메뉴 건너뛰기




Volumn 23, Issue 1, 2017, Pages 10-22

New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone

Author keywords

Adoptive cell transfer; cancer vaccines; checkpoint inhibitor; chemotherapy; combination immunotherapy; epigenetic modification; immune modulatory agent; oncolytic virus; radiotherapy; tumor microenvironment

Indexed keywords

ADENOSINE RECEPTOR BLOCKING AGENT; CANCER VACCINE; CD134 ANTIGEN; CHECKPOINT KINASE INHIBITOR; CHEMOKINE RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; ONCOLYTIC VIRUS; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TOLL LIKE RECEPTOR AGONIST; TRANSFORMING GROWTH FACTOR BETA; TUMOR ANTIGEN; CD274 PROTEIN, HUMAN; CTLA4 PROTEIN, HUMAN; PDCD1 PROTEIN, HUMAN;

EID: 85011579671     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000246     Document Type: Review
Times cited : (40)

References (205)
  • 1
    • 84887862839 scopus 로고    scopus 로고
    • A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application
    • Okazaki T, Chikuma S, Iwai Y, et al. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat Immunol. 2013;14:1212-1218.
    • (2013) Nat Immunol , vol.14 , pp. 1212-1218
    • Okazaki, T.1    Chikuma, S.2    Iwai, Y.3
  • 2
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunother-apy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunother-apy. Nat Rev Cancer. 2012;12:252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 3
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366: 2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 4
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • Robert C, Ribas A,Wolchok JD, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet. 2014;384:1109-1117.
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3
  • 5
    • 84980602745 scopus 로고    scopus 로고
    • Efficacy and safety of nivolumab in patients with BRAF V600 mutant and BRAF wild-type advanced melanoma: A pooled analysis of 4 clinical trials
    • Larkin J, Lao CD, Urba WJ, et al. Efficacy and safety of nivolumab in patients with BRAF V600 mutant and BRAF wild-type advanced melanoma: a pooled analysis of 4 clinical trials. JAMA Oncol. 2015;1:433-440.
    • (2015) JAMA Oncol , vol.1 , pp. 433-440
    • Larkin, J.1    Lao, C.D.2    Urba, W.J.3
  • 6
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372:2018-2028.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 7
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015; 373:1627-1639.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 8
    • 84946607195 scopus 로고    scopus 로고
    • Nivolumab versus everoli-mus in advanced renal-cell carcinoma
    • Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus everoli-mus in advanced renal-cell carcinoma. N Engl J Med. 2015;373:1803-1813.
    • (2015) N Engl J Med , vol.373 , pp. 1803-1813
    • Motzer, R.J.1    Escudier, B.2    McDermott, D.F.3
  • 9
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
    • Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387:1909-1920.
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3
  • 10
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • Ansell SM, Lesokhin AM, Borrello I, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med. 2015;372: 311-319.
    • (2015) N Engl J Med , vol.372 , pp. 311-319
    • Ansell, S.M.1    Lesokhin, A.M.2    Borrello, I.3
  • 11
    • 0036715411 scopus 로고    scopus 로고
    • Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity?
    • Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 2002;23:445-449.
    • (2002) Trends Immunol , vol.23 , pp. 445-449
    • Lutz, M.B.1    Schuler, G.2
  • 12
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol. 2008;8:279-289.
    • (2008) Nat Rev Immunol , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 13
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 14
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms ofT cell co-stimulation and co-inhibition
    • ChenL, Flies DB. Molecular mechanisms ofT cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013;13:227-242.
    • (2013) Nat Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 15
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271:1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 16
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
    • Schadendorf D, Hodi FS, Robert C, et al. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J Clin Oncol. 2015;33:1889-1894.
    • (2015) J Clin Oncol , vol.33 , pp. 1889-1894
    • Schadendorf, D.1    Hodi, F.S.2    Robert, C.3
  • 17
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364: 2517-2526.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 18
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010; 363:711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 19
    • 79959206459 scopus 로고    scopus 로고
    • CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans
    • Huang RR, Jalil J, Economou JS, et al. CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans. Clin Cancer Res. 2011;17:4101-4109.
    • (2011) Clin Cancer Res , vol.17 , pp. 4101-4109
    • Huang, R.R.1    Jalil, J.2    Economou, J.S.3
  • 20
    • 84902825664 scopus 로고    scopus 로고
    • Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients
    • Cha E, Klinger M, Hou Y, et al. Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Sci Transl Med. 2014;6:238ra70.
    • (2014) Sci Transl Med , vol.6 , pp. 238ra70
    • Cha, E.1    Klinger, M.2    Hou, Y.3
  • 21
    • 84893965118 scopus 로고    scopus 로고
    • Immune modulation in cancer with antibodies
    • Page DB, Postow MA, Callahan MK, et al. Immune modulation in cancer with antibodies. Annu Rev Med. 2014;65:185-202.
    • (2014) Annu Rev Med , vol.65 , pp. 185-202
    • Page, D.B.1    Postow, M.A.2    Callahan, M.K.3
  • 22
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
    • Kwon ED, Drake CG, Scher HI, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2014;15:700-712.
    • (2014) Lancet Oncol , vol.15 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3
  • 23
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and mye-loid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, et al. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and mye-loid cells within B16 melanoma tumors. Proc Natl Acad Sci. 2010;107: 4275-4280.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3
  • 24
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013;369:122-133.
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 25
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372:2006-2017.
    • (2015) N Engl J Med , vol.372 , pp. 2006-2017
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3
  • 26
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373:23-34.
    • (2015) N Engl J Med , vol.373 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 27
    • 84944261579 scopus 로고    scopus 로고
    • Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center
    • Horvat TZ, Adel NG, Dang TO, et al. Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center. J Clin Oncol. 2015;33:3193-3198.
    • (2015) J Clin Oncol , vol.33 , pp. 3193-3198
    • Horvat, T.Z.1    Adel, N.G.2    Dang, T.O.3
  • 29
    • 84914148032 scopus 로고    scopus 로고
    • Phase i study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
    • abstr 4504
    • Hammers HJ, Plimack ER, Infante JR, et al. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). J Clin Oncol. 2014;32(suppl 5; abstr 4504).
    • (2014) J Clin Oncol , vol.32
    • Hammers, H.J.1    Plimack, E.R.2    Infante, J.R.3
  • 30
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase i results
    • abstr 8023
    • Antonia SJ, Gettinger SN, Chow LQM, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase I results. J Clin Oncol. 2014;32(suppl 5; abstr 8023).
    • (2014) J Clin Oncol , vol.32
    • Antonia, S.J.1    Gettinger, S.N.2    Chow, L.Q.M.3
  • 31
    • 84942138310 scopus 로고    scopus 로고
    • Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) assecond-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D
    • abstr 8011
    • Patnaik A, Socinski MA, Gubens MA, et al. Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) assecond-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol. 2015;33(suppl; abstr 8011).
    • (2015) J Clin Oncol , vol.33
    • Patnaik, A.1    Socinski, M.A.2    Gubens, M.A.3
  • 32
    • 84938309673 scopus 로고    scopus 로고
    • Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated pro-tein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC
    • abstr 3014
    • Antonia SJ, Goldberg SB, Balmanoukian AS, et al. Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated pro-tein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. J Clin Oncol. 2015;33(suppl; abstr 3014).
    • (2015) J Clin Oncol , vol.33
    • Antonia, S.J.1    Goldberg, S.B.2    Balmanoukian, A.S.3
  • 33
    • 84984681480 scopus 로고    scopus 로고
    • CheckMate 012: Safety and efficacy of first-line (1L) nivolumab (nivo; N) and ipilimumab (ipi; I) in advanced (adv) NSCLC
    • abstr 3001
    • Hellmann MD, Gettinger SN, Goldman JW, et al. CheckMate 012: Safety and efficacy of first-line (1L) nivolumab (nivo; N) and ipilimumab (ipi; I) in advanced (adv) NSCLC. J Clin Oncol. 2016;34(suppl; abstr 3001).
    • (2016) J Clin Oncol , vol.34
    • Hellmann, M.D.1    Gettinger, S.N.2    Goldman, J.W.3
  • 34
    • 84946565742 scopus 로고    scopus 로고
    • Modulation ofAPC function and anti-tumor immunity by anti-cancer drugs
    • Martin K, Schreiner J, Zippelius A.Modulation ofAPC function and anti-tumor immunity by anti-cancer drugs. Front Immunol. 2015;6:501.
    • (2015) Front Immunol , vol.6 , pp. 501
    • Martin, K.1    Schreiner, J.2    Zippelius, A.3
  • 35
    • 84961193536 scopus 로고    scopus 로고
    • Systematic review of case reports on the abscopal effect
    • Abuodeh Y, Venkat P, Kim S. Systematic review of case reports on the abscopal effect. Curr Probl Cancer. 2016;40:25-37.
