Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

Nature

Volumn 515, Issue 7525, 2014, Pages 130-133

  Bonapace, Laura ^a,b   Coissieux, Marie May ^a   Wyckoff, Jeffrey ^a,e   Mertz, Kirsten D ^c,d   Varga, Zsuzsanna ^c   Junt, Tobias ^b   Bentires Alj, Mohamed ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d Kantonsspital Liestal   (Switzerland)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT3 PROTEIN; VASCULOTROPIN; VASCULOTROPIN A;

BLOOD; CANCER; CELLS AND CELL COMPONENTS; GENE EXPRESSION; INHIBITION; NEUTRALIZATION; RODENT; TUMOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST METASTASIS; CANCER GROWTH; CELL COUNT; CELL PROLIFERATION; CIRCULATING TUMOR CELL; COCULTURE; CONTROLLED STUDY; DEATH; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LUNG METASTASIS; MACROPHAGE; MONOCULTURE; MONOCYTE; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SURVIVAL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD VESSEL; BREAST NEOPLASMS; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; LUNG TUMOR; METABOLISM; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; SECONDARY; SECRETION (PROCESS); VASCULARIZATION;

ANIMALIA; MUS;

ANIMALS; BLOOD VESSELS; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; FEMALE; INTERLEUKIN-6; LUNG NEOPLASMS; MICE; MONOCYTES; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; SURVIVAL ANALYSIS; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84915793974     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13862     Document Type: Article

References (30)

1. Qian, B. Z. et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475, 222-225 (2011).
2. + stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J. Biol. Chem. 284, 29087-29096 (2009).
3. Wolf, M. J. et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22, 91-105 (2012).
4. Pietras, K. & Ostman, A. Hallmarks of cancer: interactions with the tumor stroma. Exp. Cell Res. 316, 1324-1331 (2010).
5. McAllister, S. S. & Weinberg, R. A. Tumor-host interactions: a far-reaching relationship. J. Clin. Oncol. 28, 4022-4028 (2010).
6. Hanahan, D. & Coussens, L. M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21, 309-322 (2012).
7. Karnoub, A. E. & Weinberg, R. A. Chemokine networks and breast cancer metastasis. Breast Dis. 26, 75-85 (2007).
8. Kleer, C. G., van Golen, K. L. & Merajver, S. D. Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants. Breast Cancer Res. 2, 423-429 (2000).
9. Palangie, T. et al. Prognostic factors in inflammatory breast cancer and therapeutic implications. Eur. J. Cancer 30, 921-927 (1994).
10. Ueno, T. et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in humanbreast cancer. Clin. Cancer Res. 6, 3282-3289 (2000).
11. Valković, T., Lucin, K., Krstulja, M., Dobi-Babic, R. & Jonjic, N. Expression of monocyte chemotactic protein-1 in human invasive ductal breast cancer. Pathol. Res. Pract. 194, 335-340 (1998).
12. Saji, H. et al. Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer 92, 1085-1091 (2001).
13. Chavey, C. et al. Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res. 9, R15 (2007).
14. Goede, V., Brogelli, L., Ziche, M. & Augustin, H. G. Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1. Int. J. Cancer 82, 765-770 (1999).
15. Li, X. et al. A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone. Cancer Res. 69, 1685-1692 (2009).
16. Bonapace, L. et al. If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer. J. Mammary Gland Biol. Neoplasia 17, 125-129 (2012).
17. Strachan, D. C. et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8 T cells. OncoImmunology 2, e26968 (2013).
18. Nilsson, M. B., Langley, R. R. & Fidler, I. J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res. 65, 10794-10800 (2005).
19. Wani, A. A., Jafarnejad, S. M., Zhou, J. & Li, G. Integrin-linked kinase regulates melanoma angiogenesis by activating NF-κB/interleukin-6 signaling pathway. Oncogene 30, 2778-2788 (2011).
20. Wei, D. et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22, 319-329 (2003).
21. Wei, L. H. et al. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22, 1517-1527 (2003).
22. The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
23. Zhu, J. et al. The UCSC Cancer Genomics Browser. Nature Methods 6, 239-240 (2009).
24. Goldman, M. et al. The UCSC Cancer Genomics Browser: update 2013. Nucleic Acids Res. 41, D949-D954 (2013).
25. Schmittgen, T. D. Real-time quantitative PCR. Methods 25, 383-385 (2001).
26. Aslakson, C. J. & Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res. 52, 1399-1405 (1992).
27. Swirski, F. K. et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325, 612-616 (2009).
28. Wyckoff, J., Gligorijevic, B., Entenberg, D., Segall, J. & Condeelis, J. High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harb. Protoc. 2011, 1167-1184 (2011).
29. Abramoff, M. D., Magelhaes, P. J. & Ram, S. J. Image Processing with Image. J. Biophotonics Intl 11, 36-42 (2004).
30. Egawa, G. et al. Intravital analysis of vascular permeability in mice using two-photon microscopy. Sci. Rep. 3, 1932 (2013).