Ophiopogonin D: A new herbal agent against osteoporosis

Bone

Volumn 74, Issue , 2015, Pages 18-28

  Huang, Qiang ^a   Gao, Bo ^a   Wang, Long ^a   Zhang, Hong Yang ^a   Li, Xiao Jie ^a   Shi, Jun ^a   Wang, Zheng ^a   Zhang, Jin Kang ^b   Yang, Liu ^a   Luo, Zhuo Jing ^a   Liu, Jian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b AIR FORCE GENERAL HOSPITAL   (China)

Author keywords

FoxO3a; Ophiopogonin D; Osteoclastogenesis; Osteogenesis; Reactive oxygen species; Catenin

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; CARBOXY TERMINAL TELOPEPTIDE; GLUTATHIONE; HERBACEOUS AGENT; HYDROGEN PEROXIDE; MALONALDEHYDE; MESSENGER RNA; OPHIOPOGONIN D; REACTIVE OXYGEN METABOLITE; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR FKHRL1; TRAP PROTEIN; TRYPTOPHAN TRANSFER RNA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, MOUSE; PROTECTIVE AGENT; SAPONIN; SPIROSTAN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOSTEOPOROTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BGLAP GENE; BONE DEFECT; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; COL1A1 GENE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; GENE; HISTOPATHOLOGY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OPHIOPOGON JAPONICUS; OSTEOCLASTOGENESIS; OSTEOPOROSIS; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPP1 GENE; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL DEATH; CELL LINE; CELL PROTECTION; CHEMISTRY; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; METABOLISM; ORGAN SIZE; OSTEOCLAST; OVARIECTOMY; PATHOLOGY; PHYTOTHERAPY;

ANIMALS; BETA CATENIN; BIOMARKERS; BLOTTING, WESTERN; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CYTOPROTECTION; DRUGS, CHINESE HERBAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MICE, INBRED BALB C; ORGAN SIZE; OSTEOCLASTS; OSTEOGENESIS; OSTEOPOROSIS; OVARIECTOMY; PHYTOTHERAPY; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SAPONINS; SIGNAL TRANSDUCTION; SPIROSTANS;

EID: 84920941629     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2015.01.002     Document Type: Article

References (54)

