Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells

Biochemical and Biophysical Research Communications

Volumn 407, Issue 3, 2011, Pages 535-540

  Seo, Won Yong ^a   Goh, Ah Ra ^a   Ju, Sung Mi ^a   Song, Ha Yong ^a   Kwon, Dong Joo ^a   Jun, Jong Gab ^a   Kim, Byung Chul ^b   Choi, Soo Young ^a   Park, Jinseu ^a  

^a Hallym University   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Celastrol; HO 1; ICAM 1; IFN ; Inflammation; Keratinocyte; Nrf2; ROS

Indexed keywords

CELASTROL; GAMMA INTERFERON; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; UPREGULATION;

ACYLTRANSFERASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; HEME OXYGENASE-1; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON-GAMMA; KERATINOCYTES; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRITERPENES; UP-REGULATION;

TRIPTERYGIUM WILFORDII;

EID: 79954537594     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.053     Document Type: Article

References (25)

1. Allison A.C., Cacabelos R., Lombardi V.R., Alvarez X.A., Vigo C. Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 2001, 25:1341-1357.
2. Sassa H., Takaishi Y., Terada H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem. Biophys. Res. Commun. 1990, 172:890-897.
3. Yang H., Chen D., Cui Q.C., Yuan X., Dou Q.P. Thunder of God Vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006, 66:4758-4765.
4. Kim D.H., Shin E.K., Kim Y.H., Lee B.W., Jun J.G., Park J.H., Kim J.K. Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii. Eur. J. Clin. Invest. 2009, 39:819-827.
5. Salminen A., Lehtonen M., Paimela T., Kaarniranta K. Celastrol: molecular targets of Thunder God Vine. Biochem. Biophys. Res. Commun. 2010, 394:439-442.
6. Pinna G.F., Fiorucci M., Reimund J.M., Taquet N., Arondel Y., Muller C.D. Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies. Biochem. Biophys. Res. Commun. 2004, 322:778-786.
7. Lee J.H., Koo T.H., Yoon H., Jung H.S., Jin H.Z., Lee K., Hong Y.S., Lee J.J. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem. Pharmacol. 2006, 72:1311-1321.
8. Jung H.W., Chung Y.S., Kim Y.S., Park Y.K. Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells. Exp. Mol. Med. 2007, 39:715-721.
9. Kim Y., Kim K., Lee H., Han S., Lee Y.S., Choe J., Kim Y.M., Hahn J.H., Ro J.Y., Jeoung D. Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect. Eur. J. Pharmacol. 2009, 612:131-142.
10. Seo W.Y., Ju S.M., Song H.Y., Goh A.R., Jun J.G., Kang Y.H., Choi S.Y., Park J. Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. Biochem Biophys Res Commun. 2010, 398:140-145.
11. Ryter S.W., Alam J., Choi A.M. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 2006, 86:583-650.
12. Wojas-Pelc A., Marcinkiewicz J. What is a role of haeme oxygenase-1 in psoriasis? Current concepts of pathogenesis. Int. J. Exp. Pathol. 2007, 88:95-102.
13. Listopad J., Asadullah K., Sievers C., Ritter T., Meisel C., Sabat R., Döcke W.D. Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells. Exp. Dermatol. 2007, 16:661-670.
14. Kirino M., Kirino Y., Takeno M., Nagashima Y., Takahashi K., Kobayashi M., Murakami S., Hirasawa T., Ueda A., Aihara M., Ikezawa Z., Ishigatsubo Y. Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease. J. Allergy Clin. Immunol. 2008, 122:290-297.
15. Pae H.O., Ha Y.A., Chai K.Y., Chung H.T. Heme oxygenase-1 attenuates contact hypersensitivity induced by 2,4-dinitrofluorobenzene in mice. Immunopharmacol. Immunotoxicol. 2008, 30:207-216.
16. Park J., Choi K., Jeong E., Kwon D., Benveniste E.N., Choi C. Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells. Glia 2004, 47:9-20.
17. Dustin M.L., Singer K.H., Tuck D.T., Springer T.A. Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1). J. Exp. Med. 1988, 167:1323-1340.
18. Lee I.T., Luo S.F., Lee C.W., Wang S.W., Lin C.C., Chang C.C., Chen Y.L., Chau L.Y., Yang C.M. Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress. Am. J. Pathol. 2009, 175:519-532.
19. Lin C.C., Liu X.M., Peyton K., Wang H., Yang W.C., Lin S.J., Durante W. Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1. Arterioscler. Thromb. Vasc. Biol. 2008, 28:739-745.
20. Seldon M.P., Silva G., Pejanovic N., Larsen R., Gregoire I.P., Filipe J., Anrather J., Soares M.P. Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276. J. Immunol. 2007, 179:7840-7851.
21. Soares M.P., Seldon M.P., Gregoire I.P., Vassilevskaia T., Berberat P.O., Yu J., Tsui T.Y., Bach F.H. Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. J. Immunol. 2004, 172:3553-3563.
22. Yu X., Tao W., Jiang F., Li C., Lin J., Liu C. Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am. J. Hypertens. 2010, 23:895-903.
23. Lin C.W., Wu M.J., Liu I.Y., Su J.D., Yen J.H. Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression. J. Agric. Food Chem. 2010, 58:4477-4486.
24. Andreadi C.K., Howells L.M., Atherfold P.A., Manson M.M. Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol. Pharmacol. 2006, 69:1033-1040.
25. Ogborne R.M., Rushworth S.A., O'Connell M.A. Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2100-2105.