메뉴 건너뛰기




Volumn 14, Issue 3, 2017, Pages 139-152

Antimicrobial-resistant sexually transmitted infections: Gonorrhoea and Mycoplasma genitalium

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CEFIXIME; CEFTRIAXONE; CEPHALOSPORIN; DOXYCYCLINE; GENTAMICIN; JOSAMYCIN; LEFAMULIN; MACROLIDE; MOXIFLOXACIN; PENICILLIN DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SOLITHROMYCIN; SPECTINOMYCIN; SULFONAMIDE; TETRACYCLINE; ZOLIFLODACIN; ANTIINFECTIVE AGENT;

EID: 85009212751     PISSN: 17594812     EISSN: 17594820     Source Type: Journal    
DOI: 10.1038/nrurol.2016.268     Document Type: Review
Times cited : (174)

References (178)
  • 1
    • 84955586000 scopus 로고    scopus 로고
    • Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting
    • Newman, L., et al. Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS ONE 10, e0143304 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0143304
    • Newman, L.1
  • 3
    • 79960130072 scopus 로고    scopus 로고
    • Mycoplasma genitalium: From Chrysalis to multicolored butterfly
    • Taylor-Robinson, D., Jensen, J. S. Mycoplasma genitalium: from Chrysalis to multicolored butterfly. Clin. Microbiol. Rev. 24, 498-514 (2011).
    • (2011) Clin. Microbiol. Rev. , vol.24 , pp. 498-514
    • Taylor-Robinson, D.1    Jensen, J.S.2
  • 5
    • 84903598016 scopus 로고    scopus 로고
    • Antimicrobial resistance in Neisseria gonorrhoeae in the 21st Century: Past, evolution, and future
    • Unemo, M., Shafer, W. M. Antimicrobial resistance in Neisseria gonorrhoeae in the 21st Century: past, evolution, and future. Clin. Microbiol. Rev. 27, 587-613 (2014).
    • (2014) Clin. Microbiol. Rev. , vol.27 , pp. 587-613
    • Unemo, M.1    Shafer, W.M.2
  • 6
    • 84870891391 scopus 로고    scopus 로고
    • Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea
    • Unemo, M., Nicholas, R. A. Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol. 7, 1401-1422 (2012).
    • (2012) Future Microbiol. , vol.7 , pp. 1401-1422
    • Unemo, M.1    Nicholas, R.A.2
  • 7
    • 84939529739 scopus 로고    scopus 로고
    • Current and future antimicrobial treatment of gonorrhoea-the rapidly evolving Neisseria gonorrhoeae continues to challenge
    • Unemo, M. Current and future antimicrobial treatment of gonorrhoea-the rapidly evolving Neisseria gonorrhoeae continues to challenge. BMC Infect. Dis. 15, 364 (2015).
    • (2015) BMC Infect. Dis. , vol.15 , pp. 364
    • Unemo, M.1
  • 8
    • 84891847324 scopus 로고    scopus 로고
    • Current and future treatment options for gonorrhoea
    • Ison, C. A., Deal, C., Unemo, M. Current and future treatment options for gonorrhoea. Sex. Transm. Infect. 89 (Suppl. 4), iv52-iv56 (2013).
    • (2013) Sex. Transm. Infect. , vol.89 , pp. iv52-iv56
    • Ison, C.A.1    Deal, C.2    Unemo, M.3
  • 9
    • 84879495636 scopus 로고    scopus 로고
    • 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults
    • Bignell, C., Unemo, M. 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults. Int. J. STD AIDS 24, 85-92 (2013).
    • (2013) Int. J. STD AIDS , vol.24 , pp. 85-92
    • Bignell, C.1    Unemo, M.2
  • 10
    • 84930940449 scopus 로고    scopus 로고
    • Sexually transmitted diseases treatment guidelines 2015
    • Workowski, K. A., Bolan, G. A. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm. Rep. 64, 1-137 (2015).
    • (2015) MMWR Recomm. Rep. , vol.64 , pp. 1-137
    • Workowski, K.A.1    Bolan, G.A.2
  • 11
    • 34249869095 scopus 로고    scopus 로고
    • Public Health Agency of Canada Gonococcal Infections Chapter (Public Health Agency of Canada
    • Public Health Agency of Canada. Canadian Guidelines on Sexually Transmitted Infections. Gonococcal Infections Chapter (Public Health Agency of Canada, 2013).
    • (2013) Canadian Guidelines on Sexually Transmitted Infections
  • 12
    • 85014504010 scopus 로고    scopus 로고
    • Australasian Sexual Health Alliance ASHA
    • Australasian Sexual Health Alliance. Australian STI management guidelines for use in primary care. ASHA www. sti. guidelines. org. au/sexually-transmissible-infections/gonorrhoea#management (2016).
    • (2016) Australian STI Management Guidelines for Use in Primary Care
  • 13
    • 84875044557 scopus 로고    scopus 로고
    • Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: A randomized controlled trial
    • Manhart, L. E., et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin. Infect. Dis. 56, 934-942 (2013).
    • (2013) Clin. Infect. Dis. , vol.56 , pp. 934-942
    • Manhart, L.E.1
  • 14
    • 66949160421 scopus 로고    scopus 로고
    • A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men
    • Mena, L. A., Mroczkowski, T. F., Nsuami, M., Martin, D. H. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. Clin. Infect. Dis. 48, 1649-1654 (2009).
    • (2009) Clin. Infect. Dis. , vol.48 , pp. 1649-1654
    • Mena, L.A.1    Mroczkowski, T.F.2    Nsuami, M.3    Martin, D.H.4
  • 15
    • 84901053865 scopus 로고    scopus 로고
    • Mycoplasma genitalium testing pattern and macrolide resistance: A Danish nationwide retrospective survey
    • Salado-Rasmussen, K., Jensen, J. S. Mycoplasma genitalium testing pattern and macrolide resistance: a Danish nationwide retrospective survey. Clin. Infect. Dis. 59, 24-30 (2014).
    • (2014) Clin. Infect. Dis. , vol.59 , pp. 24-30
    • Salado-Rasmussen, K.1    Jensen, J.S.2
  • 16
    • 84875974965 scopus 로고    scopus 로고
    • Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic
    • Anagrius, C., Lore, B., Jensen, J. S. Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic. PLoS ONE 8, e61481 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e61481
    • Anagrius, C.1    Lore, B.2    Jensen, J.S.3
  • 17
    • 79951848615 scopus 로고    scopus 로고
    • Re-evaluating the treatment of nongonococcal urethritis: Emphasizing emerging pathogens-a randomized clinical trial
    • Schwebke, J. R., et al. Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens-a randomized clinical trial. Clin. Infect. Dis. 52, 163-170 (2011).
    • (2011) Clin. Infect. Dis. , vol.52 , pp. 163-170
    • Schwebke, J.R.1
  • 18
    • 53549126639 scopus 로고    scopus 로고
    • Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: An open study
    • Jernberg, E., Moghaddam, A., Moi, H. Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study. Int. J. STD AIDS 19, 676-679 (2008).
    • (2008) Int. J. STD AIDS , vol.19 , pp. 676-679
    • Jernberg, E.1    Moghaddam, A.2    Moi, H.3
  • 19
    • 84887372872 scopus 로고    scopus 로고
    • Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance
    • Couldwell, D. L., Tagg, K. A., Jeoffreys, N. J., Gilbert, G. L. Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance. Int. J. STD AIDS 24, 822-828 (2013).
    • (2013) Int. J. STD AIDS , vol.24 , pp. 822-828
    • Couldwell, D.L.1    Tagg, K.A.2    Jeoffreys, N.J.3    Gilbert, G.L.4
  • 20
    • 84891830853 scopus 로고    scopus 로고
    • Treatment outcomes for persistent Mycoplasma genitalium associated NGU: Evidence of moxifloxacin treatment failures [abstract O02. 3]
    • Manhart, L. E., et al. Treatment outcomes for persistent Mycoplasma genitalium associated NGU: evidence of moxifloxacin treatment failures [abstract O02. 3]. Sex. Transm. Infect. 89 (Suppl. 1), A29 (2013).
    • (2013) Sex. Transm. Infect. , vol.89 , pp. A29
    • Manhart, L.E.1
  • 21
    • 84971401923 scopus 로고    scopus 로고
    • Background review for the '2015 European guideline on the management of Chlamydia trachomatis infections
    • 0956462415618838
    • Lanjouw, E., et al. Background review for the '2015 European guideline on the management of Chlamydia trachomatis infections'. Int. J. STD AIDS 2015, 0956462415618838 (2015).
    • (2015) Int. J. STD AIDS , vol.2015
    • Lanjouw, E.1
  • 22
    • 84958172231 scopus 로고    scopus 로고
    • 2015 UK national guideline for the management of infection with Chlamydia trachomatis
    • Nwokolo, N. C., et al. 2015 UK national guideline for the management of infection with Chlamydia trachomatis. Int. J. STD AIDS 27, 251-267 (2016).
    • (2016) Int. J. STD AIDS , vol.27 , pp. 251-267
    • Nwokolo, N.C.1
  • 23
    • 84860342659 scopus 로고    scopus 로고
    • Azithromycin antimicrobial resistance and genital Chlamydia trachomatis infection: Duration of therapy may be the key to improving efficacy
    • Horner, P. J. Azithromycin antimicrobial resistance and genital Chlamydia trachomatis infection: duration of therapy may be the key to improving efficacy. Sex. Transm. Infect. 88, 154-156 (2012).
    • (2012) Sex. Transm. Infect. , vol.88 , pp. 154-156
    • Horner, P.J.1
  • 24
    • 77957555426 scopus 로고    scopus 로고
    • Antibiotic resistance in Chlamydiae
    • Sandoz, K. M., Rockey, D. D. Antibiotic resistance in Chlamydiae. Future Microbiol. 5, 1427-1442 (2010).
    • (2010) Future Microbiol. , vol.5 , pp. 1427-1442
    • Sandoz, K.M.1    Rockey, D.D.2
  • 25
    • 14844320488 scopus 로고    scopus 로고
    • Evaluation of antimicrobial resistance and treatment failures for Chlamydia trachomatis: A meeting report
    • Wang, S. A., et al. Evaluation of antimicrobial resistance and treatment failures for Chlamydia trachomatis: a meeting report. J. Infect. Dis. 191, 917-923 (2005).
