Angiotensin II induces C-reactive protein expression via AT1-ROS-MAPK-NF-κB signal pathway in hepatocytes

Cellular Physiology and Biochemistry

Volumn 32, Issue 3, 2013, Pages 569-580

  Zhao, Jingjing ^a   Liu, Juntian ^a   Pang, Xiaoming ^a   Wang, Shuyue ^a   Wu, Di ^a   Zhang, Xiaolu ^a   Feng, Liuxin ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Angiotensin II; Atherosclerosis; C reactive protein; Hepatocytes; Inflammation; Liver

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; C REACTIVE PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOSARTAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; THENOYLTRIFLUOROACETONE; ANGIOTENSIN I;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL TISSUE; HEPATITIS; IN VITRO STUDY; MOLECULAR PATHOLOGY; NORMAL HUMAN; PROTEIN INDUCTION;

RATTUS;

ACETYLCYSTEINE; ANGIOTENSIN II; ANIMALS; C-REACTIVE PROTEIN; CELL LINE; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LOSARTAN; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTOR, ANGIOTENSIN, TYPE 1; RECOMBINANT PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; THENOYLTRIFLUOROACETONE;

EID: 84884997244     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000354461     Document Type: Article

References (37)

1. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR: Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347: 1557-1565.
2. Devaraj S, Singh U, Jialal I: The evolving role of C-reactive protein in atherothrombosis. Clin Chem 2009;55: 229-238.
3. Hein TW, Singh U, Vasquez-Vivar J, Devaraj S, Kuo L, Jialal I: Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis 2009;206: 61-68.
4. Majello B, Arcone R, Toniatti C, Ciliberto G: Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. Embo J 1990;9: 457-465.
5. Kleemann R, Gervois PR, Verschuren L, Staels B, Princen HMG, Kooistra T: Fibrates down-regulate IL-1- stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NF kappa B-C/EBP-beta complex formation. Blood 2003;101: 545-551.
6. Radtke S, Wueller S, Yang X-p, Lippok BE, Muetze B, Mais C, Schmitz-Van de Leur H, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM: Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation. J Cell Sci 2010;123: 947-959.
7. Ivashchenko Y, Kramer F, Schafer S, Bucher A, Veit K, Hombach V, Busch A, Ritzeler O, Dedio JR, Torzewski J: Protein kinase C pathway is involved in transcriptional regulation of C-reactive protein synthesis in human hepatocytes. Arterioscler Thromb Vasc Biol 2005;25: 186-192.
8. Black S, Kushner I, Samols D: C-reactive protein. J Biol Chem 2004;279: 48487-48490.
9. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE: Direct stimulation of JAK/STAT pathway by the angiotensin-II AT(1) receptor. Nature 1995;375: 247-250.
10. Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Egido J: Inflammation and angiotensin II. Int J Biochem Cell Biol 2003;35: 881-900.
11. Ruiz-Ortega M, Lorenzo O, Suzuki Y, Ruperez M, Egido J: Proinflammatory actions of angiotensins. Curr Opin Nephrol Hypertens 2001;10: 321-329.
12. Bataller R, Gabele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA: Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol-Gastrointest Liver Physiol 2003;285:G642-G651.
13. Bataller R, Sancho-Bru P, Gines P, Lora JM, Al-Garawi A, Sole M, Colmenero J, Nicolas JM, Jimenez W, Weich N, Gutierrez-Ramos JC, Arroyo V, Rodes J: Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology 2003;125: 117-125.
14. Paizis G, Cooper ME, Schembri JM, Tikellis C, Burrell LM, Angus PW: Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver. Gastroenterology 2002;123: 1667-1676.
15. Moreno M, Ramalho LN, Sancho-Bru P, Ruiz-Ortega M, Ramalho F, Abraldes JG, Colmenero J, Dominguez M, Egido J, Arroyo V, Gines P, Bataller R: Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver. Am J Physiol-Gastrointest Liver Physiol 2009;296:G147-G156.
16. Peng N, Liu J-T, Gao D-F, Lin R, Li R: Angiotensin II-induced C-reactive protein generation: Inflammatory role of vascular smooth muscle cells in atherosclerosis. Atherosclerosis 2007;193: 292-298.
