메뉴 건너뛰기




Volumn 2, Issue 1, 2016, Pages 20-34

Ontogeny of Tumor-Associated Macrophages and Its Implication in Cancer Regulation

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENESIS; CELL DENSITY; CELL EXPANSION; EMBRYO DEVELOPMENT; HUMAN; IMMUNITY; INFLAMMATION; MACROPHAGE; MACROPHAGE FUNCTION; MALIGNANT NEOPLASM; MONOCYTE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; REVIEW; STEADY STATE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT;

EID: 85009115863     PISSN: 24058033     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trecan.2015.11.004     Document Type: Review
Times cited : (137)

References (145)
  • 1
    • 84886654275 scopus 로고    scopus 로고
    • Tissue-resident macrophages
    • 1 Davies, L.C., et al. Tissue-resident macrophages. Nat. Immunol. 14 (2013), 986–995.
    • (2013) Nat. Immunol. , vol.14 , pp. 986-995
    • Davies, L.C.1
  • 2
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • 2 Wynn, T.A., et al. Macrophage biology in development, homeostasis and disease. Nature 496 (2013), 445–455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1
  • 3
    • 84911077979 scopus 로고    scopus 로고
    • Tissue macrophage identity and self-renewal
    • 3 Gentek, R., et al. Tissue macrophage identity and self-renewal. Immunol. Rev. 262 (2014), 56–73.
    • (2014) Immunol. Rev. , vol.262 , pp. 56-73
    • Gentek, R.1
  • 4
    • 84888063933 scopus 로고    scopus 로고
    • Beyond stem cells: self-renewal of differentiated macrophages
    • 4 Sieweke, M.H., Allen, J.E., Beyond stem cells: self-renewal of differentiated macrophages. Science, 342, 2013, 1242974.
    • (2013) Science , vol.342 , pp. 1242974
    • Sieweke, M.H.1    Allen, J.E.2
  • 5
    • 84884352076 scopus 로고    scopus 로고
    • Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes
    • 5 Jakubzick, C., et al. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity 39 (2013), 599–610.
    • (2013) Immunity , vol.39 , pp. 599-610
    • Jakubzick, C.1
  • 6
    • 84887616366 scopus 로고    scopus 로고
    • Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin
    • 6 Tamoutounour, S., et al. Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39 (2013), 925–938.
    • (2013) Immunity , vol.39 , pp. 925-938
    • Tamoutounour, S.1
  • 7
    • 84921313153 scopus 로고    scopus 로고
    • Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
    • 7 Bain, C.C., et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat. Immunol. 15 (2014), 929–937.
    • (2014) Nat. Immunol. , vol.15 , pp. 929-937
    • Bain, C.C.1
  • 8
    • 84870900504 scopus 로고    scopus 로고
    • Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
    • 8 Zigmond, E., et al. Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 37 (2012), 1076–1090.
    • (2012) Immunity , vol.37 , pp. 1076-1090
    • Zigmond, E.1
  • 9
    • 84901215262 scopus 로고    scopus 로고
    • The cellular and molecular origin of tumor-associated macrophages
    • 9 Franklin, R.A., et al. The cellular and molecular origin of tumor-associated macrophages. Science 344 (2014), 921–925.
    • (2014) Science , vol.344 , pp. 921-925
    • Franklin, R.A.1
  • 10
    • 84892450644 scopus 로고    scopus 로고
    • Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation
    • 10 Epelman, S., et al. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity 40 (2014), 91–104.
    • (2014) Immunity , vol.40 , pp. 91-104
    • Epelman, S.1
  • 11
    • 84904401883 scopus 로고    scopus 로고
    • Origin and functions of tissue macrophages
    • 11 Epelman, S., et al. Origin and functions of tissue macrophages. Immunity 41 (2014), 21–35.
    • (2014) Immunity , vol.41 , pp. 21-35
    • Epelman, S.1
  • 12
    • 84901358607 scopus 로고    scopus 로고
    • Monocytes and macrophages: developmental pathways and tissue homeostasis
    • 12 Ginhoux, F., Jung, S., Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat. Rev. Immunol. 14 (2014), 392–404.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 392-404
    • Ginhoux, F.1    Jung, S.2
  • 13
    • 84904875085 scopus 로고    scopus 로고
    • Myb-independent macrophages: a family of cells that develops with their tissue of residence and is involved in its homeostasis
    • 13 Gomez Perdiguero, E., Geissmann, F., Myb-independent macrophages: a family of cells that develops with their tissue of residence and is involved in its homeostasis. Cold Spring Harb. Symp. Quant. Biol. 78 (2013), 91–100.
    • (2013) Cold Spring Harb. Symp. Quant. Biol. , vol.78 , pp. 91-100
    • Gomez Perdiguero, E.1    Geissmann, F.2
  • 14
    • 39349096526 scopus 로고    scopus 로고
    • Hematopoiesis: an evolving paradigm for stem cell biology
    • 14 Orkin, S.H., Zon, L.I., Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132 (2008), 631–644.