    • (2016) Curr Probl Cancer , vol.40 , pp. 25-37
    • Abuodeh, Y.1    Venkat, P.2    Kim, S.3
  • 36
    • 84983489005 scopus 로고    scopus 로고
    • Role of local radiation therapy in cancer immunotherapy
    • Demaria S, Golden EB, Formenti SC. Role of local radiation therapy in cancer immunotherapy. JAMA Oncol. 2015;1:1325-1332.
    • (2015) JAMA Oncol , vol.1 , pp. 1325-1332
    • Demaria, S.1    Golden, E.B.2    Formenti, S.C.3
  • 37
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012; 366:925-931.
    • (2012) N Engl J Med , vol.366 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 38
    • 33646704729 scopus 로고    scopus 로고
    • Radiation modulates the peptide repertoire, enhances MHC class i expression, and induces successful an-titumor immunotherapy
    • Reits EA, Hodge JW, Herberts CA, et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful an-titumor immunotherapy. J Exp Med. 2006;203:1259-1271.
    • (2006) J Exp Med , vol.203 , pp. 1259-1271
    • Reits, E.A.1    Hodge, J.W.2    Herberts, C.A.3
  • 39
    • 82255195940 scopus 로고    scopus 로고
    • γ-Radiation promotes immunolog-ical recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo
    • Sharma A, Bode B, Wenger RH, et al. γ-Radiation promotes immunolog-ical recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PLoS One. 2011;6:e28217.
    • (2011) PLoS One , vol.6 , pp. e28217
    • Sharma, A.1    Bode, B.2    Wenger, R.H.3
  • 40
    • 20444406500 scopus 로고    scopus 로고
    • Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor
    • Lugade AA, Moran JP, Gerber SA, et al. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol. 2005;174:7516-7523.
    • (2005) J Immunol , vol.174 , pp. 7516-7523
    • Lugade, A.A.1    Moran, J.P.2    Gerber, S.A.3
  • 41
    • 84929366910 scopus 로고    scopus 로고
    • TGFβ isa master regulator of radiation therapy-induced antitumor immunity
    • Vanpouille-Box C, Diamond JM, Pilones KA, et al. TGFβ isa master regulator of radiation therapy-induced antitumor immunity. Cancer Res. 2015;75:2232-2242.
    • (2015) Cancer Res , vol.75 , pp. 2232-2242
    • Vanpouille-Box, C.1    Diamond, J.M.2    Pilones, K.A.3
  • 42
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • Demaria S, Kawashima N, Yang AM, et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res. 2005;11:728-734.
    • (2005) Clin Cancer Res , vol.11 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3
  • 43
    • 84983353116 scopus 로고    scopus 로고
    • Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen
    • Sharabi AB, Nirschl CJ, Kochel CM, et al. Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen. Cancer Immunol Res. 2015;3:345-355.
    • (2015) Cancer Immunol Res , vol.3 , pp. 345-355
    • Sharabi, A.B.1    Nirschl, C.J.2    Kochel, C.M.3
  • 44
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
    • Zeng J, See AP, Phallen J, et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys. 2013;86:343-349.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 343-349
    • Zeng, J.1    See, A.P.2    Phallen, J.3
  • 45
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014; 124:687-695.
    • (2014) J Clin Invest , vol.124 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3
  • 46
    • 84871694504 scopus 로고    scopus 로고
    • A systemic complete response of metastatic melanomato local radiation and immunotherapy
    • Hiniker SM, Chen DS, Reddy S, et al. A systemic complete response of metastatic melanomato local radiation and immunotherapy. Transl Oncol. 2012;5:404-407.
    • (2012) Transl Oncol , vol.5 , pp. 404-407
    • Hiniker, S.M.1    Chen, D.S.2    Reddy, S.3
  • 47
    • 85003053854 scopus 로고    scopus 로고
    • Anabscopal responsetoradiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • Golden EB, Demaria S,Schiff PB, et al. Anabscopal responsetoradiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res. 2013;1:365-372.
    • (2013) Cancer Immunol Res , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3
  • 48
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase I/II study
    • Slovin S, Higano CS, Hamid O, et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann Oncol. 2013;24: 1813-1821.
    • (2013) Ann Oncol , vol.24 , pp. 1813-1821
    • Slovin, S.1    Higano, C.S.2    Hamid, O.3
  • 49
    • 84926525215 scopus 로고    scopus 로고
    • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
    • Twyman-Saint Victor C, Rech AJ, Maity A, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 2015;520:373-377.
    • (2015) Nature , vol.520 , pp. 373-377
    • Twyman-Saint Victor, C.1    Rech, A.J.2    Maity, A.3
  • 50
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009;15: 5379-5388.
    • (2009) Clin Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3
  • 51
    • 79952390627 scopus 로고    scopus 로고
    • Immune parameters affecting the efficacy of chemotherapeutic regimens
    • Zitvogel L, Kepp O, Kroemer G. Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol. 2011;8:151-160.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 151-160
    • Zitvogel, L.1    Kepp, O.2    Kroemer, G.3
  • 52
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance
    • Zitvogel L, Galluzzi L, Smyth MJ, et al. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity. 2013;39:74-88.
    • (2013) Immunity , vol.39 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3
  • 53
    • 67349250111 scopus 로고    scopus 로고
    • Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: A role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy
    • van der Most RG, Currie AJ, Mahendran S, et al. Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy. Cancer Immunol Immunother. 2009; 58:1219-1228.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1219-1228
    • Van Der Most, R.G.1    Currie, A.J.2    Mahendran, S.3
  • 54
    • 84958124766 scopus 로고    scopus 로고
    • Immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy
    • Pfirschke C, Engblom C, Rickelt S, et al. Immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy. Immunity. 2016;44: 343-354.
    • (2016) Immunity , vol.44 , pp. 343-354
    • Pfirschke, C.1    Engblom, C.2    Rickelt, S.3
  • 55
    • 79955581263 scopus 로고    scopus 로고
    • A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma
    • Hersh EM, O'Day SJ, Powderly J, et al. A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma. Invest New Drugs. 2011;29:489-498.
    • (2011) Invest New Drugs , vol.29 , pp. 489-498
    • Hersh, E.M.1    O'Day, S.J.2    Powderly, J.3
  • 56
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non- small-cell lung cancer: Results from a randomized, double-blind, multicen-ter phase II study
    • Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non- small-cell lung cancer: results from a randomized, double-blind, multicen-ter phase II study. J Clin Oncol. 2012;30:2046-2054.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 57
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease- small-cell lung cancer: Results from a randomized, double-blind, multicen-ter phase 2 trial
    • Reck M, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease- small-cell lung cancer: results from a randomized, double-blind, multicen-ter phase 2 trial. Ann Oncol. 2013;24:75-83.
    • (2013) Ann Oncol , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3
  • 58
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) inadvanced non-small cell lung cancer (NSCLC)
    • abstr 8113
    • Antonia SJ, Brahmer JR, Gettinger SN, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) inadvanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32(suppl 5; abstr 8113).
    • (2014) J Clin Oncol , vol.32
    • Antonia, S.J.1    Brahmer, J.R.2    Gettinger, S.N.3
  • 59
    • 84947444749 scopus 로고    scopus 로고
    • Pembrolizumab (pembro; MK-3475) plus platinum doublet chemotherapy (PDC) as front-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 Cohorts A and C
    • abstr 8031
    • Papadimitrakopoulou V, Patnaik A, Borghaei H, et al. Pembrolizumab (pembro; MK-3475) plus platinum doublet chemotherapy (PDC) as front-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 Cohorts A and C. J Clin Oncol. 2015;33(suppl; abstr 8031).
    • (2015) J Clin Oncol , vol.33
    • Papadimitrakopoulou, V.1    Patnaik, A.2    Borghaei, H.3
  • 60
    • 84960402176 scopus 로고    scopus 로고
    • Preliminary efficacy and safety of pembrolizumab (MK-3475) in patients with PD-L1-positive, estrogen receptor-positive (ER+)/HER2-negative advanced breast cancer enrolled in KEYNOTE-028 [abstract]
    • December 6-10 San Antonio, TX. Philadelphia PA American Association for Cancer Research; 2015. Abstract nr S5-07
    • Rugo HS, Delord J-P, IM S-A, et al. Preliminary efficacy and safety of pembrolizumab (MK-3475) in patients with PD-L1-positive, estrogen receptor-positive (ER+)/HER2-negative advanced breast cancer enrolled in KEYNOTE-028 [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; 2015 December 6-10; San Antonio, TX. Philadelphia (PA): American Association for Cancer Research; 2015. Abstract nr S5-07.
