Regulation of different components from Ophiopogon japonicus on autophagy in human lung adenocarcinoma A549Cells through PI3K/Akt/mTOR signaling pathway

Biomedicine and Pharmacotherapy

Volumn 87, Issue , 2017, Pages 118-126

  Chen, Juan ^a,b   Yuan, Jiarui ^d   Zhou, Liqiang ^b,c   Zhu, Maomao ^a,b   Shi, Ziqi ^a,b   Song, Jie ^a,b   Xu, Qingyu ^c   Yin, Guowen ^c   Lv, You ^c   Luo, Yi ^b   Jia, Xiaobin ^a,b,e   Feng, Liang ^a,b  

^a KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c JIANGSU CANCER HOSPITAL   (China)

^d Market Supervision Administration of Dantu District   (China)

^e SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Autophagy; Non small cell lung cancer; Ophiopogon japonicus (L.f) Ker Gawl; PI3K Akt mTOR pathway

Indexed keywords

14ALPHA HYDROXY SPRENGERININ C; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; AUTOPHAGY PROTEIN 3; AUTOPHAGY PROTEIN 7; BECLIN 1; FLAVONOID; FLAVONOID OF OPHIOPOGON JAPONICUS; GONANE DERIVATIVE; KI 67 ANTIGEN; LIGHT CHAIN 3 I; LIGHT CHAIN 3 II; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; MESSENGER RNA; METHYLOPHIOPOGONANONE A; METHYLOPHIOPOGONANONE B; MYELIN; MYOSIN LIGHT CHAIN; OPHIOPOGONIN B; OPHIOPOGONIN C; OPHIOPOGONIN D; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROTEIN KINASE B; RUSCOGENIN; SAPONIN DERIVATIVE; STEROIDAL SAPONIN OF OPHIOPOGON JAPONICUS; UNCLASSIFIED DRUG; HERBACEOUS AGENT; MTOR PROTEIN, HUMAN; OPHIOPOGON ROOT; SAPONIN; TARGET OF RAPAMYCIN KINASE;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL MEMBRANE; CELL ORGANELLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG MECHANISM; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LIGHT CHAIN; MEDIATOR; OPHIOPOGON JAPONICUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; A-549 CELL LINE; ADENOCARCINOMA; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; ISOLATION AND PURIFICATION; LUNG TUMOR; METABOLISM; PHYSIOLOGY;

A549 CELLS; ADENOCARCINOMA; AUTOPHAGY; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FLAVONOIDS; HUMANS; LUNG NEOPLASMS; OPHIOPOGON; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SAPONINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 85007420835     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.12.093     Document Type: Article

References (32)

