SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

PLoS Pathogens

Volumn 13, Issue 1, 2017, Pages

  Cui, Ye ^a   Yu, Huansha ^a   Zheng, Xin ^a   Peng, Rui ^a   Wang, Qiang ^a   Zhou, Yi ^a   Wang, Rui ^a   Wang, Jiehua ^b   Qu, Bo ^b   Shen, Nan ^b   Guo, Qiang ^b   Liu, Xing ^c   Wang, Chen ^a,d  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d China Pharmaceutical University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; CYTOKINE; GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; LUCIFERASE; NITRILOTRIACETIC ACID; NUCLEOTIDYLTRANSFERASE; RECOMBINANT PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SUMO 1 PROTEIN; MB21D1 PROTEIN, HUMAN; MB21D1 PROTEIN, MOUSE; PROTEINASE; SENP7 PROTEIN, HUMAN; SENP7 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMICAL ANALYSIS; BIOPHYSICS; CELL CULTURE; CELL LYSATE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA LIBRARY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INNATE IMMUNITY; LISTERIOSIS; LUCIFERASE ASSAY; MALE; MOUSE; NONHUMAN; PLAQUE ASSAY; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SCREENING; SUMOYLATION; SURVIVAL RATE; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION; ANIMAL; C57BL MOUSE; GENE SILENCING; IMMUNOLOGY; METABOLISM;

ANIMALS; ENDOPEPTIDASES; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNITY, INNATE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NUCLEOTIDYLTRANSFERASES; REAL-TIME POLYMERASE CHAIN REACTION; SUMOYLATION;

EID: 85010966356     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006156     Document Type: Article

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