Time to eradication of Mycoplasma genitalium after antibiotic treatment in men and women

Journal of Antimicrobial Chemotherapy

Volumn 70, Issue 11, 2015, Pages 3134-3140

  Falk, Lars ^a,b,c   Enger, Martin ^d   Jensen, Jørgen Skov ^e  

^a Region Östergötland ^*  (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c R and D Department of Local Health Care   (Sweden)

^d Vastervik Hospital   (Sweden)

^e STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; DOXYCYCLINE; MACROLIDE; MOXIFLOXACIN; RNA 23S; ANTIINFECTIVE AGENT; BACTERIAL DNA; QUINOLONE DERIVATIVE; RIBOSOME DNA;

ABSORPTION LAG TIME; ADOLESCENT; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL STRAIN; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE MUTATION; GENE TARGETING; HUMAN; MAJOR CLINICAL STUDY; MALE; MYCOPLASMA GENITALIUM; MYCOPLASMA GENITALIUM INFECTION; MYCOPLASMOSIS; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDY; QUANTITATIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEXUALLY TRANSMITTED DISEASE; SINGLE DRUG DOSE; TREATMENT DURATION; URETHRITIS; UTERINE CERVICITIS; CLINICAL TRIAL; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; LONGITUDINAL STUDY; MICROBIOLOGY; MIDDLE AGED; MYCOPLASMA INFECTIONS; TIME FACTOR; TREATMENT OUTCOME; URINE; VAGINA; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; DNA, BACTERIAL; DNA, RIBOSOMAL; DRUG RESISTANCE, BACTERIAL; FEMALE; FLUOROQUINOLONES; HUMANS; LONGITUDINAL STUDIES; MACROLIDES; MALE; MIDDLE AGED; MYCOPLASMA GENITALIUM; MYCOPLASMA INFECTIONS; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; RNA, RIBOSOMAL, 23S; TIME FACTORS; TREATMENT OUTCOME; URINE; VAGINA; YOUNG ADULT;

EID: 84939480246     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkv246     Document Type: Article

References (29)

1. Björnelius E, Anagrius C, Bojs G et al. Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial. Sex Transm Infect 2008; 84: 72-6.
2. Mena LA, Mroczkowski TF, Nsuami M et al. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. Clin Infect Dis 2009; 48: 1649-54.
3. Falk L, Fredlund H, Jensen JS. Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex Transm Infect 2003; 79: 318-9.
4. Bradshaw CS, Jensen JS, Tabrizi SN et al. Azithromycin failure in Mycoplasma genitalium urethritis. Emerg Infect Dis 2006; 12: 1149-52.
5. Pond MJ, Nori AV, Witney AA et al. High prevalence of antibiotic-resistant Mycoplasma genitalium in nongonococcal urethritis: the need for routine testing and the inadequacy of current treatment options. Clin Infect Dis 2014; 58: 631-7.
6. Schwebke JR, Rompalo A, Taylor S et al. Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens-α randomized clinical trial. Clin Inf Dis 2011; 52: 163-70.
7. Manhart LE, Gillespie CW, Lowens MS et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin Infect Dis 2013; 56: 934-42.
8. Salado-Rasmussen K, Jensen JS. Mycoplasma genitalium testing pattern and macrolide resistance: a Danish nationwide retrospective survey. Clin Infect Dis 2014; 46: 24-30.
9. Ito S, Shimada Y, Yamaguchi et al. Selection of Mycoplasma genitalium strains harbouring macrolide resistance-associated 23S rRNA mutations by treatment with a single 1 g dose of azithromycin. Sex Transm Infect 2011; 87: 412-4.
10. Anagrius C, Loré B, Jensen JS. Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic. PLoS One 2013; 8: e61481.
11. Bisessor M, Tabrizi SN, Twin J et al. Macrolide resistance and azithromycin failure in a Mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens. Clin Infect Dis 2014; 60: 1228-36.
12. Jensen JS, Bradshaw CS, Tabrizi SN et al. Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin Infect Dis 2008; 47: 1546-53.
13. Shahmanesh M, Moi H, Lassau F et al. 2009 European guideline on the management of male non-gonococcal urethritis. Int J STD AIDS 2009; 20: 458-64.
14. Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines 2015. MMWR Recomm Rep 2015; 64: 1-137.
15. Jensen JS, Björnelius E, Dohn B et al. Use of TaqMan 5' nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic. J Clin Microbiol 2004; 42: 683-92.
16. Hjorth SV, Björnelius E, Lidbrink P et al. Sequence-based typing of Mycoplasma genitalium reveals sexual transmission. J Clin Microbiol 2006; 44: 2078-83.
17. Renault CA, Israelski DM, Levy V et al. Time to clearance of Chlamydia trachomatis ribosomal RNA in women treated for chlamydia infection. Sex Health 2011; 8: 69-73.
18. Dukers-Muijrers NH, Morré SA, Speksnijder A et al. Chlamydia trachomatis test-of-cure cannot be based on a single highly sensitive laboratory test taken at least 3 weeks after treatment. PLoS One 2012; 7: e34108.
19. Walker J, Fairley CK, Bradshaw CS et al. The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women. BMC Infect Dis 2011; 11: 35.
20. Falk L, Fredlund H, Jensen JS. Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex Transm Infect 2005; 81: 73-8.
21. Falk L, Fredlund H, Jensen JS. Symptomatic urethritis is more prevalent in men infected with Mycoplasma genitalium than with Chlamydia trachomatis. Sex Transm Infect 2004; 80: 289-93.
22. Jensen JS, Fernandes P, Unemo M. In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and -susceptible Mycoplasma genitalium strains. Antimicrob Agents Chemother 2014; 58: 3151-6.
23. Walker J, Fairley CK, Bradshaw CS et al. Mycoplasma genitalium incidence, organism load, and treatment failure in a cohort of young Australian women. Clin Infect Dis 2013; 56: 1094-100.
24. Gushin A, Ryzhikh P, Rumyantseva T et al. Treatment efficacy, treatment failures and selection of macrolide resistance in patients with high load of Mycoplasma genitalium during treatment of male urethritis with josamycin. BMC Infect Dis 2015; 15: 40.
25. Jernberg E, Moghaddam A, Moi H. Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study. Int J STD AIDS 2008; 19: 676-9.
26. Geisler WM, Lensing SY, Press CG et al. Spontaneous resolution of Chlamydia trachomatis infection in women and protection from reinfection. J Infect Dis 2013; 207: 1850-6.
27. Oakeshott P, Aghaizu A, Hay P et al. Is Mycoplasma genitalium in women the "new chlamydia"? A community-based prospective cohort study. Clin Infect Dis 2010; 51: 1160-6.
28. Ito S, Mizutani K, Seike K et al. Prediction of the persistence of Mycoplasma genitalium after antimicrobial chemotherapy by quantification of leukocytes in first-void urine from patients with non-gonococcal urethritis. J Infect Chemother 2014; 20: 298-302.
29. Amsel R, TottenPA, SpiegelCAet al. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 1983; 74: 14-22.