    • (2008) Cell , vol.132 , pp. 631-644
    • Orkin, S.H.1    Zon, L.I.2
  • 15
    • 84928189502 scopus 로고    scopus 로고
    • C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
    • 15 Hoeffel, G., et al. C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity 42 (2015), 665–678.
    • (2015) Immunity , vol.42 , pp. 665-678
    • Hoeffel, G.1
  • 16
    • 84946564588 scopus 로고    scopus 로고
    • Ontogeny of tissue-resident macrophages
    • 16 Hoeffel, G., Ginhoux, F., Ontogeny of tissue-resident macrophages. Front. Immunol., 6, 2015, 486.
    • (2015) Front. Immunol. , vol.6 , pp. 486
    • Hoeffel, G.1    Ginhoux, F.2
  • 17
    • 84886299230 scopus 로고    scopus 로고
    • Erythro-myeloid progenitors: ‘definitive’ hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells
    • 17 Frame, J.M., et al. Erythro-myeloid progenitors: ‘definitive’ hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells. Blood Cells Mol. Dis. 51 (2013), 220–225.
    • (2013) Blood Cells Mol. Dis. , vol.51 , pp. 220-225
    • Frame, J.M.1
  • 18
    • 84901309496 scopus 로고    scopus 로고
    • Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection
    • 18 Lin, Y., et al. Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection. Stem Cells Dev. 23 (2014), 1168–1177.
    • (2014) Stem Cells Dev. , vol.23 , pp. 1168-1177
    • Lin, Y.1
  • 19
    • 0033405452 scopus 로고    scopus 로고
    • Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    • 19 Palis, J., et al. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126 (1999), 5073–5084.
    • (1999) Development , vol.126 , pp. 5073-5084
    • Palis, J.1
  • 20
    • 84865850027 scopus 로고    scopus 로고
    • Immature hematopoietic stem cells undergo maturation in the fetal liver
    • 20 Kieusseian, A., et al. Immature hematopoietic stem cells undergo maturation in the fetal liver. Development 139 (2012), 3521–3530.
    • (2012) Development , vol.139 , pp. 3521-3530
    • Kieusseian, A.1
  • 21
    • 34247601504 scopus 로고    scopus 로고
    • Cell tracing shows the contribution of the yolk sac to adult haematopoiesis
    • 21 Samokhvalov, I.M., et al. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 446 (2007), 1056–1061.
    • (2007) Nature , vol.446 , pp. 1056-1061
    • Samokhvalov, I.M.1
  • 22
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • 22 Ginhoux, F., et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330 (2010), 841–845.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1
  • 23
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • 23 Schulz, C., et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336 (2012), 86–90.
    • (2012) Science , vol.336 , pp. 86-90
    • Schulz, C.1
  • 24
    • 0025821494 scopus 로고
    • A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
    • 24 Mucenski, M.L., et al. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65 (1991), 677–689.
    • (1991) Cell , vol.65 , pp. 677-689
    • Mucenski, M.L.1
  • 25
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
    • 25 Gomez Perdiguero, E., et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518 (2015), 547–551.
    • (2015) Nature , vol.518 , pp. 547-551
    • Gomez Perdiguero, E.1
  • 26
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    • 26 Kierdorf, K., et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat. Neurosci. 16 (2013), 273–280.
    • (2013) Nat. Neurosci. , vol.16 , pp. 273-280
    • Kierdorf, K.1
  • 27
    • 84940984138 scopus 로고    scopus 로고
    • Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells
    • 27 Sheng, J., et al. Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells. Immunity 43 (2015), 382–393.
    • (2015) Immunity , vol.43 , pp. 382-393
    • Sheng, J.1
  • 28
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • 28 Daneman, R., et al. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468 (2010), 562–566.
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1
  • 29
    • 84876775203 scopus 로고    scopus 로고
    • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    • 29 Hashimoto, D., et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38 (2013), 792–804.
    • (2013) Immunity , vol.38 , pp. 792-804
    • Hashimoto, D.1
  • 30
    • 84884214656 scopus 로고    scopus 로고
    • Multicolor fate mapping of Langerhans cell homeostasis
    • 30 Ghigo, C., et al. Multicolor fate mapping of Langerhans cell homeostasis. J. Exp. Med. 210 (2013), 1657–1664.
    • (2013) J. Exp. Med. , vol.210 , pp. 1657-1664
    • Ghigo, C.1
  • 31
    • 21144444056 scopus 로고    scopus 로고
    • Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    • 31 Kissenpfennig, A., et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22 (2005), 643–654.
    • (2005) Immunity , vol.22 , pp. 643-654
    • Kissenpfennig, A.1
  • 32
    • 84878738380 scopus 로고    scopus 로고
    • Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
    • 32 Davies, L.C., et al. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nat. Commun., 4, 2013, 1886.