    • (2015) Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium
    • Rugo, H.S.1    Delord, J.-P.2
  • 62
    • 84923166043 scopus 로고    scopus 로고
    • Safety, correlative markers, and clinical results of adjuvant nivolumab in combination with vaccine in resected high-risk metastatic melanoma
    • Gibney GT, Kudchadkar RR, DeConti RC, et al. Safety, correlative markers, and clinical results of adjuvant nivolumab in combination with vaccine in resected high-risk metastatic melanoma. Clin Cancer Res. 2015;21:712-720.
    • (2015) Clin Cancer Res , vol.21 , pp. 712-720
    • Gibney, G.T.1    Kudchadkar, R.R.2    Deconti, R.C.3
  • 64
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunother-apy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunother-apy for castration-resistant prostate cancer. N Engl J Med. 2010;363: 411-422.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 65
    • 85020442578 scopus 로고    scopus 로고
    • Sequencing of sipuleucel-T and androgen deprivation therapy in men with hormone-sensitive biochemically-recurrent prostate cancer: A phase II randomized trial [published online ahead of print November 10, 2016]
    • Antonarakis ES, Kibel AS, Yu EY, et al. Sequencing of sipuleucel-T and androgen deprivation therapy in men with hormone-sensitive biochemically-recurrent prostate cancer: a phase II randomized trial [published online ahead of print November 10, 2016]. Clin Cancer Res. 2016.
    • (2016) Clin Cancer Res
    • Antonarakis, E.S.1    Kibel, A.S.2    Yu, E.Y.3
  • 66
    • 29844436043 scopus 로고    scopus 로고
    • The effect of a therapeutic dendritic cell-based cancer vaccination depends onthe blockageofCTLA-4 signaling
    • Met Ö, Wang M, Pedersen AE, et al. The effect of a therapeutic dendritic cell-based cancer vaccination depends onthe blockageofCTLA-4 signaling. Cancer Lett. 2006;231:247-256.
    • (2006) Cancer Lett , vol.231 , pp. 247-256
    • Met, Ö.1    Wang, M.2    Pedersen, A.E.3
  • 67
    • 33745031054 scopus 로고    scopus 로고
    • Treatment of transplanted CT26 tumour with dendritic cell vaccine in combination with blockade of vascular endothelial growth factor receptor 2 and CTLA-4
    • Pedersen AE, Buus S, Claesson MH. Treatment of transplanted CT26 tumour with dendritic cell vaccine in combination with blockade of vascular endothelial growth factor receptor 2 and CTLA-4. Cancer Lett. 2006;235: 229-238.
    • (2006) Cancer Lett , vol.235 , pp. 229-238
    • Pedersen, A.E.1    Buus, S.2    Claesson, M.H.3
  • 68
    • 75149139044 scopus 로고    scopus 로고
    • + regulatory T cells enhance tumour immunity of dendritic cell-based vaccinein a mouse model of colon cancer
    • + regulatory T cells enhance tumour immunity of dendritic cell-based vaccinein a mouse model of colon cancer. Scand J Immunol. 2010;71:70-82.
    • (2010) Scand J Immunol , vol.71 , pp. 70-82
    • Saha, A.1    Chatterjee, S.K.2
  • 69
    • 84890895502 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances antitumor immunity of intratumoral injection of immature dendritic cells into irradiated tumor in a mouse colon cancer model
    • Son CH, Bae JH, Shin DY, et al. CTLA-4 blockade enhances antitumor immunity of intratumoral injection of immature dendritic cells into irradiated tumor in a mouse colon cancer model. J Immunother. 2014;37:1-7.
    • (2014) J Immunother , vol.37 , pp. 1-7
    • Son, C.H.1    Bae, J.H.2    Shin, D.Y.3
  • 70
    • 70349680756 scopus 로고    scopus 로고
    • Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
    • Ribas A, Comin-Anduix B, Chmielowski B, et al. Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res. 2009;15:6267-6276.
    • (2009) Clin Cancer Res , vol.15 , pp. 6267-6276
    • Ribas, A.1    Comin-Anduix, B.2    Chmielowski, B.3
  • 71
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metasta-tic tumors accompanied by autoimmune depigmentation
    • Van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metasta-tic tumors accompanied by autoimmune depigmentation. J Exp Med. 1999;190:355-366.
    • (1999) J Exp Med , vol.190 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 72
    • 84878570297 scopus 로고    scopus 로고
    • Phase i study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours
    • Millward M, Underhill C, Lobb S, et al. Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours. Br J Cancer. 2013;108:1998-2004.
    • (2013) Br J Cancer , vol.108 , pp. 1998-2004
    • Millward, M.1    Underhill, C.2    Lobb, S.3
  • 73
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • Hurwitz AA, Yu TF, Leach DR, et al. CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci. 1998;95:10067-10071.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 10067-10071
    • Hurwitz, A.A.1    Yu, T.F.2    Leach, D.R.3
  • 74
    • 70350234739 scopus 로고    scopus 로고
    • Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors
    • Curran MA, Allison JP. Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors. Cancer Res. 2009; 69:7747-7755.
    • (2009) Cancer Res , vol.69 , pp. 7747-7755
    • Curran, M.A.1    Allison, J.P.2
  • 75
    • 63449124514 scopus 로고    scopus 로고
    • Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors
    • Li B, VanRoey M, Wang C, et al. Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors. Clin Cancer Res. 2009;15:1623-1634.
    • (2009) Clin Cancer Res , vol.15 , pp. 1623-1634
    • Li, B.1    Vanroey, M.2    Wang, C.3
  • 76
    • 84917722205 scopus 로고    scopus 로고
    • PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors
    • Soares KC, Rucki AA, Wu AA, et al. PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors. J Immunother. 2015;38:1-11.
    • (2015) J Immunother , vol.38 , pp. 1-11
    • Soares, K.C.1    Rucki, A.A.2    Wu, A.A.3
  • 77
    • 84879104519 scopus 로고    scopus 로고
    • Dual blockade ofPD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
    • Duraiswamy J, Kaluza KM, Freeman GJ, et al. Dual blockade ofPD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 2013;73:3591-3603.
    • (2013) Cancer Res , vol.73 , pp. 3591-3603
    • Duraiswamy, J.1    Kaluza, K.M.2    Freeman, G.J.3
  • 78
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance ofef-fector and regulatory T cells
    • Quezada SA, Peggs KS, Curran MA, et al. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance ofef-fector and regulatory T cells. J Clin Invest. 2006;116:1935-1945.
    • (2006) J Clin Invest , vol.116 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3
  • 79
    • 84860436621 scopus 로고    scopus 로고
    • Combined immu-notherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial
    • van den Eertwegh AJ, Versluis J,van den Berg HP, et al. Combined immu-notherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol. 2012;13:509-517.
    • (2012) Lancet Oncol , vol.13 , pp. 509-517
    • Van Den Eertwegh, A.J.1    Versluis, J.2    Van Den Berg, H.P.3
  • 80
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • Le DT, Lutz E, Uram JN, et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother. 2013;36: 382-389.
    • (2013) J Immunother , vol.36 , pp. 382-389
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3
  • 81
    • 0026060863 scopus 로고
    • The treatment of malignant tumors by repeated inoculations of erysipelas. with a report of ten original cases. 1893
    • Coley WB. The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893. Clin Orthop Relat Res;1991:3-11.
    • (1991) Clin Orthop Relat Res , pp. 3-11
    • Coley, W.B.1
  • 82
    • 84861133805 scopus 로고    scopus 로고
    • Clinical development of Listeria monocytogenes-based immunotherapies
    • Le DT, Dubensky TW Jr, Brockstedt DG. Clinical development of Listeria monocytogenes-based immunotherapies. Semin Oncol. 2012;39:311-322.
    • (2012) Semin Oncol , vol.39 , pp. 311-322
    • Le, D.T.1    Dubensky, T.W.2    Brockstedt, D.G.3
  • 83
    • 84929431322 scopus 로고    scopus 로고
    • Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
    • Le DT, Wang-Gillam A, Picozzi V, et al. Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J Clin Oncol. 2015;33:1325-1333.
    • (2015) J Clin Oncol , vol.33 , pp. 1325-1333
    • Le, D.T.1    Wang-Gillam, A.2    Picozzi, V.3
  • 84
    • 84907415255 scopus 로고    scopus 로고
    • Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses
    • Roberts NJ, Zhang L, Janku F, et al. Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Sci Transl Med. 2014; 6:249ra111.