    • (2005) J. Infect. Dis. , vol.191 , pp. 917-923
    • Wang, S.A.1
  • 26
    • 84875700825 scopus 로고    scopus 로고
    • Chlamydia trachomatis clinical isolates identified as tetracycline resistant do not exhibit resistance in vitro: Whole-genome sequencing reveals a mutation in porB but no evidence for tetracycline resistance genes
    • O'Neill, C. E., et al. Chlamydia trachomatis clinical isolates identified as tetracycline resistant do not exhibit resistance in vitro: whole-genome sequencing reveals a mutation in porB but no evidence for tetracycline resistance genes. Microbiology 159, 748-756 (2013).
    • (2013) Microbiology , vol.159 , pp. 748-756
    • O'Neill, C.E.1
  • 27
    • 80054115542 scopus 로고    scopus 로고
    • Questioning azithromycin for chlamydial infection
    • Handsfield, H. H. Questioning azithromycin for chlamydial infection. Sex. Transm. Dis. 38, 1028-1029 (2011).
    • (2011) Sex. Transm. Dis. , vol.38 , pp. 1028-1029
    • Handsfield, H.H.1
  • 28
    • 84863896789 scopus 로고    scopus 로고
    • Chlamydia trachomatis Mycoplasma genitalium, and Trichomonas vaginalis infections in men with nongonococcal urethritis: Predictors and persistence after therapy
    • Sena, A. C., et al. Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis infections in men with nongonococcal urethritis: predictors and persistence after therapy. J. Infect. Dis. 206, 357-365 (2012).
    • (2012) J. Infect. Dis. , vol.206 , pp. 357-365
    • Sena, A.C.1
  • 29
    • 84938092817 scopus 로고    scopus 로고
    • Treatment challenges for urogenital and anorectal Chlamydia trachomatis
    • Kong, F. Y., Hocking, J. S. Treatment challenges for urogenital and anorectal Chlamydia trachomatis. BMC Infect. Dis. 15, 293 (2015).
    • (2015) BMC Infect. Dis. , vol.15 , pp. 293
    • Kong, F.Y.1    Hocking, J.S.2
  • 30
    • 0034105041 scopus 로고    scopus 로고
    • Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure
    • Somani, J., Bhullar, V. B., Workowski, K. A., Farshy, C. E., Black, C. M. Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure. J. Infect. Dis. 181, 1421-1427 (2000).
    • (2000) J. Infect. Dis. , vol.181 , pp. 1421-1427
    • Somani, J.1    Bhullar, V.B.2    Workowski, K.A.3    Farshy, C.E.4    Black, C.M.5
  • 31
    • 79959729027 scopus 로고    scopus 로고
    • Lack of mutation in macrolide resistance genes in Chlamydia trachomatis clinical isolates with decreased susceptibility to azithromycin
    • Bhengraj, A. R., Srivastava, P., Mittal, A. Lack of mutation in macrolide resistance genes in Chlamydia trachomatis clinical isolates with decreased susceptibility to azithromycin. Int. J. Antimicrob. Agents 38, 178-179 (2011).
    • (2011) Int. J. Antimicrob. Agents , vol.38 , pp. 178-179
    • Bhengraj, A.R.1    Srivastava, P.2    Mittal, A.3
  • 32
    • 33645980677 scopus 로고    scopus 로고
    • Effects of sustained antibiotic bactericidal treatment on Chlamydia trachomatis-infected epithelial-like cells (HeLa) and monocyte-like cells (THP-1 and U-937)
    • Mpiga, P., Ravaoarinoro, M. Effects of sustained antibiotic bactericidal treatment on Chlamydia trachomatis-infected epithelial-like cells (HeLa) and monocyte-like cells (THP-1 and U-937). Int. J. Antimicrob. Agents 27, 316-324 (2006).
    • (2006) Int. J. Antimicrob. Agents , vol.27 , pp. 316-324
    • Mpiga, P.1    Ravaoarinoro, M.2
  • 33
    • 84932162013 scopus 로고    scopus 로고
    • The five days azithromycin treatment regimen (500 mg×1, 250 mg×4) used for Mycoplasma genitalium infections also effectively eradicates Chlamydia trachomatis
    • Unemo, M., Endre, K. M. A., Moi, H. The five days azithromycin treatment regimen (500 mg×1, 250 mg×4) used for Mycoplasma genitalium infections also effectively eradicates Chlamydia trachomatis. Acta Derm. Venereol. 95, 730-732 (2015).
    • (2015) Acta Derm. Venereol. , vol.95 , pp. 730-732
    • Unemo, M.1    Endre, K.M.A.2    Moi, H.3
  • 34
    • 84988418788 scopus 로고    scopus 로고
    • 2016 European guideline on the management of non-gonococcal urethritis
    • Horner, P. J., Blee, K., Falk, L., van der Meijden, W., Moi, H. 2016 European guideline on the management of non-gonococcal urethritis. Int. J. STD AIDS 27, 928-937 (2016).
    • (2016) Int. J. STD AIDS , vol.27 , pp. 928-937
    • Horner, P.J.1    Blee, K.2    Falk, L.3    Van Der Meijden, W.4    Moi, H.5
  • 35
    • 84911926573 scopus 로고    scopus 로고
    • 2014 European guideline on the management of syphilis
    • Janier, M., et al. 2014 European guideline on the management of syphilis. J. Eur. Acad. Dermatol. Venereol. 28, 1581-1593 (2014).
    • (2014) J. Eur. Acad. Dermatol. Venereol. , vol.28 , pp. 1581-1593
    • Janier, M.1
  • 36
    • 84929294383 scopus 로고    scopus 로고
    • Syphilis: Antibiotic treatment and resistance
    • Stamm, L. V. Syphilis: antibiotic treatment and resistance. Epidemiol. Infect. 143, 1567-1574 (2015).
    • (2015) Epidemiol. Infect. , vol.143 , pp. 1567-1574
    • Stamm, L.V.1
  • 37
    • 84920920228 scopus 로고    scopus 로고
    • Syphilis testing, typing, and treatment follow-up: A new era for an old disease
    • Tipple, C., Taylor, G. P. Syphilis testing, typing, and treatment follow-up: a new era for an old disease. Curr. Opin. Infect. Dis. 28, 53-60 (2015).
    • (2015) Curr. Opin. Infect. Dis. , vol.28 , pp. 53-60
    • Tipple, C.1    Taylor, G.P.2
  • 39
    • 1642301383 scopus 로고    scopus 로고
    • False-positive gonorrhea test results with a nucleic acid amplification test: The impact of low prevalence on positive predictive value
    • Katz, A. R., et al. False-positive gonorrhea test results with a nucleic acid amplification test: the impact of low prevalence on positive predictive value. Clin. Infect. Dis. 38, 814-819 (2004).
    • (2004) Clin. Infect. Dis. , vol.38 , pp. 814-819
    • Katz, A.R.1
  • 40
    • 12244302907 scopus 로고    scopus 로고
    • Evaluation of the specificities of five DNA amplification methods for the detection of Neisseria gonorrhoeae
    • Palmer, H. M., Mallinson, H., Wood, R. L., Herring, A. J. Evaluation of the specificities of five DNA amplification methods for the detection of Neisseria gonorrhoeae. J. Clin. Microbiol. 41, 835-837 (2003).
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 835-837
    • Palmer, H.M.1    Mallinson, H.2    Wood, R.L.3    Herring, A.J.4
  • 41
    • 80053492077 scopus 로고    scopus 로고
    • Evaluation of six commercial nucleic acid amplification tests for detection of Neisseria gonorrhoeae and other Neisseria species
    • Tabrizi, S. N., et al. Evaluation of six commercial nucleic acid amplification tests for detection of Neisseria gonorrhoeae and other Neisseria species. J. Clin. Microbiol. 49, 3610-3615 (2011).
    • (2011) J. Clin. Microbiol. , vol.49 , pp. 3610-3615
    • Tabrizi, S.N.1
  • 42
    • 32944465964 scopus 로고    scopus 로고
    • Nucleic acid amplification testing for Neisseria gonorrhoeae: An ongoing challenge
    • Whiley, D. M., Tapsall, J. W., Sloots, T. P. Nucleic acid amplification testing for Neisseria gonorrhoeae: an ongoing challenge. J. Mol. Diagn. 8, 3-15 (2006).
    • (2006) J. Mol. Diagn. , vol.8 , pp. 3-15
    • Whiley, D.M.1    Tapsall, J.W.2    Sloots, T.P.3
  • 43
    • 84947795754 scopus 로고    scopus 로고
    • Evaluation of the new BD Max GC real-time PCR assay, analytically and clinically as a supplementary test for the BD ProbeTec GC Qx Amplified DNA Assay, for molecular detection of Neisseria gonorrhoeae
    • Golparian, D., Boräng, S., Sundqvist, M., Unemo, M. Evaluation of the new BD Max GC real-time PCR assay, analytically and clinically as a supplementary test for the BD ProbeTec GC Qx Amplified DNA Assay, for molecular detection of Neisseria gonorrhoeae. J. Clin. Microbiol. 53, 3935-3937 (2015).
    • (2015) J. Clin. Microbiol. , vol.53 , pp. 3935-3937
    • Golparian, D.1    Boräng, S.2    Sundqvist, M.3    Unemo, M.4
  • 44
    • 33749993594 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of nucleic acid detection tests for Neisseria gonorrhoeae in Australia: A position paper on behalf of the Public Health Laboratory Network
    • Smith, D. W., Tapsall, J. W., Lum, G. Guidelines for the use and interpretation of nucleic acid detection tests for Neisseria gonorrhoeae in Australia: a position paper on behalf of the Public Health Laboratory Network. Commun. Dis. Intell. Q. Rep. 29, 358-365 (2005).
