-
1
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
Ciccia A and Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010; 40: 179-204.
-
(2010)
Mol Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
2
-
-
84865114161
-
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family
-
Finlay MR and Griffin RJ. Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg Med Chem Lett 2012; 22: 5352-5359.
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 5352-5359
-
-
Finlay, M.R.1
Griffin, R.J.2
-
3
-
-
84856019858
-
The DNA damage response and cancer therapy
-
Lord CJ and Ashworth A. The DNA damage response and cancer therapy. Nature 2012; 481: 287-294.
-
(2012)
Nature
, vol.481
, pp. 287-294
-
-
Lord, C.J.1
Ashworth, A.2
-
4
-
-
84874107696
-
Targeting DNA repair mechanisms in cancer
-
Furgason JM and Bahassi el M. Targeting DNA repair mechanisms in cancer. Pharmacol Ther 2013; 137: 298-308.
-
(2013)
Pharmacol Ther
, vol.137
, pp. 298-308
-
-
Furgason, J.M.1
Bahassi, E.M.2
-
5
-
-
84877842420
-
Chemotherapy induced DNA damage response: convergence of drugs and pathways
-
Woods D and Turchi JJ. Chemotherapy induced DNA damage response: convergence of drugs and pathways. Cancer Biol Ther 2013; 14: 379-389.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 379-389
-
-
Woods, D.1
Turchi, J.J.2
-
6
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist CJ and Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421: 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
7
-
-
64649090292
-
Targeting DNA topoisomerase II in cancer chemotherapy
-
Nitiss JL. Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer 2009; 9: 338-350.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 338-350
-
-
Nitiss, J.L.1
-
8
-
-
0025147256
-
DNA double-strand break repair pathways and cellular tolerance to inhibitors of topoisomerase II
-
Caldecott K, Banks G and Jeggo P. DNA double-strand break repair pathways and cellular tolerance to inhibitors of topoisomerase II. Cancer Res 1990; 50: 5778-5783.
-
(1990)
Cancer Res
, vol.50
, pp. 5778-5783
-
-
Caldecott, K.1
Banks, G.2
Jeggo, P.3
-
9
-
-
0031879187
-
Increased expression of DNA-dependent protein kinase confers resistance to adriamycin
-
Shen H, Schultz M, Kruh GD and Tew KD. Increased expression of DNA-dependent protein kinase confers resistance to adriamycin. Biochim Biophys Acta 1998; 1381: 131-138.
-
(1998)
Biochim Biophys Acta
, vol.1381
, pp. 131-138
-
-
Shen, H.1
Schultz, M.2
Kruh, G.D.3
Tew, K.D.4
-
10
-
-
12444250680
-
DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer
-
Hansen LT, Lundin C, Helleday T, Poulsen HS, Sorensen CS, Petersen LN and Spang-Thomsen M. DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer. Lung Cancer 2003; 40: 157-164.
-
(2003)
Lung Cancer
, vol.40
, pp. 157-164
-
-
Hansen, L.T.1
Lundin, C.2
Helleday, T.3
Poulsen, H.S.4
Sorensen, C.S.5
Petersen, L.N.6
Spang-Thomsen, M.7
-
12
-
-
63049099775
-
RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?
-
Kinoshita E, van der Linden E, Sanchez H and Wyman C. RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function? Chromosome Res 2009; 17: 277-288.
-
(2009)
Chromosome Res
, vol.17
, pp. 277-288
-
-
Kinoshita, E.1
van der Linden, E.2
Sanchez, H.3
Wyman, C.4
-
13
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
14
-
-
37449024702
-
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G and Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
15
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB and Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 2004; 16: 819-830.
-
(2004)
Mol Cell
, vol.16
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
Chandel, N.S.7
Thompson, C.B.8
Robey, R.B.9
Hay, N.10
-
16
-
-
20544449673
-
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation
-
Buzzai M, Bauer DE, Jones RG, Deberardinis RJ, Hatzivassiliou G, Elstrom RL and Thompson CB. The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 2005; 24: 4165-4173.
