PINK1/Parkin mitophagy and neurodegeneration—what do we really know in vivo?

Current Opinion in Genetics and Development

Volumn 44, Issue , 2017, Pages 47-53

  Whitworth, Alexander J ^a   Pallanck, Leo J ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; PARKIN; PINK PROTEIN; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; UBIQUITIN; UNCLASSIFIED DRUG; CALCIUM; PTEN-INDUCED PUTATIVE KINASE; UBIQUITIN PROTEIN LIGASE;

DOPAMINERGIC NERVE CELL; FLIGHT MUSCLE; GENE MUTATION; HUMAN; MEMBRANE DEPOLARIZATION; MEMBRANE FUSION; MITOCHONDRIAL GENOME; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; NERVE DEGENERATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PARKINSON DISEASE; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN METABOLISM; RESPIRATORY CHAIN; REVIEW; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY;

CALCIUM; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; NERVE DEGENERATION; PARKINSON DISEASE; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; UBIQUITIN-PROTEIN LIGASES;

EID: 85012975461     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2017.01.016     Document Type: Review

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59. 59• Sun, N., Yun, J., Liu, J., Malide, D., Liu, C., Rovira, I.I., Holmstrom, K.M., Fergusson, M.M., Yoo, Y.H., Combs, C.A., et al. Measuring in vivo mitophagy. Mol Cell 60 (2015), 685–696 These two publications described the first transgenic mouse lines engineered to express fluorescent reporter constructs to monitor mitopahgy in vivo. These initial reports do not analyse PINK1/Parkin function but do describe a surprisingly abundant basal mitophagy that varies widely between and even within tissues.