    • (2005) Commun. Dis. Intell. Q. Rep. , vol.29 , pp. 358-365
    • Smith, D.W.1    Tapsall, J.W.2    Lum, G.3
  • 45
    • 84989946020 scopus 로고    scopus 로고
    • A comparison of agar dilution with the Calibrated Dichotomous Sensitivity (CDS) and Etest methods for determining the minimum inhibitory concentration of ceftriaxone against Neisseria gonorrhoeae
    • Enriquez, R. P., Goire, N., Kundu, R., Gatus, B. J., Lahra, M. M. A comparison of agar dilution with the Calibrated Dichotomous Sensitivity (CDS) and Etest methods for determining the minimum inhibitory concentration of ceftriaxone against Neisseria gonorrhoeae. Diagn. Microbiol. Infect. Dis. 86, 40-43 (2016).
    • (2016) Diagn. Microbiol. Infect. Dis. , vol.86 , pp. 40-43
    • Enriquez, R.P.1    Goire, N.2    Kundu, R.3    Gatus, B.J.4    Lahra, M.M.5
  • 46
    • 84952719585 scopus 로고    scopus 로고
    • Molecular tests for the detection of antimicrobial resistant Neisseria gonorrhoeae: When, where, and how to use?
    • Low, N., Unemo, M. Molecular tests for the detection of antimicrobial resistant Neisseria gonorrhoeae: when, where, and how to use? Curr. Opin. Infect. Dis. 29, 45-51 (2016).
    • (2016) Curr. Opin. Infect. Dis. , vol.29 , pp. 45-51
    • Low, N.1    Unemo, M.2
  • 47
    • 84895423728 scopus 로고    scopus 로고
    • Molecular diagnostics for gonorrhoea: Implications for antimicrobial resistance and the threat of untreatable gonorrhoea
    • Low, N., Unemo, M., Jensen, J. S., Breuer, J., Stephenson, J. M. Molecular diagnostics for gonorrhoea: implications for antimicrobial resistance and the threat of untreatable gonorrhoea. PLoS Med. 11, e1001598 (2014).
    • (2014) PLoS Med. , vol.11 , pp. e1001598
    • Low, N.1    Unemo, M.2    Jensen, J.S.3    Breuer, J.4    Stephenson, J.M.5
  • 48
    • 84894059217 scopus 로고    scopus 로고
    • Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance
    • Goire, N., et al. Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. Nat. Rev. Microbiol. 12, 223-229 (2014).
    • (2014) Nat. Rev. Microbiol. , vol.12 , pp. 223-229
    • Goire, N.1
  • 49
    • 70350627375 scopus 로고    scopus 로고
    • Meeting the public health challenge of multidrug-and extensively drug-resistant Neisseria gonorrhoeae
    • Tapsall, J. W., Ndowa, F., Lewis, D. A., Unemo, M. Meeting the public health challenge of multidrug-and extensively drug-resistant Neisseria gonorrhoeae. Expert Rev. Anti. Infect. Ther. 7, 821-834 (2009).
    • (2009) Expert Rev. Anti. Infect. Ther. , vol.7 , pp. 821-834
    • Tapsall, J.W.1    Ndowa, F.2    Lewis, D.A.3    Unemo, M.4
  • 50
    • 78649801372 scopus 로고    scopus 로고
    • Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment Norway 2010
    • Unemo, M., Golparian, D., Syversen, G., Vestrheim, D. F., Moi, H. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. Euro Surveill. 15, 19721 (2010).
    • (2010) Euro Surveill. , vol.15 , pp. 19721
    • Unemo, M.1    Golparian, D.2    Syversen, G.3    Vestrheim, D.F.4    Moi, H.5
  • 51
    • 79955441458 scopus 로고    scopus 로고
    • Gonorrhoea treatment failures to cefixime and azithromycin in England
    • Ison, C. A., Hussey, J., Sankar, K. N., Evans, J., Alexander, S. Gonorrhoea treatment failures to cefixime and azithromycin in England. Euro Surveill. 16, 19833 (2011).
    • (2011) Euro Surveill. , vol.16 , pp. 19833
    • Ison, C.A.1    Hussey, J.2    Sankar, K.N.3    Evans, J.4    Alexander, S.5
  • 52
    • 80455144975 scopus 로고    scopus 로고
    • First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria 2011
    • Unemo, M., Golparian, D., Stary, A., Eigentler, A. First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. Euro Surveill. 16, 19998 (2011).
    • (2011) Euro Surveill. , vol.16 , pp. 19998
    • Unemo, M.1    Golparian, D.2    Stary, A.3    Eigentler, A.4
  • 53
    • 84857146496 scopus 로고    scopus 로고
    • High-level cefixime-and ceftriaxone-resistant N. Gonorrhoeae in France: Novel penA mosaic allele in a successful international clone causes treatment failure
    • Unemo, M., et al. High-level cefixime-and ceftriaxone-resistant N. gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob. Agents Chemother. 56, 1273-1280 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 1273-1280
    • Unemo, M.1
  • 54
    • 84872054118 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto Canada
    • Allen, V. G., et al. Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada. JAMA 309, 163-170 (2013).
    • (2013) JAMA , vol.309 , pp. 163-170
    • Allen, V.G.1
  • 55
    • 84929883999 scopus 로고    scopus 로고
    • Gonorrhea treatment failures with oral and injectable expanded spectrum cephalosporin monotherapy versus dual therapy at 4 Canadian sexually transmitted infection clinics 2010-2013
    • Singh, A. E., et al. Gonorrhea treatment failures with oral and injectable expanded spectrum cephalosporin monotherapy versus dual therapy at 4 Canadian sexually transmitted infection clinics, 2010-2013. Sex. Transm. Dis. 42, 331-336 (2015).
    • (2015) Sex. Transm. Dis. , vol.42 , pp. 331-336
    • Singh, A.E.1
  • 56
    • 84884922548 scopus 로고    scopus 로고
    • Phenotypic and genetic characterization of the first two cases of extended-spectrum cephalosporin resistant Neisseria gonorrhoeae infection in South Africa and association with cefixime treatment failure
    • Lewis, D. A., et al. Phenotypic and genetic characterization of the first two cases of extended-spectrum cephalosporin resistant Neisseria gonorrhoeae infection in South Africa and association with cefixime treatment failure. J. Antimicrob. Chemother. 68, 1267-1270 (2013).
    • (2013) J. Antimicrob. Chemother. , vol.68 , pp. 1267-1270
    • Lewis, D.A.1
  • 57
    • 79959189164 scopus 로고    scopus 로고
    • Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea? Detailed characterization of the first strain with high-level resistance to ceftriaxone
    • Ohnishi, M., et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea? Detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob. Agents Chemother. 55, 3538-3545 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 3538-3545
    • Ohnishi, M.1
  • 58
    • 67650488213 scopus 로고    scopus 로고
    • Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods
    • Tapsall, J., et al. Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods. J. Med. Microbiol. 58, 683-687 (2009).
    • (2009) J. Med. Microbiol. , vol.58 , pp. 683-687
    • Tapsall, J.1
  • 59
    • 84891462477 scopus 로고    scopus 로고
    • Failure of ceftriaxone 500 mg to eradicate pharyngeal gonorrhoea Australia
    • Chen, Y. M., et al. Failure of ceftriaxone 500 mg to eradicate pharyngeal gonorrhoea, Australia. J. Antimicrob. Chemother. 68, 1445-1447 (2013).
    • (2013) J. Antimicrob. Chemother. , vol.68 , pp. 1445-1447
    • Chen, Y.M.1
  • 60
    • 84886926874 scopus 로고    scopus 로고
    • One confirmed and one suspected case of pharyngeal gonorrhoea treatment failure following 500 mg ceftriaxone in Sydney Australia
    • Read, P. J., Limnios, E. A., McNulty, A., Whiley, D., Lahra, L. M. One confirmed and one suspected case of pharyngeal gonorrhoea treatment failure following 500 mg ceftriaxone in Sydney, Australia. Sex. Health 10, 460-462 (2013).
    • (2013) Sex. Health , vol.10 , pp. 460-462
    • Read, P.J.1    Limnios, E.A.2    McNulty, A.3    Whiley, D.4    Lahra, L.M.5
  • 61
    • 79951640425 scopus 로고    scopus 로고
    • Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010
    • Unemo, M., Golparian, D., Hestner, A. Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010. Euro Surveill. 16, 1-3 (2011).
    • (2011) Euro Surveill. , vol.16 , pp. 1-3
    • Unemo, M.1    Golparian, D.2    Hestner, A.3
  • 62
    • 85029592986 scopus 로고    scopus 로고
    • Four treatment failures of pharyngeal gonorrhoea with ceftriaxone (500 mg) or cefotaxime (500 mg), Sweden, 2013 and 2014
    • Golparian, D., et al. Four treatment failures of pharyngeal gonorrhoea with ceftriaxone (500 mg) or cefotaxime (500 mg), Sweden, 2013 and 2014. Euro Surveill. 19, 20862 (2014).
    • (2014) Euro Surveill. , vol.19 , pp. 20862
    • Golparian, D.1
  • 63
    • 84862838826 scopus 로고    scopus 로고
    • Treatment failure of pharyngeal gonorrhoea with internationally recommended first-line ceftriaxone verified in Slovenia, September 2011
    • Unemo, M., Golparian, D., Potoc?nik, M., Jeverica, S. Treatment failure of pharyngeal gonorrhoea with internationally recommended first-line ceftriaxone verified in Slovenia, September 2011. Euro Surveill. 17, 1-4 (2012).
    • (2012) Euro Surveill. , vol.17 , pp. 1-4
    • Unemo, M.1    Golparian, D.2    Potocnik, M.3    Jeverica, S.4
  • 64
    • 84864505639 scopus 로고    scopus 로고
    • Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia Spain
    • Cámara, J., et al. Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J. Antimicrob. Chemother. 67, 1858-1860 (2012).
    • (2012) J. Antimicrob. Chemother. , vol.67 , pp. 1858-1860
    • Cámara, J.1
  • 65
    • 78449242759 scopus 로고    scopus 로고
    • Recommended antimicrobial treatment of uncomplicated gonorrhoea in 2009 in 11 East European countries: Implementation of a Neisseria gonorrhoeae antimicrobial susceptibility programme in this region is crucial
    • Unemo, M., Shipitsyna, E., Domeika, M. Recommended antimicrobial treatment of uncomplicated gonorrhoea in 2009 in 11 East European countries: implementation of a Neisseria gonorrhoeae antimicrobial susceptibility programme in this region is crucial. Sex. Transm. Infect. 86, 442-444 (2010).
