-
1
-
-
84892143010
-
Methicillin-resistant Staphylococcus aureus therapy: Past, present and future
-
Rodvolk, K. A. , McConeghy, K. W. Methicillin-resistant Staphylococcus aureus therapy: past, present and future. Clin. Infect. Dis. 58, S20-S27 (2014).
-
(2014)
Clin. Infect. Dis.
, vol.58
, pp. S20-S27
-
-
Rodvolk, K.A.1
McConeghy, K.W.2
-
2
-
-
84901020224
-
Challenges with gonorrhea in the era of multi-drug and extensively drug resistance-are we on the right track?
-
Unemo, M., Golparian, D. , Shafer, W. M. Challenges with gonorrhea in the era of multi-drug and extensively drug resistance-are we on the right track? Expert Rev. Anti Infect. Ther. 12, 653-656 (2014).
-
(2014)
Expert Rev. Anti Infect. Ther.
, vol.12
, pp. 653-656
-
-
Unemo, M.1
Golparian, D.2
Shafer, W.M.3
-
3
-
-
66649090346
-
The diarylquinoline TMC207 for multidrug-resistant tuberculosis
-
Diacon, A. H. et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 360, 2397-2405 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2397-2405
-
-
Diacon, A.H.1
-
4
-
-
67749147313
-
Synthesis of (-)-PNU-286607 by asymmetric cyclization of alkylidene barbiturates
-
Ruble, J. C. et al. Synthesis of (-)-PNU-286607 by asymmetric cyclization of alkylidene barbiturates. J. Am. Chem. Soc. 131, 3991-3997 (2009).
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 3991-3997
-
-
Ruble, J.C.1
-
5
-
-
84919636297
-
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold-SAR and in vivo characterization
-
Basarab, G. S. et al. Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold-SAR and in vivo characterization. J. Med. Chem. 57, 9078-9095 (2014).
-
(2014)
J. Med. Chem.
, vol.57
, pp. 9078-9095
-
-
Basarab, G.S.1
-
6
-
-
84919681480
-
Synthesis of a tetrahydronaphthyridine spiropyrimidinetrione DNA gyrase inhibiting antibacterial agent-differential substitution at all five carbon atoms of pyridine
-
Basarab, G. S. et al. Synthesis of a tetrahydronaphthyridine spiropyrimidinetrione DNA gyrase inhibiting antibacterial agent-differential substitution at all five carbon atoms of pyridine. Org. Lett. 16, 6456-6459 (2014).
-
(2014)
Org. Lett.
, vol.16
, pp. 6456-6459
-
-
Basarab, G.S.1
-
7
-
-
84920148657
-
In vitro antibacterial activity of AZD0914: A new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-negative, and atypical bacteria
-
Huband, M. D. et al. In vitro antibacterial activity of AZD0914: a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-negative, and atypical bacteria. Antimicrob. Agents and Chemother. 59, 467-474 (2015).
-
(2015)
Antimicrob. Agents and Chemother
, vol.59
, pp. 467-474
-
-
Huband, M.D.1
-
8
-
-
84906090956
-
High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrugresistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea
-
Jacobsson, S. et al. High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrugresistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea. Antimicrob. Agents Chemother. 58, 5585-5588 (2014).
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 5585-5588
-
-
Jacobsson, S.1
-
9
-
-
84923240925
-
Characterization of the novel DNA gyrase inhibitor AZD0914: Low resistance potential and lack of crossresistance in Neisseria gonorrhoeae
-
Alm, R. A. et al. Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of crossresistance in Neisseria gonorrhoeae. Antimicrob. Agents Chemother. 59, 1478-1486 (2015).
-
(2015)
Antimicrob. Agents Chemother.
, vol.59
, pp. 1478-1486
-
-
Alm, R.A.1
-
10
-
-
84904808187
-
Prioritized current unmet needs for antibacterial therapies
-
Spellberg, B. , Shlaes, D. Prioritized current unmet needs for antibacterial therapies. Clin. Pharmacol. Ther. 96, 151-153 (2014).
