Characterization of SENP7, a SUMO-2/3-specific isopeptidase

Biochemical Journal

Volumn 421, Issue 2, 2009, Pages 223-230

  Shen, Lin Nan ^a   Geoffroy, Marie Claude ^a   Jaffray, Ellis G ^a   Hay, Ronald T ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Conjugation; Deconjugation; Isopeptidase; Small ubiquitin related modifier (SUMO); SUMO 1 sentrin SMT3 specific peptidase 7 (SENP7); Ubiquitin

Indexed keywords

CONJUGATION; DECONJUGATION; ISOPEPTIDASE; SMALL UBIQUITIN-RELATED MODIFIER (SUMO); SUMO-1/SENTRIN/SMT3-SPECIFIC PEPTIDASE 7 (SENP7); UBIQUITIN;

PROTEINS;

PEPTIDASE; PROMYELOCYTIC LEUKEMIA PROTEIN; RAN PROTEIN; SMALL INTERFERING RNA; SMALL UBIQUITIN RELATED MODIFIER 1 SENTRIN SUPPRESSOR OF MIF TWO 3 HOMOLOGUE 1 SPECIFIC PEPTIDASE 7; SUMO 1 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; SUMO PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS INCLUSION BODY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPOLYMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME PURIFICATION; ENZYME SPECIFICITY; FETUS; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; METABOLIC REGULATION; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANIMALS; CARBON-NITROGEN LYASES; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPEPTIDASES; GTPASE-ACTIVATING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 67650911884     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090246     Document Type: Article

References (35)