    • (2010) Sex. Transm. Infect. , vol.86 , pp. 442-444
    • Unemo, M.1    Shipitsyna, E.2    Domeika, M.3
  • 66
    • 68249126403 scopus 로고    scopus 로고
    • Implications of current recommendations for third-generation cephalosporin use in the WHO Western Pacific Region following the emergence of multiresistant gonococci
    • Tapsall, J. W. Implications of current recommendations for third-generation cephalosporin use in the WHO Western Pacific Region following the emergence of multiresistant gonococci. Sex. Transm. Infect. 85, 256-258 (2009).
    • (2009) Sex. Transm. Infect. , vol.85 , pp. 256-258
    • Tapsall, J.W.1
  • 67
    • 84870998337 scopus 로고    scopus 로고
    • Sexually transmitted infections, diagnosis and treatment guidelines 2011
    • Japanese Society of Sexually Transmitted Infection. Gonococcal infection
    • Japanese Society of Sexually Transmitted Infection. Gonococcal infection. Sexually transmitted infections, diagnosis and treatment guidelines 2011. Jpn J. Sex. Transm. Dis. 22 (Suppl. 1), 52-59 (2011).
    • (2011) Jpn J. Sex. Transm. Dis. , vol.22 , pp. 52-59
  • 68
    • 85013350957 scopus 로고    scopus 로고
    • Microbiological efficacy and tolerability of a single-dose regimen of 1 g of ceftriaxone in men with gonococcal urethritis
    • Ito, S., et al. Microbiological efficacy and tolerability of a single-dose regimen of 1 g of ceftriaxone in men with gonococcal urethritis. J. Antimicrob. Chemother. 71, 2559-2562 (2016).
    • (2016) J. Antimicrob. Chemother. , vol.71 , pp. 2559-2562
    • Ito, S.1
  • 69
    • 78449263982 scopus 로고    scopus 로고
    • The gonococcus fights back: Is this time a knock out?
    • Lewis, D. A. The gonococcus fights back: is this time a knock out? Sex. Transm. Infect. 86, 415-421 (2010).
    • (2010) Sex. Transm. Infect. , vol.86 , pp. 415-421
    • Lewis, D.A.1
  • 71
    • 19944429215 scopus 로고    scopus 로고
    • Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan
    • Ito, M., et al. Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan. Antimicrob. Agents Chemother. 49, 137-143 (2005).
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 137-143
    • Ito, M.1
  • 72
    • 84938791537 scopus 로고    scopus 로고
    • Is the tide turning again for cephalosporin resistance in Neisseria gonorrhoeae in Europe? Results from the 2013 European surveillance
    • Cole, M. J., et al. Is the tide turning again for cephalosporin resistance in Neisseria gonorrhoeae in Europe? Results from the 2013 European surveillance. BMC Infect. Dis. 15, 321 (2015).
    • (2015) BMC Infect. Dis. , vol.15 , pp. 321
    • Cole, M.J.1
  • 73
    • 84981318930 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae antimicrobial susceptibility surveillance-the Gonococcal Isolate Surveillance Project, 27 sites, United States 2014
    • Kirkcaldy, R. D., et al. Neisseria gonorrhoeae antimicrobial susceptibility surveillance-the Gonococcal Isolate Surveillance Project, 27 sites, United States, 2014. MMWR Surveill. Summ. 65, 1-19 (2016).
    • (2016) MMWR Surveill. Summ. , vol.65 , pp. 1-19
    • Kirkcaldy, R.D.1
  • 74
    • 84982932015 scopus 로고    scopus 로고
    • An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England
    • Chisholm, S. A., et al. An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England. Sex. Transm. Infect. 92, 365-367 (2016).
    • (2016) Sex. Transm. Infect. , vol.92 , pp. 365-367
    • Chisholm, S.A.1
  • 75
    • 84964950008 scopus 로고    scopus 로고
    • Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014
    • Demczuk, W., et al. Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014. J. Clin. Microbiol. 54, 1304-1313 (2016).
    • (2016) J. Clin. Microbiol. , vol.54 , pp. 1304-1313
    • Demczuk, W.1
  • 76
    • 84975463539 scopus 로고    scopus 로고
    • Failure of dual antimicrobial therapy in treatment of gonorrhea
    • Fifer, H., et al. Failure of dual antimicrobial therapy in treatment of gonorrhea. N. Engl. J. Med. 374, 2504-2506 (2016).
    • (2016) N. Engl. J. Med. , vol.374 , pp. 2504-2506
    • Fifer, H.1
  • 77
    • 84986268624 scopus 로고    scopus 로고
    • The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea
    • Kirkcaldy, R. D., et al. The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea. Clin. Infect. Dis. 59, 1083-1091 (2014).
    • (2014) Clin. Infect. Dis. , vol.59 , pp. 1083-1091
    • Kirkcaldy, R.D.1
  • 78
    • 84862583917 scopus 로고    scopus 로고
    • In vitro activity of ertapenem versus ceftriaxone against Neisseria gonorrhoeae isolates with highly diverse ceftriaxone MIC values and effects of ceftriaxone resistance determinants-ertapenem for treatment of gonorrhea?
    • Unemo, M., et al. In vitro activity of ertapenem versus ceftriaxone against Neisseria gonorrhoeae isolates with highly diverse ceftriaxone MIC values and effects of ceftriaxone resistance determinants-ertapenem for treatment of gonorrhea? Antimicrob. Agents Chemother. 56, 3603-3609 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3603-3609
    • Unemo, M.1
  • 79
    • 84903899178 scopus 로고    scopus 로고
    • Evaluation of the activity of ertapenem against gonococcal isolates exhibiting a range of susceptibilities to cefixime
    • Quaye, N., Cole, M. J., Ison, C. A. Evaluation of the activity of ertapenem against gonococcal isolates exhibiting a range of susceptibilities to cefixime. J. Antimicrob. Chemother. 69, 1568-1571 (2014).
    • (2014) J. Antimicrob. Chemother. , vol.69 , pp. 1568-1571
    • Quaye, N.1    Cole, M.J.2    Ison, C.A.3
  • 80
    • 84923234000 scopus 로고    scopus 로고
    • In vitro activity of fosfomycin alone and in combination with ceftriaxone or azithromycin against clinical Neisseria gonorrhoeae isolates
    • Hauser, C., Hirzberger, L., Unemo, M., Furrer, H., Endimiani, A. In vitro activity of fosfomycin alone and in combination with ceftriaxone or azithromycin against clinical Neisseria gonorrhoeae isolates. Antimicrob. Agents Chemother. 59, 1605-1611 (2015).
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 1605-1611
    • Hauser, C.1    Hirzberger, L.2    Unemo, M.3    Furrer, H.4    Endimiani, A.5
  • 81
    • 77649123172 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi 2007
    • Brown, L. B., et al. Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007. Sex. Transm. Dis. 37, 169-172 (2010).
    • (2010) Sex. Transm. Dis. , vol.37 , pp. 169-172
    • Brown, L.B.1
  • 82
    • 79951520585 scopus 로고    scopus 로고
    • An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe
    • Chisholm, S. A., et al. An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe. J. Antimicrob. Chemother. 66, 592-595 (2011).
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 592-595
    • Chisholm, S.A.1
  • 83
    • 84877265507 scopus 로고    scopus 로고
    • Effectiveness of gentamicin for gonorrhoea treatment: Systematic review and meta-analysis
    • Dowell, D., Kirkcaldy, R. D. Effectiveness of gentamicin for gonorrhoea treatment: systematic review and meta-analysis. Sex. Transm. Infect. 89, 142-147 (2013).
    • (2013) Sex. Transm. Infect. , vol.89 , pp. 142-147
    • Dowell, D.1    Kirkcaldy, R.D.2
  • 84
    • 84928045158 scopus 로고    scopus 로고
    • The effectiveness of gentamicin in the treatment of Neisseria gonorrhoeae: A systematic review
    • Hathorn, E., Dhasmana, D., Duley, L., Ross, J. D. The effectiveness of gentamicin in the treatment of Neisseria gonorrhoeae: a systematic review. Syst. Rev. 3, 104 (2014).
    • (2014) Syst. Rev. , vol.3 , pp. 104
    • Hathorn, E.1    Dhasmana, D.2    Duley, L.3    Ross, J.D.4
  • 85
    • 84957624350 scopus 로고    scopus 로고
    • New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae
    • Lee, H., Lee, K., Chong, Y. New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae. Expert Rev. Anti. Infect. Ther. 14, 243-256 (2016).
    • (2016) Expert Rev. Anti. Infect. Ther. , vol.14 , pp. 243-256
    • Lee, H.1    Lee, K.2    Chong, Y.3
  • 86
    • 84860176932 scopus 로고    scopus 로고
    • In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains including those with various high-level antimicrobial resistance-potential treatment option for gonorrhea?
    • Golparian, D., Fernandes, P., Ohnishi, M., Jensen, J. S., Unemo, M. In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains including those with various high-level antimicrobial resistance-potential treatment option for gonorrhea? Antimicrob. Agents Chemother. 56, 2739-2742 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2739-2742
    • Golparian, D.1    Fernandes, P.2    Ohnishi, M.3    Jensen, J.S.4    Unemo, M.5
  • 87
    • 78649681337 scopus 로고    scopus 로고
    • Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis
    • Llano-Sotelo, B., et al. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob. Agents Chemother. 54, 4961-4970 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 4961-4970
    • Llano-Sotelo, B.1
  • 88
    • 79955542813 scopus 로고    scopus 로고
    • Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects
    • Still, J. G., et al. Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects. Antimicrob. Agents Chemother. 55, 1997-2003 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 1997-2003
    • Still, J.G.1
  • 89
    • 84942087886 scopus 로고    scopus 로고
    • A Phase 2 trial of oral solithromycin 1200 mg or 1000 mg as single-dose oral therapy for uncomplicated gonorrhea
    • Hook, E. W. III, et al. A Phase 2 trial of oral solithromycin 1200 mg or 1000 mg as single-dose oral therapy for uncomplicated gonorrhea. Clin. Infect. Dis. 61, 1043-1048 (2015).
