Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis

Chemico-Biological Interactions

Volumn 246, Issue , 2016, Pages 52-62

  Divya, Thomas ^a   Dineshbabu, Vadivel ^a   Soumyakrishnan, Syamala ^a   Sureshkumar, Anandasadagopan ^b   Sudhandiran, Ganapasam ^a  

^a UNIVERSITY OF MADRAS   (India)

^b CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

Bleomycin; Celastrol; Collagen; Nrf2; Phase II enzymes; Pulmonary fibrosis

Indexed keywords

CELASTROL; COLLAGEN; ENZYME; GELATINASE A; GELATINASE B; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; HYDROXYPROLINE; OXIDOREDUCTASE; QUININE OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; BLEOMYCIN; TRIPTERINE; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; LUNG; MALE; MAST CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BLEOMYCIN; COLLAGEN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPID PEROXIDATION; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NF-E2-RELATED FACTOR 2; PULMONARY FIBROSIS; RATS; RATS, WISTAR; TRITERPENES;

EID: 84955093620     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2016.01.006     Document Type: Article

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