Azithromycin failure in Mycoplasma genitalium urethritis

Emerging Infectious Diseases

Volumn 12, Issue 7, 2006, Pages 1149-1152

  Bradshaw, Catriona S ^a,b,e   Jensen, Jorgen S ^c   Tabrizi, Sepehr N ^b,d   Read, Timothy R H ^a   Garland, Suzanne M ^b,d   Hopkins, Carol A ^a   Moss, Lorna M ^a   Fairley, Christopher K ^a,b  

^a ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c STATENS SERUM INSTITUT   (Denmark)

^d ROYAL WOMEN'S HOSPITAL   (Australia)

^e MELBOURNE SEXUAL HEALTH CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; CLARITHROMYCIN; DOXYCYCLINE; ERYTHROMYCIN; MACROLIDE; MOXIFLOXACIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; CONFIDENCE INTERVAL; DRUG EFFICACY; ERADICATION THERAPY; HUMAN; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOPLASMA GENITALIUM; NONHUMAN; NONSPECIFIC URETHRITIS; PERSISTENT INFECTION; SINGLE DRUG DOSE; SYMPTOMATOLOGY; TREATMENT FAILURE; URETHRITIS;

EID: 33745949316     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid1207.051558     Document Type: Article

References (15)

1. Jensen JS. Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases. J Eur Acad Dermatol Venereol. 2004;18:1-11.
2. Hannan PC, Woodnutt G. In vitro activity of gemifloxacin (SB 265805; LB20304a) against human mycoplasmas. J Antimicrob Chemother. 2000;45:367-9.
3. Duffy LB, Crabb D, Searcey K, Kempf MC. Comparative potency of gemifloxacin, new quinolones, macrolides, tetracycline and clindamycin against Mycoplasma spp. J Antimicrob Chemother. 2000;45(Suppl 1):29-33.
4. Yasuda M, Maeda S, Deguchi T. In vitro activity of fluoroquinolones against Mycoplasma genitalium and their bacteriological efficacy for treatment of M. genitalium-positive nongonococcal urethritis in men. Clin Infect Dis. 2005;41:1357-9.
5. Hannan PC. Comparative susceptibilities of various AIDS-associated and human urogenital tract mycoplasmas and strains of Mycoplasma pneumoniae to 10 classes of antimicrobial agent in vitro. J Med Microbiol. 1998;47:1115-22.
6. Hamasuna R, Osada Y, Jensen JS. Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5′ nuclease real-time PCR. Antimicrob Agents Chemother. 2005;49:4993-8.
7. Falk L, Fredlund H, Jensen JS. Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex Transm Infect. 2003;79:318-9.
8. Johannisson G, Enstrom Y, Lowhagen GB, Nagy V, Ryberg K, Seeberg S, et al. Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden. Int J STD AIDS. 2000;11:324-6.
9. Maeda SI, Tamaki M, Kojima K, Yoshida T, Ishiko H, Yasuda M, et al. Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis. Sex Transm Dis. 2001;28:472-6.
10. Bjornelius E, Anagrius C, Bojs G, Hans G, Johanisson G, Lidrink P, et al. Mycoplasma genitalium: when to test and treat. Present status in Scandinavia. In: 15th Biennial Meeting of the International Society for Sexually Transmitted Diseases Research. Ottawa, Canada; 2003 [cited 2006 May 22]. Available from http://www.isstdr.org
11. Mroczowski TF, Mena LA, Nsumai M, Martin DH. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. In: 16th Biennial Meeting of the International Society for Sexually Transmitted Diseases Research. Amsterdam, the Netherlands; 2005 [cited 2006 May 22]. Available from http://www.isstdr.org
12. Bradshaw CS, Tabrizi SN, Read TRH, Garland SM, Hopkins CA, Moss LM, et al. Etiologies of non-gonococcal urethritis: bacteria, viruses and the association with oro-genital exposure. J Infect Dis. 2006;193:336-45.
13. Yoshida T, Deguchi T, Ito M, Maeda S, Tamaki M, Ishiko H. Quantitative detection of Mycoplasma genitalium from first-pass urine of men with urethritis and asymptomatic men by real-time PCR. J Clin Microbiol. 2002;40:1451-5.
14. Iverson Cabral SL, Astete SG, Cohen CR, Totten PA. Heterogeneity of the MGPB gene in Mycoplasma genitalium, a mechanism for persistence. In: 16th Biennial meeting of the International Society for Sexually Transmitted Diseases Research, Amsterdam, the Netherlands; 2005 [cited 2006 May 22]. Available from http://www.isstdr.org
15. Pereyre S, Guyot C, Renaudin H, Charron A, Bebear C, Bebear CM. In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae. Antimicrob Agents Chemother. 2004;48:460-5.