    • (2013) Nat. Commun. , vol.4 , pp. 1886
    • Davies, L.C.1
  • 33
    • 79960706327 scopus 로고    scopus 로고
    • A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation
    • 33 Davies, L.C., et al. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. Eur. J. Immunol. 41 (2011), 2155–2164.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 2155-2164
    • Davies, L.C.1
  • 34
    • 80052621954 scopus 로고    scopus 로고
    • Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1
    • 34 Tagliani, E., et al. Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. J. Exp. Med. 208 (2011), 1901–1916.
    • (2011) J. Exp. Med. , vol.208 , pp. 1901-1916
    • Tagliani, E.1
  • 35
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • 35 Ajami, B., et al. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 10 (2007), 1538–1543.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1
  • 36
    • 73949147392 scopus 로고    scopus 로고
    • Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
    • 36 Chorro, L., et al. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J. Exp. Med. 206 (2009), 3089–3100.
    • (2009) J. Exp. Med. , vol.206 , pp. 3089-3100
    • Chorro, L.1
  • 37
    • 79958715229 scopus 로고    scopus 로고
    • Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
    • 37 Jenkins, S.J., et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 332 (2011), 1284–1288.
    • (2011) Science , vol.332 , pp. 1284-1288
    • Jenkins, S.J.1
  • 38
    • 84929030461 scopus 로고    scopus 로고
    • Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas
    • 38 Van Gassen, N., et al. Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas. Eur. J. Immunol. 45 (2015), 1482–1493.
    • (2015) Eur. J. Immunol. , vol.45 , pp. 1482-1493
    • Van Gassen, N.1
  • 39
    • 33645953640 scopus 로고    scopus 로고
    • Langerhans cells arise from monocytes in vivo
    • 39 Ginhoux, F., et al. Langerhans cells arise from monocytes in vivo. Nat. Immunol. 7 (2006), 265–273.
    • (2006) Nat. Immunol. , vol.7 , pp. 265-273
    • Ginhoux, F.1
  • 40
    • 84883800208 scopus 로고    scopus 로고
    • Local proliferation dominates lesional macrophage accumulation in atherosclerosis
    • 40 Robbins, C.S., et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat. Med. 19 (2013), 1166–1172.
    • (2013) Nat. Med. , vol.19 , pp. 1166-1172
    • Robbins, C.S.1
  • 41
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • 41 Shi, C., Pamer, E.G., Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 11 (2011), 762–774.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 762-774
    • Shi, C.1    Pamer, E.G.2
  • 42
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets with distinct migratory properties
    • 42 Geissmann, F., et al. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19 (2003), 71–82.
    • (2003) Immunity , vol.19 , pp. 71-82
    • Geissmann, F.1
  • 43
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • 43 Jung, S., et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20 (2000), 4106–4114.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4106-4114
    • Jung, S.1
  • 44
    • 36549033197 scopus 로고    scopus 로고
    • The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    • 44 Nahrendorf, M., et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 204 (2007), 3037–3047.
    • (2007) J. Exp. Med. , vol.204 , pp. 3037-3047
    • Nahrendorf, M.1
  • 45
    • 34547728312 scopus 로고    scopus 로고
    • Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    • 45 Auffray, C., et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science 317 (2007), 666–670.
    • (2007) Science , vol.317 , pp. 666-670
    • Auffray, C.1
  • 46
    • 80051959957 scopus 로고    scopus 로고
    • The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes
    • 46 Hanna, R.N., et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes. Nat. Immunol. 12 (2011), 778–785.
    • (2011) Nat. Immunol. , vol.12 , pp. 778-785
    • Hanna, R.N.1
  • 47
    • 84876207357 scopus 로고    scopus 로고
    • Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal
    • 47 Carlin, L.M., et al. Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell 153 (2013), 362–375.
    • (2013) Cell , vol.153 , pp. 362-375
    • Carlin, L.M.1
  • 48
    • 84355162334 scopus 로고    scopus 로고
    • Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo
    • 48 Biburger, M., et al. Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo. Immunity 35 (2011), 932–944.
    • (2011) Immunity , vol.35 , pp. 932-944
    • Biburger, M.1
  • 49
    • 84884375843 scopus 로고    scopus 로고
    • A close encounter of the third kind: monocyte-derived cells
    • 49 Mildner, A., et al. A close encounter of the third kind: monocyte-derived cells. Adv. Immunol. 120 (2013), 69–103.
    • (2013) Adv. Immunol. , vol.120 , pp. 69-103
    • Mildner, A.1
  • 50
    • 84872765982 scopus 로고    scopus 로고
    • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    • 50 Yona, S., et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38 (2013), 79–91.
    • (2013) Immunity , vol.38 , pp. 79-91
    • Yona, S.1
  • 51
    • 84896366680 scopus 로고    scopus 로고
    • Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
    • 51 Haldar, M., et al. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell 156 (2014), 1223–1234.