-
(2014)
Clin. Pharmacol. Ther.
, vol.96
, pp. 151-153
-
-
Spellberg, B.1
Shlaes, D.2
-
11
-
-
84937070005
-
-
CDC Fact Sheet Gonorrhea Treatment Guidelines Available at: Accessed: 28 April 2015
-
CDC Fact Sheet, Gonorrhea Treatment Guidelines. (2013) Available at: http://www.cdc.gov/nchhstp/newsroom/docs/Gonorrhea-Treatment-Guidelines-FactSheet.pdf. (Accessed: 28 April 2015).
-
(2013)
-
-
-
12
-
-
84857737837
-
Antibiotic resistance in Neisseria gonorrhoeae: Origin, evolution, and lessons learned for the future
-
Unemo, M. , Shafer, W. M. Antibiotic resistance in Neisseria gonorrhoeae: origin, evolution, and lessons learned for the future. Ann. N. Y. Acad. Sci. 1230, E19-E28 (2011).
-
(2011)
Ann. N. Y. Acad. Sci.
, vol.1230
, pp. E19-E28
-
-
Unemo, M.1
Shafer, W.M.2
-
13
-
-
84904581813
-
Treatment failure with 2 g of azithromycin (extended-release formulation) in gonorrhoea in Japan caused by the international multidrug-resistant ST1407 strain of Neisseria gonorrhoeae
-
Morita-Ishihara, T. et al. Treatment failure with 2 g of azithromycin (extended-release formulation) in gonorrhoea in Japan caused by the international multidrug-resistant ST1407 strain of Neisseria gonorrhoeae. J. Antimicrob. Chemother. 69, 2086-2090 (2014).
-
(2014)
J. Antimicrob. Chemother.
, vol.69
, pp. 2086-2090
-
-
Morita-Ishihara, T.1
-
14
-
-
67650488213
-
Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods
-
Tapsall, J. et al. Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods. J. Med. Microbiol. 58, 683-687 (2009).
-
(2009)
J. Med. Microbiol.
, vol.58
, pp. 683-687
-
-
Tapsall, J.1
-
15
-
-
84856770379
-
The emerging threat of untreatable gonococcal infection
-
Bolan, G. A., Sparling, P. F. , Wasserheit, J. N. The emerging threat of untreatable gonococcal infection. N. Engl. J. Med. 366, 485-487 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 485-487
-
-
Bolan, G.A.1
Sparling, P.F.2
Wasserheit, J.N.3
-
16
-
-
0034812537
-
Mechanisms and frequency of resistance to gatifloxacin in comparison to AM-1121 and ciprofloxacin in Staphylococcus aureus
-
Ince, D. , Hooper, D. C. Mechanisms and frequency of resistance to gatifloxacin in comparison to AM-1121 and ciprofloxacin in Staphylococcus aureus. Antimicrob. Agents and Chemother. 45, 2755-2764 (2001).
-
(2001)
Antimicrob. Agents and Chemother.
, vol.45
, pp. 2755-2764
-
-
Ince, D.1
Hooper, D.C.2
-
17
-
-
84891859404
-
Trends in antimicrobial resistance in Neisseria gonorrhoeae in the USA: The Gonococcal Isolate Surveillance Project (GISP) January 2006-June 2012
-
Kirkcaldy, R. D., Kidd, S., Weinstock, H. S., Papp, J. R. , Bolan, G. A. Trends in antimicrobial resistance in Neisseria gonorrhoeae in the USA: the Gonococcal Isolate Surveillance Project (GISP), January 2006-June 2012. Sexually Transmitted Infections 89, iv5-iv10 (2013).
-
(2013)
Sexually Transmitted Infections
, vol.89
, pp. 45-410
-
-
Kirkcaldy, R.D.1
Kidd, S.2
Weinstock, H.S.3
Papp, J.R.4
Bolan, G.A.5
-
18
-
-
50949110901
-
Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases
-
Black, M. T. et al. Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases. Antimicrob. Agents Chemother. 52, 3339-3349 (2008).