-
(2005)
Oncogene
, vol.24
, pp. 4165-4173
-
-
Buzzai, M.1
Bauer, D.E.2
Jones, R.G.3
Deberardinis, R.J.4
Hatzivassiliou, G.5
Elstrom, R.L.6
Thompson, C.B.7
-
17
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R and Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
18
-
-
58149481284
-
The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma
-
Baumann P, Mandl-Weber S, Oduncu F and Schmidmaier R. The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma. Exp Cell Res 2009; 315: 485-497.
-
(2009)
Exp Cell Res
, vol.315
, pp. 485-497
-
-
Baumann, P.1
Mandl-Weber, S.2
Oduncu, F.3
Schmidmaier, R.4
-
19
-
-
84858706673
-
Up-regulation of hexokinaseII in myeloma cells: targeting myeloma cells with 3-bromopyruvate
-
Nakano A, Miki H, Nakamura S, Harada T, Oda A, Amou H, Fujii S, Kagawa K, Takeuchi K, Ozaki S, Matsumoto T and Abe M. Up-regulation of hexokinaseII in myeloma cells: targeting myeloma cells with 3-bromopyruvate. J Bioenerg Biomembr 2012; 44: 31-38.
-
(2012)
J Bioenerg Biomembr
, vol.44
, pp. 31-38
-
-
Nakano, A.1
Miki, H.2
Nakamura, S.3
Harada, T.4
Oda, A.5
Amou, H.6
Fujii, S.7
Kagawa, K.8
Takeuchi, K.9
Ozaki, S.10
Matsumoto, T.11
Abe, M.12
-
20
-
-
84859739738
-
Akt: a double-edged sword in cell proliferation and genome stability
-
Xu N, Lao Y, Zhang Y and Gillespie DA. Akt: a double-edged sword in cell proliferation and genome stability. J Oncol 2012; 2012: 951724.
-
(2012)
J Oncol
, vol.2012
-
-
Xu, N.1
Lao, Y.2
Zhang, Y.3
Gillespie, D.A.4
-
21
-
-
0025075721
-
Over-expression of facilitative glucose transporter genes in human cancer
-
Yamamoto T, Seino Y, Fukumoto H, Koh G, Yano H, Inagaki N, Yamada Y, Inoue K, Manabe T and Imura H. Over-expression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun 1990; 170: 223-230.
-
(1990)
Biochem Biophys Res Commun
, vol.170
, pp. 223-230
-
-
Yamamoto, T.1
Seino, Y.2
Fukumoto, H.3
Koh, G.4
Yano, H.5
Inagaki, N.6
Yamada, Y.7
Inoue, K.8
Manabe, T.9
Imura, H.10
-
22
-
-
0031409708
-
Deregulated simultaneous expression of multiple glucose transporter isoforms in malignant cells and tissues
-
Binder C, Binder L, Marx D, Schauer A and Hiddemann W. Deregulated simultaneous expression of multiple glucose transporter isoforms in malignant cells and tissues. Anticancer Res 1997; 17: 4299-4304.
-
(1997)
Anticancer Res
, vol.17
, pp. 4299-4304
-
-
Binder, C.1
Binder, L.2
Marx, D.3
Schauer, A.4
Hiddemann, W.5
-
23
-
-
0033405705
-
Facilitative glucose transporter expression in human cancer tissue
-
Smith TA. Facilitative glucose transporter expression in human cancer tissue. Br J Biomed Sci 1999; 56: 285-292.
-
(1999)
Br J Biomed Sci
, vol.56
, pp. 285-292
-
-
Smith, T.A.1
-
24
-
-
33744921104
-
Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F] fluorodeoxyglucose positron emission tomography
-
Tateishi U, Yamaguchi U, Seki K, Terauchi T, Arai Y and Hasegawa T. Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F] fluorodeoxyglucose positron emission tomography. Eur J Nucl Med Mol Imaging 2006; 33: 683-691.