1. Li, T., Evdokimov, E., Shen, R. F., Chao, C. C., Tekle, E., Wang, T., Stadtman, E. R., Yang, D. C. and Chock, P. B. (2004) Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. Proc. Natl. Acad. Sci. U.S.A. 101, 8551-8556
2. Vassileva, M. T. and Matunis, M. J. (2004) SUMO modification of heterogeneous nuclear ribonucleoproteins. Mol. Cell. Biol. 24, 3623-3632
3. Vertegaal, A. C., Ogg, S. C., Jaffray, E., Rodriguez, M. S., Hay, R. T., Andersen, J. S., Mann, M. and Lamond, A. I. (2004) A proteomic study of SUMO-2 target proteins. J. Biol. Chem. 279, 33791-33798
4. Zhao, Y., Kwon, S. W., Anselmo, A., Kaur, K. and White, M. A. (2004) Broad spectrum identification of cellular small ubiquitin-related modifier (SUMO) substrate proteins. J. Biol. Chem. 279, 20999-21002
5. Su, H. and Li, S. (2002) Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296, 65-73
6. Hay, R. T. (2005) SUMO: a history of modification. Mol. Cell 18, 1-12
7. Hay, R. T. (2001) Protein modification by SUMO. Trends Biochem. Sci. 26, 332-333
8. Rodriguez, M. S., Dargemont, C. and Hay, R. T. (2001) SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J. Biol. Chem. 276, 12654-12659
9. Melchior, F., Schergaut, M. and Pichler, A. (2003) SUMO: ligases, isopeptidases and nuclear pores. Trends Biochem. Sci. 28, 612-618
10. Tatham, M. H., Jaffray, E., Vaughan, O. A., Desterro, J. M., Botting, C. H., Naismith, J. H. and Hay, R. T. (2001) Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9, J. Biol. Chem. 276, 35368-35374
11. Bencsath, K. P., Podgorski, M. S., Pagala, V. R., Slaughter, C. A. and Schulman, B. A. (2002) Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation. J. Biol. Chem. 277, 47938-47945
12. Bylebyl G.R., Belichenko and I., Johnson E. S. (2003) The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast. J. Biol. Chem. 278, 44113-44120
13. Li, Y., Wang, H., Wang, S., Quon, D., Liu, Y. W. and Cordell, B. (2003) Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc. Natl. Acad. Sci. U.S.A. 100, 259-264
14. Fu, C., Ahmed, K., Ding, H., Ding, X., Lan, J., Yang, Z., Miao, Y., Zhu, Y., Shi, Y., Zhu, J. et al. (2005) Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3. Oncogene 24, 5401-5413
15. Zhang, X. D., Goeres, J., Zhang, H., Yen, T. J., Porter, A. C. and Matunis, M. J. (2008) SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. Mol. Cell 28, 729-741
16. Mukhopadhyay, D. and Dasso, M. (2007) Modification in reverse: the SUMO proteases. Trends Biochem. Sci. 32, 286-295
17. Li, S. J. and Hochstrasser, M. (1999) A new protease required for cell-cycle progression in yeast. Nature 398, 246-251
18. Li, S. J. and Hochstrasser, M. (2000) The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol. Cell. Biol. 20, 2367-2377
19. Takahashi, Y., Mizoi, J., Toh, E. A. and Kikuchi, Y. (2000) Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. J. Biochem. (Tokyo) 128, 723-725
20. Gong, L., Millas, S., Maul, G. G. and Yeh, E. T. (2000) Differential regulation of sentrinized proteins by a novel sentrin-specific protease. J. Biol. Chem. 275, 3355-3359
21. Zhang, H., Saitoh, H. and Matunis, M. J. (2002) Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol. Cell. Biol. 22, 6498-6508
22. Itahana, Y., Yeh, E. T. H. and Zhang, Y. (2006) Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Mol. Cell. Biol. 26, 4675-4689
23. Gong, L. and Yeh, E. T. (2006) Characterization of a family of nucleolar SUMO specific proteases with preference for SUMO-2 or SUMO-3. J. Biol. Chem. 281, 15869-15877
24. Mukhopadhyay, D., Ayaydin, F., Kolli, N., Tan, S. H., Anan, T., Kametaka, A., Azuma, Y., Wilkinson, K. D. and Dasso, M. (2006) SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J. Cell Biol. 174, 939-949
25. Drag, M., Mikolajczyk, J., Krishnakumar, I. M., Huang, Z. and Salvesen, G. S. (2008) Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. Biochem. J. 409, 461-469
26. Mikolajczyk, J., Drag, M., Békés, M., Cao, J. T., Ronai, Z. and Salvesen, G. S. (2007) Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. J. Biol. Chem. 282, 26217-26224
27. Brøns-Poulsen, J., Petersen, N. E., Horder, M. and Kristiansen, K. (1998) An improved PCR-based method for site directed mutagenesis using megaprimers. Mol. Cell. Probes 12, 345-348
28. Shen, L. N., Dong, C., Liu, H., Naismith, J. H. and Hay, R. T. (2006) The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem. J. 397, 279-288
29. Shen, L., Tatham, M. H., Dong, C., Zag'orska, A., Naismith, J. H. and Hay, R. T. (2006) SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat. Struct. Mol. Biol. 13, 1069-1077
30. Cheng, J., Bawa, T., Lee, P., Gong, L. and Yeh, E. T. (2006) Role of desumoylation in the development of prostate cancer. Neoplasia 8, 667-676
31. Lima, C. D. and Reverter, D. (2008) Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J. Biol. Chem. 283, 32045-32055
32. Matic, I., van Hagen, M., Schimmel, J., Macek, B., Ogg, S. C., Tatham, M. H., Hay, R. T., Lamond, A. I., Mann, M. and Vertegaal, A. C. (2008) In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. Mol. Cell. Proteomics 7, 132-144
33. Tatham, M. H., Geoffroy, M. C., Shen, L., Plechanovova, A., Hattersley, N., Jaffray, E. G., Palvimo, J. J. and Hay, R. T. (2008) RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat. Cell Biol. 10, 538-546
34. Lallemand-Breitenbach, V., Jeanne, M., Benhenda, S., Nasr, R., Lei, M., Peres, L., Zhou, J., Zhu, J., Raught, B. and de Thé, H. (2008) Arsenic degrades PML or PML-RARα through a SUMO-triggered RNF4/ ubiquitin-mediated pathway. Nat. Cell Biol. 10, 547-555
35. Thompson, J. D., Higgins, D. G. and Gibson, T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680