1. [1] Chen, S., Rehman, S.K., Zhang, W., Wen, A., Yao, L., Zhang, J., Autophagy is a therapeutic target in anticancer drug resistance. Biochim. Biophys. Acta 1806 (2010), 220–229.
2. [2] Yang, Z.J., Chee, Ch E., Huang, S.B., Sinicrope, F.A., The role of autophagy in cancer: therapeutic implications. Mol. Cancer Ther. 9 (2011), 533–1542.
3. [3] Li, L., Chen, Y., Gibson, S.B., Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation. Cell. Signal. 25 (2013), 50–65.
4. [4] Janku, F., McConkey, D.J., Hong, D.S., Kurzrock, R., Autophagy as a target for anticancer therapy. Nat. Rev. Clin. Oncol. 8 (2011), 528–539.
5. [5] Kondo, Y., Kanzawa, T., Sawaya, R., Kondo, S., The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer 5 (2005), 726–734.
6. [6] Levine, B., Kroemer, G., Autophagy in the pathogenesis of disease. Cell 132 (2008), 27–42.
7. [7] Mathew, R., Kongara, S., Beaudoin, B., Karp, C.M., Bray, K., Degenhardt, K., Chen, G., Jin, S., White, E., Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 21 (2007), 1367–1381.
8. [8] Zhang, W., Zhang, Q., Jiang, Y., Li, F., Xin, H., Effects of ophiopogonin B on the proliferation and apoptosis of SGC-7901 human gastric cancer cells. Mol. Med. Rep. 13 (2016), 4981–4986.
9. [9] Ye, Y., Qu, Y., Tang, R.Q., Cao, S.N., Yang, W., Xiang, L., Qi, J.H., Three new neuritogenic steroidal saponins from Ophiopogon japonicus (Thunb.) Ker- Gawl. Steroids 78 (2013), 1171–1176.
10. [10] Huang, Q., Gao, B., Wang, L., Zhang, H.Y., Li, X.J., Shi, J., Wang, Z., Zhang, J.K., Yang, L., Luo, Z.J., Liu, J., Ophiopogonin D: A new herbal agent against osteoporosis. Bone 74 (2015), 18–28.
11. [11] Chen, M., Guo, Y., Zhao, R., Wang, X., Jiang, M., Fu, H., Zhang, X., Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells. Int. J. Oncol. 49 (2016), 316–324.
12. [12] Chen, Y.T., Yuan, Q., Shan, L.T., Lin, M.A., Cheng, D.Q., Li, C.Y., Antitumor activity of bacterial exopolysaccharides from the endophyte Bacillus amyloliquefaciens sp. isolated from Ophiopogon japonicus. Oncol. Lett. 5 (2013), 1787–1792.
13. [13] Wei, X.H., Lin, S.S., Liu, Y., Zhao, R.P., Khan, G.J., Du, H.Z., Mao, T.T., Yu, B.Y., Li, R.M., Yuan, S.T., Sun, L., DT-13 attenuates human lung cancer metastasis via regulating NMIIA activity under hypoxia condition. Oncol. Rep. 36 (2016), 991–999.
14. [14] Zhang, H., Chen, L., Kou, J.P., Zhua, D.N., Qi, J., Yua, B.Y., Steroidal sapogenins and glycosides from the fibrous roots of Ophiopogon japonicus and Liriope spicata var. prolifera with anti-inflammatory activity. Steroids 63 (2015), 187–194.
15. [15] Li, N., Zhang, J.Y., Zeng, K.W., Zhang, L., Che, Y.Y., Tu, P.F., Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus. Fitoterapia 83 (2012), 1042–1045.
16. [16] Chen, M., Du, Y., Qui, M., Wang, M., Chen, K., Huang, Z., Jiang, M., Xiong, F., Chen, J., Zhou, J., Jiang, F., Yin, L., Tang, Y., Ye, L., Zhan, Z., Duan, J., Fu, H., Zhang, X., Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncol. Rep. 29 (2013), 430–436.
17. [17] Xu, L., Liu, J.H., Zhang, J., Zhang, N., Wang, Z.H., Blockade of autophagy aggravates endoplasmic reticulum stress and improves paclitaxel cytotoxicity in human cervical cancer cells. Cancer Res. Treat. 2 (2015), 313–321.
18. [18] Tang, Zh.H., Zhang, L.L., Li, T., Lu, J.H., Ma, D.L., Leung, Ch.H., Chen, X.P., Jiang, H.L., Wang, Y.T., Lu, J.J., Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Oncotarget 6 (2015), 43911–43926.
19. [19] Luo, C.L., Liu, Y.Q., Wang, P., Song, C.H., Wang, K.J., Dai, L.P., Zhang, J.Y., Ye, H., The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomed. Pharmacother. 82 (2016), 595–605.
20. [20] Zhang, F., Wang, B., Long, H., Yu, J., Li, F., Hou, H., Yang, Q., Decreased miR-124-3p expression prompted breast cancer cell progression mainly by targeting Beclin-1. Clin. Lab. 62 (2016), 1139–1145.
21. [21] Li, Y., Liu, F., Wang, Y., Li, D., Guo, F., Xu, L., Zeng, Z., Zhong, X., Qian, K., Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition. Thorac. Cancer 7 (2016), 79–86.
22. [22] Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J., Autophagy fights disease through cellular self-digestion. Nature 451 (2008), 1069–1075.
23. [23] Klionsky, D.J., Abeliovich, H., Agostinis, P., Agrawal, D.K., Aliev, G., Askew, D.S., Baba, M., Baehrecke, E.H., Bahr, B.A., Ballabio, A., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 4 (2013), 151–175.
24. [24] Djeddi, A., Al, R.S., Deuve, J.L., Perrois, C., Liu, Y.Y., Russeau, M., Sachse, M., Galy, V., Sperm-inherited organelle clearance in C. elegans relies on LC3-dependent autophagosome targeting to the pericentrosomal area. Development 142 (2015), 1705–1716.
25. [25] Szalai, P., Hagen, L.K., Sætre, F., Luhr, M., Sponheim, M., Øverbye, A., Mills, I.G., Seglen, P.O., Engedal, N., Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs. Exp. Cell Res. 333 (2015), 21–38.
26. [26] Berrak, O., Arisan, E.D., Obakan-Yerlikaya, P., Coker-Gürkan, A., Palavan-Unsa, N., mTOR is a fine tuning molecule in CDK inhibitors-induced distinct cell death mechanisms via PI3üK/AKT/mTOR signaling axis in prostate cancer cells. Apoptosis, 2016, 10.1007/s10495-016-1275-9.
27. [27] Li, H., Hu, J., Wu, S., Wang, L., Cao, X., Zhang, X., Dai, B., Cao, M., Shao, R., Zhang, R., Majidi, M., Ji, L., Heymach, J.V., Wang, M., Pan, S., Minna, J., Mehran, R.J., Swisher, S.G., Roth, J.A., Fang, B., Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget 7 (2016), 3548–3558.
28. [28] Zhao, R., Chen, M., Jiang, Z., Zhao, F., Xi, B., Zhang, X., Fu, H., Zhou, K., Platycodin-D induced autophagy in non-small cell lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathways. J. Cancer 6 (2015), 623–631.
29. [29] Zhang, Q., Zhu, H., Xu, X., Li, L., Tan, H., Cai, X., Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in humannon-small cell lung cancer cells. Biochem. Biophys. Res. Commun. 465 (2015), 64–70.
30. [30] Hans-Richard, D., Benedikt, F., Guido, P., Christof, S., Birgit, B., Anja, P., Markus, E., Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells. Am. J. Cancer Res. 5 (2015), 1649–1664.
31. [31] Yuan, J.P., Wang, L.W., Qu, A.P., Chen, J.M., Xiang, Q.M., Chen, C., Sun, S.R., Pang, D.W., Liu, J., Li, Y., Quantum dots-based quantitative and In situ multiple imaging on ki67 and cytokeratin to improve ki67 assessment in Breast cancer. PLoS One, 10, 2015, e0122734.
32. [32] Ganapathy, S., Li, P., Fagman, J., Yu, T., Lafontant, J., Zhang, G., Chen, C., Low doses of arsenic via perturbing p53, promotes tumorigenesis. Toxicol. Appl. Pharmacol. 306 (2016), 98–104.