Macrolide resistance and azithromycin failure in a mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens

Clinical Infectious Diseases

Volumn 60, Issue 8, 2015, Pages 1228-1236

  Bissessor, Melanie ^a,b   Tabrizi, Sepehr N ^a,c   Twin, Jimmy ^c   Abdo, Houda ^c   Fairley, Christopher K ^a,d   Chen, Marcus Y ^a,d   Vodstrcil, Lenka A ^a,b,c   Jensen, Jorgen S ^e   Hocking, Jane S ^b   Garland, Suzanne M ^a   Bradshaw, Catriona S ^a,b,d  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ROYAL WOMEN'S HOSPITAL   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e STATENS SERUM INSTITUT   (Denmark)

Author keywords

azithromycin; macrolide resistance; moxifloxacin; Mycoplasma genitalium; pristinamycin

Indexed keywords

AZITHROMYCIN; MOXIFLOXACIN; PRISTINAMYCIN; ANTIINFECTIVE AGENT; MACROLIDE; QUINOLONE DERIVATIVE;

ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG TREATMENT FAILURE; FEMALE; FOLLOW UP; GENE MUTATION; HIGH RESOLUTION MELTING ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MYCOPLASMA GENITALIUM; MYCOPLASMOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REINFECTION; SEXUALLY TRANSMITTED DISEASE; TREATMENT OUTCOME; DRUG EFFECTS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; MYCOPLASMA INFECTIONS; TREATMENT FAILURE; YOUNG ADULT;

ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; DRUG RESISTANCE, BACTERIAL; FEMALE; FLUOROQUINOLONES; HUMANS; MACROLIDES; MALE; MIDDLE AGED; MYCOPLASMA GENITALIUM; MYCOPLASMA INFECTIONS; PRISTINAMYCIN; TREATMENT FAILURE; YOUNG ADULT;

EID: 84926639944     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciu1162     Document Type: Article

References (39)