    • (2015) Clin. Infect. Dis. , vol.61 , pp. 1043-1048
    • Hook, E.W.1
  • 90
    • 84906090956 scopus 로고    scopus 로고
    • High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea
    • Jacobsson, S., et al. High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea. Antimicrob. Agents Chemother. 58, 5585-5588 (2014).
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 5585-5588
    • Jacobsson, S.1
  • 91
    • 84920148657 scopus 로고    scopus 로고
    • In vitro antibacterial activity of AZD0914: A new spiropyrimidinetrione DNA Gyrase/Topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-negative, and atypical bacteria
    • Huband, M. D., et al. In vitro antibacterial activity of AZD0914: a new spiropyrimidinetrione DNA Gyrase/Topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-negative, and atypical bacteria. Antimicrob. Agents Chemother. 59, 467-474 (2015).
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 467-474
    • Huband, M.D.1
  • 92
    • 84940951189 scopus 로고    scopus 로고
    • High in vitro susceptibility to the novel spiropyrimidinetrione ETX0914 (also known as AZD0914) among 873 contemporary clinical Neisseria gonorrhoeae isolates in 21 European countries during 2012-2014
    • Unemo, M., et al. High in vitro susceptibility to the novel spiropyrimidinetrione ETX0914 (also known as AZD0914) among 873 contemporary clinical Neisseria gonorrhoeae isolates in 21 European countries during 2012-2014. Antimicrob. Agents Chemother. 59, 5220-5225 (2015).
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 5220-5225
    • Unemo, M.1
  • 93
    • 84954123504 scopus 로고    scopus 로고
    • Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae
    • Foerster, S., et al. Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae. Front. Microbiol. 6, 1377 (2015).
    • (2015) Front. Microbiol. , vol.6 , pp. 1377
    • Foerster, S.1
  • 94
    • 84937047439 scopus 로고    scopus 로고
    • Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial type II topoisomerases
    • Basarab, G. S., et al. Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial type II topoisomerases. Sci. Rep. 5, 11827 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 11827
    • Basarab, G.S.1
  • 95
    • 84923240925 scopus 로고    scopus 로고
    • Characterization of the novel DNA gyrase inhibitor AZD0914: Low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae
    • Alm, R. A., et al. Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae. Antimicrob. Agents Chemother. 59, 1478-1486 (2015).
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 1478-1486
    • Alm, R.A.1
  • 96
    • 84942849082 scopus 로고    scopus 로고
    • Non-clinical safety profile of a novel gyrase inhibitor for treatment of Neisseria gonorrhoeae infections, poster F-268 [abstract]
    • American Society for Microbiology, Washington, District of Columbia, USA
    • Basarab, G. S., et al. Non-clinical safety profile of a novel gyrase inhibitor for treatment of Neisseria gonorrhoeae infections, poster F-268 [abstract]. 54th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, District of Columbia, USA (2014).
    • (2014) 54th Intersci. Conf. Antimicrob. Agents Chemother
    • Basarab, G.S.1
  • 97
    • 85014482348 scopus 로고    scopus 로고
    • Safety pharmacokinetics of single escalating oral doses of A. Z. D. 0914: A novel spiropyrimidinetrione antibacterial agent, poster F.-267 [abstract]
    • American Society for Microbiology, Washington, District of Columbia, USA
    • Lawrence, K. O'Connor, K., Atuah, K., Matthews, D., Gardner, H. Safety, pharmacokinetics of single escalating oral doses of A. Z. D. 0914: a novel spiropyrimidinetrione antibacterial agent, poster F.-267 [abstract]. 54th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, District of Columbia, USA (2014).
    • (2014) 54th Intersci. Conf. Antimicrob. Agents Chemother
    • Lawrence O'Connor, K.K.1    Atuah, K.2    Matthews, D.3    Gardner, H.4
  • 98
    • 84957877111 scopus 로고    scopus 로고
    • Multidrug-resistant Neisseria gonorrhoeae isolates from Nanjing, China, are sensitive to killing by a novel DNA Gyrase inhibitor, ETX0914 (AZD0914)
    • Su, X. H., et al. Multidrug-resistant Neisseria gonorrhoeae isolates from Nanjing, China, are sensitive to killing by a novel DNA Gyrase inhibitor, ETX0914 (AZD0914). Antimicrob. Agents Chemother. 60, 621-623 (2015).
    • (2015) Antimicrob. Agents Chemother. , vol.60 , pp. 621-623
    • Su, X.H.1
  • 99
    • 84962251251 scopus 로고    scopus 로고
    • ClinicalTrials. gov
    • US National Library of Medicine. ClinicalTrials. gov https://clinicaltrials. gov/ct2/show/NCT02210325 (2016).
    • (2016) US National Library of Medicine
  • 100
    • 85014489108 scopus 로고    scopus 로고
    • A phase II trial of single-dose oral ETX0914 (AZD0914) for treatment of uncomplicated urogenital gonorrhea [abstract 5B5]
    • Taylor, S. N., et al. A phase II trial of single-dose oral ETX0914 (AZD0914) for treatment of uncomplicated urogenital gonorrhea [abstract 5B5]. 2016 STD Prevention Conference https://cdc. confex. com/cdc/std2016/webprogram/Paper37739. html (2016).
    • (2016) 2016 STD Prevention Conference
    • Taylor, S.N.1
  • 101
    • 0019473954 scopus 로고
    • A newly discovered mycoplasma in the human urogenital tract
    • Tully, J. G., Taylor-Robinson, D., Cole, R. M., Rose, D. L. A newly discovered mycoplasma in the human urogenital tract. Lancet 1, 1288-1291 (1981).
    • (1981) Lancet , vol.1 , pp. 1288-1291
    • Tully, J.G.1    Taylor-Robinson, D.2    Cole, R.M.3    Rose, D.L.4
  • 103
    • 0030049587 scopus 로고    scopus 로고
    • Isolation of Mycoplasma genitalium strains from the male urethra
    • Jensen, J. S., Hansen, H. T., Lind, K. Isolation of Mycoplasma genitalium strains from the male urethra. J. Clin. Microbiol. 34, 286-291 (1996).
    • (1996) J. Clin. Microbiol. , vol.34 , pp. 286-291
    • Jensen, J.S.1    Hansen, H.T.2    Lind, K.3
  • 104
    • 28844450228 scopus 로고    scopus 로고
    • Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5' nuclease real-time PCR
    • Hamasuna, R., Osada, Y., Jensen, J. S. Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5' nuclease real-time PCR. Antimicrob. Agents Chemother. 49, 4993-4998 (2005).
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 4993-4998
    • Hamasuna, R.1    Osada, Y.2    Jensen, J.S.3
  • 105
    • 56749097771 scopus 로고    scopus 로고
    • Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance
    • Jensen, J. S., Bradshaw, C. S., Tabrizi, S. N., Fairley, C. K., Hamasuna, R. Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin. Infect. Dis. 47, 1546-1553 (2008).
    • (2008) Clin. Infect. Dis. , vol.47 , pp. 1546-1553
    • Jensen, J.S.1    Bradshaw, C.S.2    Tabrizi, S.N.3    Fairley, C.K.4    Hamasuna, R.5
  • 107
    • 0026424255 scopus 로고
    • Development and evaluation of the polymerase chain reaction to detect Mycoplasma genitalium
    • Palmer, H. M., Gilroy, C. B., Furr, P. M., Taylor-Robinson, D. Development and evaluation of the polymerase chain reaction to detect Mycoplasma genitalium. FEMS Microbiol. Lett. 61, 199-203 (1991).
    • (1991) FEMS Microbiol. Lett. , vol.61 , pp. 199-203
    • Palmer, H.M.1    Gilroy, C.B.2    Furr, P.M.3    Taylor-Robinson, D.4
  • 109
    • 84938604217 scopus 로고    scopus 로고
    • Mycoplasma genitalium infection and female reproductive tract disease: A meta-analysis
    • Lis, R., Rowhani-Rahbar, A., Manhart, L. E. Mycoplasma genitalium infection and female reproductive tract disease: a meta-analysis. Clin. Infect. Dis. 61, 418-426 (2015).
    • (2015) Clin. Infect. Dis. , vol.61 , pp. 418-426
    • Lis, R.1    Rowhani-Rahbar, A.2    Manhart, L.E.3
  • 110
    • 0027234069 scopus 로고
    • Mycoplasma genitalium: A cause of male urethritis?
    • Jensen, J. S., et al. Mycoplasma genitalium: a cause of male urethritis? Genitourin. Med. 69, 265-269 (1993).
    • (1993) Genitourin. Med. , vol.69 , pp. 265-269
    • Jensen, J.S.1
  • 111
    • 0027305503 scopus 로고
    • Association of Mycoplasma genitalium with acute non-gonococcal urethritis
    • Horner, P. J., Gilroy, C. B., Thomas, B. J., Naidoo, R. O., Taylor-Robinson, D. Association of Mycoplasma genitalium with acute non-gonococcal urethritis. Lancet 342, 582-585 (1993).
    • (1993) Lancet , vol.342 , pp. 582-585
    • Horner, P.J.1    Gilroy, C.B.2    Thomas, B.J.3    Naidoo, R.O.4    Taylor-Robinson, D.5
  • 112
    • 4143049181 scopus 로고    scopus 로고
    • Symptomatic urethritis is more prevalent in men infected with Mycoplasma genitalium than with Chlamydia trachomatis
    • Falk, L., Fredlund, H., Jensen, J. S. Symptomatic urethritis is more prevalent in men infected with Mycoplasma genitalium than with Chlamydia trachomatis. Sex. Transm. Infect. 80, 289-293 (2004).
    • (2004) Sex. Transm. Infect. , vol.80 , pp. 289-293
    • Falk, L.1    Fredlund, H.2    Jensen, J.S.3
  • 113
    • 0034015547 scopus 로고    scopus 로고
    • Mycoplasma genitalium in non-gonococcal urethritis-a study in Swedish male STD patients
    • Björnelius, E., Lidbrink, P., Jensen, J. S. Mycoplasma genitalium in non-gonococcal urethritis-a study in Swedish male STD patients. Int. J. STD AIDS 11, 292-296 (2000).
