In Vitro Selection and Characterization of Resistance to Macrolides and Related Antibiotics in Mycoplasma pneumoniae

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 2, 2004, Pages 460-465

  Pereyre, S ^a   Guyot, C ^a   Renaudin, H ^a   Charron, A ^a   Bebear C ^a   Bebear C M ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; BACTERIAL DNA; CLINDAMYCIN; DALFOPRISTIN PLUS QUINUPRISTIN; ERYTHROMYCIN; GLYCINE; JOSAMYCIN; KETOLIDE; MACROLIDE; PRISTINAMYCIN; QUINUPRISTIN; RIBOSOME PROTEIN; RIBOSOME PROTEIN L22; RIBOSOME PROTEIN L4; RIBOSOME RNA; RNA 23S; STREPTOGRAMIN DERIVATIVE; TELITHROMYCIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM MUTANT; DRUG EFFECT; GENE AMPLIFICATION; GENE DELETION; GENE LOCUS; GENE MUTATION; GENETIC SELECTION; GENETICS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MUTATION; MYCOPLASMA PNEUMONIAE; MYCOPLASMA PNEUMONIAE M129; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME SUBUNIT; RNA GENE;

EID: 0942279624     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.2.460-465.2004     Document Type: Article

References (35)

1. Ban, N., P. Nissen, J. Hansen, P. B. Moore, and T. A. Steitz. 2000. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science 289:905-920.
2. Bébéar, C., and J. Robertson. 1996. Determination of minimal inhibitory concentration, p. 189-199. In J. G. Tully and S. Razin (ed.), Molecular and diagnostic procedures in mycoplasmology, vol. II. Academic Press, San Diego. Calif.
3. Bébéar, C. M., and C. Bébéar. 2002. Antimycoplasmal agents, p. 545-566. In S. Razin and R. Herrmann (ed.), Molecular biology and pathogenicity of mycoplasmas. Kluwer Academic/Plenum Publishers, London, United Kingdom.
4. Berisio, R., J. Harms, F. Schluenzen, R. Zarivach, H. A. S. Hansen, P. Fucini, and A. Yonath. 2003. Structural insight into the antibiotic action of telithromycin against resistant mutants. J. Bacteriol. 185:4276-4279.
5. Canu, A., B. Malhruny, M. Coquemont, T. A. Davies, P. C. Appelbaum, and R. Leclercq. 2002. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 46:125-131.
6. Carret, G., J.-D. Cavallo, H. Chardon, C. Chidiac, P. Choutet, P. Courvalin, H. Dabernat, H. Drugeon, L. Dubreuil, F. Goldstein, V. Jarlier, R. Leclercq, M.-H. Nicolas-Chanoine, A. Philippon, C. Quentin-Noury, B. Rouveix, J. Sirot, and C.-J. Soussy. 2003. Comité de l'Antibiogramme de la Société Française de microbiologie report 2003. Int. J. Antimicrob. Agents. 21:364-391.
7. Cousin-Allery, A., A. Charron, B. de Barbeyrac, G. Fremy, J. S. Jensen, H. Renaudin, and C. Bébéar. 2000. Molecular typing of Mycoplasma pneumoniae strains by PCR-based methods and pulsed-field gel electrophoresis. Application to French and Danish isolates. Epidemiol. Infect. 124:103-111.
8. Critchley, I. A., M. E. Jones, P. D. Heinze, D. Hubbard, H. D. Engler, A. T. Evangelista, C. Thornsberry, J. A. Karlowsky, and D. F. Sahm. 2002. In vitro activity of levofloxacin against contemporary clinical isolates of Legionella pneumophila, Mycoplasma pneumoniae and Chlamydia pneumoniae from North America and Europe. Clin. Microbiol. Infect. 8:214-221.
9. Davies, T. A., B. E. Dewasse, and P. C. Appelbaum. 2000. In vitro development of resistance to telithromycin (HMR 3647), four macrolides, clindamycin, and pristinamycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44:414-417.
10. Davydova, N., V. Streltsov, M. Wilce, A. Liljas, and M. Garber. 2002. L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin. J. Mol. Biol. 322:635-644.
11. Depardieu, F., and P. Courvalin. 2001. Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococus pneumoniae. Antimicrob. Agents Chemother. 45:319-323.
12. Douthwaite, S., L. H. Hansen, and P. Mauvais. 2000. Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. Mol. Microbiol. 36:183-192.
13. Furneri, P. M., G. Rappazzo, M. P. Musumarra, P. Dipietro, L. S. Catania, and L. S. Roccasalva. 2001. Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis. Antimicrob. Agents Chemother. 45:2958-2960.