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 3339-3349
-
-
Black, M.T.1
-
19
-
-
84903762701
-
Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent
-
Ross, J. E., Scangarella-Oman, N. E., Flamm, R. K. , Jones, R. N. Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent. J. Clin. Microbiol. 52, 2629-2632 (2014).
-
(2014)
J. Clin. Microbiol.
, vol.52
, pp. 2629-2632
-
-
Ross, J.E.1
Scangarella-Oman, N.E.2
Flamm, R.K.3
Jones, R.N.4
-
20
-
-
84864941895
-
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pKa: Antibacterial agents with an improved safety profile
-
Reck, F. et al. Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pKa: antibacterial agents with an improved safety profile. J. Med. Chem. 55, 6916-6933 (2012).
-
(2012)
J. Med. Chem.
, vol.55
, pp. 6916-6933
-
-
Reck, F.1
-
21
-
-
84969286340
-
A new-class antibacterial-almost. Lessons in drug discovery and development: A critical analysis of > 50 years of effort toward ATPase inhibitors of DNA gyrase and topoisomerase IV
-
Bisacchi, G. S. , Manchester, J. I. A new-class antibacterial-almost. Lessons in drug discovery and development: a critical analysis of > 50 years of effort toward ATPase inhibitors of DNA gyrase and topoisomerase IV. ACS Infect. Dis. 1, 4-41 (2015).
-
(2015)
ACS Infect. Dis.
, vol.1
, pp. 4-41
-
-
Bisacchi, G.S.1
Manchester, J.I.2
-
22
-
-
84897672254
-
Non-quinolone inhibitors of bacterial type IIA topoisomerases: A feat of bioisosterism
-
Mayer, C. , Janin, Y. L. Non-quinolone inhibitors of bacterial type IIA topoisomerases: a feat of bioisosterism. Chem. Rev. 114, 2313-2342 (2014).
-
(2014)
Chem. Rev.
, vol.114
, pp. 2313-2342
-
-
Mayer, C.1
Janin, Y.L.2
-
23
-
-
84937033113
-
-
Federal Register Determination That ALBAMYCIN (Novobiocin Sodium) Available at: (Accessed: 28 April 2015
-
Federal Register, Determination That ALBAMYCIN (Novobiocin Sodium) Capsule, 250 Milligrams, Was Withdrawn From Sale for Reasons of Safety or Effectiveness. (2011) Available at: https://www.federalregister.gov/articles/2011/01/19/2011-1000/determination-that-albamycin-novobiocin-sodium-capsule-250-milligrams-was-withdrawn-from-sale-for. (Accessed: 28 April 2015).
-
(2011)
Capsule, 250 Milligrams, Was Withdrawn from Sale for Reasons of Safety or Effectiveness
-
-
-
24
-
-
84937029096
-
Spirocyclic heteroaromatic compounds for the treatment of bacterial infections
-
Barvian, K., Basarab, G. S., Gowravaram, M. R., Hauck, S. I. , Zhou, F. Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections. USP 8, 658, 641 (2014).
-
(2014)
USP
, vol.8
, pp. 658-641
-
-
Barvian, K.1
Basarab, G.S.2
Gowravaram, M.R.3
Hauck, S.I.4
Fused, Z.F.5
-
25
-
-
84937027636
-
-
United States Patent 8 ,889, 671
-
Basarab, G. S., Gowravaram, M. R., Hauck, S. I. , Zhou, F. Compounds and methods for treating bacterial infections. United States Patent 8, 889, 671 (2014).
-
(2014)
Compounds and Methods for Treating Bacterial Infections
-
-
Basarab, G.S.1
Gowravaram, M.R.2
Hauck, S.I.3
Zhou, F.4
-
26
-
-
58149464184
-
-
European Medicines Agency Available at: Accessed: 28 April 2015
-
European Medicines Agency, Pre-authorisation Evaluation of Medicines for Human Use. (2009), Available at: http://www.ema. europa.eu/docs/en-GB/document-library/Application-withdrawal-assessment-report/2010/01/WC500060988.pdf. (Accessed: 28 April 2015).