    • (2000) Int. J. STD AIDS , vol.11 , pp. 292-296
    • Björnelius, E.1    Lidbrink, P.2    Jensen, J.S.3
  • 114
    • 0028223065 scopus 로고
    • Mycoplasma genitalium and non-gonococcal urethritis
    • Horner, P. J., Taylor-Robinson, D. Mycoplasma genitalium and non-gonococcal urethritis. Lancet 343, 790-791 (1994).
    • (1994) Lancet , vol.343 , pp. 790-791
    • Horner, P.J.1    Taylor-Robinson, D.2
  • 115
    • 31044454940 scopus 로고    scopus 로고
    • Etiologies of nongonococcal urethritis: Bacteria, viruses, and the association with orogenital exposure
    • Bradshaw, C. S., et al. Etiologies of nongonococcal urethritis: bacteria, viruses, and the association with orogenital exposure. J. Infect. Dis. 193, 336-345 (2006).
    • (2006) J. Infect. Dis. , vol.193 , pp. 336-345
    • Bradshaw, C.S.1
  • 116
    • 33747154784 scopus 로고    scopus 로고
    • Mycoplasma genitalium: A common cause of persistent urethritis among men treated with doxycycline
    • Wikström, A., Jensen, J. S. Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline. Sex. Transm. Infect. 82, 276-279 (2006).
    • (2006) Sex. Transm. Infect. , vol.82 , pp. 276-279
    • Wikström, A.1    Jensen, J.S.2
  • 117
    • 84973644358 scopus 로고    scopus 로고
    • Urethritis-associated pathogens in urine from men with non-gonococcal urethritis: A case-control study
    • Frølund, M., Björnelius, E., Lidbrink, P., Ahrens, P., Jensen, J. S. Urethritis-associated pathogens in urine from men with non-gonococcal urethritis: a case-control study. Acta Derm. Venereol. 96, 689-694 (2016).
    • (2016) Acta Derm. Venereol. , vol.96 , pp. 689-694
    • Frølund, M.1    Björnelius, E.2    Lidbrink, P.3    Ahrens, P.4    Jensen, J.S.5
  • 118
    • 84939513951 scopus 로고    scopus 로고
    • Management of Mycoplasma genitalium infections-can we hit a moving target?
    • Jensen, J. S., Bradshaw, C. Management of Mycoplasma genitalium infections-can we hit a moving target? BMC Infect. Dis. 15, 343 (2015).
    • (2015) BMC Infect. Dis. , vol.15 , pp. 343
    • Jensen, J.S.1    Bradshaw, C.2
  • 119
    • 0037006632 scopus 로고    scopus 로고
    • Association between Mycoplasma genitalium and acute endometritis
    • Cohen, C. R., et al. Association between Mycoplasma genitalium and acute endometritis. Lancet 359, 765-766 (2002).
    • (2002) Lancet , vol.359 , pp. 765-766
    • Cohen, C.R.1
  • 120
    • 0037442502 scopus 로고    scopus 로고
    • Mucopurulent cervicitis and Mycoplasma genitalium
    • Manhart, L. E., et al. Mucopurulent cervicitis and Mycoplasma genitalium. J. Infect. Dis. 187, 650-657 (2003).
    • (2003) J. Infect. Dis. , vol.187 , pp. 650-657
    • Manhart, L.E.1
  • 121
    • 29144438883 scopus 로고    scopus 로고
    • Mycoplasma genitalium: Prevalence, clinical significance, and transmission
    • Anagrius, C., Loré, B., Jensen, J. S. Mycoplasma genitalium: prevalence, clinical significance, and transmission. Sex. Transm. Infect. 81, 458-462 (2005).
    • (2005) Sex. Transm. Infect. , vol.81 , pp. 458-462
    • Anagrius, C.1    Loré, B.2    Jensen, J.S.3
  • 122
    • 13544271664 scopus 로고    scopus 로고
    • Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection
    • Falk, L., Fredlund, H., Jensen, J. S. Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex. Transm. Infect. 81, 73-78 (2005).
    • (2005) Sex. Transm. Infect. , vol.81 , pp. 73-78
    • Falk, L.1    Fredlund, H.2    Jensen, J.S.3
  • 123
    • 10844264570 scopus 로고    scopus 로고
    • Prevalence of Mycoplasma genitalium in early pregnancy and relationship between its presence and pregnancy outcome
    • Oakeshott, P., et al. Prevalence of Mycoplasma genitalium in early pregnancy and relationship between its presence and pregnancy outcome. BJOG 111, 1464-1467 (2004).
    • (2004) BJOG , vol.111 , pp. 1464-1467
    • Oakeshott, P.1
  • 124
    • 84864067900 scopus 로고    scopus 로고
    • The spread of Mycoplasma genitalium among men who have sex with men
    • Edlund, M., Blaxhult, A., Bratt, G. The spread of Mycoplasma genitalium among men who have sex with men. Int. J. STD AIDS 23, 455-456 (2012).
    • (2012) Int. J. STD AIDS , vol.23 , pp. 455-456
    • Edlund, M.1    Blaxhult, A.2    Bratt, G.3
  • 125
    • 77449102870 scopus 로고    scopus 로고
    • The prevalence of urethral and rectal Mycoplasma genitalium and its associations in men who have sex with men attending a genitourinary medicine clinic
    • Soni, S., et al. The prevalence of urethral and rectal Mycoplasma genitalium and its associations in men who have sex with men attending a genitourinary medicine clinic. Sex. Transm. Infect. 86, 21-24 (2010).
    • (2010) Sex. Transm. Infect. , vol.86 , pp. 21-24
    • Soni, S.1
  • 126
    • 79955526112 scopus 로고    scopus 로고
    • Utility of urine, vaginal, cervical, and rectal specimens for detection of Mycoplasma genitalium in women
    • Lillis, R. A., Nsuami, M. J., Myers, L., Martin, D. H. Utility of urine, vaginal, cervical, and rectal specimens for detection of Mycoplasma genitalium in women. J. Clin. Microbiol. 49, 1990-1992 (2011).
    • (2011) J. Clin. Microbiol. , vol.49 , pp. 1990-1992
    • Lillis, R.A.1    Nsuami, M.J.2    Myers, L.3    Martin, D.H.4
  • 127
    • 3342979406 scopus 로고    scopus 로고
    • Comparison of first void urine and urogenital swab specimens for detection of Mycoplasma genitalium and Chlamydia trachomatis by polymerase chain reaction in patients attending a sexually transmitted disease clinic
    • Jensen, J. S., Björnelius, E., Dohn, B., Lidbrink, P. Comparison of first void urine and urogenital swab specimens for detection of Mycoplasma genitalium and Chlamydia trachomatis by polymerase chain reaction in patients attending a sexually transmitted disease clinic. Sex. Transm. Dis. 31, 499-507 (2004).
    • (2004) Sex. Transm. Dis. , vol.31 , pp. 499-507
    • Jensen, J.S.1    Björnelius, E.2    Dohn, B.3    Lidbrink, P.4
  • 128
    • 84962737609 scopus 로고    scopus 로고
    • Epidemiology of Mycoplasma genitalium in British men and women aged 16-44 years: Evidence from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)
    • Sonnenberg, P., et al. Epidemiology of Mycoplasma genitalium in British men and women aged 16-44 years: evidence from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Int. J. Epidemiol. 44, 1982-1994 (2015).
    • (2015) Int. J. Epidemiol. , vol.44 , pp. 1982-1994
    • Sonnenberg, P.1
  • 129
    • 33947200740 scopus 로고    scopus 로고
    • Isolation of Mycoplasma genitalium from first-void urine specimens by coculture with Vero cells
    • Hamasuna, R., Osada, Y., Jensen, J. S. Isolation of Mycoplasma genitalium from first-void urine specimens by coculture with Vero cells. J. Clin. Microbiol. 45, 847-850 (2007).
    • (2007) J. Clin. Microbiol. , vol.45 , pp. 847-850
    • Hamasuna, R.1    Osada, Y.2    Jensen, J.S.3
  • 130
    • 84979539460 scopus 로고    scopus 로고
    • Evaluation of the Hologic Panther transcription mediated amplification assay for detection of Mycoplasma genitalium
    • Tabrizi, S. N., et al. Evaluation of the Hologic Panther transcription mediated amplification assay for detection of Mycoplasma genitalium. J. Clin. Microbiol. 54, 2201-2203 (2016).
    • (2016) J. Clin. Microbiol. , vol.54 , pp. 2201-2203
    • Tabrizi, S.N.1
  • 132
    • 70350331088 scopus 로고    scopus 로고
    • Antimicrobial susceptibilities of Mycoplasma genitalium by broth dilution and quantitative PCR
    • Hamasuna, R., Jensen, J. S., Osada, Y. Antimicrobial susceptibilities of Mycoplasma genitalium by broth dilution and quantitative PCR. Antimicrob. Agents Chemother. 53, 4938-4939 (2009).
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4938-4939
    • Hamasuna, R.1    Jensen, J.S.2    Osada, Y.3
  • 133
    • 84901053866 scopus 로고    scopus 로고
    • In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and-susceptible Mycoplasma genitalium strains
    • Jensen, J. S., Fernandes, P., Unemo, M. In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and-susceptible Mycoplasma genitalium strains. Antimicrob. Agents Chemother. 58, 3151-3156 (2014).
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 3151-3156
    • Jensen, J.S.1    Fernandes, P.2    Unemo, M.3
  • 134
    • 84867564077 scopus 로고    scopus 로고
    • Standardized methods and quality control limits for agar and broth microdilution susceptibility testing of Mycoplasma pneumoniae Mycoplasma hominis, and Ureaplasma urealyticum
    • Waites, K. B., et al. Standardized methods and quality control limits for agar and broth microdilution susceptibility testing of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum. J. Clin. Microbiol. 50, 3542-3547 (2012).
    • (2012) J. Clin. Microbiol. , vol.50 , pp. 3542-3547
    • Waites, K.B.1
  • 135
    • 33745949316 scopus 로고    scopus 로고
    • Azithromycin failure in Mycoplasma genitalium urethritis
    • Bradshaw, C. S., et al. Azithromycin failure in Mycoplasma genitalium urethritis. Emerg. Infect. Dis. 12, 1149-1152 (2006).
