-
1
-
-
80052184362
-
Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
-
Kawasaki T, Kawai T, Akira S, (2011) Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity. Immunol Rev 243: 61–73.
-
(2011)
Immunol Rev
, vol.243
, pp. 61-73
-
-
Kawasaki, T.1
Kawai, T.2
Akira, S.3
-
2
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi O, Akira S, (2010) Pattern recognition receptors and inflammation. Cell 140: 805–820.
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
3
-
-
24944538819
-
VISA is an adapter protein required for virus-triggered IFN-beta signaling
-
Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, et al. (2005) VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 19: 727–740.
-
(2005)
Mol Cell
, vol.19
, pp. 727-740
-
-
Xu, L.G.1
Wang, Y.Y.2
Han, K.J.3
Li, L.Y.4
Zhai, Z.5
-
4
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
-
Seth RB, Sun L, Ea CK, Chen ZJ, (2005) Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122: 669–682.
-
(2005)
Cell
, vol.122
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.K.3
Chen, Z.J.4
-
5
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, et al. (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167–1172.
-
(2005)
Nature
, vol.437
, pp. 1167-1172
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
-
6
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
Kawai T, Takahashi K, Sato S, Coban C, Kumar H, et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6: 981–988.
-
(2005)
Nat Immunol
, vol.6
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
-
7
-
-
53349168904
-
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
-
Zhong B, Yang Y, Li S, Wang YY, Li Y, et al. (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29: 538–550.
-
(2008)
Immunity
, vol.29
, pp. 538-550
-
-
Zhong, B.1
Yang, Y.2
Li, S.3
Wang, Y.Y.4
Li, Y.5
-
8
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa H, Barber GN, (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455: 674–678.
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
9
-
-
49449115516
-
MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
-
Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, et al. (2008) MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol 28: 5014–5026.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5014-5026
-
-
Jin, L.1
Waterman, P.M.2
Jonscher, K.R.3
Short, C.M.4
Reisdorph, N.A.5
-
10
-
-
66649109939
-
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
-
Sun W, Li Y, Chen L, Chen H, You F, et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A 106: 8653–8658.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 8653-8658
-
-
Sun, W.1
Li, Y.2
Chen, L.3
Chen, H.4
You, F.5
-
11
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, et al. (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448: 501–505.
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
Negishi, H.5
-
12
-
-
77958140656
-
IFI16 is an innate immune sensor for intracellular DNA
-
Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, et al. (2010) IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11: 997–1004.
-
(2010)
Nat Immunol
, vol.11
, pp. 997-1004
-
-
Unterholzner, L.1
Keating, S.E.2
Baran, M.3
Horan, K.A.4
Jensen, S.B.5
-
13
-
-
80052969639
-
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
-
Zhang Z, Yuan B, Bao M, Lu N, Kim T, et al. (2011) The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol 12: 959–965.
-
(2011)
Nat Immunol
, vol.12
, pp. 959-965
-
-
Zhang, Z.1
Yuan, B.2
Bao, M.3
Lu, N.4
Kim, T.5
-
14
-
-
84874278336
-
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
-
Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, et al. (2013) DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A 110: 2969–2974.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 2969-2974
-
-
Kondo, T.1
Kobayashi, J.2
Saitoh, T.3
Maruyama, K.4
Ishii, K.J.5
-
15
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
-
Sun L, Wu J, Du F, Chen X, Chen ZJ, (2013) Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339: 786–791.
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
16
-
-
84878190840
-
Immune sensing of DNA
-
Paludan SR, Bowie AG, (2013) Immune sensing of DNA. Immunity 38: 870–880.
-
(2013)
Immunity
, vol.38
, pp. 870-880
-
-
Paludan, S.R.1
Bowie, A.G.2
-
17
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
-
Ishikawa H, Ma Z, Barber GN, (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461: 788–792.
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
18
-
-
73949083594
-
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
-
Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, et al. (2009) Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A 106: 20842–20846.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 20842-20846
-
-
Saitoh, T.1
Fujita, N.2
Hayashi, T.3
Takahara, K.4
Satoh, T.5
-
19
-
-
80054694130
-
Activation of STAT6 by STING is critical for antiviral innate immunity
-
Chen H, Sun H, You F, Sun W, Zhou X, et al. (2011) Activation of STAT6 by STING is critical for antiviral innate immunity. Cell 147: 436–446.
-
(2011)
Cell
, vol.147
, pp. 436-446
-
-
Chen, H.1
Sun, H.2
You, F.3
Sun, W.4
Zhou, X.5
-
20
-
-
84857937262
-
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
-
Tanaka Y, Chen ZJ, (2012) STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5: ra20.
-
(2012)
Sci Signal
, vol.5
, pp. ra20
-
-
Tanaka, Y.1
Chen, Z.J.2
-
21
-
-
84886789626
-
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling
-
Konno H, Konno K, Barber GN, (2013) Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155: 688–698.