    • (2014) Sci Transl Med , vol.6 , pp. 249ra111
    • Roberts, N.J.1    Zhang, L.2    Janku, F.3
  • 85
    • 84901044424 scopus 로고    scopus 로고
    • Oncolytic immunotherapy: Dying the right way is a key to eliciting potent antitumor immunity
    • Guo ZS, Liu Z, Bartlett DL. Oncolytic immunotherapy: dying the right way is a key to eliciting potent antitumor immunity. Front Oncol. 2014;4:74.
    • (2014) Front Oncol , vol.4 , pp. 74
    • Guo, Z.S.1    Liu, Z.2    Bartlett, D.L.3
  • 86
    • 84933586864 scopus 로고    scopus 로고
    • Talimogene Laherparepvec Improves Durable Response Rate in Patients with Advanced Melanoma
    • Andtbacka RH, Kaufman HL, Collichio F, et al. Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma. J Clin Oncol. 2015;33:2780-2788.
    • (2015) J Clin Oncol , vol.33 , pp. 2780-2788
    • Andtbacka, R.H.1    Kaufman, H.L.2    Collichio, F.3
  • 87
    • 84979599378 scopus 로고    scopus 로고
    • Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma
    • Puzanov I, Milhem MM, Minor D, et al. Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma. J Clin Oncol. 2016;34:2619-2626.
    • (2016) J Clin Oncol , vol.34 , pp. 2619-2626
    • Puzanov, I.1    Milhem, M.M.2    Minor, D.3
  • 88
    • 84978867458 scopus 로고    scopus 로고
    • A Phase I/III, multicenter, open-label trial of talimogene laherparepvec (T-VEC) in combination with pembrolizumab for the treatment of unresected, stage IIIb-IV melanoma (MASTERKEY-265)
    • Long GV, Dummer R, Ribas A, et al. A Phase I/III, multicenter, open-label trial of talimogene laherparepvec (T-VEC) in combination with pembrolizumab for the treatment of unresected, stage IIIb-IV melanoma (MASTERKEY-265). J Immunother Cancer. 2015;3:1.
    • (2015) J Immunother Cancer , vol.3 , pp. 1
    • Long, G.V.1    Dummer, R.2    Ribas, A.3
  • 89
    • 84982149173 scopus 로고    scopus 로고
    • Efficacy analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma
    • abstr 9568
    • Long G, Dummer R, Ribas A, et al. Efficacy analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma. J Clin Oncol. 2016; 34:abstr 9568.
    • (2016) J Clin Oncol , vol.34
    • Long, G.1    Dummer, R.2    Ribas, A.3
  • 90
    • 84940004588 scopus 로고    scopus 로고
    • CALM study: A phase II study of an intratumorally delivered oncolytic immunotherapeutic agent, coxsackievirus A21, in patients with stage IIIc and stage IV malignant melanoma
    • abstr 3031
    • Andtbacka RHI, Curti BD, Kaufman H, et al. CALM study: A phase II study of an intratumorally delivered oncolytic immunotherapeutic agent, coxsackievirus A21, in patients with stage IIIc and stage IV malignant melanoma. J Clin Oncol. 2014;32:(suppl 5; abstr 3031).
    • (2014) J Clin Oncol , vol.32
    • Andtbacka, R.H.I.1    Curti, B.D.2    Kaufman, H.3
  • 91
    • 84897476768 scopus 로고    scopus 로고
    • Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
    • Zamarin D, Holmgaard RB, Subudhi SK, et al. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci Transl Med. 2014;6:226ra32.
    • (2014) Sci Transl Med , vol.6 , pp. 226ra32
    • Zamarin, D.1    Holmgaard, R.B.2    Subudhi, S.K.3
  • 92
    • 0037443573 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model
    • Espenschied J, Lamont J, Longmate J, et al. CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. J Immunol. 2003;170:3401-3407.
    • (2003) J Immunol , vol.170 , pp. 3401-3407
    • Espenschied, J.1    Lamont, J.2    Longmate, J.3
  • 93
    • 34547630506 scopus 로고    scopus 로고
    • A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model
    • Ko HJ, Kim YJ, Kim YS, et al. A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model. Cancer Res. 2007;67:7477-7486.
    • (2007) Cancer Res , vol.67 , pp. 7477-7486
    • Ko, H.J.1    Kim, Y.J.2    Kim, Y.S.3
  • 94
    • 34347398452 scopus 로고    scopus 로고
    • The combined activationofpositive costimulatory signals with modulation of a negative costimulatory signal for the enhancement of vaccine-mediated T-cell responses
    • Chakraborty M, Schlom J, Hodge JW. The combined activationofpositive costimulatory signals with modulation of a negative costimulatory signal for the enhancement of vaccine-mediated T-cell responses. Cancer Immunol Immunother. 2007;56:1471-1484.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1471-1484
    • Chakraborty, M.1    Schlom, J.2    Hodge, J.W.3
  • 95
    • 84860455345 scopus 로고    scopus 로고
    • Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial
    • Madan RA, Mohebtash M, Arlen PM, et al. Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol. 2012;13: 501-508.
    • (2012) Lancet Oncol , vol.13 , pp. 501-508
    • Madan, R.A.1    Mohebtash, M.2    Arlen, P.M.3
  • 96
    • 84897934799 scopus 로고    scopus 로고
    • TLR agonists for cancer immunotherapy: Tipping the balance between the immune stimulatory and inhibitory effects
    • Lu H. TLR agonists for cancer immunotherapy: tipping the balance between the immune stimulatory and inhibitory effects. Front Immunol. 2014;5:83.
    • (2014) Front Immunol , vol.5 , pp. 83
    • Lu, H.1
  • 97
    • 85065699055 scopus 로고    scopus 로고
    • Toll-like receptors: The swiss army knife of immunity and vaccine development
    • Dowling JK, Mansell A. Toll-like receptors: the swiss army knife of immunity and vaccine development. Clin Transl Immunol. 2016;5:e85.
    • (2016) Clin Transl Immunol , vol.5 , pp. e85
    • Dowling, J.K.1    Mansell, A.2
  • 98
    • 84907499681 scopus 로고    scopus 로고
    • TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer
    • Chatterjee S, Crozet L, Damotte D, et al. TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer. Cancer Res. 2014;74:5008-5018.
    • (2014) Cancer Res , vol.74 , pp. 5008-5018
    • Chatterjee, S.1    Crozet, L.2    Damotte, D.3
  • 99
    • 84903884741 scopus 로고    scopus 로고
    • The yin and yang of Toll-like receptors in cancer
    • Pradere JP, Dapito DH, Schwabe R. The yin and yang of Toll-like receptors in cancer. Oncogene. 2014;33:3485-3495.
    • (2014) Oncogene , vol.33 , pp. 3485-3495
    • Pradere, J.P.1    Dapito, D.H.2    Schwabe, R.3
  • 100
    • 84878414390 scopus 로고    scopus 로고
    • TLR agonists: Our best frenemy in cancer immunotherapy
    • Kaczanowska S, Joseph AM, DavilaE. TLR agonists: our best frenemy in cancer immunotherapy. J Leukoc Biol. 2013;93:847-863.
    • (2013) J Leukoc Biol , vol.93 , pp. 847-863
    • Kaczanowska, S.1    Joseph, A.M.2    Davila, E.3
  • 101
    • 84904055758 scopus 로고    scopus 로고
    • Immune cell-poor melanomas benefit from PD-1 blockade after targeted type i IFN activation
    • Bald T, Landsberg J, Lopez-Ramos D, et al. Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov. 2014;4:674-687.
    • (2014) Cancer Discov , vol.4 , pp. 674-687
    • Bald, T.1    Landsberg, J.2    Lopez-Ramos, D.3
  • 102
    • 84856824651 scopus 로고    scopus 로고
    • Intratumoral injection of CpG oligo-nucleotides induces the differentiation and reduces the immunosuppres-sive activity of myeloid-derived suppressor cells
    • Shirota Y, Shirota H, Klinman DM. Intratumoral injection of CpG oligo-nucleotides induces the differentiation and reduces the immunosuppres-sive activity of myeloid-derived suppressor cells. J Immunol. 2012;188: 1592-1599.
    • (2012) J Immunol , vol.188 , pp. 1592-1599
    • Shirota, Y.1    Shirota, H.2    Klinman, D.M.3
  • 103
    • 65349153756 scopus 로고    scopus 로고
    • T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy
    • Houot R, Levy R. T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. Blood. 2009;113:3546-3552.
    • (2009) Blood , vol.113 , pp. 3546-3552
    • Houot, R.1    Levy, R.2
  • 104
    • 77954938867 scopus 로고    scopus 로고
    • Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy
    • Mangsbo SM, Sandin LC, Anger K, et al. Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy. J Immunother. 2010;33:225-235.
