Prediction of the persistence of Mycoplasma genitalium after antimicrobial chemotherapy by quantification of leukocytes in firstvoid urine from patients with non-gonococcal urethritis

Journal of Infection and Chemotherapy

Volumn 20, Issue 5, 2014, Pages 298-302

  Ito, Shin ^a   Mizutani, Kohsuke ^b   Seike, Kensaku ^b   Sugawara, Takashi ^b   Tsuchiya, Tomohiro ^b   Yasuda, Mitsuru ^b   Yokoi, Shigeaki ^b   Nakano, Masahiro ^b   Deguchi, Takashi ^b  

^a IClinic   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Antimicrobial chemotherapy; Mycoplasma genitalium; Non gonococcal urethritis; Recurrent urethritis

Indexed keywords

AZITHROMYCIN; DOXYCYCLINE; GATIFLOXACIN; MOXIFLOXACIN; SITAFLOXACIN; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL ARTICLE; CLINICAL PRACTICE; CONTROLLED STUDY; DRUG RELEASE; DYSURIA; FIRST VOID URINE; HUMAN; LEUKOCYTE COUNT; MALE; MYCOPLASMA GENITALIUM; MYCOPLASMA HOMINIS; NONSPECIFIC URETHRITIS; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREDICTION; PRESCRIPTION; RETROSPECTIVE STUDY; TREATMENT DURATION; TREATMENT FAILURE; TREATMENT OUTCOME; UREAPLASMA PARVUM; UREAPLASMA UREALYTICUM; URETHRA DISEASE; URETHRAL BURNING; URETHRAL DISCHARGE; URETHRAL ITCHING; URINE; ADOLESCENT; AGED; BLOOD; CYTOLOGY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGY; MIDDLE AGED; URETHRITIS;

ADOLESCENT; ADULT; AGED; ANTI-INFECTIVE AGENTS; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; MYCOPLASMA GENITALIUM; URETHRITIS; URINE;

EID: 84903723836     PISSN: 1341321X     EISSN: 14377780     Source Type: Journal    
DOI: 10.1016/j.jiac.2014.01.002     Document Type: Article

References (17)

1. Deguchi T, Maeda S. Mycoplasma genitalium: another important pathogen of nongonococcal urethritis. J Urol 2002;167: 1210-7.
2. Taylor-Robinson D, Jensen JS. Mycoplasma genitalium: from Chrysalis to multicolored butterfly. Clin Microbiol Rev 2011;24: 498-514.
3. Manhart LE, Gillespie CW, Lowens MS, Khosropour CM, Colombara DV, Golden MR, et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin Infect Dis 2013;56: 934-42.
4. Schwebke JR, Rompalo A, Taylor S, Seña AC, Martin DH, Lopez LM, et al. Reevaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens - a randomized clinical trial. Clin Infect Dis 2011;52: 163-70.
5. Deguchi T, Ito S, Hagiwara N, Yasuda M, Maeda S. Antimicrobial chemotherapy of Mycoplasma genitalium-positive non-gonococcal urethritis. Expert Rev Anti Infect Ther 2012;10: 791-803.
6. Maeda SI, Tamaki M, Kojima K, Yoshida T, Ishiko H, Yasuda M, et al. Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis. Sex Transm Dis 2001;28: 472-6.
7. Wikström A, Jensen JS. Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline. Sex Transm Infect 2006;82: 276-9.
8. Deguchi T, Maeda S, Tamaki M, Yoshida T, Ishiko H, Ito M, et al. Analysis of the gyrA and parC genes of Mycoplasma genitalium detected in first-pass urine of men with non-gonococcal urethritis before and after fluoroquinolone treatment. J Antimicrob Chemother 2001;48: 742-4.
9. Jensen JS, Bradshaw CS, Tabrizi SN, Fairley CK, Hamasuna R. Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin Infect Dis 2008;47: 1546-53.
10. Shimada Y, Deguchi T, Nakane K, Yasuda M, Yokoi S, Ito S, et al. Macrolide resistance-associated 23S rRNA mutation in Mycoplasma genitalium, Japan. Emerg Infect Dis 2011;17: 1148-50.
11. Chrisment D, Charron A, Cazanave C, Pereyre S, Bébéar C. Detection of macrolide resistance in Mycoplasma genitalium in France. J Antimicrob Chemother 2012;67: 2598-601.
12. Anagrius C, Loré B, Jensen JS. Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic. PLoS One 2013;8:e61481.
13. Tagg KA, Jeoffreys NJ, Couldwell DL, Donald JA, Gilbert GL. Fluoroquinolone and macrolide resistance-associated mutations in Mycoplasma genitalium. J Clin Microbiol 2013;51: 2245-9.
14. Jensen JS. Protocol for the detection of Mycoplasma genitalium by PCR from clinical specimens and subsequent detection of macrolide resistancemediating mutations in region V of the 23S rRNA gene. Methods Mol Biol 2012;903: 129-39.
15. Yoshida T, Maeda S, Deguchi T, Miyazawa T, Ishiko H. Rapid detection of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum organisms in genitourinary samples by PCRmicrotiter plate hybridization assay. J Clin Microbiol 2003;41: 1850-5.
16. Deguchi T, Yoshida T, Yokoi S, Ito M, Tamaki M, Ishiko H, et al. Longitudinal quantitative detection by real-time PCR of Mycoplasma genitalium in first-pass urine of men with recurrent nongonococcal urethritis. J Clin Microbiol 2002;40: 3854-6.
17. Seña AC, Lensing S, Rompalo A, Taylor SN, Martin DH, Lopez LM, et al. Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis infections in men with nongonococcal urethritis: predictors and persistence after therapy. J Infect Dis 2012;206: 357-65.