-
(2006)
Eur J Nucl Med Mol Imaging
, vol.33
, pp. 683-691
-
-
Tateishi, U.1
Yamaguchi, U.2
Seki, K.3
Terauchi, T.4
Arai, Y.5
Hasegawa, T.6
-
25
-
-
34548544377
-
Expression of glucose transporters in epithelial ovarian carcinoma: correlation with clinical characteristics and tumor angiogenesis
-
Tsukioka M, Matsumoto Y, Noriyuki M, Yoshida C, Nobeyama H, Yoshida H, Yasui T, Sumi T, Honda K and Ishiko O. Expression of glucose transporters in epithelial ovarian carcinoma: correlation with clinical characteristics and tumor angiogenesis. Oncol Rep 2007; 18: 361-367.
-
(2007)
Oncol Rep
, vol.18
, pp. 361-367
-
-
Tsukioka, M.1
Matsumoto, Y.2
Noriyuki, M.3
Yoshida, C.4
Nobeyama, H.5
Yoshida, H.6
Yasui, T.7
Sumi, T.8
Honda, K.9
Ishiko, O.10
-
26
-
-
34249799003
-
Glucose transporter type 1 expression are associated with poor prognosis in patients with salivary gland tumors
-
Mori Y, Tsukinoki K, Yasuda M, Miyazawa M, Kaneko A and Watanabe Y. Glucose transporter type 1 expression are associated with poor prognosis in patients with salivary gland tumors. Oral Oncol 2007; 43: 563-569.
-
(2007)
Oral Oncol
, vol.43
, pp. 563-569
-
-
Mori, Y.1
Tsukinoki, K.2
Yasuda, M.3
Miyazawa, M.4
Kaneko, A.5
Watanabe, Y.6
-
27
-
-
0037056002
-
Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
-
Pedersen PL, Mathupala S, Rempel A, Geschwind JF and Ko YH. Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim Biophys Acta 2002; 1555: 14-20.
-
(2002)
Biochim Biophys Acta
, vol.1555
, pp. 14-20
-
-
Pedersen, P.L.1
Mathupala, S.2
Rempel, A.3
Geschwind, J.F.4
Ko, Y.H.5
-
28
-
-
33746879141
-
Glycolysis inhibition for anticancer treatment
-
Pelicano H, Martin DS, Xu RH and Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25: 4633-4646.
-
(2006)
Oncogene
, vol.25
, pp. 4633-4646
-
-
Pelicano, H.1
Martin, D.S.2
Xu, R.H.3
Huang, P.4
-
29
-
-
60249083822
-
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy
-
Mathupala SP, Ko YH and Pedersen PL. Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. Semin Cancer Biol 2009; 19: 17-24.
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 17-24
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
30
-
-
0036176751
-
Positron emission tomography scanning: current and future applications
-
Czernin J and Phelps ME. Positron emission tomography scanning: current and future applications. Annu Rev Med 2002; 53: 89-112.
-
(2002)
Annu Rev Med
, vol.53
, pp. 89-112
-
-
Czernin, J.1
Phelps, M.E.2
-
31
-
-
66149156964
-
Assessing tumor response to therapy
-
Weber WA. Assessing tumor response to therapy. J Nucl Med 2009; 50 Suppl 1: 1S-10S.
-
(2009)
J Nucl Med
, vol.50
, pp. 1S-10S
-
-
Weber, W.A.1
-
32
-
-
0037096742
-
Genotoxic exposure is associated with alterations in glucose uptake and metabolism
-
Zhou R, Vander Heiden MG and Rudin CM. Genotoxic exposure is associated with alterations in glucose uptake and metabolism. Cancer Res 2002; 62: 3515-3520.
-
(2002)
Cancer Res
, vol.62
, pp. 3515-3520
-
-
Zhou, R.1
Vander Heiden, M.G.2
Rudin, C.M.3
-
33
-
-
78649644992
-
DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells
-
Watanabe M, Naraba H, Sakyo T and Kitagawa T. DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells. Mol Cancer Res 2010; 8: 1547-1557.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 1547-1557
-
-
Watanabe, M.1
Naraba, H.2
Sakyo, T.3
Kitagawa, T.4
-
34
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC and Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
35
-
-
0027489912
-
Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study
-
Brown RS and Wahl RL. Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer 1993; 72: 2979-2985.