    • (2010) J Immunother , vol.33 , pp. 225-235
    • Mangsbo, S.M.1    Sandin, L.C.2    Anger, K.3
  • 105
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune suppression
    • Motz GT, Coukos G. Deciphering and reversing tumor immune suppression. Immunity. 2013;39:61-73.
    • (2013) Immunity , vol.39 , pp. 61-73
    • Motz, G.T.1    Coukos, G.2
  • 106
    • 84938350452 scopus 로고    scopus 로고
    • Combination cancer immuno-therapy and new immunomodulatory targets
    • Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immuno-therapy and new immunomodulatory targets. Nat Rev Drug Discov. 2015; 14:561-584.
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 561-584
    • Mahoney, K.M.1    Rennert, P.D.2    Freeman, G.J.3
  • 107
    • 0036604470 scopus 로고    scopus 로고
    • Immune responses in 4-1BB (CD137)-deficient mice
    • Kwon BS, Hurtado JC, Lee ZH, et al. Immune responses in 4-1BB (CD137)-deficient mice. J Immunol. 2002;168:5483-5490.
    • (2002) J Immunol , vol.168 , pp. 5483-5490
    • Kwon, B.S.1    Hurtado, J.C.2    Zh, L.3
  • 108
    • 84892164928 scopus 로고    scopus 로고
    • CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor
    • Ye Q, Song DG, Poussin M, et al. CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor. Clin Cancer Res. 2014;20:44-55.
    • (2014) Clin Cancer Res , vol.20 , pp. 44-55
    • Ye, Q.1    Song, D.G.2    Poussin, M.3
  • 109
    • 33746924449 scopus 로고    scopus 로고
    • Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity
    • Kocak E, Lute K, Chang X, et al. Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res. 2006;66:7276-7284.
    • (2006) Cancer Res , vol.66 , pp. 7276-7284
    • Kocak, E.1    Lute, K.2    Chang, X.3
  • 110
    • 84904207094 scopus 로고    scopus 로고
    • Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model
    • Belcaid Z, Phallen JA, Zeng J, et al. Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. PLoS One. 2014;9:e101764.
    • (2014) PLoS One , vol.9 , pp. e101764
    • Belcaid, Z.1    Phallen, J.A.2    Zeng, J.3
  • 112
    • 84934277025 scopus 로고    scopus 로고
    • Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model
    • Chen S, Lee LF, Fisher TS, et al. Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model. Cancer Immunol Res. 2015;3: 149-160.
    • (2015) Cancer Immunol Res , vol.3 , pp. 149-160
    • Chen, S.1    Lee, L.F.2    Fisher, T.S.3
  • 113
    • 84920448880 scopus 로고    scopus 로고
    • Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor
    • Shindo Y, Yoshimura K, Kuramasu A,et al. Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor. Anticancer Res. 2015;35:129-136.
    • (2015) Anticancer Res , vol.35 , pp. 129-136
    • Shindo, Y.1    Yoshimura, K.2    Kuramasu, A.3
  • 114
    • 84954053287 scopus 로고    scopus 로고
    • Cancer immu-notherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells
    • Sanchez-Paulete AR, Cueto FJ, Martínez-López M, et al. Cancer immu-notherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells. Cancer Discov. 2016;6:71-79.
    • (2016) Cancer Discov , vol.6 , pp. 71-79
    • Sanchez-Paulete, A.R.1    Cueto, F.J.2    Martínez-López, M.3
  • 115
    • 84969419824 scopus 로고    scopus 로고
    • Phase i study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
    • abstr 3007
    • Sznol M, Hodi FS, Margolin K, et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). J Clin Oncol. 2008;26(suppl 15; abstr 3007).
    • (2008) J Clin Oncol , vol.26
    • Sznol, M.1    Hodi, F.S.2    Margolin, K.3
  • 116
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto PA, Simeone E, Sznol M, et al. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol. 2010; 37:508-516.
    • (2010) Semin Oncol , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3
  • 117
    • 84923303086 scopus 로고    scopus 로고
    • A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer
    • abstr 3007
    • Segal NH, Gopal AK, Bhatia S, et al. A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer. J Clin Oncol. 2014;32 (suppl 5; abstr 3007).
    • (2014) J Clin Oncol , vol.32
    • Segal, N.H.1    Gopal, A.K.2    Bhatia, S.3
  • 118
    • 84902137525 scopus 로고    scopus 로고
    • Targeting CD137 enhances the efficacy of cetuximab
    • Kohrt HE, Colevas AD, Houot R, et al. Targeting CD137 enhances the efficacy of cetuximab. J Clin Invest. 2014;124:2668-2682.
    • (2014) J Clin Invest , vol.124 , pp. 2668-2682
    • Kohrt, H.E.1    Colevas, A.D.2    Houot, R.3
  • 119
    • 84863230537 scopus 로고    scopus 로고
    • Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xeno-transplant models of breast cancer
    • Kohrt HE, Houot R, Weiskopf K, et al. Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xeno-transplant models of breast cancer. J Clin Invest. 2012;122:1066-1075.
    • (2012) J Clin Invest , vol.122 , pp. 1066-1075
    • Kohrt, H.E.1    Houot, R.2    Weiskopf, K.3
  • 120
    • 79952124960 scopus 로고    scopus 로고
    • CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
    • Kohrt HE, Houot R, Goldstein MJ, et al. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood. 2011;117: 2423-2432.
    • (2011) Blood , vol.117 , pp. 2423-2432
    • Kohrt, H.E.1    Houot, R.2    Goldstein, M.J.3
  • 121
    • 84890429971 scopus 로고    scopus 로고
    • Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: Evidence for augmented NK cell function complementing ADCC
    • Collins SM, Bakan CE, Swartzel GD, et al. Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC. Cancer Immunol Immunother. 2013;62:1841-1849.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1841-1849
    • Collins, S.M.1    Bakan, C.E.2    Swartzel, G.D.3
  • 122
    • 84940378016 scopus 로고    scopus 로고
    • Agonistsof co-stimulation in cancer immunotherapy directed against CD137, OX40, GITR, CD27, CD28, and ICOS
    • Sanmamed MF, Pastor F, Rodriguez A,et al. Agonistsof co-stimulation in cancer immunotherapy directed against CD137, OX40, GITR, CD27, CD28, and ICOS. Semin Oncol. 2015;42:640-655.
    • (2015) Semin Oncol , vol.42 , pp. 640-655
    • Sanmamed, M.F.1    Pastor, F.2    Rodriguez, A.3
  • 124
    • 84886945019 scopus 로고    scopus 로고
    • Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation
    • Adler AJ, Vella AT. Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation. Oncoimmunology. 2013;2:e22837.
    • (2013) Oncoimmunology , vol.2 , pp. e22837
    • Adler, A.J.1    Vella, A.T.2
  • 125
    • 84897854198 scopus 로고    scopus 로고
    • PD-1 blockade and OX40 triggering syn-ergistically protects against tumor growth in a murine model of ovarian cancer
    • Guo Z, Wang X, Cheng D, et al. PD-1 blockade and OX40 triggering syn-ergistically protects against tumor growth in a murine model of ovarian cancer. PLoS One. 2014;9:e89350.
    • (2014) PLoS One , vol.9 , pp. e89350
    • Guo, Z.1    Wang, X.2    Cheng, D.3
  • 126
    • 84996554960 scopus 로고    scopus 로고
    • Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity
    • Redmond WL, Linch SN, Kasiewicz MJ. Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity. Cancer Immunol Res. 2014;2:142-153.
    • (2014) Cancer Immunol Res , vol.2 , pp. 142-153
    • Redmond, W.L.1    Linch, S.N.2    Kasiewicz, M.J.3
  • 127
    • 84891275907 scopus 로고    scopus 로고
    • OX40 is a potent immune-stimulating target in late-stage cancer patients
    • Curti BD, Kovacsovics-Bankowski M, Morris N, et al. OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 2013;73:7189-7198.
    • (2013) Cancer Res , vol.73 , pp. 7189-7198
    • Curti, B.D.1    Kovacsovics-Bankowski, M.2    Morris, N.3
  • 128
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 2011;331:1612-1616.
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3
  • 129
    • 84951178450 scopus 로고    scopus 로고
    • Abstract CT137: Combination of agonistic CD40 monoclonal antibody CP-870,893 and anti-CTLA-4 antibody tremelimumab in patients with metastatic melanoma
    • Bajor DL, Mick R, Riese MJ, et al. Abstract CT137: combination of agonistic CD40 monoclonal antibody CP-870,893 and anti-CTLA-4 antibody tremelimumab in patients with metastatic melanoma. Cancer Res. 2015;75(suppl 15):CT137-CT137.
    • (2015) Cancer Res , vol.75 , pp. CT137-CT137
    • Bajor, D.L.1    Mick, R.2    Riese, M.J.3
  • 130
    • 84938356701 scopus 로고    scopus 로고
    • Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment
    • Zippelius A, Schreiner J, Herzig P, et al. Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment. Cancer Immunol Res. 2015;3:236-244.