    • (2014) Cell , vol.156 , pp. 1223-1234
    • Haldar, M.1
  • 52
    • 84943384367 scopus 로고    scopus 로고
    • The pancreas anatomy conditions the origin and properties of resident macrophages
    • 52 Calderon, B., et al. The pancreas anatomy conditions the origin and properties of resident macrophages. J. Exp. Med. 212 (2015), 1497–1512.
    • (2015) J. Exp. Med. , vol.212 , pp. 1497-1512
    • Calderon, B.1
  • 53
    • 84908227801 scopus 로고    scopus 로고
    • Progressive replacement of embryo-derived cardiac macrophages with age
    • 53 Molawi, K., et al. Progressive replacement of embryo-derived cardiac macrophages with age. J. Exp. Med. 211 (2014), 2151–2158.
    • (2014) J. Exp. Med. , vol.211 , pp. 2151-2158
    • Molawi, K.1
  • 54
    • 84869208905 scopus 로고    scopus 로고
    • Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
    • 54 Ramachandran, P., et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc. Natl. Acad. Sci. U.S.A. 109 (2012), E3186–E3195.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. E3186-E3195
    • Ramachandran, P.1
  • 55
    • 84255197264 scopus 로고    scopus 로고
    • Transcriptomic analyses of murine resolution-phase macrophages
    • 55 Stables, M.J., et al. Transcriptomic analyses of murine resolution-phase macrophages. Blood 118 (2011), e192–e208.
    • (2011) Blood , vol.118 , pp. e192-e208
    • Stables, M.J.1
  • 56
    • 33845989083 scopus 로고    scopus 로고
    • Monocyte subsets differentially employ CCR2 CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
    • 56 Tacke, F., et al. Monocyte subsets differentially employ CCR2 CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J. Clin. Invest. 117 (2007), 185–194.
    • (2007) J. Clin. Invest. , vol.117 , pp. 185-194
    • Tacke, F.1
  • 57
    • 34248997759 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
    • 57 Arnold, L., et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 204 (2007), 1057–1069.
    • (2007) J. Exp. Med. , vol.204 , pp. 1057-1069
    • Arnold, L.1
  • 58
    • 68049143269 scopus 로고    scopus 로고
    • Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    • 58 Shechter, R., et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med., 6, 2009, e1000113.
    • (2009) PLoS Med. , vol.6 , pp. e1000113
    • Shechter, R.1
  • 59
    • 84875508135 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4
    • 59 Egawa, M., et al. Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity 38 (2013), 570–580.
    • (2013) Immunity , vol.38 , pp. 570-580
    • Egawa, M.1
  • 60
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • 60 De Palma, M., Lewis, C.E., Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 23 (2013), 277–286.
    • (2013) Cancer Cell , vol.23 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 61
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • 61 Qian, B.Z., Pollard, J.W., Macrophage diversity enhances tumor progression and metastasis. Cell 141 (2010), 39–51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 62
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • 62 Sica, A., Mantovani, A., Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 122 (2012), 787–795.
    • (2012) J. Clin. Invest. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 63
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • 63 De Palma, M., et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8 (2005), 211–226.
    • (2005) Cancer Cell , vol.8 , pp. 211-226
    • De Palma, M.1
  • 64
    • 0038644403 scopus 로고    scopus 로고
    • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
    • 64 De Palma, M., et al. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat. Med. 9 (2003), 789–795.
    • (2003) Nat. Med. , vol.9 , pp. 789-795
    • De Palma, M.1
  • 65
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • 65 Movahedi, K., et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 70 (2010), 5728–5739.
    • (2010) Cancer Res. , vol.70 , pp. 5728-5739
    • Movahedi, K.1
  • 66
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • 66 DeNardo, D.G., et al. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16 (2009), 91–102.
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • DeNardo, D.G.1
  • 67
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • 67 Lin, E.Y., et al. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193 (2001), 727–740.
    • (2001) J. Exp. Med. , vol.193 , pp. 727-740
    • Lin, E.Y.1
  • 68
    • 84961638765 scopus 로고    scopus 로고
    • The ontogeny of tumor-associated macrophages: a new understanding of cancer–elicited inflammation
    • 68 Franklin, R.A., Li, M.O., The ontogeny of tumor-associated macrophages: a new understanding of cancer–elicited inflammation. Oncoimmunology, 3, 2014, e955346.
    • (2014) Oncoimmunology , vol.3 , pp. e955346
    • Franklin, R.A.1    Li, M.O.2
  • 69
    • 84906097515 scopus 로고    scopus 로고
    • In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors
    • 69 Tymoszuk, P., et al. In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors. Eur. J. Immunol. 44 (2014), 2247–2262.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 2247-2262
    • Tymoszuk, P.1
  • 70
    • 84915793974 scopus 로고    scopus 로고
    • Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
    • 70 Bonapace, L., et al. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature 515 (2014), 130–133.