-
(1993)
Cancer
, vol.72
, pp. 2979-2985
-
-
Brown, R.S.1
Wahl, R.L.2
-
36
-
-
0030884030
-
Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma
-
Reske SN, Grillenberger KG, Glatting G, Port M, Hildebrandt M, Gansauge F and Beger HG. Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma. J Nucl Med 1997; 38: 1344-1348.
-
(1997)
J Nucl Med
, vol.38
, pp. 1344-1348
-
-
Reske, S.N.1
Grillenberger, K.G.2
Glatting, G.3
Port, M.4
Hildebrandt, M.5
Gansauge, F.6
Beger, H.G.7
-
37
-
-
12944262229
-
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
-
Macheda ML, Rogers S and Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005; 202: 654-662.
-
(2005)
J Cell Physiol
, vol.202
, pp. 654-662
-
-
Macheda, M.L.1
Rogers, S.2
Best, J.D.3
-
38
-
-
0028957006
-
Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma
-
Adams V, Kempf W, Hassam S and Briner J. Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma. Biochem Mol Med 1995; 54: 53-58.
-
(1995)
Biochem Mol Med
, vol.54
, pp. 53-58
-
-
Adams, V.1
Kempf, W.2
Hassam, S.3
Briner, J.4
-
39
-
-
57049132739
-
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
-
Vaughn AE and Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol 2008; 10: 1477-1483.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1477-1483
-
-
Vaughn, A.E.1
Deshmukh, M.2
-
40
-
-
70349331678
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
-
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA Jr, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B and Papadopoulos N. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009; 325: 1555-1559.
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
Schmidt, K.7
Willson, J.K.8
Markowitz, S.9
Zhou, S.10
Diaz, L.A.11
Velculescu, V.E.12
Lengauer, C.13
Kinzler, K.W.14
Vogelstein, B.15
Papadopoulos, N.16
-
41
-
-
0642345198
-
DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling
-
Kaina B. DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling. Biochem Pharmacol 2003; 66: 1547-1554.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 1547-1554
-
-
Kaina, B.1
-
42
-
-
0034904776
-
Growth factors can influence cell growth and survival through effects on glucose metabolism
-
Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH and Thompson CB. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 2001; 21: 5899-5912.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5899-5912
-
-
Vander Heiden, M.G.1
Plas, D.R.2
Rathmell, J.C.3
Fox, C.J.4
Harris, M.H.5
Thompson, C.B.6
-
43
-
-
80355146252
-
Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells
-
Nakano A, Tsuji D, Miki H, Cui Q, El Sayed SM, Ikegame A, Oda A, Amou H, Nakamura S, Harada T, Fujii S, Kagawa K, Takeuchi K, Sakai A, Ozaki S, Okano K, Nakamura T, Itoh K, Matsumoto T and Abe M. Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. PLoS One 2011; 6: e27222.
-
(2011)
PLoS One
, vol.6
-
-
Nakano, A.1
Tsuji, D.2
Miki, H.3
Cui, Q.4
El Sayed, S.M.5
Ikegame, A.6
Oda, A.7
Amou, H.8
Nakamura, S.9
Harada, T.10
Fujii, S.11
Kagawa, K.12
Takeuchi, K.13
Sakai, A.14
Ozaki, S.15
Okano, K.16
Nakamura, T.17
Itoh, K.18
Matsumoto, T.19
Abe, M.20
more..
-
45
-
-
84866031870
-
3D tumour spheroids as a model to assess the suitability of [18F]FDG-PET as an early indicator of response to PI3K inhibition
-
Kelly CJ, Hussien K and Muschel RJ. 3D tumour spheroids as a model to assess the suitability of [18F]FDG-PET as an early indicator of response to PI3K inhibition. Nucl Med Biol 2012; 39: 986-992.
