Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance

International Journal of STD and AIDS

Volumn 24, Issue 10, 2013, Pages 822-828

  Couldwell, Deborah L ^a,b   Tagg, Kaitlin A ^a,c   Jeoffreys, Neisha J ^a   Gilbert, Gwendolyn L ^a,b  

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c MACQUARIE UNIVERSITY   (Australia)

Author keywords

antibiotic; Australia; bacterial disease; location; Mycoplasma genitalium; non gonococcal urethritis; resistance; Sexually transmitted infections; STI; treatment; treatment failure

Indexed keywords

AZITHROMYCIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; MOXIFLOXACIN; PROTEIN PARC; RNA 23S;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DRUG TREATMENT FAILURE; FEMALE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MYCOPLASMA GENITALIUM; MYCOPLASMA GENITALIUM INFECTION; MYCOPLASMOSIS; NONHUMAN; NONSPECIFIC URETHRITIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 84887372872     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1177/0956462413502008     Document Type: Article

References (12)

1. Taylor-Robinson D,Jensen JS.Mycoplasma genitalium: from Chrysalis to multicolored butterfly.Clin Microbiol Rev. 2011;24:498-514.
2. Couldwell DL,Gidding HF,Freedman EV, et al.Ureaplasma urealyticum is significantly associated with non-gonococcal urethritis in heterosexual Sydney men.Int J STD AIDS. 2010;21:337-341.
3. Bradshaw CS,Tabrizi SN,Read TRH, et al.Etiologies of nongonococcal urethritis: bacteria, viruses, and the association with orogenital exposure.J Infect Dis. 2006;193:336-345.
4. Manhart LE,Gillespie CW,Lowens MS, et al.Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial.Clin Infect Dis. 2013;56:934-942.
5. Twin J,Jensen JS,Bradshaw CS, et al.Transmission and selection of macrolide resistant Mycoplasma genitalium infections detected by rapid high resolution melt analysis.PLoS One. 2012;7 (4): e35593-e35593.
6. Bjornelius E,Anagrius C,Bojs G, et al.Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial.Sex Transm Infect. 2008;84:72-76.
7. Jernberg E,Moghaddam A,Moi H.Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study.Int J STD AIDS. 2008;19:676-679.
8. Shimada Y,Deguchi T,Nakane K, et al.Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistance.Int J Antimicrob Agents. 2010;36:255-258.
9. Tagg KA, Jeoffreys NJ, Couldwell DL,et al.Macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium. J Clin Microbiol 2013; 51: 2245-2249.
10. Jensen JS,Bjornelius E,Dohn B, et al.Use of a TaqMan 5' nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic.J Clin Microbiol. 2004;42:683-692.
11. Vandepitte J,Weiss HA,Kyakuwa N, et al.Natural history of Mycoplasma genitalium infection in a cohort of female sex workers in Kampala, Uganda.Sex Transm Dis. 2013;40:422-427.
12. Walker J,Fairley CK,Bradshaw CS, et al.The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women.BMC Infect Dis. 2011;11:35-35.