    • (2014) Nature , vol.515 , pp. 130-133
    • Bonapace, L.1
  • 71
    • 79960833961 scopus 로고    scopus 로고
    • Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome
    • 71 Campbell, M.J., et al. Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome. Breast Cancer Res. Treat. 128 (2011), 703–711.
    • (2011) Breast Cancer Res. Treat. , vol.128 , pp. 703-711
    • Campbell, M.J.1
  • 72
    • 84892747845 scopus 로고    scopus 로고
    • Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population
    • 72 Laoui, D., et al. Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res. 74 (2014), 24–30.
    • (2014) Cancer Res. , vol.74 , pp. 24-30
    • Laoui, D.1
  • 73
    • 84863151366 scopus 로고    scopus 로고
    • Origins of tumor-associated macrophages and neutrophils
    • 73 Cortez-Retamozo, V., et al. Origins of tumor-associated macrophages and neutrophils. Proc. Natl. Acad. Sci. U.S.A. 109 (2012), 2491–2496.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 2491-2496
    • Cortez-Retamozo, V.1
  • 74
    • 84901675728 scopus 로고    scopus 로고
    • Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes
    • 74 Shand, F.H., et al. Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 7771–7776.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 7771-7776
    • Shand, F.H.1
  • 75
    • 84885454468 scopus 로고    scopus 로고
    • Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
    • 75 Guilliams, M., et al. Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J. Exp. Med. 210 (2013), 1977–1992.
    • (2013) J. Exp. Med. , vol.210 , pp. 1977-1992
    • Guilliams, M.1
  • 76
    • 84908148912 scopus 로고    scopus 로고
    • Induction of the nuclear receptor PPAR-gamma by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
    • 76 Schneider, C., et al. Induction of the nuclear receptor PPAR-gamma by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat. Immunol. 15 (2014), 1026–1037.
    • (2014) Nat. Immunol. , vol.15 , pp. 1026-1037
    • Schneider, C.1
  • 77
    • 81855169964 scopus 로고    scopus 로고
    • Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
    • 77 Kang, T.W., et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479 (2011), 547–551.
    • (2011) Nature , vol.479 , pp. 547-551
    • Kang, T.W.1
  • 78
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • 78 Du, R., et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13 (2008), 206–220.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1
  • 79
    • 84887481716 scopus 로고    scopus 로고
    • CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • 79 Pyonteck, S.M., et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat. Med. 19 (2013), 1264–1272.
    • (2013) Nat. Med. , vol.19 , pp. 1264-1272
    • Pyonteck, S.M.1
  • 80
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • 80 Gabrilovich, D.I., et al. Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12 (2012), 253–268.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 253-268
    • Gabrilovich, D.I.1
  • 81
    • 33646468643 scopus 로고    scopus 로고
    • Apoptotic cell removal in development and tissue homeostasis
    • 81 Henson, P.M., Hume, D.A., Apoptotic cell removal in development and tissue homeostasis. Trends Immunol. 27 (2006), 244–250.
    • (2006) Trends Immunol. , vol.27 , pp. 244-250
    • Henson, P.M.1    Hume, D.A.2
  • 82
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • 82 Pollard, J.W., Trophic macrophages in development and disease. Nat. Rev. Immunol. 9 (2009), 259–270.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 259-270
    • Pollard, J.W.1
  • 83
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • 83 Wynn, T.A., Cellular and molecular mechanisms of fibrosis. J. Pathol. 214 (2008), 199–210.
    • (2008) J. Pathol. , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 84
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • 84 Ajami, B., et al. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat. Neurosci. 14 (2011), 1142–1149.
    • (2011) Nat. Neurosci. , vol.14 , pp. 1142-1149
    • Ajami, B.1
  • 85
    • 63049083734 scopus 로고    scopus 로고
    • A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • 85 Saijo, K., et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137 (2009), 47–59.
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo, K.1
  • 86
    • 84920724792 scopus 로고    scopus 로고
    • Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
    • 86 Gosselin, D., et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 159 (2014), 1327–1340.
    • (2014) Cell , vol.159 , pp. 1327-1340
    • Gosselin, D.1
  • 87
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • 87 Lavin, Y., et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159 (2014), 1312–1326.
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1
  • 88
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • 88 Gautier, E.L., et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13 (2012), 1118–1128.
    • (2012) Nat. Immunol. , vol.13 , pp. 1118-1128
    • Gautier, E.L.1
  • 89
    • 84894574217 scopus 로고    scopus 로고
    • Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
    • 89 Parkhurst, C.N., et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155 (2013), 1596–1609.
    • (2013) Cell , vol.155 , pp. 1596-1609
    • Parkhurst, C.N.1
  • 90
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • 90 Paolicelli, R.C., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 333 (2011), 1456–1458.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 91
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • 91 Schafer, D.P., et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74 (2012), 691–705.