-
(2012)
Nucl Med Biol
, vol.39
, pp. 986-992
-
-
Kelly, C.J.1
Hussien, K.2
Muschel, R.J.3
-
46
-
-
84856993479
-
The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM-and DNA-PKCs-mediated DNA damage responses
-
Mukherjee B, Tomimatsu N, Amancherla K, Camacho CV, Pichamoorthy N and Burma S. The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM-and DNA-PKCs-mediated DNA damage responses. Neoplasia 2012; 14: 34-43.
-
(2012)
Neoplasia
, vol.14
, pp. 34-43
-
-
Mukherjee, B.1
Tomimatsu, N.2
Amancherla, K.3
Camacho, C.V.4
Pichamoorthy, N.5
Burma, S.6
-
47
-
-
67650995912
-
Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
-
McMillin DW, Ooi M, Delmore J, Negri J, Hayden P, Mitsiades N, Jakubikova J, Maira SM, Garcia-Echeverria C, Schlossman R, Munshi NC, Richardson PG, Anderson KC and Mitsiades CS. Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Cancer Res 2009; 69: 5835-5842.
-
(2009)
Cancer Res
, vol.69
, pp. 5835-5842
-
-
McMillin, D.W.1
Ooi, M.2
Delmore, J.3
Negri, J.4
Hayden, P.5
Mitsiades, N.6
Jakubikova, J.7
Maira, S.M.8
Garcia-Echeverria, C.9
Schlossman, R.10
Munshi, N.C.11
Richardson, P.G.12
Anderson, K.C.13
Mitsiades, C.S.14
-
48
-
-
84881558195
-
Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma
-
Muller A, Zang C, Chumduri C, Dorken B, Daniel PT and Scholz CW. Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma. Int J Cancer 2013; 133: 1813-1824.
-
(2013)
Int J Cancer
, vol.133
, pp. 1813-1824
-
-
Muller, A.1
Zang, C.2
Chumduri, C.3
Dorken, B.4
Daniel, P.T.5
Scholz, C.W.6
-
49
-
-
84864883430
-
Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype
-
Stengel C, Cheung CW, Quinn J, Yong K and Khwaja A. Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype. Leukemia 2012; 26: 1761-1770.
-
(2012)
Leukemia
, vol.26
, pp. 1761-1770
-
-
Stengel, C.1
Cheung, C.W.2
Quinn, J.3
Yong, K.4
Khwaja, A.5
-
50
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB and Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 2001; 15: 1406-1418.
-
(2001)
Genes Dev
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
51
-
-
84868193873
-
Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells
-
Korwek Z, Sewastianik T, Bielak-Zmijewska A, Mosieniak G, Alster O, Moreno-Villanueva M, Burkle A and Sikora E. Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells. DNA Repair (Amst) 2012; 11: 864-873.
-
(2012)
DNA Repair (Amst)
, vol.11
, pp. 864-873
-
-
Korwek, Z.1
Sewastianik, T.2
Bielak-Zmijewska, A.3
Mosieniak, G.4
Alster, O.5
Moreno-Villanueva, M.6
Burkle, A.7
Sikora, E.8
-
52
-
-
69249240178
-
The combined status of ATM and p53 link tumor development with therapeutic response
-
Jiang H, Reinhardt HC, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB and Hemann MT. The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev 2009; 23: 1895-1909.
-
(2009)
Genes Dev
, vol.23
, pp. 1895-1909
-
-
Jiang, H.1
Reinhardt, H.C.2
Bartkova, J.3
Tommiska, J.4
Blomqvist, C.5
Nevanlinna, H.6
Bartek, J.7
Yaffe, M.B.8
Hemann, M.T.9
-
53
-
-
42949165854
-
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
-
Bozulic L, Surucu B, Hynx D and Hemmings BA. PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 2008; 30: 203-213.
-
(2008)
Mol Cell
, vol.30
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
|