Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity

European Journal of Pharmacology

Volumn 767, Issue , 2015, Pages 201-210

  Zheng, Wen Xia ^b   Cao, Xiao Lu ^a   Wang, Feng ^a   Wang, Jun ^a   Ying, Ting Zi ^a   Xiao, Wan ^a   Zhang, Ying ^a   Xing, Hong ^a   Dong, Wei ^a   Xu, Shi Qiang ^a   Min, Zhen Li ^a   Wu, Fang Jian ^b   Hu, Xia Min ^a  

^a WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b General Hospital of the Yangtze River Shipping   (China)

Author keywords

Baicalin; BCL 2; ERK1 2; MCL 1; MRTF A; Neuronal apoptosis; PI3K

Indexed keywords

BAICALIN; HYDROGEN PEROXIDE; LUCIFERASE; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; PROTEIN BCL 2; PROTEIN MCL 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; FLAVONOID; MCL1 PROTEIN, RAT; MORPHOLINE DERIVATIVE; MYOCARDIN-RELATED TRANSCRIPTION FACTOR-A, RAT; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CELL CULTURE; BRAIN INFARCTION SIZE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ASSAY; HEMISPHERE; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CORTEX; DOSE RESPONSE; DRUG EFFECTS; HYPOXIA-ISCHEMIA, BRAIN; METABOLISM; NERVE CELL; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; APOPTOSIS; CEREBRAL CORTEX; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HYPOXIA-ISCHEMIA, BRAIN; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84946560076     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.10.027     Document Type: Article

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