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1
  • 92
    • 84878444005 scopus 로고    scopus 로고
    • CD169(+) macrophages provide a niche promoting erythropoiesis under homeostasis and stress
    • 92 Chow, A., et al. CD169(+) macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat. Med. 19 (2013), 429–436.
    • (2013) Nat. Med. , vol.19 , pp. 429-436
    • Chow, A.1
  • 93
    • 58249104981 scopus 로고    scopus 로고
    • Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
    • 93 Kohyama, M., et al. Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature 457 (2009), 318–321.
    • (2009) Nature , vol.457 , pp. 318-321
    • Kohyama, M.1
  • 94
    • 84900413094 scopus 로고    scopus 로고
    • Tissue-specific signals control reversible program of localization and functional polarization of macrophages
    • 94 Okabe, Y., Medzhitov, R., Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell 157 (2014), 832–844.
    • (2014) Cell , vol.157 , pp. 832-844
    • Okabe, Y.1    Medzhitov, R.2
  • 95
    • 84925441813 scopus 로고    scopus 로고
    • Control of adaptive immunity by the innate immune system
    • 95 Iwasaki, A., Medzhitov, R., Control of adaptive immunity by the innate immune system. Nat. Immunol. 16 (2015), 343–353.
    • (2015) Nat. Immunol. , vol.16 , pp. 343-353
    • Iwasaki, A.1    Medzhitov, R.2
  • 96
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • 96 Wu, J., Chen, Z.J., Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 32 (2014), 461–488.
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 97
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • 97 Mosser, D.M., Edwards, J.P., Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8 (2008), 958–969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 98
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: nomenclature and experimental guidelines
    • 98 Murray, P.J., et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41 (2014), 14–20.
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 99
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • 99 Gordon, S., Alternative activation of macrophages. Nat. Rev. Immunol. 3 (2003), 23–35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 100
    • 84908504223 scopus 로고    scopus 로고
    • Inflammatory monocyte effector mechanisms
    • 100 Lauvau, G., et al. Inflammatory monocyte effector mechanisms. Cell. Immunol. 291 (2014), 32–40.
    • (2014) Cell. Immunol. , vol.291 , pp. 32-40
    • Lauvau, G.1
  • 101
    • 0037625155 scopus 로고    scopus 로고
    • TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    • 101 Serbina, N.V., et al. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19 (2003), 59–70.
    • (2003) Immunity , vol.19 , pp. 59-70
    • Serbina, N.V.1
  • 102
    • 34247161891 scopus 로고    scopus 로고
    • MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection
    • 102 Copin, R., et al. MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection. J. Immunol. 178 (2007), 5182–5191.
    • (2007) J. Immunol. , vol.178 , pp. 5182-5191
    • Copin, R.1
  • 103
    • 0034947236 scopus 로고    scopus 로고
    • Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis
    • 103 Peters, W., et al. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 98 (2001), 7958–7963.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 7958-7963
    • Peters, W.1
  • 104
    • 70350441863 scopus 로고    scopus 로고
    • Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
    • 104 Barbalat, R., et al. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat. Immunol. 10 (2009), 1200–1207.
    • (2009) Nat. Immunol. , vol.10 , pp. 1200-1207
    • Barbalat, R.1
  • 105
    • 71749100858 scopus 로고    scopus 로고
    • Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection
    • 105 Hohl, T.M., et al. Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe 6 (2009), 470–481.
    • (2009) Cell Host Microbe , vol.6 , pp. 470-481
    • Hohl, T.M.1
  • 106
    • 34247104151 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania
    • 106 Leon, B., et al. Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity 26 (2007), 519–531.
    • (2007) Immunity , vol.26 , pp. 519-531
    • Leon, B.1
  • 107
    • 84855259895 scopus 로고    scopus 로고
    • Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo
    • 107 Narni-Mancinelli, E., et al. Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo. PLoS Pathog., 7, 2011, e1002457.
    • (2011) PLoS Pathog. , vol.7 , pp. e1002457
    • Narni-Mancinelli, E.1
  • 108
    • 22344454821 scopus 로고    scopus 로고
    • Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis
    • 108 Robben, P.M., et al. Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J. Exp. Med. 201 (2005), 1761–1769.
    • (2005) J. Exp. Med. , vol.201 , pp. 1761-1769
    • Robben, P.M.1
  • 109
    • 65249145291 scopus 로고    scopus 로고
    • TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
    • 109 Aldridge, J.R. Jr., et al. TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc. Natl. Acad. Sci. U.S.A. 106 (2009), 5306–5311.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 5306-5311
    • Aldridge, J.R.1
  • 110
    • 77958124602 scopus 로고    scopus 로고
    • Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2 IFN-gamma and MyD88 signaling
    • 110 Bosschaerts, T., et al. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2 IFN-gamma and MyD88 signaling. PLoS Pathog., 6, 2010, e1001045.
