High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Nature

Volumn 504, Issue 7479, 2013, Pages 291-295

  Hasson, Samuel A ^a,b   Kane, Lesley A ^a   Yamano, Koji ^a   Huang, Chiu Hui ^a   Sliter, Danielle A ^a   Buehler, Eugen ^b   Wang, Chunxin ^a   Heman Ackah, Sabrina M ^c   Hessa, Tara ^a   Guha, Rajarshi ^b   Martin, Scott E ^b   Youle, Richard J ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HEAT SHOCK PROTEIN 70; PARKIN; PROTEIN BAG4; PROTEIN SIAH3; PROTEIN TOMM7; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

CYTOLOGY; GENE EXPRESSION; GENOME; MEMBRANE; MITOCHONDRION; MOLECULAR ANALYSIS; NERVOUS SYSTEM DISORDER; PROTEIN; TRANSLOCATION;

ARTICLE; CONTROLLED STUDY; GENE CLUSTER; GENETIC SCREENING; GENOME ANALYSIS; HELA CELL; INTRACELLULAR TRANSPORT; MICROSCOPY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MITOPHAGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; RNA INTERFERENCE; VALIDATION STUDY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; GENOME, HUMAN; HCT116 CELLS; HEK293 CELLS; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; MULTIGENE FAMILY; PARKINSON DISEASE; PROTEIN KINASES; PROTEIN TRANSPORT; REPRODUCIBILITY OF RESULTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; UBIQUITIN-PROTEIN LIGASES;

EID: 84890429468     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12748     Document Type: Article

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