1. Taylor-Robinson D, Jensen JS. Mycoplasma genitalium: from chrysalis to multicolored butterfly. Clin Microbiol Rev 2011; 24:498-514.
2. Haggerty CL, Taylor BD. Mycoplasma genitalium: an emerging cause of pelvic inflammatory disease. Infect Dis Obstet Gynecol 2011; 2011:959816.
3. Mavedzenge SN, Van Der Pol B, Weiss HA, et al. The association between Mycoplasma genitalium and HIV-1 acquisition in African women. AIDS 2012; 26:617-24.
4. Manhart LE. Another STI associated with HIV-1 acquisition: now what?. AIDS 2012; 26:635-7.
5. McGowin CL, Annan RS, Quayle AJ, et al. Persistent Mycoplasma genitalium infection of human endocervical epithelial cells elicits chronic inflammatory cytokine secretion. Infect Immun 2012; 80:3842-9.
6. Chrisment D, Charron A, Cazanave C, et al. Detection of macrolide resistance in Mycoplasma genitalium in France. J Antimicrob Chemother 2012; 67:2598-601.
7. Gesink DC, Mulvad G, Montgomery-Andersen R, et al. Mycoplasma genitalium presence, resistance and epidemiology in Greenland. Int J Circumpolar Health 2012; 71:1-8.
8. Anagrius C, Lore B, Jensen JS. Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic. PLoS One 2013; 8:e61481.
9. Manhart LE, Gillespie CW, Lowens MS, et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin Infect Dis 2013; 56: 934-42.
10. Twin J, Jensen JS, Bradshaw CS, et al. Transmission and selection of macrolide resistant Mycoplasma genitalium infections detected by rapid high resolution melt analysis. PLoS One 2012; 7:e35593.
11. Tagg KA, Jeoffreys NJ, Couldwell DL, Donald JA, Gilbert GL. Fluoroquinolone and macrolide resistance-Associated mutations in Mycoplasma genitalium. J Clin Microbiol 2013; 51:2245-9.
12. Yew HS, Anderson T, Coughlan E, Werno A. Induced macrolide resistance in Mycoplasma genitalium isolates from patients with recurrent nongonococcal urethritis. J Clin Microbiol 2011; 49:1695-6.
13. Shimada Y, Deguchi T, Nakane K, et al. Macrolide resistance-Associated 23S rRNA mutation in Mycoplasma genitalium, Japan. Emerg Infect Dis 2011; 17:1148-50.
14. Bradshaw CS, Jensen JS, Tabrizi SN, et al. Azithromycin failure in Mycoplasma genitalium urethritis. Emerg Infect Dis 2006; 12:1149-52.
15. Bradshaw CS, Chen MY, Fairley CK. Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS One 2008; 3:e3618.
16. Jensen JS. Protocol for the detection of Mycoplasma genitalium by PCR from clinical specimens and subsequent detection of macrolide resistance-mediating mutations in region V of the 23S rRNA gene. Methods Mol Biol 2012; 903:129-39.
17. Manhart LE, Broad JM, Golden MR. Mycoplasma genitalium: should we treat and how?. Clin Infect Dis 2011; 53(suppl 3):S129-42.
18. Deguchi T, Maeda S, Tamaki M, et al. Analysis of the gyrA and parC genes of Mycoplasma genitalium detected in first-pass urine of men with non-gonococcal urethritis before and after fluoroquinolone treatment. J Antimicrob Chemother 2001; 48:742-4.
19. Couldwell DL, Tagg KA, Jeoffreys NJ, Gilbert GL. Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance. Int J STD AIDS 2013; 24:822-8.
20. Twin J, Taylor N, Garland SM, et al. Comparison of two Mycoplasma genitalium real-Time PCR detection methodologies. J Clin Microbiol 2011; 49:1140-2.
21. Edberg A, Jurstrand M, Johansson E, et al. A comparative study of three different PCR assays for detection of Mycoplasma genitalium in urogenital specimens from men and women. J Med Microbiol 2008; 57( pt 3):304-9.
22. Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 2010; 59(RR-12):1-110.
23. Shahmanesh M, Moi H, Lassau F, Janier M. 2009 European guideline on the management of male non-gonococcal urethritis. Int J STD AIDS 2009; 20:458-64.
24. Bjornelius E, Anagrius C, Bojs G, et al. Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial. Sex Transm Infect 2008; 84:72-6.
25. Mena LA, Mroczkowski TF, Nsuami M, Martin DH. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. Clin Infect Dis 2009; 48:1649-54.
26. FitzGerald M, Bedford C. National standards for the management of gonorrhoea. Int J STD AIDS 1996; 7:298-300.
27. Salado-Rasmussen K, Jensen JS. Mycoplasma genitalium testing pattern and macrolide resistance: a Danish nationwide retrospective survey. Clin Infect Dis 2014; 59:24-30.
28. Pond MJ, Nori AV, Witney AA, Lopeman RC, Butcher PD, Sadiq ST. High prevalence of antibiotic-resistant Mycoplasma genitalium in nongonococcal urethritis: the need for routine testing and the inadequacy of current treatment options. Clin Infect Dis 2014; 58:631-7.
29. Walker J, Fairley CK, Bradshaw CS, et al. Mycoplasma genitalium incidence, organism load, and treatment failure in a cohort of young Australian women. Clin Infect Dis 2013; 56:1094-100.
30. Horner P. The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection. Sex Transm Infect 2006; 82:340-3.
31. Jensen JS, Bradshaw CS, Tabrizi SN, Fairley CK, Hamasuna R. Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin Infect Dis 2008; 47:1546-53.
32. Jernberg E, Moghaddam A, Moi H. Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study. Int J STD AIDS 2008; 19:676-9.
33. Shimada Y, Deguchi T, Nakane K, et al. Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistance. Int J Antimicrob Agents 2010; 36:255-8.
34. Gruson D, Pereyre S, Renaudin H, Charron A, Bebear C, Bebear CM. In vitro development of resistance to six and four fluoroquinolones in Mycoplasma pneumoniae and Mycoplasma hominis, respectively. Antimicrob Agents Chemother 2005; 49:1190-3.
35. Taylor-Robinson D. Diagnosis and antimicrobial treatment of Mycoplasma genitalium infection: sobering thoughts. Expert Rev Anti Infect Ther 2014; 12:715-22.
36. Gaydos CA, Crotchfelt KA, Howell MR, Kralian S, Hauptman P, Quinn TC. Molecular amplification assays to detect chlamydial infections in urine specimens from high school female students and to monitor the persistence of chlamydial DNA after therapy. J Infect Dis 1998; 177:417-24.
37. Bachmann LH, Desmond RA, Stephens J, Hughes A, Hook EW III. Duration of persistence of gonococcal DNA detected by ligase chain reaction in men and women following recommended therapy for uncomplicated gonorrhea. J Clin Microbiol 2002; 40:3596-601.
38. Manhart LE. Diagnostic and resistance testing for Mycoplasma genitalium: what will it take?. Clin Infect Dis 2014; 59:31-3.
39. Ison CA. Antimicrobial resistance in sexually transmitted infections in the developed world: implications for rational treatment. Curr Opin Infect Dis 2012; 25:73-8.