    • (2010) PLoS Pathog. , vol.6 , pp. e1001045
    • Bosschaerts, T.1
  • 111
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
    • 111 Bingle, L., et al. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196 (2002), 254–265.
    • (2002) J. Pathol. , vol.196 , pp. 254-265
    • Bingle, L.1
  • 112
    • 84871694284 scopus 로고    scopus 로고
    • Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
    • 112 Zhang, Q.W., et al. Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS ONE, 7, 2012, e50946.
    • (2012) PLoS ONE , vol.7 , pp. e50946
    • Zhang, Q.W.1
  • 113
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumor microenvironment
    • 113 Ruffell, B., et al. Differential macrophage programming in the tumor microenvironment. Trends Immunol. 33 (2012), 119–126.
    • (2012) Trends Immunol. , vol.33 , pp. 119-126
    • Ruffell, B.1
  • 114
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • 114 Noy, R., Pollard, J.W., Tumor-associated macrophages: from mechanisms to therapy. Immunity 41 (2014), 49–61.
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 115
    • 84907223092 scopus 로고    scopus 로고
    • Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
    • 115 Colegio, O.R., et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513 (2014), 559–563.
    • (2014) Nature , vol.513 , pp. 559-563
    • Colegio, O.R.1
  • 116
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • 116 Lin, E.Y., et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66 (2006), 11238–11246.
    • (2006) Cancer Res. , vol.66 , pp. 11238-11246
    • Lin, E.Y.1
  • 117
    • 84902208605 scopus 로고    scopus 로고
    • Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer
    • 117 Yeo, E.J., et al. Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer. Cancer Res. 74 (2014), 2962–2973.
    • (2014) Cancer Res. , vol.74 , pp. 2962-2973
    • Yeo, E.J.1
  • 118
    • 79953750307 scopus 로고    scopus 로고
    • Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
    • 118 Mazzieri, R., et al. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell 19 (2011), 512–526.
    • (2011) Cancer Cell , vol.19 , pp. 512-526
    • Mazzieri, R.1
  • 119
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    • 119 Gocheva, V., et al. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24 (2010), 241–255.
    • (2010) Genes Dev. , vol.24 , pp. 241-255
    • Gocheva, V.1
  • 120
    • 84858613590 scopus 로고    scopus 로고
    • Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells
    • 120 Engelhardt, J.J., et al. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell 21 (2012), 402–417.
    • (2012) Cancer Cell , vol.21 , pp. 402-417
    • Engelhardt, J.J.1
  • 121
    • 66149118659 scopus 로고    scopus 로고
    • Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism
    • 121 Norian, L.A., et al. Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res. 69 (2009), 3086–3094.
    • (2009) Cancer Res. , vol.69 , pp. 3086-3094
    • Norian, L.A.1
  • 122
    • 84882637084 scopus 로고    scopus 로고
    • Tumor-associated macrophages: functional diversity, clinical significance, and open questions
    • 122 Biswas, S.K., et al. Tumor-associated macrophages: functional diversity, clinical significance, and open questions. Semin. Immunopathol. 35 (2013), 585–600.
    • (2013) Semin. Immunopathol. , vol.35 , pp. 585-600
    • Biswas, S.K.1
  • 123
    • 84926523845 scopus 로고    scopus 로고
    • Macrophages and cancer: from mechanisms to therapeutic implications
    • 123 Ostuni, R., et al. Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol. 36 (2015), 229–239.
    • (2015) Trends Immunol. , vol.36 , pp. 229-239
    • Ostuni, R.1
  • 124
    • 84958863725 scopus 로고    scopus 로고
    • Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment
    • Published online July 2, 2015
    • 124 Lahmar, Q., et al. Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment. Biochim. Biophys. Acta, 2015, 10.1016/j.bbcan.2015.06.009 Published online July 2, 2015.
    • (2015) Biochim. Biophys. Acta
    • Lahmar, Q.1
  • 125
    • 84912089439 scopus 로고    scopus 로고
    • Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells
    • 125 Ruffell, B., et al. Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Cancer Cell 26 (2014), 623–637.
    • (2014) Cancer Cell , vol.26 , pp. 623-637
    • Ruffell, B.1
  • 126
    • 84891930215 scopus 로고    scopus 로고
    • Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
    • 126 Casazza, A., et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell 24 (2013), 695–709.
    • (2013) Cancer Cell , vol.24 , pp. 695-709
    • Casazza, A.1
  • 127
    • 84919468025 scopus 로고    scopus 로고
    • Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity
    • 127 Broz, M.L., et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell 26 (2014), 638–652.
    • (2014) Cancer Cell , vol.26 , pp. 638-652
    • Broz, M.L.1
  • 128
    • 64249152007 scopus 로고    scopus 로고
    • Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy
    • discussion 165
    • 128 Egeblad, M., et al. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis. Model. Mech. 1 (2008), 155–167 discussion 165.