-
(2009)
Pre-authorisation Evaluation of Medicines for Human Use
-
-
-
27
-
-
4544287059
-
The safety and efficacy of linezolid in orthopaedic practice for the treatment of infection due to antibiotic-resistant organisms
-
Harwood, P. J. , Giannoudis, P. V. The safety and efficacy of linezolid in orthopaedic practice for the treatment of infection due to antibiotic-resistant organisms Expert Opinion in Drug Safety 3, 405-414 (2002).
-
(2002)
Expert Opinion in Drug Safety
, vol.3
, pp. 405-414
-
-
Harwood, P.J.1
Giannoudis, P.V.2
-
28
-
-
84881539517
-
Bone marrow micronucleus frequencies in the rat after oral administration of cyclophosphamide, hexamethylphosphoramide or gemifloxacin for 2 and 28 days
-
Doherty, A. T. et al. Bone marrow micronucleus frequencies in the rat after oral administration of cyclophosphamide, hexamethylphosphoramide or gemifloxacin for 2 and 28 days Toxicol. Res. 2, 321-327 (2013).
-
(2013)
Toxicol Res
, vol.2
, pp. 321-327
-
-
Doherty, A.T.1
-
29
-
-
71049126548
-
Escape from flatland: Increasing saturation as an approach to improving clinical success
-
Lovering, F., Bikker, J. , Humblet, C. Escape from flatland: Increasing saturation as an approach to improving clinical success. J. Med. Chem. 52, 6752-6756 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6752-6756
-
-
Lovering, F.1
Bikker, J.2
Humblet, C.3
-
30
-
-
0036498896
-
Thrombocytopenia associated with linezolid therapy Clin
-
Attassi, K., Hershberger, E., Alam, R. , Zervos, M. J. Thrombocytopenia associated with linezolid therapy Clin. Infect. Dis. 34, 695-698 (2002).
-
(2002)
Infect. Dis.
, vol.34
, pp. 695-698
-
-
Attassi, K.1
Hershberger, E.2
Alam, R.3
Zervos, M.J.4
-
31
-
-
70349330402
-
Fluoroquinolone-induced immune thrombocytopenia: A report and review
-
Cheah, C. Y., De Keulenaer, B. , Leahy, M. F. Fluoroquinolone-induced immune thrombocytopenia: a report and review. Intern. Med. J. 39, 619-623 (2009).
-
(2009)
Intern. Med. J.
, vol.39
, pp. 619-623
-
-
Cheah, C.Y.1
De Keulenaer, B.2
Leahy, M.F.3
-
32
-
-
84904717224
-
Third and fourth generation fluoroquinolone antibacterials: A systematic review of safety and toxicity profiles
-
Sousa, J., Alves, G., Fortuna, A. , Falcao, A. Third and fourth generation fluoroquinolone antibacterials: A systematic review of safety and toxicity profiles. Curr. Drug Safety 9, 89-105 (2014).
-
(2014)
Curr. Drug Safety
, vol.9
, pp. 89-105
-
-
Sousa, J.1
Alves, G.2
Fortuna, A.3
Falcao, A.4
-
33
-
-
33847401389
-
Arrhythmias associated with fluoroquinolone therapy
-
Falagas, M. E., Rafailidis, P. I. , Rosmarakis, E. S. Arrhythmias associated with fluoroquinolone therapy. Int. J. Antimicrob. Agents 29, 374-379 (2007).
-
(2007)
Int. J. Antimicrob. Agents
, vol.29
, pp. 374-379
-
-
Falagas, M.E.1
Rafailidis, P.I.2
Rosmarakis, E.S.3
-
34
-
-
0347992772
-
Quinolones: Cardioprotective or cardiotoxic
-
Katritsis, D. , Camm, A. J. Quinolones: Cardioprotective or cardiotoxic? PACE 26, 2317-2320 (2003).