14. Gabashvili, I. S., S. T. Gregory, M. Valle, R. Grassucci, M. Worbs, M. C. Wahl, A. E. Dahlberg, and J. Frank. 2001. The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22. Mol. Cell 8:181-188.
15. Gregory, S. T., and A. E. Dahlberg. 1999. Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23S ribosomal RNA. J. Mol. Biol. 289:827-834.
16. Hansen, J.L., J.A. Ippolito, N. Ban, P. Nissen, P. B. Moore, and T. A. Steitz. 2002. The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol. Cell 10:117-128.
17. Hansen, L. H., P. Mauvais, and S. Douthwaite. 1999. The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA. Mol. Microbiol. 31:623-631.
18. Himmelreich, R., H. Hilbert, H. Plagens, E. Pirkl, B. C. Li, and R. Herrmann. 1996. Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res. 24:4420-4449.
19. Leclercq, R., and P. Courvalin. 2002. Resistance macrolides and related antibiotics in Streptoccus pneumoniae. Antimicrob. Agents Chemother. 46:2727-2734.
20. Lucier, T. S., K. Heitzman, S. K. Liu, and P. C. Hu. 1995. Transition mutations in the 23S rRNA of erythromycin-resistant isolates of Mycoplasma pneumoniae. Antimicrob. Agents Chemother. 39:2770-2773.
21. Mankin, A. S., and R. A. Garrett. 1991. Chloramphenicol resistance mutations in the single 23S rRNA gene of the archacon Halobacterium halobium. J. Bacteriol. 173:3559-3563.
22. Okazaki, N., M. Narita, S. Yamada, K. Izumikawa, M. Umetsu, T. Kenri, Y. Sasaki, Y. Arakawa, and T. Sasaki. 2001. Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol. Immunol. 45:617-620.
23. Pereyre, S., P. Gonzalez, B. de Barbeyrac, A. Darnige, H. Renaudin, A. Charron, S. Raberison, C. Bébéar, and C. M. Bébéar. 2002. Mutations in 23S rRNA account for intrinsic resistance to macrolides in Mycoplasma hominis and Mycoplasma fermentans and for acquired resistance to macrolides in M. hominis. Antimicrob. Agents Chemother. 46:3142-3150.
24. Porse, B. T., and R. A. Garrett. 1999. Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23S rRNA and the synergism of their inhibitory mechanisms. J. Mol. Biol. 286:375-387.
25. Prunier, A. L., B. Malbruny, D. Tande, B. Picard, and R. Leclercq. 2002. Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides. Antimicrob. Agents Chemother. 46:3054-3056.
26. Schlunzen, F., R. Zarivach, J. Harms, A. Bashan, A. Tocilj, R. Albrecht, A. Yonath, and F. Franceschi. 2001. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in cubacteria. Nature 413:814-821.
27. Stopler, T., and D. Branski. 1986. Resistance of Mycoplasma pneumoniae to macrolides, lincomycin and streptogramin B. J. Antimicrob. Chemother. 18:359-364.
28. Sutcliffe, J., A. Tait-Kamradt, and L. Wondrack. 1996. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob. Agents Chemother. 40:1817-1824.
29. Sutcliffe, J. A., and R. Leclercq. 2002. Mechanisms of resistance to macrolides, lincosamides, and ketolides, p. 281-317. In W. Schönfeld and H. A. Kirst (ed.), Macrolide antibiotics. Birkhauser Verlag, Boston, Mass.
30. Tait-Kamradt, A., T. Davies, M. Cronan, M. R. Jacobs, P. C. Appelbaum, and J. Sutcliffe. 2000. Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage. Antimicrob. Agents Chemother. 44:2118-2125.
31. Unge, J., A. Aberg, S. Al-Kharadaghi, A. Nikulin, S. Nikonov, N. Davydova, N. Nevskaya, M. Garber, and A. Liljas. 1998. The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance. Structure 6:1577-1586.
32. Vester, B., and S. Douthwaite. 2001. Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob. Agents Chemother. 45:1-12.
33. Waites, K. B., C. M. Bébéar, J. A. Roberston, D. F. Talkington, and G. E. Kenny. 2001. Cumitech 34, Laboratory diagnosis of mycoplasmal infections. Coordinating ed., F. S. Nolte. American Society for Microbiology, Washington, D.C.
34. Weisblum, B. 2000 Resistance to macrolide-lincosamide-streptogramin antibiotics, p. 694-710. In V. A. Fischetti, R. P. Novick, J. J. Ferretti, D. A. Portnoy, and J. I. Rood (ed.), Gram-positive pathogens. American Society for Microbiology, Washington, D.C.
35. Worbs, M., R. Huber, and M. C. Wahl. 2000. Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon. EMBO J. 19:807-818.