Failure of dual antimicrobial therapy in treatment of gonorrhea

New England Journal of Medicine

Volumn 374, Issue 25, 2016, Pages 2504-2506

  Fifer, Helen ^a   Natarajan, Usha ^b   Jones, Lucy ^b   Alexander, Sarah ^a   Hughes, Gwenda ^a   Golparian, Daniel ^c   Unemo, Magnus ^c  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b Virgin Care   (United Kingdom)

^c ÖREBRO UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; CEFTRIAXONE; PORIN A;

BACTERIUM DETECTION; DRUG EFFICACY; DRUG TREATMENT FAILURE; GONORRHEA; HUMAN; LETTER; NEISSERIA GONORRHOEAE; OPA GENE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PORA GENE; PRIORITY JOURNAL; PSEUDOGENE; THROAT CULTURE; URINALYSIS; CASE REPORT; COMBINATION DRUG THERAPY; GENETICS; ISOLATION AND PURIFICATION; MALE; MULTIDRUG RESISTANCE; TREATMENT FAILURE;

ANTI-INFECTIVE AGENTS; AZITHROMYCIN; CEFTRIAXONE; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG THERAPY, COMBINATION; GONORRHEA; HUMANS; MALE; NEISSERIA GONORRHOEAE; TREATMENT FAILURE;

EID: 84975463539     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1512757     Document Type: Letter

References (5)

1. Unemo M, Shafer WM. Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future. Clin Microbiol Rev 2014;27:587-613.
2. Bolan GA, Sparling PF, Wasserheit JN. The emerging threat of untreatable gonococcal infection. N Engl J Med 2012;366:485-7.
3. Unemo M. Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. BMC Infect Dis 2015;15:364.
4. Shimuta K, Unemo M, Nakayama S, et al. Antimicrobial resistance and molecular typing of Neisseria gonorrhoeae isolates in Kyoto and Osaka, Japan, 2010 to 2012: intensified surveillance after identification of the first strain (H041) with highlevel ceftriaxone resistance. Antimicrob Agents Chemother 2013;57:5225-32.
5. Shigemura K, Osawa K, Miura M, et al. Azithromycin resistance and its mechanism in Neisseria gonorrhoeae strains in Hyogo, Japan. Antimicrob Agents Chemother 2015;59:2695-9.