Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway

European Journal of Pharmacology

Volumn 797, Issue , 2017, Pages 124-133

  Li, Miao ^a   Liu, Xin ^a   He, Yongpeng ^a   Zheng, Qingyin ^a,b   Wang, Min ^a   Wu, Yu ^a   Zhang, Yuanpeng ^a   Wang, Chaoyun ^a  

^a BINZHOU MEDICAL UNIVERSITY   (China)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Angiotensin II; Celastrol; Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase; Nox2; Nuclear factor erythroid 2 related factor 2; Reactive oxygen species

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BRUSATOL; CELASTROL; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TRANSCRIPTION FACTOR NRF2; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYBB PROTEIN, HUMAN; MEMBRANE PROTEIN; NFE2L2 PROTEIN, HUMAN; TRIPTERINE; TRITERPENE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; RECEPTOR, ANGIOTENSIN, TYPE 1; TRITERPENES;

EID: 85010204461     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2017.01.027     Document Type: Article

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