    • (2008) Dis. Model. Mech. , vol.1 , pp. 155-167
    • Egeblad, M.1
  • 129
    • 34047246527 scopus 로고    scopus 로고
    • Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    • 129 Wyckoff, J.B., et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67 (2007), 2649–2656.
    • (2007) Cancer Res. , vol.67 , pp. 2649-2656
    • Wyckoff, J.B.1
  • 130
    • 67651111095 scopus 로고    scopus 로고
    • A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood ‘resident’ monocytes, and embryonic macrophages suggests common functions and developmental relationships
    • 130 Pucci, F., et al. A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood ‘resident’ monocytes, and embryonic macrophages suggests common functions and developmental relationships. Blood 114 (2009), 901–914.
    • (2009) Blood , vol.114 , pp. 901-914
    • Pucci, F.1
  • 131
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    • 131 Mitchem, J.B., et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res. 73 (2013), 1128–1141.
    • (2013) Cancer Res. , vol.73 , pp. 1128-1141
    • Mitchem, J.B.1
  • 132
    • 84922658111 scopus 로고    scopus 로고
    • Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1
    • 132 Szulzewsky, F., et al. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS ONE, 10, 2015, e0116644.
    • (2015) PLoS ONE , vol.10 , pp. e0116644
    • Szulzewsky, F.1
  • 133
    • 84861152312 scopus 로고    scopus 로고
    • miR-511-3p modulates genetic programs of tumor-associated macrophages
    • 133 Squadrito, M.L., et al. miR-511-3p modulates genetic programs of tumor-associated macrophages. Cell Rep. 1 (2012), 141–154.
    • (2012) Cell Rep. , vol.1 , pp. 141-154
    • Squadrito, M.L.1
  • 134
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • 134 Hanahan, D., Coussens, L.M., Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21 (2012), 309–322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 135
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • 135 Sharma, P., Allison, J.P., The future of immune checkpoint therapy. Science 348 (2015), 56–61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 136
    • 30044448462 scopus 로고    scopus 로고
    • Colony-stimulating factor-1 in immunity and inflammation
    • 136 Chitu, V., Stanley, E.R., Colony-stimulating factor-1 in immunity and inflammation. Curr. Opin. Immunol. 18 (2006), 39–48.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 39-48
    • Chitu, V.1    Stanley, E.R.2
  • 137
    • 84918831817 scopus 로고    scopus 로고
    • Functional relationship between tumor-associated macrophages and macrophage colony-stimulating factor as contributors to cancer progression
    • 137 Laoui, D., et al. Functional relationship between tumor-associated macrophages and macrophage colony-stimulating factor as contributors to cancer progression. Front. Immunol., 5, 2014, 489.
    • (2014) Front. Immunol. , vol.5 , pp. 489
    • Laoui, D.1
  • 138
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • 138 DeNardo, D.G., et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1 (2011), 54–67.
    • (2011) Cancer Discov. , vol.1 , pp. 54-67
    • DeNardo, D.G.1
  • 139
    • 84894520967 scopus 로고    scopus 로고
    • CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8 T cells
    • 139 Strachan, D.C., et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8 T cells. Oncoimmunology, 2, 2013, e26968.
    • (2013) Oncoimmunology , vol.2 , pp. e26968
    • Strachan, D.C.1
  • 140
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • 140 Quail, D.F., Joyce, J.A., Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 19 (2013), 1423–1437.
    • (2013) Nat. Med. , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 141
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • 141 Beatty, G.L., et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331 (2011), 1612–1616.
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1
  • 142
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: a magic bullet?
    • 142 Coussens, L.M., et al. Neutralizing tumor-promoting chronic inflammation: a magic bullet?. Science 339 (2013), 286–291.
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1
  • 143
    • 84925611946 scopus 로고    scopus 로고
    • Microenvironmental regulation of therapeutic response in cancer
    • 143 Klemm, F., Joyce, J.A., Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol. 25 (2015), 198–213.
    • (2015) Trends Cell Biol. , vol.25 , pp. 198-213
    • Klemm, F.1    Joyce, J.A.2
  • 144
    • 84928226005 scopus 로고    scopus 로고
    • The interaction of anticancer therapies with tumor-associated macrophages
    • 144 Mantovani, A., Allavena, P., The interaction of anticancer therapies with tumor-associated macrophages. J. Exp. Med. 212 (2015), 435–445.
    • (2015) J. Exp. Med. , vol.212 , pp. 435-445
    • Mantovani, A.1    Allavena, P.2
  • 145
    • 79952390627 scopus 로고    scopus 로고
    • Immune parameters affecting the efficacy of chemotherapeutic regimens
    • 145 Zitvogel, L., et al. Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat. Rev. Clin. Oncol. 8 (2011), 151–160.
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 151-160
    • Zitvogel, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.