behavior
-
26 Gunaydin, L.A., Grosenick, L., Finkelstein, J.C., Kauvar, I.V., Fenno, L.E., Adhikari, A., Lammel, S., Mirzabekov, J.J., Airan, R.D., Zalocusky, K.A., et al. Natural neural projection dynamics underlying social behavior. Cell 157 (2014), 1535–1551.
-
(2014)
Cell
, vol.157
, pp. 1535-1551
-
-
Gunaydin, L.A.1
Grosenick, L.2
Finkelstein, J.C.3
Kauvar, I.V.4
Fenno, L.E.5
Adhikari, A.6
Lammel, S.7
Mirzabekov, J.J.8
Airan, R.D.9
Zalocusky, K.A.10
-
27
-
-
0034899321
-
Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice
-
27 Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Noda, M., Inui, Y., Mekada, E., Kimata, Y., Tsuru, A., Kohno, K., Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat. Biotechnol. 19 (2001), 746–750.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 746-750
-
-
Saito, M.1
Iwawaki, T.2
Taya, C.3
Yonekawa, H.4
Noda, M.5
Inui, Y.6
Mekada, E.7
Kimata, Y.8
Tsuru, A.9
Kohno, K.10
-
28
-
-
27344431720
-
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
-
28 Luquet, S., Perez, F.A., Hnasko, T.S., Palmiter, R.D., NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310 (2005), 683–685.
-
(2005)
Science
, vol.310
, pp. 683-685
-
-
Luquet, S.1
Perez, F.A.2
Hnasko, T.S.3
Palmiter, R.D.4
-
29
-
-
84857004469
-
Glucose tolerance in patients with narcolepsy
-
29 Beitinger, P.A., Fulda, S., Dalal, M.A., Wehrle, R., Keckeis, M., Wetter, T.C., Han, F., Pollmächer, T., Schuld, A., Glucose tolerance in patients with narcolepsy. Sleep 35 (2012), 231–236.
-
(2012)
Sleep
, vol.35
, pp. 231-236
-
-
Beitinger, P.A.1
Fulda, S.2
Dalal, M.A.3
Wehrle, R.4
Keckeis, M.5
Wetter, T.C.6
Han, F.7
Pollmächer, T.8
Schuld, A.9
-
30
-
-
42149137874
-
High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study
-
30 Fortuyn, H.A., Swinkels, S., Buitelaar, J., Renier, W.O., Furer, J.W., Rijnders, C.A., Hodiamont, P.P., Overeem, S., High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study. Sleep 31 (2008), 335–341.
-
(2008)
Sleep
, vol.31
, pp. 335-341
-
-
Fortuyn, H.A.1
Swinkels, S.2
Buitelaar, J.3
Renier, W.O.4
Furer, J.W.5
Rijnders, C.A.6
Hodiamont, P.P.7
Overeem, S.8
-
31
-
-
77956643915
-
Assessment of feeding behavior in laboratory mice
-
31 Ellacott, K.L., Morton, G.J., Woods, S.C., Tso, P., Schwartz, M.W., Assessment of feeding behavior in laboratory mice. Cell Metab. 12 (2010), 10–17.
-
(2010)
Cell Metab.
, vol.12
, pp. 10-17
-
-
Ellacott, K.L.1
Morton, G.J.2
Woods, S.C.3
Tso, P.4
Schwartz, M.W.5
-
32
-
-
34249671063
-
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
-
32 Zhang, S., Zeitzer, J.M., Sakurai, T., Nishino, S., Mignot, E., Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J. Physiol. 581 (2007), 649–663.
-
(2007)
J. Physiol.
, vol.581
, pp. 649-663
-
-
Zhang, S.1
Zeitzer, J.M.2
Sakurai, T.3
Nishino, S.4
Mignot, E.5
-
33
-
-
84861464553
-
Energy expenditure: role of orexin
-
33 Teske, J.A., Mavanji, V., Energy expenditure: role of orexin. Vitam. Horm. 89 (2012), 91–109.
-
(2012)
Vitam. Horm.
, vol.89
, pp. 91-109
-
-
Teske, J.A.1
Mavanji, V.2
-
34
-
-
34447531745
-
Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder
-
34 Brundin, L., Björkqvist, M., Petersén, A., Träskman-Bendz, L., Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder. Eur. Neuropsychopharmacol. 17 (2007), 573–579.
-
(2007)
Eur. Neuropsychopharmacol.
, vol.17
, pp. 573-579
-
-
Brundin, L.1
Björkqvist, M.2
Petersén, A.3
Träskman-Bendz, L.4
-
35
-
-
63149122905
-
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture
-
35 Matsuki, T., Nomiyama, M., Takahira, H., Hirashima, N., Kunita, S., Takahashi, S., Yagami, K., Kilduff, T.S., Bettler, B., Yanagisawa, M., Sakurai, T., Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc. Natl. Acad. Sci. USA 106 (2009), 4459–4464.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4459-4464
-
-
Matsuki, T.1
Nomiyama, M.2
Takahira, H.3
Hirashima, N.4
Kunita, S.5
Takahashi, S.6
Yagami, K.7
Kilduff, T.S.8
Bettler, B.9
Yanagisawa, M.10
Sakurai, T.11
-
36
-
-
84865717083
-
Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ
-
36 Schöne, C., Cao, Z.F., Apergis-Schoute, J., Adamantidis, A., Sakurai, T., Burdakov, D., Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ. J. Neurosci. 32 (2012), 12437–12443.
-
(2012)
J. Neurosci.
, vol.32
, pp. 12437-12443
-
-
Schöne, C.1
Cao, Z.F.2
Apergis-Schoute, J.3
Adamantidis, A.4
Sakurai, T.5
Burdakov, D.6
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