-
(2003)
PACE
, vol.26
, pp. 2317-2320
-
-
Katritsis, D.1
Camm, A.J.2
-
35
-
-
84898948830
-
Mechanism of quinolone action and resistance
-
Aldred, K. J., Kerns, R. J. , Osheroff, N. Mechanism of quinolone action and resistance. Biochemistry 53, 1565-1574 (2014).
-
(2014)
Biochemistry
, vol.53
, pp. 1565-1574
-
-
Aldred, K.J.1
Kerns, R.J.2
Osheroff, N.3
-
36
-
-
0034923502
-
DNA topisomerases: Structure, function, and mechanism
-
Champoux, J. J. DNA topisomerases: structure, function, and mechanism. Annu. Rev. Biochem. 70, 369-413 (2001).
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 369-413
-
-
Champoux, J.J.1
-
37
-
-
84877257450
-
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: Mechanistic basis of quinolone resistance
-
Aldred, K. J., McPherson, S. A., Turnbough, C. L., Kerns, R. J. , Osheroff, N. Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance. Nucleic Acids Res. 41, 4628-4639 (2013).
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 4628-4639
-
-
Aldred, K.J.1
McPherson, S.A.2
Turnbough, C.L.3
Kerns, R.J.4
Osheroff, N.5
-
38
-
-
55249100552
-
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage
-
Pan, X. S., Dias, M., Palumbo, M. , Fisher, L. M. Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage. Nucleic Acids Res. 36, 5516-5529 (2008).
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 5516-5529
-
-
Pan, X.S.1
Dias, M.2
Palumbo, M.3
Fisher, L.M.4
-
39
-
-
84919629271
-
Bypassing fluoroquinolone resistance with quinazolinediones: Studies of drug-gyrase-DNA complexes having implications for drug design
-
Drlica, K. et al. Bypassing fluoroquinolone resistance with quinazolinediones: Studies of drug-gyrase-DNA complexes having implications for drug design. ACS Chem. Biol. 9, 2895-2904 (2014).
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 2895-2904
-
-
Drlica, K.1
-
40
-
-
48749117988
-
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors
-
Miller, A. A. et al. Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Antimicrob. Agents Chemother. 52, 2806-2812 (2008).
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 2806-2812
-
-
Miller, A.A.1
-
41
-
-
84887882612
-
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents
-
Basarab, G. S. et al. Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents. J. Med. Chem. 56, 8712-8735 (2013).
-
(2013)
J. Med. Chem.
, vol.56
, pp. 8712-8735
-
-
Basarab, G.S.1
-
42
-
-
0034752425
-
Frequency of selection of fluoroquinolone-resistant mutants of Neisseria gonorrhoeae exposed to gemifloxacin and four other quinolones
-
Ruiz, J. et al. Frequency of selection of fluoroquinolone-resistant mutants of Neisseria gonorrhoeae exposed to gemifloxacin and four other quinolones. J. Antimicrob. Chemother. 48, 545-548 (2001).
-
(2001)
J. Antimicrob. Chemother.
, vol.48
, pp. 545-548
-
-
Ruiz, J.1
-
43
-
-
0025930861
-
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli
-
Yoshida, H., Bogaki, M., Nakamura, M., Yamanaka, L. M. , Nakamura, S. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob. Agents Chemother. 35, 1647-1650 (1991).
-
(1991)
Antimicrob. Agents Chemother.
, vol.35
, pp. 1647-1650
-
-
Yoshida, H.1
Bogaki, M.2
Nakamura, M.3
Yamanaka, L.M.4
Nakamura, S.5
-
44
-
-
4644267929
-
Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling
-
Balani, S. K. et al. Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling. Drug Metab. Dispos. 32, 1092-1095 (2004).
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1092-1095
-
-
Balani, S.K.1
-
45
-
-
0001632565
-
-
Eds Kuhlman, J., Dalhoff, A. , Zeiller, H. J) Springer Verlag, Berlin, Germany
-
Craig, W. A. , Dalhoff, A. in Handbook of experimental pharmacology (eds Kuhlman, J., Dalhoff, A. , Zeiller, H. J) 208-232 (Springer-Verlag, Berlin, Germany, 1998).