    • (2006) Emerg. Infect. Dis. , vol.12 , pp. 1149-1152
    • Bradshaw, C.S.1
  • 136
    • 0026538607 scopus 로고
    • In-vitro susceptibilities of Mycoplasma genitalium to antibiotics
    • Renaudin, H., Tully, J. G., Bebear, C. In-vitro susceptibilities of Mycoplasma genitalium to antibiotics. Antimicrob. Agents Chemother. 36, 870-872 (1992).
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 870-872
    • Renaudin, H.1    Tully, J.G.2    Bebear, C.3
  • 137
    • 0031725507 scopus 로고    scopus 로고
    • Comparative susceptibilities of various AIDS-associated and human urogenital tract mycoplasmas and strains of Mycoplasma pneumoniae to 10 classes of antimicrobial agent in vitro
    • Hannan, P. C. Comparative susceptibilities of various AIDS-associated and human urogenital tract mycoplasmas and strains of Mycoplasma pneumoniae to 10 classes of antimicrobial agent in vitro. J. Med. Microbiol. 47, 1115-1122 (1998).
    • (1998) J. Med. Microbiol. , vol.47 , pp. 1115-1122
    • Hannan, P.C.1
  • 138
    • 84860000290 scopus 로고    scopus 로고
    • Transmission and selection of macrolide resistant Mycoplasma genitalium infections detected by rapid high resolution melt analysis
    • Twin, J., et al. Transmission and selection of macrolide resistant Mycoplasma genitalium infections detected by rapid high resolution melt analysis. PLoS ONE 7, e35593 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e35593
    • Twin, J.1
  • 140
    • 84899540393 scopus 로고    scopus 로고
    • Direct detection of macrolide resistance in Mycoplasma genitalium isolates from clinical specimens from France by use of real-time PCR and melting curve analysis
    • Touati, A., Peuchant, O., Jensen, J. S., Bebear, C., Pereyre, S. Direct detection of macrolide resistance in Mycoplasma genitalium isolates from clinical specimens from France by use of real-time PCR and melting curve analysis. J. Clin. Microbiol. 52, 1549-1555 (2014).
    • (2014) J. Clin. Microbiol. , vol.52 , pp. 1549-1555
    • Touati, A.1    Peuchant, O.2    Jensen, J.S.3    Bebear, C.4    Pereyre, S.5
  • 141
    • 84948718569 scopus 로고    scopus 로고
    • Identification of macrolide-resistant Mycoplasma genitalium using real-time PCR
    • Wold, C., et al. Identification of macrolide-resistant Mycoplasma genitalium using real-time PCR. J. Eur. Acad. Dermatol. Venereol. 29, 1616-1620 (2015).
    • (2015) J. Eur. Acad. Dermatol. Venereol. , vol.29 , pp. 1616-1620
    • Wold, C.1
  • 142
    • 84974725329 scopus 로고    scopus 로고
    • Multiplex assay for simultaneous detection of Mycoplasma genitalium and macrolide resistance using PlexZyme and PlexPrime technology
    • Tabrizi, S. N., et al. Multiplex assay for simultaneous detection of Mycoplasma genitalium and macrolide resistance using PlexZyme and PlexPrime technology. PLoS ONE 11, e0156740 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0156740
    • Tabrizi, S.N.1
  • 143
    • 85014458799 scopus 로고    scopus 로고
    • Multiplex real-time PCR assay targeting macrolide resistance mutations in Mycoplasma genitalium [abstract P0926]
    • Thellin, O., et al. Multiplex real-time PCR assay targeting macrolide resistance mutations in Mycoplasma genitalium [abstract P0926]. 26th European Congress of Clinical Microbiology and Infectious Diseases https://www. escmid. org/escmid-publications/escmid-elibrary/?q=thellin&id= 2173&L=0&x=0&y=0 (2016).
    • (2016) 26th European Congress of Clinical Microbiology and Infectious Diseases
    • Thellin, O.1
  • 144
    • 0035184291 scopus 로고    scopus 로고
    • Analysis of the gyrA and parC genes of Mycoplasma genitalium detected in first-pass urine of men with non-gonococcal urethritis before and after fluoroquinolone treatment
    • Deguchi, T., et al. Analysis of the gyrA and parC genes of Mycoplasma genitalium detected in first-pass urine of men with non-gonococcal urethritis before and after fluoroquinolone treatment. J. Antimicrob. Chemother. 48, 742-744 (2001).
    • (2001) J. Antimicrob. Chemother. , vol.48 , pp. 742-744
    • Deguchi, T.1
  • 145
    • 85014494730 scopus 로고    scopus 로고
    • Simultaneous detection of Mycoplasma genitalium and key mutations conferring resistance to fluoroquinolone antibiotics using a novel real-time QPCR technology [abstract S5]
    • Walker, S., et al. Simultaneous detection of Mycoplasma genitalium and key mutations conferring resistance to fluoroquinolone antibiotics using a novel real-time QPCR technology [abstract S5]. 21st Congress of the International Organization for Mycoplasmology (2016).
    • (2016) 21st Congress of the International Organization for Mycoplasmology
    • Walker, S.1
  • 146
    • 84894247045 scopus 로고    scopus 로고
    • High prevalence of antibiotic-resistant Mycoplasma genitalium in nongonococcal urethritis: The need for routine testing and the inadequacy of current treatment options
    • Pond, M. J., et al. High prevalence of antibiotic-resistant Mycoplasma genitalium in nongonococcal urethritis: the need for routine testing and the inadequacy of current treatment options. Clin. Infect. Dis. 58, 631-637 (2014).
    • (2014) Clin. Infect. Dis. , vol.58 , pp. 631-637
    • Pond, M.J.1
  • 147
    • 84905979525 scopus 로고    scopus 로고
    • Remarkable increase in fluoroquinolone-resistant Mycoplasma genitalium in Japan
    • Kikuchi, M., et al. Remarkable increase in fluoroquinolone-resistant Mycoplasma genitalium in Japan. J. Antimicrob. Chemother. 69, 2376-2382 (2014).
    • (2014) J. Antimicrob. Chemother. , vol.69 , pp. 2376-2382
    • Kikuchi, M.1
  • 148
    • 77954958494 scopus 로고    scopus 로고
    • Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistance
    • Shimada, Y., et al. Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistance. Int. J. Antimicrob. Agents 36, 255-258 (2010).
    • (2010) Int. J. Antimicrob. Agents , vol.36 , pp. 255-258
    • Shimada, Y.1
  • 149
    • 0026778726 scopus 로고
    • A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis
    • Martin, D. H., et al. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. N. Engl. J. Med. 327, 921-925 (1992).
    • (1992) N. Engl. J. Med. , vol.327 , pp. 921-925
    • Martin, D.H.1
  • 150
    • 84891835202 scopus 로고    scopus 로고
    • Time to manage Mycoplasma genitalium as an STI: But not with azithromycin 1 g
    • Horner, P., Blee, K., Adams, E. Time to manage Mycoplasma genitalium as an STI: but not with azithromycin 1 g! Curr. Opin. Infect. Dis. 27, 68-74 (2014).
    • (2014) Curr. Opin. Infect. Dis. , vol.27 , pp. 68-74
    • Horner, P.1    Blee, K.2    Adams, E.3
  • 151
    • 38849199660 scopus 로고    scopus 로고
    • Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: A controlled clinical trial
    • Björnelius, E., et al. Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial. Sex. Transm. Infect. 84, 72-76 (2008).
    • (2008) Sex. Transm. Infect. , vol.84 , pp. 72-76
    • Björnelius, E.1
  • 153
    • 84860324649 scopus 로고    scopus 로고
    • Mycoplasma genitalium presence, resistance and epidemiology in Greenland
    • Gesink, D. C., et al. Mycoplasma genitalium presence, resistance and epidemiology in Greenland. Int. J. Circumpolar Health 71, 1-8 (2012).
    • (2012) Int. J. Circumpolar Health , vol.71 , pp. 1-8
    • Gesink, D.C.1
  • 154
    • 84924045162 scopus 로고    scopus 로고
    • Treatment efficacy, treatment failures and selection of macrolide resistance in patients with high load of Mycoplasma genitalium during treatment of male urethritis with josamycin
    • Guschin, A., Ryzhikh, P., Rumyantseva, T., Gomberg, M., Unemo, M. Treatment efficacy, treatment failures and selection of macrolide resistance in patients with high load of Mycoplasma genitalium during treatment of male urethritis with josamycin. BMC Infect. Dis. 15, 40 (2015).
    • (2015) BMC Infect. Dis. , vol.15 , pp. 40
    • Guschin, A.1    Ryzhikh, P.2    Rumyantseva, T.3    Gomberg, M.4    Unemo, M.5
  • 155
    • 0942279624 scopus 로고    scopus 로고
    • In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae
    • Pereyre, S., et al. In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae. Antimicrob. Agents Chemother. 48, 460-465 (2004).
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 460-465
    • Pereyre, S.1
  • 156
    • 0034096392 scopus 로고    scopus 로고
    • Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden
    • Johannisson, G., et al. Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden. Int. J. STD AIDS 11, 324-326 (2000).
    • (2000) Int. J. STD AIDS , vol.11 , pp. 324-326
    • Johannisson, G.1
  • 157
    • 0034897185 scopus 로고    scopus 로고
    • Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis
    • Maeda, S. I., et al. Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis. Sex. Transm. Dis. 28, 472-476 (2001).
    • (2001) Sex. Transm. Dis. , vol.28 , pp. 472-476
    • Maeda, S.I.1
  • 158
    • 27444446953 scopus 로고    scopus 로고
    • In vitro activity of fluoroquinolones against Mycoplasma genitalium and their bacteriological efficacy for treatment of M. Genitalium-positive nongonococcal urethritis in men
    • Yasuda, M., Maeda, S., Deguchi, T. In vitro activity of fluoroquinolones against Mycoplasma genitalium and their bacteriological efficacy for treatment of M. genitalium-positive nongonococcal urethritis in men. Clin. Infect. Dis. 41, 1357-1359 (2005).
