Platycodin-D induced autophagy in non-small cell lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathways

Journal of Cancer

Volumn 6, Issue 7, 2015, Pages 623-631

  Zhao, Ruolin ^a   Chen, Meijuan ^a   Jiang, Zequn ^a   Zhao, Fengming ^a   Xi, Beili ^a   Zhang, Xu ^a   Fu, Haian ^b   Zhou, Kunfu ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; MAPK signaling pathways; Non small cell lung cancer; PI3K Akt mTOR; Platycodin D

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PLATYCODON GRANDIFLORUM EXTRACT; PROTEIN C JUN; PROTEIN KINASE B; SAPONIN DERIVATIVE; TRITERPENE DERIVATIVE;

ARTICLE; AUTOPHAGY; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; NON SMALL CELL LUNG CANCER; PROTEIN EXPRESSION; UPREGULATION;

EID: 84938382982     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.11291     Document Type: Article

References (28)

1. Chun J, Joo EJ, Kang M, et al. Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells. Journal of cellular biochemistry 2013, 114(2):456-470.
2. Yu JS, Kim AK. Platycodin D induces apoptosis in MCF-7 human breast cancer cells. Journal of medicinal food 2010, 13(2):298-305.
3. Kim MO, Moon DO, Choi YH, et al. Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells. International journal of cancer Journal international du cancer 2008, 122(12):2674-2681.
4. Janku F, McConkey DJ, Hong DS, et al. Autophagy as a target for anticancer therapy. Nature reviews Clinical oncology 2011, 8(9):528-539.
5. Chen S, Rehman SK, Zhang W, et al. Autophagy is a therapeutic target in anticancer drug resistance. Biochimica et biophysica acta 2010, 1806(2):220-229.
6. Yang ZJ, Chee CE, Huang S, et al. The role of autophagy in cancer: therapeutic implications. Molecular cancer therapeutics 2011, 10(9):1533-1541.
7. Sui X, Kong N, Ye L, et al. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer letters 2014, 344(2):174-179.
8. Sun Y, Zou M, Hu C, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 2013, 51:53-60.
9. Saiki S, Sasazawa Y, Imamichi Y, et al. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 2011, 7(2):176-187.
10. Chen M, Du Y, Qui M, et al. Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncology reports 2013, 29(2):430-436.
11. Vlahos CJ, Matter WF, Hui KY, et al. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). The Journal of biological chemistry 1994, 269(7):5241-5248.
12. Kunz J, Henriquez R, Schneider U, et al. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 1993, 73(3):585-596.
13. Yao H, Han X, Han X. The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway. American journal of cardiovascular drugs: drugs, devices, and other interventions 2014, 14(6):433-442.
14. Garami A, Zwartkruis FJ, Nobukuni T, et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Molecular cell 2003, 11(6):1457-1466.
15. Beljanski V, Knaak C, Smith CD. A novel sphingosine kinase inhibitor induces autophagy in tumor cells. The Journal of pharmacology and experimental therapeutics 2010, 333(2):454-464.
16. Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature 2008, 451(7182):1069-1075.
17. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8(4):445-544.
18. Bommareddy A, Hahm ER, Xiao D, et al. Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer research 2009, 69(8):3704-3712.
19. Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annual review of cell and developmental biology 2011, 27:107-132.
20. Kabeya Y, Mizushima N, Yamamoto A, et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. Journal of cell science 2004, 117(Pt 13):2805-2812.
21. Kang R, Zeh HJ, Lotze MT, et al. The Beclin 1 network regulates autophagy and apoptosis. Cell death and differentiation 2011, 18(4):571-580.
22. Viola G, Bortolozzi R, Hamel E, et al. MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochemical pharmacology 2012, 83(1):16-26.
23. Rong Y, McPhee CK, Deng S, et al. Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(19):7826-7831.
24. O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer research 2006, 66(3):1500-1508.
25. Zhang C, Yang L, Wang XB, et al. Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells. Cancer letters 2013, 340(1):51-62.
26. Webber JL. Regulation of autophagy by p38alpha MAPK. Autophagy 2010, 6(2):292-293.
27. Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. The FEBS journal 2010, 277(1):2-21.
28. Kohno M, Tanimura S, Ozaki K. Targeting the extracellular signal-regulated kinase pathway in cancer therapy. Biological & pharmaceutical bulletin 2011, 34(12):1781-1784.