1. Baek K.H., Oh K.W., Lee W.Y., Lee S.S., Kim M.K., Kwon H.S., et al. Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcif Tissue Int 2010, 87:226-235.
2. Arslan A., Orkun S., Aydin G.L., Keles I., Tosun A., Arslan M., et al. Effects of ovariectomy and ascorbic acid supplement on oxidative stress parameters and bone mineral density in rats. Libyan J Med 2011, 6:5965.
3. Basu S., Michaelsson K., Olofsson H., Johansson S., Melhus H. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 2001, 288:275-279.
4. Sendur O.F., Turan Y., Tastaban E., Serter M. Antioxidant status in patients with osteoporosis: a controlled study. Joint Bone Spine 2009, 76:514-518.
5. Ozgocmen S., Kaya H., Fadillioglu E., Aydogan R., Yilmaz Z. Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol Cell Biochem 2007, 295:45-52.
6. Witko-Sarsat V., Friedlander M., Capeillere-Blandin C., Nguyen-Khoa T., Nguyen A.T., Zingraff J., et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 1996, 49:1304.
7. Muthusami S., Ramachandran I., Muthusamy B., Vasudevan G., Prabhu V., Subramaniam V., et al. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta 2005, 360:81-86.
8. Manolagas S.C. De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol. Endocrinology 2008, 149:3264-3266.
9. Li N., Lee W.Y., Lin S.E., Ni M., Zhang T., Huang X.R., et al. Partial loss of Smad7 function impairs bone remodeling, osteogenesis and enhances osteoclastogenesis in mice. Bone 2014, 67:46-55.
10. Soltanoff C.S., Yang S., Chen W., Li Y.P. Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr 2009, 19:1-46.
11. Huang W., Yang S.Y., Shao J.Z., Li Y.P. Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci 2007, 12:3068-3092.
12. Mody N., Parhami F., Sarafian T.A., Demer L.L. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 2001, 31:509-519.
13. Bai X.C., Lu D., Bai J., Zheng H., Ke Z.Y., Li X.M., et al. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-jB. Biochem Biophys Res Commun 2004, 314:197-207.
14. Isomura H., Fujie K., Shibata K., Inoue N., Iizuka T., Takebe G., et al. Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology 2004, 197:93-100.
15. Garrett I.R., Boyce B.F., Oreffo R.O., Bonewald L., Poser J., Mundy G.R. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990, 85:632-639.
16. Almeida M., Han L., Martin-Millan M., Plotkin L.I., Stewart S.A., Roberson P.K., et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007, 282:27285-27297.
17. Jilka R.L., Almeida M., Ambrogini E., Han L., Roberson P.K., Weinstein R.S., et al. Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone. Aging Cell 2010, 9:851-867.
18. Van der H.A., Burgering B.M. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 2007, 8:440-450.
19. Arden K.C. FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 2008, 27:2345-2350.
20. Puig O., Mattila J. Understanding forkhead box class O function: lessons from Drosophila melanogaster. Antioxid Redox Signal 2011, 14:635-647.
21. Ambrogini E., Almeida M., Martin-Millan M., Paik J.H., DePinho R.A., Han L., et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 2010, 11(2):136-146.
22. Cadigan K.M., Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997, 11:3286-3305.
23. Bienz M., Clevers H. Armadillo/-catenin signals in the nucleus-proof beyond a reasonable doubt?. Nat Cell Biol 2003, 5:179-182.
24. Manolagas S.C., Almeida M. Gone with the Wnts: β-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol 2007, 21(11):2605-2614.
25. Kou J., Tian Y., Tang Y., Yan J., Yu B.Y. Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol Pharm Bull 2006, 29:1267-1270.
26. Kou J., Sun Y., Lin Y., Cheng Z.H., Zheng W., Yu B.Y., et al. Anti-inflammatory activities of aqueous extract from radix ophiopogon japonicus and its two constituents. Biol Pharm Bull 2005, 28:1234-1238.
27. Takahama K., Miyata T. Cough-diversity and the peripheral mechanisms of production. Folia Pharmacol Jnp 1995, 105:41-52.
28. 2-induced injury in primary human umbilical vein endothelial cells. J Ethnopharmacol 2010, 128:438-445.
29. Zhang J.K., Yang L., Meng G.L., Yuan Z., Fan J., Li D., et al. Protection by salidroside against bone loss via inhibition of oxidative stress and bone-resorbing mediators. PLoS One 2013, 8(2):e57251.
30. Zheng Z.H., Zhang L., Kong L.J., Wang A.J., Gong Y.D., Zhang X.F. The behavior of MC3T3-E1 cells on chitosan/poly-l-lysine composite films: effect of nanotopography, surface chemistry, and wettability. J Biomed Mater Res A 2009, 89:453-465.
31. Chiang H.M., Chen H.C., Lin T.J., Shih I.C., Wen K.C. Michelia alba extract attenuates UVB-induced expression of matrix metalloproteinases via MAP kinase pathway in human dermal fibroblast. Food Chem Toxicol 2012, 50:4250-4269.
32. Chen J.J., Zhang N.F., Mao G.X., Hea X.B., Zhana Y.C., Deng H.B., et al. Salidroside stimulates osteoblast differentiation through BMP signaling pathway. Food Chem Toxicol 2013, 62:499-505.
33. Zhang J.K., Yang L., Meng G.L., Fan J., Chen J.Z., He Q.Z., et al. Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells. Eur J Pharmacol 2012, 689:31-37.
34. Finkel T., Holbrook N.J. Oxidants, oxidative stress and biology of ageing. Nature 2000, 408:147-239.
35. Maggio D., Barabani M., Pierandrei M., Polidori M.C., Catani M., Mecocci P., et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 2003, 88:1523-1527.
36. Liu A.L., Zhang Z.M., Zhu B.F., Liao Z.H., Liu Z. Metallothionein protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. Cell Biol Int 2004, 28:905-911.
37. Lippuner K. The future of osteoporosis treatment-a research update. Swiss Med Wkly 2012, 142:w13624.
38. Ollivere B., Wimhurst J.A., Clark I.M., Donell S.T. Current concepts in osteolysis. J Bone Joint Surg Br 2012, 94:10-15.
39. Moriwaki S., Suzuki K., Muramatsu M., Nomura A., Inoue F., Into T., et al. Delphinidin, one of the major anthocyanidins, prevents bone loss through the inhibition of excessive osteoclastogenesis in osteoporosis model mice. PLoS One 2014, 9(5):e97177.
40. Tezuka K., Tezuka Y., Maejima A., Sato T., Nemoto K., Kamioka H., et al. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts. J Biol Chem 1994, 269:1106-1109.
41. Delaissé J.M., Andersen T.L., Engsig M.T., Henriksen K., Troen T., Blavier L. Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc Res Tech 2003, 61:504-513.
42. Manolagas S.C. From oestrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 2010, 31:266-300.
43. Chappard D., Basle M.F., Legrand E., Audran M. Trabecular bone microarchitecture: a review. Morphologie 2008, 92:162-170.
44. Ferreri S.L., Talish R., Trandafir T., Qin Y.X. Mitigation of bone loss with ultrasound induced dynamic mechanical signals in an OVX induced rat model of osteopenia. Bone 2011, 48:1095-1102.
45. Estrela J.M., Ortega A., Obrador E. Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 2006, 43:143-181.
46. Almeida M. Unraveling the role of FoxOs in bone-insights from mouse models. Bone 2011, 49(3):319-327.
47. Rached M.T., Kode A., Xu L., Yoshikawa Y., Paik J.H., DePinho R.A., et al. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 2010, 11:147-160.
48. Miyamoto K., Araki K.Y., Naka K., Arai F., Takubo K., Yamazaki S., et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 2007, 1:101-112.
49. Marinkovic D., Zhang X., Yalcin S., Luciano J.P., Brugnara C., Huber T., et al. Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest 2007, 117:2133-2144.
50. Essers M.A., Vries-Smits L.M., Barker N., Polderman P.E., Burgering B.M., Korswagen H.C. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 2005, 308:1181-1184.
51. Tseng P.C., Hou S.M., Chen R.J., Peng H.W., Hsieh C.F., Kuo M.L., et al. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. J Bone Miner Res 2011, 26:10.
52. Yang Y.J., Su Y.J., Wang D.T., Chen Y.H., Wu T., Li G., et al. Tanshinol attenuates the deleterious effects of oxidative stress on osteoblastic differentiation via Wnt/FoxO3a signaling. Oxid Med Cell Longev 2013, 351895:18.
53. Ha H., Kwak H.B., Lee S.W., Jin H.M., Kim H.M., Kim H.H., et al. Reactive oxygen species mediate RANK signaling in osteoclasts. Exp Cell Res 2004, 301:119-127.
54. Lee N.K., Choi Y.G., Baik J.Y., Han S.Y., Jeong D.W., Bae Y.S., et al. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005, 106:852-859.