Effects of ophiopogonin B on the proliferation and apoptosis of SGC-7901 human gastric cancer cells

Molecular Medicine Reports

Volumn 13, Issue 6, 2016, Pages 4981-4986

  Zhang, Weiyue ^a   Zhang, Qiaoyan ^b   Jiang, Yiping ^b   Li, Feng ^a   Xin, Hailiang ^b  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antitumor; Apoptosis; Gastric cancer; Ophiopogonin B

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE 1; OPHIOPOGONIN B; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; MATRIX METALLOPROTEINASE; SAPONIN; SPIROSTAN DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STOMACH CANCER; WESTERN BLOTTING; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; STOMACH TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOMARKERS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; MATRIX METALLOPROTEINASES; REACTIVE OXYGEN SPECIES; SAPONINS; SPIROSTANS; STOMACH NEOPLASMS;

EID: 84966480852     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5198     Document Type: Article

References (24)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. de Martel C, Forman D and Plummer M: Gastric cancer: Epidemiology and risk factors. Gastroenterol Clin North Am 42: 219-240, 2013.
3. Wong H and Yau T: Targeted therapy in the management of advanced gastric cancer: Are we making progress in the era of personalized medicine? Oncologist 17: 346-358, 2012.
4. Qi F, Li A, Inagaki Y, Gao J, Li J, Kokudo N, Li XK and Tang W: Chinese herbal medicines as adjuvant treatment during chemo-or radio-therapy for cancer. Biosci Trends 4: 297-307, 2010.
5. Li R, Chen WC, Wang WP, Tian WY and Zhang XG: Extraction, characterization of Astragalus polysaccharides and its immune modulating activities in rats with gastric cancer. Carbohydr Polym 78: 738-742, 2009.
6. Li X, Yang G, Li X, Zhang Y, Yang J, Chang J, Sun X, Zhou X, Guo Y, Xu Y, et al: Traditional Chinese medicine in cancer care: A review of controlled clinical studies published in Chinese. PLoS One 8: e60338, 2013.
7. Ling Y: Traditional Chinese medicine in the treatment of symptoms in patients with advanced cancer. Ann Palliat Med 2: 141-152, 2013.
8. Boyang Y and Guojun X: Studies on resource utilization of Chinese drug dwarf lilyturf (Ophiopogon japonicus). Zhongyao Maidong De Ziyuan Liyong Yanjiu 26: 205-210, 1995 (In Chinese).
9. Xiao P, Li DP and Yang SL: Modern Chinese materia medica. Chemical Industry Press 4: 253-272, 2002.
10. Kou J, Sun Y, Lin Y, Cheng Z, Zheng W, Yu B and Xu Q: Anti-inflammatory activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol Pharm Bull 28: 1234-1238, 2005.
11. Lin X, Zhou QF and Xu D: Research progress of the pharmacological actions of ophiopogon root. Shang Hai Zhong Yi Yao Za Zhi She 38, 59-61, 2004 (In Chinese).
12. Chen M, Du Y, Qui M, Wang M, Chen K, Huang Z, Jiang M, Xiong F, Chen J, Zhou J, et al: Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3 K/Akt signaling pathway. Oncol Rep 29: 430-436, 2013.
13. Xu QJ, Hou LL, Hu GQ and Xie SQ: Molecular mechanism of ophiopogonin B induced cellular autophagy of human cervical cancer HeLa cells. Yao Xue Xue Bao 48: 855-859, 2013 (In Chinese).
14. Kabeer FA, Sreedevi GB, Nair MS, Rajalekshmi DS, Gopalakrishnan LP, Kunjuraman S and Prathapan R: Antineoplastic effects of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, on lung adenocarcinoma (A549) cells. J Integr Med 11: 269-277, 2013.
15. Mondal J, Bishayee K, Panigrahi AK and Khuda-Bukhsh AR. Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro. J Integr Med 12: 425-438, 2014.
16. Wang YH, Qiu C, Wang DW, Hu ZF, Yu BY and Zhu DN: Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC-DAD-MS/MS. J Pharm Biomed Anal 54: 1110-1127, 2011.
17. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462, 1995.
18. Mohamad N, Gutiérrez A, Núñez M, Cocca C, Martín G, Cricco G, Medina V, Rivera E and Bergoc R: Mitochondrial apoptotic pathways. Biocell 29: 149-161, 2005.
19. Lucken-Ardjomande S and Martinou JC: Newcomers in the process of mitochondrial permeabilization. J Cell Sci 118: 473-483, 2005.
20. Ott M, Gogvadze V, Orrenius S and Zhivotovsky B: Mitochondria, oxidative stress and cell death. Apoptosis 12: 913-922, 2007.
21. Götz ME, Künig G, Riederer P and Youdim MB: Oxidative stress: Free radical production in neural degeneration. Pharmacol Ther 63: 37-122, 1994.
22. Cagnol S and Chambard JC: ERK and cell death: Mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J 277: 2-21, 2010.
23. Kralova J, Dvorak M, Koc M and Kral V: P38 MAPK plays an essential role in apoptosis induced by photoactivation of a novel ethylene glycol porphyrin derivative. Oncogene 27: 3010-3020, 2008.
24. Dhanasekaran DN and Reddy EP: JNK signaling in apoptosis. Oncogene 27: 6245-6251, 2008.