    • (2005) Clin. Infect. Dis. , vol.41 , pp. 1357-1359
    • Yasuda, M.1    Maeda, S.2    Deguchi, T.3
  • 159
    • 80051592408 scopus 로고    scopus 로고
    • Clinical efficacy of levofloxacin 500 mg once daily for 7 days for patients with non-gonococcal urethritis
    • Takahashi, S., et al. Clinical efficacy of levofloxacin 500 mg once daily for 7 days for patients with non-gonococcal urethritis. J. Infect. Chemother. 17, 392-396 (2011).
    • (2011) J. Infect. Chemother. , vol.17 , pp. 392-396
    • Takahashi, S.1
  • 160
    • 84863315906 scopus 로고    scopus 로고
    • Antimicrobial efficacies of several antibiotics against uterine cervicitis caused by Mycoplasma genitalium
    • Terada, M., Izumi, K., Ohki, E., Yamagishi, Y., Mikamo, H. Antimicrobial efficacies of several antibiotics against uterine cervicitis caused by Mycoplasma genitalium. J. Infect. Chemother. 18, 313-317 (2012).
    • (2012) J. Infect. Chemother. , vol.18 , pp. 313-317
    • Terada, M.1    Izumi, K.2    Ohki, E.3    Yamagishi, Y.4    Mikamo, H.5
  • 161
    • 56149087235 scopus 로고    scopus 로고
    • Persistence of Mycoplasma genitalium following azithromycin therapy
    • Bradshaw, C. S., Chen, M. Y., Fairley, C. K. Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS ONE 3, e3618 (2008).
    • (2008) PLoS ONE , vol.3 , pp. e3618
    • Bradshaw, C.S.1    Chen, M.Y.2    Fairley, C.K.3
  • 162
    • 84928202016 scopus 로고    scopus 로고
    • Positivity at test of cure following first-line treatment for genital Mycoplasma genitalium: Follow-up of a clinical cohort
    • Gundevia, Z., Foster, R., Jamil, M. S., McNulty, A. Positivity at test of cure following first-line treatment for genital Mycoplasma genitalium: follow-up of a clinical cohort. Sex. Transm. Infect. 91, 11-13 (2015).
    • (2015) Sex. Transm. Infect. , vol.91 , pp. 11-13
    • Gundevia, Z.1    Foster, R.2    Jamil, M.S.3    McNulty, A.4
  • 163
    • 84926639944 scopus 로고    scopus 로고
    • Macrolide resistance and azithromycin failure in a Mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens
    • Bissessor, M., et al. Macrolide resistance and azithromycin failure in a Mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens. Clin. Infect. Dis. 60, 1228-1236 (2015).
    • (2015) Clin. Infect. Dis. , vol.60 , pp. 1228-1236
    • Bissessor, M.1
  • 164
    • 84879431312 scopus 로고    scopus 로고
    • Fluoroquinolone and macrolide resistance-associated mutations in Mycoplasma genitalium
    • Tagg, K. A., Jeoffreys, N. J., Couldwell, D. L., Donald, J. A., Gilbert, G. L. Fluoroquinolone and macrolide resistance-associated mutations in Mycoplasma genitalium. J. Clin. Microbiol. 51, 2245-2249 (2013).
    • (2013) J. Clin. Microbiol. , vol.51 , pp. 2245-2249
    • Tagg, K.A.1    Jeoffreys, N.J.2    Couldwell, D.L.3    Donald, J.A.4    Gilbert, G.L.5
  • 165
    • 0042388383 scopus 로고    scopus 로고
    • Tetracycline treatment does not eradicate Mycoplasma genitalium
    • Falk, L., Fredlund, H., Jensen, J. S. Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex. Transm. Infect. 79, 318-319 (2003).
    • (2003) Sex. Transm. Infect. , vol.79 , pp. 318-319
    • Falk, L.1    Fredlund, H.2    Jensen, J.S.3
  • 166
    • 84878492596 scopus 로고    scopus 로고
    • Development of doxycycline MIC and disk diffusion interpretive breakpoints and revision of tetracycline breakpoints for Streptococcus pneumoniae
    • Dallas, S. D., et al. Development of doxycycline MIC and disk diffusion interpretive breakpoints and revision of tetracycline breakpoints for Streptococcus pneumoniae. J. Clin. Microbiol. 51, 1798-1802 (2013).
    • (2013) J. Clin. Microbiol. , vol.51 , pp. 1798-1802
    • Dallas, S.D.1
  • 167
    • 84863332784 scopus 로고    scopus 로고
    • Clinical and microbiological outcomes in treatment of men with non-gonococcal urethritis with a 100-mg twice-daily dose regimen of sitafloxacin
    • Ito, S., et al. Clinical and microbiological outcomes in treatment of men with non-gonococcal urethritis with a 100-mg twice-daily dose regimen of sitafloxacin. J. Infect. Chemother. 18, 414-418 (2012).
    • (2012) J. Infect. Chemother. , vol.18 , pp. 414-418
    • Ito, S.1
  • 168
    • 84885948177 scopus 로고    scopus 로고
    • Clinical efficacy of sitafloxacin 100 mg twice daily for 7 days for patients with non-gonococcal urethritis
    • Takahashi, S., et al. Clinical efficacy of sitafloxacin 100 mg twice daily for 7 days for patients with non-gonococcal urethritis. J. Infect. Chemother. 19, 941-945 (2013).
    • (2013) J. Infect. Chemother. , vol.19 , pp. 941-945
    • Takahashi, S.1
  • 169
    • 84903723836 scopus 로고    scopus 로고
    • Prediction of the persistence of Mycoplasma genitalium after antimicrobial chemotherapy by quantification of leukocytes in first-void urine from patients with non-gonococcal urethritis
    • Ito, S., et al. Prediction of the persistence of Mycoplasma genitalium after antimicrobial chemotherapy by quantification of leukocytes in first-void urine from patients with non-gonococcal urethritis. J. Infect. Chemother. 20, 298-302 (2014).
    • (2014) J. Infect. Chemother. , vol.20 , pp. 298-302
    • Ito, S.1
  • 170
    • 84882334233 scopus 로고    scopus 로고
    • Antimicrobial activity of the pleuromutilin antibiotic BC-3781 against bacterial pathogens isolated in the SENTRY antimicrobial surveillance program in 2010
    • Paukner, S., Sader, H. S., Ivezic-Schoenfeld, Z., Jones, R. N. Antimicrobial activity of the pleuromutilin antibiotic BC-3781 against bacterial pathogens isolated in the SENTRY antimicrobial surveillance program in 2010. Antimicrob. Agents Chemother. 57, 4489-4495 (2013).
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 4489-4495
    • Paukner, S.1    Sader, H.S.2    Ivezic-Schoenfeld, Z.3    Jones, R.N.4
  • 172
    • 84876239981 scopus 로고    scopus 로고
    • Phase II clinical study of BC-3781, a pleuromutilin antibiotic, in treatment of patients with acute bacterial skin and skin structure infections
    • Prince, W. T., et al. Phase II clinical study of BC-3781, a pleuromutilin antibiotic, in treatment of patients with acute bacterial skin and skin structure infections. Antimicrob. Agents Chemother. 57, 2087-2094 (2013).
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 2087-2094
    • Prince, W.T.1
  • 173
    • 84929613792 scopus 로고    scopus 로고
    • In vitro antibacterial activity of AZD0914 against human mycoplasmas and ureaplasmas
    • Waites, K. B., Crabb, D. M., Duffy, L. B., Huband, M. D. In vitro antibacterial activity of AZD0914 against human mycoplasmas and ureaplasmas. Antimicrob. Agents Chemother. 59, 3627-3629 (2015).
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 3627-3629
    • Waites, K.B.1    Crabb, D.M.2    Duffy, L.B.3    Huband, M.D.4
  • 174
    • 84952056755 scopus 로고    scopus 로고
    • Azithromycin versus doxycycline for urogenital Chlamydia trachomatis infection
    • Geisler, W. M., et al. Azithromycin versus doxycycline for urogenital Chlamydia trachomatis infection. N. Engl. J. Med. 373, 2512-2521 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 2512-2521
    • Geisler, W.M.1
  • 175
    • 84939480246 scopus 로고    scopus 로고
    • Time to eradication of Mycoplasma genitalium after antibiotic treatment in men and women
    • Falk, L., Enger, M., Jensen, J. S. Time to eradication of Mycoplasma genitalium after antibiotic treatment in men and women. J. Antimicrob. Chemother. 70, 3134-3140 (2015).
    • (2015) J. Antimicrob. Chemother. , vol.70 , pp. 3134-3140
    • Falk, L.1    Enger, M.2    Jensen, J.S.3
  • 176
    • 84864252012 scopus 로고    scopus 로고
    • The serious threat of multidrug-resistant and untreatable gonorrhoea: The pressing need for global action to control the spread of antimicrobial resistance, and mitigate the impact on sexual and reproductive health
    • Ndowa, F., Lusti-Narasimhan, M., Unemo, M. The serious threat of multidrug-resistant and untreatable gonorrhoea: the pressing need for global action to control the spread of antimicrobial resistance, and mitigate the impact on sexual and reproductive health. Sex. Transm. Infect. 88, 317-318 (2012).
    • (2012) Sex. Transm. Infect. , vol.88 , pp. 317-318
    • Ndowa, F.1    Lusti-Narasimhan, M.2    Unemo, M.3
  • 177
    • 84930592840 scopus 로고    scopus 로고
    • Will targeting oropharyngeal gonorrhoea delay the further emergence of drug-resistant Neisseria gonorrhoeae strains?
    • Lewis, D. A. Will targeting oropharyngeal gonorrhoea delay the further emergence of drug-resistant Neisseria gonorrhoeae strains? Sex. Transm. Infect. 91, 234-237 (2015).
    • (2015) Sex. Transm. Infect. , vol.91 , pp. 234-237
    • Lewis, D.A.1
  • 178
    • 84979622689 scopus 로고    scopus 로고
    • Multiplex real-time PCR with high-resolution melting analysis for the characterization of antimicrobial resistance in Neisseria gonorrhoeae
    • Donà, V., et al. Multiplex real-time PCR with high-resolution melting analysis for the characterization of antimicrobial resistance in Neisseria gonorrhoeae. J. Clin. Microbiol. 54, 2074-2081 (2016).
    • (2016) J. Clin. Microbiol. , vol.54 , pp. 2074-2081
    • Donà, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.