Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in human non-small cell lung cancer cells

Biochemical and Biophysical Research Communications

Volumn 465, Issue 1, 2015, Pages 64-70

  Zhang, Quan ^a   Zhu, Huixia ^a   Xu, Xiaoshuang ^a   Li, Lingyu ^a   Tan, Haiming ^a   Cai, Xiaoyao ^a  

^a YANGZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Inactivated Sendai virus (HVJ E); PI3K AKT mTOR p70S6K

Indexed keywords

BETA ACTIN; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ONCOLYTIC VIRUS; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAPAMYCIN; S6 KINASE; ANTINEOPLASTIC AGENT; CISPLATIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

A549 CELL LINE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; SENDAI VIRUS; SIGNAL TRANSDUCTION; VIRUS INACTIVATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; RESPIRATORY TRACT MUCOSA; TUMOR CELL LINE; VIROLOGY;

SENDAI VIRUS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CISPLATIN; DRUG RESISTANCE, NEOPLASM; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE KINASE 4; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RESPIRATORY MUCOSA; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SENDAI VIRUS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; VIRUS INACTIVATION;

EID: 84940453221     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.07.130     Document Type: Article

References (24)

1. L.A. Torre, F. Bray, R.L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal Global cancer statistics, 2012 CA. Cancer J. Clin. 65 2015 87 108
2. S. Meng, Z. Zhou, F. Chen, X. Kong, H. Liu, K. Jiang, W. Liu, M. Hu, X. Zhang, C. Ding, and Y. Wu Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo Cancer Lett. 317 2012 56 64
3. K. Jiang, Y. Li, Q. Zhu, J. Xu, Y. Wang, W. Deng, Q. Liu, G. Zhang, and S. Meng Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells BMC Cancer 14 2014 551
4. Q. Zhang, W.F. Yuan, G.Q. Zhai, S.Y. Zhu, Z.F. Xue, H.F. Zhu, and X.M. Xu Inactivated sendai virus suppresses murine melanoma growth by inducing host immune responses and down-regulating β-catenin expression Biomed. Environ. Sci. 25 2012 509 516
5. M. Matsuda, K. Nimura, T. Shimbo, T. Hamasaki, T. Yamamoto, A. Matsumura, and Y. Kaneda Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma J. Neurooncol. 103 2011 19 31
6. Y. Kawaguchi, Y. Miyamoto, T. Inoue, and Y. Kaneda Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle Int. J. Cancer 124 2009 2478 2487
7. Q. Zhang, X. Xu, Y. Yuan, X. Gong, Z. Chen, and X. Xu IPS-1 plays a dual function to directly induce apoptosis in murine melanoma cells by inactivated Sendai virus Int. J. Cancer 134 2014 224 234
8. H. Gao, X.C. Gong, Z.D. Chen, X.S. Xu, Q. Zhang, and X.M. Xu Induction of apoptosis in hormone-resistant human prostate cancer PC3 cells by inactivated Sendai virus Biomed. Environ. Sci. 27 2014 506 514
9. H. Gao, X.S. Xu, Z.D. Chen, Q. Zhang, and X.M. Xu Inactivated Sendai virus induces apoptosis in murine melanoma cells by IGF-1R down-regulation Biomed. Environ. Sci. 26 2013 998 1002
10. H. Yue, W. Li, P. Liu, J. Gao, J. Miao, and J. Zhao Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells Biochem. Biophys. Res. Commun. 453 2014 502 507
11. L. Zhang, H. Wang, J. Zhu, J. Xu, and K. Ding Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways Biochem. Biophys. Res. Commun. 450 2014 247 254
12. A. Ko, A. Kanehisa, I. Martins, L. Senovilla, C. Chargari, D. Dugue, G. Marino, O. Kepp, M. Michaud, J.L. Perfettini, G. Kroemer, and E. Deutsch Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling Cell Death Differ. 21 2014 92 99
13. Q. Zhang, Z. Wang, Y. Yuan, Z. Xue, G. Zhai, W. Zuo, S. Zhu, G. Zhu, and X. Xu Immunoadjuvant effects of hemagglutinating virus of Japan envelope (HVJ-E) on the inactivated H9 subtype avian influenza virus vaccine Vet. Immunol. Immunopathol. 141 2011 116 123
14. J. Bian, K. Wang, X. Kong, H. Liu, F. Chen, M. Hu, X. Zhang, X. Jiao, B. Ge, Y. Wu, and S. Meng Caspase- and p38-MAPK-dependent induction of apoptosis in A549 lung cancer cells by Newcastle disease virus Arch. Virol. 156 2011 1335 1344
15. H. Tazawa, S. Kagawa, and T. Fujiwara Oncolytic adenovirus-induced autophagy: tumor-suppressive effect and molecular basis Acta Med. Okayama 67 2013 333 342
16. V.V. Sumbayev, and I.M. Yasinska Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection Scand. J. Immunol. 63 2006 391 400
17. A. Petiot, S. Pattingre, S. Arico, D. Meley, and P. Codogno Diversity of signaling controls of macroautophagy in mammalian cells Cell Struct. Funct. 27 2002 431 441
18. G. Botta, C. Passaro, S. Libertini, A. Abagnale, S. Barbato, A.S. Maione, G. Hallden, F. Beguinot, P. Formisano, and G. Portella Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo Hum. Gene Ther. 23 2012 623 634
19. M. Nomura, A. Ueno, K. Saga, M. Fukuzawa, and Y. Kaneda Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma Cancer Res. 74 2014 1056 1066
20. Y. Wang, B. Lin, J. Wu, H. Zhang, and B. Wu Metformin inhibits the proliferation of A549/CDDP cells by activating p38 mitogen-activated protein kinase Oncol. Lett. 8 2014 1269 1274
21. Y. Liu, X. Chen, Y. Gu, L. Zhu, Y. Qian, D. Pei, W. Zhang, and Y. Shu FOXM1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and mediates sensitivity to cisplatin in A549 cells via the JNK/mitochondrial pathway Neoplasma 62 2015 61 71
22. D. Glick, S. Barth, and K.F. Macleod Autophagy: cellular and molecular mechanisms J. Pathol. 221 2010 3 12
23. J.H. Ren, W.S. He, L. Nong, Q.Y. Zhu, K. Hu, R.G. Zhang, L.L. Huang, F. Zhu, and G. Wu Acquired cisplatin resistance in human lung adenocarcinoma cells is associated with enhanced autophagy Cancer Biother. Radiopharm. 25 2010 75 80
24. X.Q. Lun, J.H. Jang, N. Tang, H. Deng, R. Head, J.C. Bell, D.F. Stojdl, C.L. Nutt, D.L. Senger, P.A. Forsyth, and J.A. McCart Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide Clin. Cancer Res. 15 2009 2777 2788