Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

Oncotarget

Volumn 7, Issue 3, 2016, Pages 3548-3558

  Li, Hongyu ^a,b   Hu, Jing ^a   Wu, Shuhong ^a   Wang, Li ^a   Cao, Xiaobo ^a   Zhang, Xiaoshan ^a   Dai, Bingbing ^a   Cao, Mengru ^a   Shao, Ruping ^a   Zhang, Ran ^a   Majidi, Mourad ^a   Ji, Lin ^a   Heymach, John V ^a   Wang, Michael ^a   Pan, Shiyang ^c   Minna, John ^d   Mehran, Reza J ^a   Swisher, Stephen G ^a   Roth, Jack A ^a   Fang, Bingliang ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b JILIN PROVINCIAL CANCER HOSPITAL   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Anticancer agent; Biomarkers; Drug repurposing; Lung cancer

Indexed keywords

AURANOFIN; GLYCOGEN SYNTHASE KINASE 3; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN S6; PROTEOME; RICTOR; S6 KINASE; THIOREDOXIN REDUCTASE 1; TUBERIN; TUMOR MARKER; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; ANTIRHEUMATIC AGENT; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TXNRD1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DRUG RESISTANCE; ECTOPIC EXPRESSION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; IC50; LUNG CANCER CELL LINE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NECROPTOSIS; NON SMALL CELL LUNG CANCER; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; FLOW CYTOMETRY; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; PROTEIN MICROARRAY; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; ANTIRHEUMATIC AGENTS; APOPTOSIS; AURANOFIN; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; FLOW CYTOMETRY; HUMANS; LUNG NEOPLASMS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN ARRAY ANALYSIS; PROTO-ONCOGENE PROTEINS C-AKT; THIOREDOXIN REDUCTASE 1; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84962205847     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6516     Document Type: Article

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