Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

Cell Systems

Volumn 4, Issue 2, 2017, Pages 157-170.e14

  Khurana, Vikram ^a,b,c   Peng, Jian ^a,d   Chung, Chee Yeun ^a   Auluck, Pavan K ^a   Fanning, Saranna ^a   Tardiff, Daniel F ^a   Bartels, Theresa ^a   Koeva, Martina ^a,e   Eichhorn, Stephen W ^a   Benyamini, Hadar ^a   Lou, Yali ^a   Nutter Upham, Andy ^a   Baru, Valeriya ^a   Freyzon, Yelena ^a   Tuncbag, Nurcan ^e   Costanzo, Michael ^f   San Luis, Bryan Joseph ^f   Schöndorf, David C ^g   Barrasa, M Inmaculada ^a   Ehsani, Sepehr ^a   Sanjana, Neville ^h,i   Zhong, Quan ^j   Gasser, Thomas ^g   Bartel, David P ^a   Vidal, Marc ^k,l   Deleidi, Michela ^g   Boone, Charles ^f   Fraenkel, Ernest ^e   Berger, Bonnie ^c   Lindquist, Susan ^a,m   more..

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e Massachusetts Institute of Technology Cambridge   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁱ NEW YORK UNIVERSITY   (United States)

^j WRIGHT STATE UNIVERSITY   (United States)

^k DANA FARBER CANCER INSTITUTE   (United States)

^l HARVARD MEDICAL SCHOOL   (United States)

^m MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

more..

Author keywords

alpha synuclein; iPS cell; LRRK2; mRNA translation; Parkinson's disease; RNA binding protein; stem cell; vesicle trafficking; VPS35; yeast

Indexed keywords

ALPHA SYNUCLEIN; ATAXIN 2; INITIATION FACTOR 4G; LEUCINE RICH REPEAT KINASE 2; MESSENGER RNA; TAR DNA BINDING PROTEIN; AMYLOID BETA PROTEIN; DNA BINDING PROTEIN; EIF4G1 PROTEIN, HUMAN; TDP-43 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CELL VACUOLE; CONTROLLED STUDY; ECTOPIC EXPRESSION; EMBRYO; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR MATRIX; GENE DELETION; GENE OVEREXPRESSION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MOLECULAR INTERACTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; QUALITY CONTROL; RAT; RNA METABOLISM; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; UBIQUITINATION; CHEMISTRY; CYTOLOGY; DEGENERATIVE DISEASE; DISEASE PREDISPOSITION; ENDOPLASMIC RETICULUM; FUNGAL GENOME; GENE REGULATORY NETWORK; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; SACCHAROMYCES CEREVISIAE;

ALPHA-SYNUCLEIN; AMYLOID BETA-PEPTIDES; ATAXIN-2; DISEASE SUSCEPTIBILITY; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-4G; GENE REGULATORY NETWORKS; GENOME, FUNGAL; HUMANS; INDUCED PLURIPOTENT STEM CELLS; NEURODEGENERATIVE DISEASES; NEURONS; SACCHAROMYCES CEREVISIAE;

EID: 85010868689     PISSN: 24054712     EISSN: 24054720     Source Type: Journal    
DOI: 10.1016/j.cels.2016.12.011     Document Type: Article

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