17. Han C, Liu J, Liu X, Li M: Angiotensin II induces C-reactive protein expression through ERK1/2 and JNK signaling in human aortic endothelial cells. Atherosclerosis 2010;212: 206-212.
18. Li M, Liu J, Han C, Wang B, Pang X, Mao J: Angiotensin II induces the expression of C-reactive protein via MAPK-dependent signal pathway in U937 macrophages. Cell Physiol Biochem 2011;27: 63-70.
19. Li JT, Hou FF, Guo ZJ, Shan YX, Zhang X, Liu ZQ: Advanced glycation end products upregulate C-reactive protein synthesis by human hepatocytes through stimulation of monocyte IL-6 and IL-1 beta production. Scand J Immunol 2007;66: 555-562.
20. Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJA, Ley SV, Aquilina JA, Robinson CV, Sharif I, Gray GA, Sabin CA, Jenvey MC, Kolstoe SE, Thompson D, Wood SP: Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 2006;440: 1217-1221.
21. Bota DP, Van Nuffelen M, Zakariah AN, Vincent JL: Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver. J Lab Clin Med 2005;146: 347-351.
22. Cervoni J-P, Thévenot T, Weil D, Muel E, Barbot O, Sheppard F, Monnet E, Di Martino V: C-reactive protein predicts short-term mortality in patients with cirrhosis. J Hepatol 2012;56: 1299-1304.
23. Jang JW, Oh BS, Kwon JH, You CR, Chung KW, Kay CS, Jung HS: Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma. Cytokine 2012;60: 686-693.
24. Ayabe N, Babaev VR, Tang YW, Tanizawa T, Fogo AB, Linton MF, Ichikawaa I, Fazio S, Kon V: Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis 2006;184: 312-321.
25. Cunha DV, Tham MD, Martin-Mcnulty B, Deng G, Ho JJ, Wilson DW, Rutledge JC, Vergona R, Sullivan ME, Wang YX: Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation. Atherosclerosis 2005;178: 9-17.
26. Herath CB, Warner FJ, Lubel JS, Dean RG, Jia Z, Lew RA, Smith AI, Burrell LM, Angus PW: Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. J Hepatol 2007;47: 387-395.
27. Paizis G, Tikellis C, Cooper ME, Schembri JM, Lew RA, Smith AI, Shaw T, Warner FJ, Zuilli A, Burrell LM, Angus PW: Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Gut 2005;54: 1790-1796.
28. Schulte S, Oidtmann A, Kociok N, Demir M, Odenthal M, Drebber U, Dienes H-P, Nierhoff D, Goeser T, Toex U, Steffen H-M: Hepatocyte expression of angiotensin II type 1 receptor is downregulated in advanced human liver fibrosis. Liver Int 2009;29: 384-391.
29. Wei Y, Chen K, Whaley-Connell AT, Stump CS, Ibdah JA, Sowers JR: Skeletal muscle insulin resistance: Role of inflammatory cytokines and reactive oxygen species. Am J Physiol-Regul Integr Comp Physiol 2008;294:R673-R680.
30. Zhang G-X, Lu X-M, Kimura S, Nishiyama A: Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation. Cardiovasc Res 2007;76: 204-212.
31. Hsu YH, Chen JJ, Chang NC, Chen CH, Liu JC, Chen TH, Jeng CJ, Chao HH, Cheng TH: Role of reactive oxygen species-sensitive extracellular signal-regulated kinase pathway in angiotensin II -induced endothelin-1 gene expression in vascular endothelial cells. J Vasc Res 2004;41: 64-74.
32. Griendling KK, Ushio-Fukai M: Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 2000;91: 21-27.
33. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK: P38 mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II - role in vascular smooth muscle cell hypertrophy. J Biol Chem 1998;273: 15022-15029.
34. Viedt C, Soto U, Krieger-Brauer HI, Fei JW, Elsing C, Kubler W, Kreuzer J: Differential activation of mitogen-activated protein kinases in smooth mascle cells by angiotensin II - involvement of p22phox and reactive oxygen species. Arterioscler Thromb Vasc Biol 2000;20: 940-948.
35. Voleti B, Agrawal A: Regulation of basal and induced expression of c-reactive protein through an overlapping element for OCT-1 and NF-kappa B on the proximal promoter. J Immunol 2005;175: 3386-3390.
36. Patel DN, King CA, Bailey SR, Holt JW, Venkatachalam K, Agrawal A, Valente AJ, Chandrasekar B: Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappa B and C/EBP beta activation. J Biol Chem 2007;282: 27229-27238.
37. Liu C-M, Sun Y-Z, Sun J-M, Ma J-Q, Cheng C: Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-kappa B pathway. Biochim Biophys Acta 2012;1820: 1693-1703.