-
(1998)
Handbook of Experimental Pharmacology
, pp. 208-232
-
-
Craig, W.A.1
Dalhoff, A.2
-
46
-
-
0036093097
-
Pharmacodynamics of the new fluoroquinolone gatifloxacin in murine thigh and lung infection models
-
Andes, D. , Craig, W. A. Pharmacodynamics of the new fluoroquinolone gatifloxacin in murine thigh and lung infection models. Antimicrob. Agents Chemother. 46, 1665-1670 (2002).
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 1665-1670
-
-
Andes, D.1
Craig, W.A.2
-
47
-
-
81055136806
-
Estradiol-treated female mice as surrogate hosts for neisseria gonorrhoeae genital tract infections
-
Jerse, A. E. et al. Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections. Front. Microbiol. 2, 1-13 (2011).
-
(2011)
Front. Microbiol.
, vol.2
, pp. 1-13
-
-
Jerse, A.E.1
-
48
-
-
0031952586
-
Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men
-
Craig, W. A. Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men. Clin. Infect. Dis. 26, 1-10 (1998).
-
(1998)
Clin. Infect. Dis.
, vol.26
, pp. 1-10
-
-
Craig, W.A.1
-
49
-
-
0024501170
-
Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thighinfection models
-
Leggett, J. E. et al. Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thighinfection models. J. Infect. Dis. 159, 281-292 (1989).
-
(1989)
J. Infect. Dis.
, vol.159
, pp. 281-292
-
-
Leggett, J.E.1
-
50
-
-
0027161344
-
Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients
-
Forrest, A. et al. Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob. Agents Chemother. 37, 1073-1081 (1993).
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1073-1081
-
-
Forrest, A.1
-
51
-
-
0027293476
-
Ofloxacin susceptibilities of 5, 667 Neisseria gonorrhoeae strains isolated in Hong Kong
-
Kam, K. M., Lo, K. K., Lai, C., Lee, Y. S. , Chan, C. B. Ofloxacin susceptibilities of 5, 667 Neisseria gonorrhoeae strains isolated in Hong Kong. Antimicrob. Agents Chemother. 37, 2007-2008 (1997).
-
(1997)
Antimicrob. Agents Chemother.
, vol.37
, pp. 2007-2008
-
-
Kam, K.M.1
Lo, K.K.2
Lai, C.3
Lee, Y.S.4
Chan, C.B.5
-
53
-
-
33750988182
-
Antimicrobial therapy of multidrug-resistant S. Pneumoniae, vancomycin-resistant Enterococci, and methicillinresistant S. Aureus
-
Cunha, B. A. Antimicrobial therapy of multidrug-resistant S. pneumoniae, vancomycin-resistant Enterococci, and methicillinresistant S. aureus. Med. Clin. N. Am. 90, 1165-1182 (2006).
-
(2006)
Med. Clin. N. Am.
, vol.90
, pp. 1165-1182
-
-
Cunha, B.A.1
-
54
-
-
0036839738
-
In vivo pharmacodynamics of a new oxazolidinone (linezolid)
-
Andes, D., van Ogtrop, M. L., Peng, J. , Craig, W. A. In vivo pharmacodynamics of a new oxazolidinone (linezolid). Antimicrob. Agents Chemother. 46, 3484-3489 (2002).
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 3484-3489
-
-
Andes, D.1
Van Ogtrop, M.L.2
Peng, J.3
Craig, W.A.4
-
55
-
-
0029097440
-
Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad spectrum cephalosporins
-
Craig, W. A. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad spectrum cephalosporins. Diagn. Microbiol. Infect. Dis. 22, 89-96 (1995).
-
(1995)
Diagn. Microbiol. Infect. Dis.
, vol.22
, pp. 89-96
-
-
Craig, W.A.1
-
56
-
-
15944382760
-
Quinolones in 2005: An update
-
Van Bambeke, F., Michot, J.-M., Van Eldere, J. , Tulkens, P. M. Quinolones in 2005: an update. Clin. Microbiol. Infect. 11, 256-280 (2005).
-
(2005)
Clin. Microbiol. Infect.