-
(2013)
Cell
, vol.155
, pp. 688-698
-
-
Konno, H.1
Konno, K.2
Barber, G.N.3
-
22
-
-
80052662208
-
MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP
-
Jin L, Hill KK, Filak H, Mogan J, Knowles H, et al. (2011) MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol 187: 2595–2601.
-
(2011)
J Immunol
, vol.187
, pp. 2595-2601
-
-
Jin, L.1
Hill, K.K.2
Filak, H.3
Mogan, J.4
Knowles, H.5
-
23
-
-
84873724533
-
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
-
Wu J, Sun L, Chen X, Du F, Shi H, et al. (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339: 826–830.
-
(2013)
Science
, vol.339
, pp. 826-830
-
-
Wu, J.1
Sun, L.2
Chen, X.3
Du, F.4
Shi, H.5
-
24
-
-
84861678659
-
Induction of type I IFNs by intracellular DNA-sensing pathways
-
Cavlar T, Ablasser A, Hornung V, (2012) Induction of type I IFNs by intracellular DNA-sensing pathways. Immunol Cell Biol 90: 474–482.
-
(2012)
Immunol Cell Biol
, vol.90
, pp. 474-482
-
-
Cavlar, T.1
Ablasser, A.2
Hornung, V.3
-
25
-
-
62049084519
-
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA
-
Zhong B, Zhang L, Lei C, Li Y, Mao AP, et al. (2009) The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 30: 397–407.
-
(2009)
Immunity
, vol.30
, pp. 397-407
-
-
Zhong, B.1
Zhang, L.2
Lei, C.3
Li, Y.4
Mao, A.P.5
-
26
-
-
78650214109
-
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
-
Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33: 765–776.
-
(2010)
Immunity
, vol.33
, pp. 765-776
-
-
Tsuchida, T.1
Zou, J.2
Saitoh, T.3
Kumar, H.4
Abe, T.5
-
27
-
-
84865270570
-
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination
-
Zhang J, Hu MM, Wang YY, Shu HB, (2012) TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem 287: 28646–28655.
-
(2012)
J Biol Chem
, vol.287
, pp. 28646-28655
-
-
Zhang, J.1
Hu, M.M.2
Wang, Y.Y.3
Shu, H.B.4
-
28
-
-
0032545292
-
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy
-
Mizushima N, Sugita H, Yoshimori T, Ohsumi Y, (1998) A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem 273: 33889–33892.
-
(1998)
J Biol Chem
, vol.273
, pp. 33889-33892
-
-
Mizushima, N.1
Sugita, H.2
Yoshimori, T.3
Ohsumi, Y.4
-
29
-
-
77955417276
-
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
-
Bremm A, Freund SM, Komander D, (2010) Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol 17: 939–947.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 939-947
-
-
Bremm, A.1
Freund, S.M.2
Komander, D.3
-
30
-
-
84875071402
-
Assembly of k11-linked ubiquitin chains by the anaphase-promoting complex
-
Rape M, (2010) Assembly of k11-linked ubiquitin chains by the anaphase-promoting complex. Subcell Biochem 54: 107–115.
-
(2010)
Subcell Biochem
, vol.54
, pp. 107-115
-
-
Rape, M.1
-
31
-
-
76549089605
-
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex
-
Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, et al. (2010) UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A 107: 1355–1360.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 1355-1360
-
-
Wu, T.1
Merbl, Y.2
Huo, Y.3
Gallop, J.L.4
Tzur, A.5
-
32
-
-
80755153309
-
K11-linked ubiquitin chains as novel regulators of cell division
-
Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M, (2011) K11-linked ubiquitin chains as novel regulators of cell division. Trends Cell Biol 21: 656–663.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 656-663
-
-
Wickliffe, K.E.1
Williamson, A.2
Meyer, H.J.3
Kelly, A.4
Rape, M.5
-
33
-
-
84861397625
-
Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation
-
Budhavarapu VN, White ED, Mahanic CS, Chen L, Lin FT, et al. (2012) Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle 11: 2030–2038.
-
(2012)
Cell Cycle
, vol.11
, pp. 2030-2038
-
-
Budhavarapu, V.N.1
White, E.D.2
Mahanic, C.S.3
Chen, L.4
Lin, F.T.5
-
34
-
-
84893393844
-
TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3
-
Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, et al. (2014) TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A 111: 1509–1514.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 1509-1514
-
-
Hu, M.M.1
Yang, Q.2
Zhang, J.3
Liu, S.M.4
Zhang, Y.5
-
35
-
-
84863962538
-
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection
-
Li Y, Chen R, Zhou Q, Xu Z, Li C, et al. (2012) LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A 109: 11770–11775.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 11770-11775
-
-
Li, Y.1
Chen, R.2
Zhou, Q.3
Xu, Z.4
Li, C.5
|