    • (2015) Cancer Immunol Res , vol.3 , pp. 236-244
    • Zippelius, A.1    Schreiner, J.2    Herzig, P.3
  • 131
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi K, Apetoh L, Sullivan JM, et al. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med. 2010;207:2187-2194.
    • (2010) J Exp Med , vol.207 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3
  • 132
    • 84883853182 scopus 로고    scopus 로고
    • Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer
    • Guo Z, Cheng D, Xia Z, et al. Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer. J Transl Med. 2013;11:215.
    • (2013) J Transl Med , vol.11 , pp. 215
    • Guo, Z.1    Cheng, D.2    Xia, Z.3
  • 134
    • 65949085379 scopus 로고    scopus 로고
    • Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients
    • Menard C, Blay JY, Borg C, et al. Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cancer Res. 2009;69:3563-3569.
    • (2009) Cancer Res , vol.69 , pp. 3563-3569
    • Menard, C.1    Blay, J.Y.2    Borg, C.3
  • 135
    • 84934976308 scopus 로고    scopus 로고
    • Long-term outcome in BRAF(V600E) melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression
    • Puzanov I, Amaravadi RK, McArthur GA, et al. Long-term outcome in BRAF(V600E) melanoma patients treated with vemurafenib: patterns of disease progression and clinical management of limited progression. Eur J Cancer. 2015;51:1435-1443.
    • (2015) Eur J Cancer , vol.51 , pp. 1435-1443
    • Puzanov, I.1    Amaravadi, R.K.2    McArthur, G.A.3
  • 136
    • 84964792419 scopus 로고    scopus 로고
    • Combining targeted therapy with im-munotherapy. Can 1+1 equal more than 2?
    • Robert L, Ribas A,Hu-Lieskovan S.Combining targeted therapy with im-munotherapy. Can 1+1 equal more than 2? Semin Immunol. 2016;28:73-80.
    • (2016) Semin Immunol , vol.28 , pp. 73-80
    • Robert, L.1    Ribas, A.2    Hu-Lieskovan, S.3
  • 137
    • 84905825810 scopus 로고    scopus 로고
    • Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: Promise and challenges
    • Hu-Lieskovan S, Robert L, Homet Moreno B, et al. Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: promise and challenges. J Clin Oncol. 2014;32:2248-2254.
    • (2014) J Clin Oncol , vol.32 , pp. 2248-2254
    • Hu-Lieskovan, S.1    Robert, L.2    Homet Moreno, B.3
  • 138
    • 84877051042 scopus 로고    scopus 로고
    • Combining cancer immunotherapy and targeted therapy
    • Ribas A, Wolchok JD. Combining cancer immunotherapy and targeted therapy. Curr Opin Immunol. 2013;25:291-296.
    • (2013) Curr Opin Immunol , vol.25 , pp. 291-296
    • Ribas, A.1    Wolchok, J.D.2
  • 139
    • 84874595712 scopus 로고    scopus 로고
    • Host immunity contributes to the anti-melanoma activity of BRAF inhibitors
    • Knight DA, Ngiow SF, Li M, et al. Host immunity contributes to the anti-melanoma activity of BRAF inhibitors. J Clin Invest. 2013;123: 1371-1381.
    • (2013) J Clin Invest , vol.123 , pp. 1371-1381
    • Knight, D.A.1    Ngiow, S.F.2    Li, M.3
  • 140
    • 84939258997 scopus 로고    scopus 로고
    • Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab
    • Minor DR, Puzanov I, Callahan MK, et al. Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab. Pigment Cell Melanoma Res. 2015;28:611-612.
    • (2015) Pigment Cell Melanoma Res , vol.28 , pp. 611-612
    • Minor, D.R.1    Puzanov, I.2    Callahan, M.K.3
  • 141
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science. 2011; 331:1565-1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 142
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9:239-252.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 143
    • 84903816506 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer
    • Prendergast GC, Smith C, Thomas S, et al. Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer. Cancer Immunol Immunother. 2014;63:721-735.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 721-735
    • Prendergast, G.C.1    Smith, C.2    Thomas, S.3
  • 144
    • 0043076307 scopus 로고
    • Induction of pulmonary indoleamine 2,3-dioxygenase by interferon
    • Yoshida R, Imanishi J, Oku T, et al. Induction of pulmonary indoleamine 2,3-dioxygenase by interferon. Proc Natl Acad Sci. 1981;78:129-132.
    • (1981) Proc Natl Acad Sci , vol.78 , pp. 129-132
    • Yoshida, R.1    Imanishi, J.2    Oku, T.3
  • 145
    • 0032555614 scopus 로고    scopus 로고
    • Prevention ofallogeneic fetal rejection by tryptophan catabolism
    • Munn DH, ZhouM,Attwood JT,et al. Prevention ofallogeneic fetal rejection by tryptophan catabolism. Science. 1998;281:1191-1193.
    • (1998) Science , vol.281 , pp. 1191-1193
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3
  • 146
    • 0037136266 scopus 로고    scopus 로고
    • Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells mediation of suppression by tryptophan metabolites
    • Terness P, Bauer TM, Röse L, et al. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells mediation of suppression by tryptophan metabolites. J Exp Med. 2002;196: 447-457.
    • (2002) J Exp Med , vol.196 , pp. 447-457
    • Terness, P.1    Bauer, T.M.2    Röse, L.3
  • 147
    • 0037136328 scopus 로고    scopus 로고
    • Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase
    • Frumento G, Rotondo R, Tonetti M, et al. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med. 2002;196:459-468.
    • (2002) J Exp Med , vol.196 , pp. 459-468
    • Frumento, G.1    Rotondo, R.2    Tonetti, M.3
  • 148
    • 0346119234 scopus 로고    scopus 로고
    • Modulation of tryptophan ca-tabolism by regulatory T cells
    • Fallarino F, Grohmann U, Hwang KW, et al. Modulation of tryptophan ca-tabolism by regulatory T cells. Nat Immunol. 2003;4:1206-1212.
    • (2003) Nat Immunol , vol.4 , pp. 1206-1212
    • Fallarino, F.1    Grohmann, U.2    Hwang, K.W.3
  • 149
    • 84866242667 scopus 로고    scopus 로고
    • IDO is a nodal pathogenic driver of lung cancer and metastasis development
    • Smith C, Chang MY, Parker KH, et al. IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov. 2012; 2:722-735.
    • (2012) Cancer Discov , vol.2 , pp. 722-735
    • Smith, C.1    Chang, M.Y.2    Parker, K.H.3
  • 150
    • 84880664259 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immu-notherapy targeting CTLA-4
    • Holmgaard RB, Zamarin D, Munn DH, et al. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immu-notherapy targeting CTLA-4. J Exp Med. 2013;210:1389-1402.
    • (2013) J Exp Med , vol.210 , pp. 1389-1402
    • Holmgaard, R.B.1    Zamarin, D.2    Munn, D.H.3
  • 151
    • 84977161108 scopus 로고    scopus 로고
    • Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
    • Spranger S, Koblish HK, Horton B, et al. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J Immunother Cancer. 2014;2:3.
    • (2014) J Immunother Cancer , vol.2 , pp. 3
    • Spranger, S.1    Koblish, H.K.2    Horton, B.3
  • 152
    • 84920081022 scopus 로고    scopus 로고
    • Preliminary results from a phase 1/2 study of INCB024360 combined with ipilimumab (ipi) in patients (pts) with melanoma
    • abstr 3010
    • Gibney GT, Hamid O, Gangadhar TC, et al. Preliminary results from a phase 1/2 study of INCB024360 combined with ipilimumab (ipi) in patients (pts) with melanoma. J Clin Oncol. 2014;32(suppl 5; abstr 3010).
    • (2014) J Clin Oncol , vol.32
    • Gibney, G.T.1    Hamid, O.2    Gangadhar, T.C.3
  • 153
    • 85011563659 scopus 로고    scopus 로고
    • 511 Updated results from a phase 1/2 study of epacadostat (INCB024360) in combination with ipilimumab in patients with metastatic melanoma
    • Gibney G, Hamid O, Lutzky J, et al. 511 Updated results from a phase 1/2 study of epacadostat (INCB024360) in combination with ipilimumab in patients with metastatic melanoma. Eur J Cancer. 2016;51:S106-S107.
    • (2016) Eur J Cancer , vol.51 , pp. S106-S107
    • Gibney, G.1    Hamid, O.2    Lutzky, J.3
  • 155
    • 84965054294 scopus 로고    scopus 로고
    • A phase i study of indoximod in patients with advanced malignancies
    • Soliman HH, Minton SE, Han HS, et al. A phase I study of indoximod in patients with advanced malignancies. Oncotarget. 2016;7:22928-22938.