, vol.11
, pp. 256-280
-
-
Van Bambeke, F.1
Michot, J.-M.2
Van Eldere, J.3
Tulkens, P.M.4
-
57
-
-
0242287626
-
Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme
-
Rayner, C. R., Forrest, A., Meagher, A. K., Birmingham, M. C. , Schentag, J. J. Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme. Clin. Pharmacokinet. 42, 1411-1423 (2003).
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 1411-1423
-
-
Rayner, C.R.1
Forrest, A.2
Meagher, A.K.3
Birmingham, M.C.4
Schentag, J.J.5
-
58
-
-
0347989421
-
Levofloxacin: A review of its use in the treatment of bacterial infections in the United States
-
Croom, K. F. , Goa, K. L. Levofloxacin: a review of its use in the treatment of bacterial infections in the United States. Drugs 63, 2769-2802 (2003).
-
(2003)
Drugs
, vol.63
, pp. 2769-2802
-
-
Croom, K.F.1
Goa, K.L.2
-
59
-
-
84937070006
-
-
B. Braun Medical Inc Available at: Accessed: 8th March 2015
-
B. Braun Medical Inc., Ceftriaxone for Injection and Dextrose Injection (2012) Available at: http://www.accessdata.fda.gov/drugsatfda-docs/label/2012/050796orig1s011lbledt.pdf. (Accessed: 8th March 2015).
-
(2012)
Ceftriaxone for Injection and Dextrose Injection
-
-
-
60
-
-
0023232967
-
Plasma protein binding of ceftriaxone
-
Popick, A. C. et al. Plasma protein binding of ceftriaxone. Xenobiotica. 17, 1139-1145 (1987).
-
(1987)
Xenobiotica
, vol.17
, pp. 1139-1145
-
-
Popick, A.C.1
-
61
-
-
84865473314
-
Allosteric inhibition of the DNA-dependent ATPase activity of Escherichia coli DNA gyrase by a representative of a novel class of inhibitors
-
Shapiro, A. B. , Andrews, B. Allosteric inhibition of the DNA-dependent ATPase activity of Escherichia coli DNA gyrase by a representative of a novel class of inhibitors. Biochem. Pharmacol. 84, 900-904 (2012).
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 900-904
-
-
Shapiro, A.B.1
Andrews, B.2
-
62
-
-
67749095984
-
Pyrazolopyrimidinediones are selective agents for Helicobacter pylori that suppress growth through inhibition of glutamate racemase (MurI)
-
de Jonge, B. L. M., Kutschke, A., Uria-Nickelsen, M., Kamp, H. D. , Mills, S. D. Pyrazolopyrimidinediones are selective agents for Helicobacter pylori that suppress growth through inhibition of glutamate racemase (MurI). Antimicrob. Agents Chemother. 53, 3331-3336 (2009).
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 3331-3336
-
-
De Jonge, B.L.M.1
Kutschke, A.2
Uria-Nickelsen, M.3
Kamp, H.D.4
Mills, S.D.5
-
63
-
-
0023176033
-
Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentrations to MIC for bactericidal activity and emergence of resistance
-
Blaser, J., Stone, B. B., Groner, M. C. , Zinner, S. H. Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentrations to MIC for bactericidal activity and emergence of resistance. Antimicrob. Agents Chemother. 31, 1054-1060 (1987).
-
(1987)
Antimicrob. Agents Chemother.
, vol.31
, pp. 1054-1060
-
-
Blaser, J.1
Stone, B.B.2
Groner, M.C.3
Zinner, S.H.4
-
64
-
-
34249870835
-
Impact of drug-exposure intensity and duration of therapy on the emergence of Staphylococcus aureus resistance to a quinolone
-
Tam, V. H. et al. Impact of drug-exposure intensity and duration of therapy on the emergence of Staphylococcus aureus resistance to a quinolone. J. Infect. Dis. 195, 1818-1827 (2007).
-
(2007)
J. Infect. Dis.
, vol.195
, pp. 1818-1827
-
-
Tam, V.H.1
|