    • (2016) Oncotarget , vol.7 , pp. 22928-22938
    • Soliman, H.H.1    Minton, S.E.2    Han, H.S.3
  • 158
    • 84928077532 scopus 로고    scopus 로고
    • Macrophages and therapeutic resistance in cancer
    • Ruffell B, Coussens LM. Macrophages and therapeutic resistance in cancer. Cancer Cell. 2015;27:462-472.
    • (2015) Cancer Cell , vol.27 , pp. 462-472
    • Ruffell, B.1    Coussens, L.M.2
  • 159
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo DG, Brennan DJ, Rexhepaj E, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 2011;1:54-67.
    • (2011) Cancer Discov , vol.1 , pp. 54-67
    • Denardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3
  • 160
    • 77949345555 scopus 로고    scopus 로고
    • Tumor-associated macrophages and survival in classic Hodgkin's lymphoma
    • Steidl C, Lee T, Shah SP, et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med. 2010;362: 875-885.
    • (2010) N Engl J Med , vol.362 , pp. 875-885
    • Steidl, C.1    Lee, T.2    Shah, S.P.3
  • 161
    • 84871694284 scopus 로고    scopus 로고
    • Prognostic significance of tumor-associated macrophages in solid tumor: A meta-analysis of the literature
    • Zhang QW, Liu L, Gong CY, et al. Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One. 2012;7:e50946.
    • (2012) PLoS One , vol.7 , pp. e50946
    • Zhang, Q.W.1    Liu, L.2    Gong, C.Y.3
  • 162
    • 84867504992 scopus 로고    scopus 로고
    • The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer
    • Edin S, Wikberg ML, Dahlin AM, et al. The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer. PLoS One. 2012;7:e47045.
    • (2012) PLoS One , vol.7 , pp. e47045
    • Edin, S.1    Wikberg, M.L.2    Dahlin, A.M.3
  • 163
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • Noy R, Pollard J.W. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014;41:49-61.
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 164
    • 33645853780 scopus 로고    scopus 로고
    • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    • Kryczek I, Zou L, Rodriguez P, et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med. 2006;203:871-881.
    • (2006) J Exp Med , vol.203 , pp. 871-881
    • Kryczek, I.1    Zou, L.2    Rodriguez, P.3
  • 165
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • Kuang DM, Zhao Q, Peng C, et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med. 2009;206:1327-1337.
    • (2009) J Exp Med , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3
  • 166
    • 84907484156 scopus 로고    scopus 로고
    • CSF1/CSF1R blockade repro-grams tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
    • Zhu Y, Knolhoff BL, Meyer MA, et al. CSF1/CSF1R blockade repro-grams tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014;74:5057-5069.
    • (2014) Cancer Res , vol.74 , pp. 5057-5069
    • Zhu, Y.1    Knolhoff, B.L.2    Meyer, M.A.3
  • 167
    • 84903815776 scopus 로고    scopus 로고
    • The dual role of TGF inhuman cancer: From tumor suppression to cancer metastasis
    • Lebrun JJ. The dual role of TGF inhuman cancer: from tumor suppression to cancer metastasis. ISRN Mol Biol. 2012.
    • (2012) ISRN Mol Biol
    • Lebrun, J.J.1
  • 168
    • 84954317176 scopus 로고    scopus 로고
    • Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer
    • Lin RL, Zhao L.J. Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer. Cancer Biol Med. 2015;12:385-393.
    • (2015) Cancer Biol Med , vol.12 , pp. 385-393
    • Lin, R.L.1    Zhao, L.J.2
  • 169
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massague J. TGFbeta in Cancer. Cell. 2008;134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 171
    • 84939783826 scopus 로고    scopus 로고
    • Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
    • Herbertz S, Sawyer JS, Stauber AJ, et al. Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Des Devel Ther. 2015;9:4479-4499.
    • (2015) Drug des Devel Ther , vol.9 , pp. 4479-4499
    • Herbertz, S.1    Sawyer, J.S.2    Stauber, A.J.3
  • 172
    • 3142669817 scopus 로고    scopus 로고
    • Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes: Role of cyclic adenosine 3′,5′-monophosphate and phosphatases
    • Zhang H, Conrad DM, Butler JJ, et al. Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes: role of cyclic adenosine 3′,5′-monophosphate and phosphatases. J Immunol. 2004;173:932-944.
    • (2004) J Immunol , vol.173 , pp. 932-944
    • Zhang, H.1    Conrad, D.M.2    Butler, J.J.3
  • 173
    • 84982693488 scopus 로고    scopus 로고
    • Adenosine 2B receptor expression on cancer cells promotes metastasis
    • Mittal D, Sinha D, Barkauskas D, et al. Adenosine 2B receptor expression on cancer cells promotes metastasis. Cancer Res. 2016;76:4372-4382.
    • (2016) Cancer Res , vol.76 , pp. 4372-4382
    • Mittal, D.1    Sinha, D.2    Barkauskas, D.3
  • 174
    • 75949112218 scopus 로고    scopus 로고
    • Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
    • Stagg J, Divisekera U, McLaughlin N, et al. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci. 2010; 107:1547-1552.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 1547-1552
    • Stagg, J.1    Divisekera, U.2    McLaughlin, N.3
  • 175
    • 84891824680 scopus 로고    scopus 로고
    • Anti-CD73 therapy impairs tumor angiogenesis
    • Allard B, Turcotte M, Spring K, et al. Anti-CD73 therapy impairs tumor angiogenesis. Int J Cancer. 2014;134:1466-1473.
    • (2014) Int J Cancer , vol.134 , pp. 1466-1473
    • Allard, B.1    Turcotte, M.2    Spring, K.3
  • 176
    • 84879705407 scopus 로고    scopus 로고
    • CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
    • Loi S, Pommey S, Haibe-Kains B, et al. CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer. Proc Natl Acad Sci. 2013;110:11091-11096.
    • (2013) Proc Natl Acad Sci , vol.110 , pp. 11091-11096
    • Loi, S.1    Pommey, S.2    Haibe-Kains, B.3
  • 177
    • 84954542005 scopus 로고    scopus 로고
    • CD73 expression is an independent prognostic factor in prostate cancer
    • Leclerc BG, Charlebois R, Chouinard G, et al. CD73 expression is an independent prognostic factor in prostate cancer. Clin Cancer Res. 2016;22: 158-166.
    • (2016) Clin Cancer Res , vol.22 , pp. 158-166
    • Leclerc, B.G.1    Charlebois, R.2    Chouinard, G.3
  • 178
    • 84946599682 scopus 로고    scopus 로고
    • CD73 is associated with poor prognosis in high-grade serous ovarian cancer
    • Turcotte M, Spring K, Pommey S, et al. CD73 is associated with poor prognosis in high-grade serous ovarian cancer. Cancer Res. 2015;75:4494-4503.
    • (2015) Cancer Res , vol.75 , pp. 4494-4503
    • Turcotte, M.1    Spring, K.2    Pommey, S.3
  • 179
    • 84941774489 scopus 로고    scopus 로고
    • CD73: A potential biomarker for anti-PD-1 therapy
    • Beavis PA, Slaney CY, Milenkovski N, et al. CD73: a potential biomarker for anti-PD-1 therapy. Oncoimmunology. 2015;4:e1046675.
    • (2015) Oncoimmunology , vol.4 , pp. e1046675
    • Beavis, P.A.1    Slaney, C.Y.2    Milenkovski, N.3
  • 180
    • 84913604670 scopus 로고    scopus 로고
    • Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model
    • Iannone R, Miele L, Maiolino P, et al. Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model. Am J Cancer Res. 2014;4:172.
    • (2014) Am J Cancer Res , vol.4 , pp. 172
    • Iannone, R.1    Miele, L.2    Maiolino, P.3
  • 181
    • 84904254163 scopus 로고    scopus 로고
    • Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor
    • Mittal D, Young A, Stannard K, et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Res. 2014;74:3652-3658.
    • (2014) Cancer Res , vol.74 , pp. 3652-3658
    • Mittal, D.1    Young, A.2    Stannard, K.3
  • 182
    • 84962273457 scopus 로고    scopus 로고
    • Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced antitumor T-cell responses
    • Beavis PA, Milenkovski N, Henderson MA, et al. Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced antitumor T-cell responses. Cancer Immunol Res. 2015;3:506-517.
    • (2015) Cancer Immunol Res , vol.3 , pp. 506-517
    • Beavis, P.A.1    Milenkovski, N.2    Henderson, M.A.3
  • 183
    • 84886432843 scopus 로고    scopus 로고
    • Targeting CD73 enhances the an-titumor activity of anti-PD-1 and anti-CTLA-4 mAbs
    • Allard B, Pommey S, Smyth MJ, et al. Targeting CD73 enhances the an-titumor activity of anti-PD-1 and anti-CTLA-4 mAbs. Clin Cancer Res. 2013;19:5626-5635.
    • (2013) Clin Cancer Res , vol.19 , pp. 5626-5635
    • Allard, B.1    Pommey, S.2    Smyth, M.J.3
  • 184
    • 84901334642 scopus 로고    scopus 로고
    • Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy
    • Highfill SL, et al. Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy. Sci Transl Med. 2014;6:237ra67-237ra67.
    • (2014) Sci Transl Med , vol.6 , pp. 237ra67-237ra67
    • Highfill, S.L.1
  • 185
    • 85006487572 scopus 로고    scopus 로고
    • Abstract A90: Combination therapy of chemokine receptor inhibition plus PDL-1 blockade potentiates anti-tumor effects in a murine model of breast cancer
    • Jung H. Abstract A90: combination therapy of chemokine receptor inhibition plus PDL-1 blockade potentiates anti-tumor effects in a murine model of breast cancer. Mol Cancer Ther. 2015;14(12 suppl 2):A90-A90.
    • (2015) Mol Cancer Ther , vol.14 , Issue.12 , pp. A90-A90
    • Jung, H.1
  • 186
  • 187
    • 84869211107 scopus 로고    scopus 로고
    • Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells
    • Chang DK, Sui J, Geng S, et al. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Mol Cancer Ther. 2012;11:2451-2461.
    • (2012) Mol Cancer Ther , vol.11 , pp. 2451-2461
    • Chang, D.K.1    Sui, J.2    Geng, S.3
  • 188
    • 84910148214 scopus 로고    scopus 로고
    • CXCL12/CXCR4 blockade by oncolytic virotherapy inhibits ovarian cancer growth by decreasing immu-nosuppression and targeting cancer-initiating cells
    • Gil M, Komorowski MP, SeshadriM, et al. CXCL12/CXCR4 blockade by oncolytic virotherapy inhibits ovarian cancer growth by decreasing immu-nosuppression and targeting cancer-initiating cells. J Immunol. 2014;193: 5327-5337.
    • (2014) J Immunol , vol.193 , pp. 5327-5337
    • Gil, M.1    Komorowski, M.P.2    Seshadri, M.3
  • 189
    • 84928207236 scopus 로고    scopus 로고
    • CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immuno-therapy in sorafenib-treated hepatocellular carcinoma in mice
    • Chen Y, Ramjiawan RR, Reiberger T, et al. CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immuno-therapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology. 2015;61:1591-1602.
    • (2015) Hepatology , vol.61 , pp. 1591-1602
    • Chen, Y.1    Ramjiawan, R.R.2    Reiberger, T.3
  • 190
    • 79952932076 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action and clinical trials as anti-cancer drugs
    • Kim HJ, Bae SC. Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. Am J Transl Res. 2011; 3:166-179.
    • (2011) Am J Transl Res , vol.3 , pp. 166-179
    • Kim, H.J.1    Bae, S.C.2
  • 191
    • 0037068358 scopus 로고    scopus 로고
    • Reactivating the expression of methylation silenced genes in human cancer
    • Karpf AR, Jones DA. Reactivating the expression of methylation silenced genes in human cancer. Oncogene. 2002;21:5496-5503.
    • (2002) Oncogene , vol.21 , pp. 5496-5503
    • Karpf, A.R.1    Jones, D.A.2
  • 192
    • 84926617120 scopus 로고    scopus 로고
    • Augmenting antitumor immune responses with epigenetic modifying agents
    • Héninger E, Krueger TE, Lang JM. Augmenting antitumor immune responses with epigenetic modifying agents. Front Immunol. 2015;6:29.
    • (2015) Front Immunol , vol.6 , pp. 29
    • Héninger, E.1    Krueger, T.E.2    Lang, J.M.3
  • 193
    • 72249084921 scopus 로고    scopus 로고
    • Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824
    • Vo DD, Prins RM, Begley JL, et al. Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824. Cancer Res. 2009;69:8693-8699.
    • (2009) Cancer Res , vol.69 , pp. 8693-8699
    • Vo, D.D.1    Prins, R.M.2    Begley, J.L.3
  • 194
    • 84877355904 scopus 로고    scopus 로고
    • Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumor specific cytotoxic T lymphocyte responses
    • Wang LX, Mei ZY, Zhou JH, et al. Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumor specific cytotoxic T lymphocyte responses. PLoS One. 2013;8:e62924.
    • (2013) PLoS One , vol.8 , pp. e62924
    • Wang, L.X.1    Mei, Z.Y.2    Zhou, J.H.3
  • 195
    • 84940473692 scopus 로고    scopus 로고
    • Antitumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models
    • Covre A, Coral S, Nicolay H, et al. Antitumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models. Oncoimmunology. 2015;4:e1019978.
    • (2015) Oncoimmunology , vol.4 , pp. e1019978
    • Covre, A.1    Coral, S.2    Nicolay, H.3
  • 196
    • 84905994658 scopus 로고    scopus 로고
    • Eradication of metastatic mouse cancers re-sistantto immune checkpoint blockadebysuppression ofmyeloid-derived cells
    • Kim K, Skora AD, Li Z, et al. Eradication of metastatic mouse cancers re-sistantto immune checkpoint blockadebysuppression ofmyeloid-derived cells. Proc Natl Acad Sci. 2014;111:11774-11779.
    • (2014) Proc Natl Acad Sci , vol.111 , pp. 11774-11779
    • Kim, K.1    Skora, A.D.2    Li, Z.3
  • 197
    • 84999663822 scopus 로고    scopus 로고
    • Harnessing NK cell memory for cancer immunotherapy
    • Fehniger TA, Cooper MA. Harnessing NK cell memory for cancer immunotherapy. Trends Immunol. 2016;37:877-888.
    • (2016) Trends Immunol , vol.37 , pp. 877-888
    • Fehniger, T.A.1    Cooper, M.A.2
  • 198
    • 84991543926 scopus 로고    scopus 로고
    • Killer immunoglobulin-like receptors and tumor immunity
    • Benson DM, Caligiuri MA. Killer immunoglobulin-like receptors and tumor immunity. Cancer Immunol Res. 2014;2:99-104.
    • (2014) Cancer Immunol Res , vol.2 , pp. 99-104
    • Benson, D.M.1    Caligiuri, M.A.2
  • 199
    • 84983216790 scopus 로고    scopus 로고
    • Mutations associated with acquired resistance to PD-1 blockade in melanoma
    • Zaretsky JM, Garcia-Diaz A, Shin DS, et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med. 2016; 375:819-829.
    • (2016) N Engl J Med , vol.375 , pp. 819-829
    • Zaretsky, J.M.1    Garcia-Diaz, A.2    Shin, D.S.3
  • 200
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011;17:4550-4557.
    • (2011) Clin Cancer Res , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 201
    • 84880733312 scopus 로고    scopus 로고
    • Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology
    • Kalos M, June CH. Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. Immunity. 2013;39:49-60.
    • (2013) Immunity , vol.39 , pp. 49-60
    • Kalos, M.1    June, C.H.2
  • 202
    • 84859471907 scopus 로고    scopus 로고
    • Adoptive T-cell therapy using autolo-gous tumor-infiltrating lymphocytes for metastatic melanoma: Current status and future outlook
    • Wu R, Forget MA, Chacon J, et al. Adoptive T-cell therapy using autolo-gous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook. Cancer J. 2012;18:160-175.
    • (2012) Cancer J , vol.18 , pp. 160-175
    • Wu, R.1    Forget, M.A.2    Chacon, J.3
  • 203
    • 84867544962 scopus 로고    scopus 로고
    • PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines
    • Peng W, Liu C, Xu C, et al. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines. Cancer Res. 2012;72:5209-5218.
    • (2012) Cancer Res , vol.72 , pp. 5209-5218
    • Peng, W.1    Liu, C.2    Xu, C.3
  • 204
    • 84924090823 scopus 로고    scopus 로고
    • Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment
    • Blake SJ, Ching AL, Kenna TJ, et al. Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment. PLoS One. 2015;10:e0119483.
    • (2015) PLoS One , vol.10 , pp. e0119483
    • Blake, S.J.1    Ching, A.L.2    Kenna, T.J.3
  • 205
    • 84886397930 scopus 로고    scopus 로고
    • Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells
    • John LB, Devaud C, Duong CP, et al. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin Cancer Res. 2013;19:5636-5646.
    • (2013) Clin Cancer Res , vol.19 , pp. 5636-5646
    • John, L.B.1    Devaud, C.2    Duong, C.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.