DT-13 attenuates human lung cancer metastasis via regulating NMIIA activity under hypoxia condition

Oncology Reports

Volumn 36, Issue 2, 2016, Pages 991-999

  Wei, Xiao Hui ^a   Lin, Sen Sen ^a   Liu, Yang ^a   Zhao, Ren Ping ^a   Khan, Ghulam Jilany ^a   Du, Hong Zhi ^a   Mao, Ting Ting ^a   Yu, Bo Yang ^a   Li, Rui Ming ^b   Yuan, Sheng Tao ^a   Sun, Li ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Tasly Holding Group Co Ltd Tianjin Tasly Medicine Distribution Group Co Ltd   (China)

Author keywords

DT 13; Hypoxia; Lung cancer; Metastasis; NMIIA; Raf ERK1 2

Indexed keywords

DT 13; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN IIA; PROTEIN NMIIA; RAF PROTEIN; SAPONIN; TOPOTECAN; UNCLASSIFIED DRUG; ACTIN; MOLECULAR MOTOR; MYH9 PROTEIN, HUMAN; MYOSIN HEAVY CHAIN; RUSCOGENIN-1-O-(GLUCOPYRANOSYL-(1-2))(XYLOPYRANOSYL-(1-3))FUCOPYRANOSIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CELL HYPOXIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; FEMALE; GENE EXPRESSION REGULATION; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG METASTASIS; METASTASIS INHIBITION; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; CELL MOTION; DRUG EFFECTS; HUMAN; LUNG NEOPLASMS; METABOLISM; NEOPLASM METASTASIS; NUDE MOUSE; TUMOR CELL LINE;

ACTINS; ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; MOLECULAR MOTOR PROTEINS; MYOSIN HEAVY CHAINS; NEOPLASM METASTASIS; SAPONINS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84976470698     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2016.4879     Document Type: Article

References (29)

1. Edwards BK, Noone AM, Mariotto AB, Simard EP, Boscoe FP, Henley SJ, Jemal A, Cho H, Anderson RN, Kohler BA, et al: Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer 120: 1290-1314, 2014.
2. Wang Y, Liu Y, Malek SN, Zheng P and Liu Y: Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8: 399-411, 2011.
3. Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A and Semenza GL: Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145: 732-744, 2011.
4. Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti CA, Gouvin LM, Sharma VM and Mercurio AM: ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: Implications for Gleason grading. Cancer Cell 17: 319-332, 2010.
5. Swietach P, Vaughan-Jones RD and Harris AL: Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev 26: 299-310, 2007.
6. Chan DA and Giaccia AJ: Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 26: 333-339, 2007.
7. Semenza GL: Hypoxia-inducible factors in physiology and medicine. Cell 148: 399-408, 2012.
8. Zhang H, Wong CCL, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, et al: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31: 1757-1770, 2012.
9. Estecha A, Sánchez-Martín L, Puig-Kröger A, Bartolomé RA, Teixidó J, Samaniego R and Sánchez-Mateos P: Moesin orchestrates cortical polarity of melanoma tumour cells to initiate 3D invasion. J Cell Sci 122: 3492-3501, 2009.
10. Poincloux R, Collin O, Lizárraga F, Romao M, Debray M, Piel M and Chavrier P: Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc Natl Acad Sci USA 108: 1943-1948, 2011.
11. Dahan I, Yearim A, Touboul Y and Ravid S: The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration. Mol Biol Cell 23: 591-601, 2012.
12. Vicente-Manzanares M, Ma X, Adelstein RS and Horwitz AR: Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol 10: 778-790, 2009.
13. Clark K, Langeslag M, Figdor CG and van Leeuwen FN: Myosin II and mechanotransduction: A balancing act. Trends Cell Biol 17: 178-186, 2007.
14. Betapudi V: Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading. PLoS One 5: e8560, 2010.
15. Doyle AD, Kutys ML, Conti MA, Matsumoto K, Adelstein RS and Yamada KM: Micro-environmental control of cell migration-myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci 125: 2244-2256, 2012.
16. Liu Z, van Grunsven LA, Van Rossen E, Schroyen B, Timmermans JP, Geerts A and Reynaert H: Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells. Br J Pharmacol 159: 304-315, 2010.
17. Liu Z, Van Rossen E, Timmermans JP, Geerts A, van Grunsven LA and Reynaert H: Distinct roles for non-muscle myosin II isoforms in mouse hepatic stellate cells. J Hepatol 54: 132-141, 2011.
18. Betapudi V, Licate LS and Egelhoff TT: Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration. Cancer Res 66: 4725-4733, 2006.
19. Zhao R, Sun L, Lin S, Bai X, Yu B, Yuan S and Zhang L: The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi-targeting activity. Oncol Rep 29: 1379-1386, 2013.
20. Zhang YY, Liu JH, Kou JP, Yu J and Yu BY: DT-13, a steroidal saponin from Liriope muscari L. H. Bailey, suppresses A549 cells adhesion and invasion by inhibiting MMP-2/9. Chin J Nat Med 10: 436-440, 2012.
21. Yu XW, Lin S, Du HZ, Zhao RP, Feng SY, Yu BY, Zhang LY, Li RM, Qian CM, Luo XJ, et al: Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of egf receptor in vitro and in vivo. Oncotarget doi: 10.18632, 2016.
22. Schramek D, Sendoel A, Segal JP, Beronja S, Heller E, Oristian D, Reva B and Fuchs E: Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. Science 343: 309-313, 2014.
23. Liu Z, Ho CH and Grinnell F: The different roles of myosin IIA and myosin IIB in contraction of 3D collagen matrices by human fibroblasts. Exp Cell Res 326: 295-306, 2014.
24. Casalou C, Seixas C, Portelinha A, Pintado P, Barros M, Ramalho JS, Lopes SS and Barral DC: Arl13b and the non-muscle myosin heavy chain IIA are required for circular dorsal ruffle formation and cell migration. J Cell Sci 127: 2709-2722, 2014.
25. Derycke L, Stove C, Vercoutter-Edouart AS, De Wever O, Dollé L, Colpaert N, Depypere H, Michalski JC and Bracke M: The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells. Int J Dev Biol 55: 835-840, 2011.
26. Xia ZK, Yuan YC, Yin N, Yin BL, Tan ZP and Hu YR: Nonmuscle myosin IIA is associated with poor prognosis of esophageal squamous cancer. Dis Esophagus 25: 427-436, 2012.
27. Jorrisch MH, Shih W and Yamada S: Myosin IIA deficient cells migrate efficiently despite reduced traction forces at cell periphery. Biol Open 2: 368-372, 2013.
28. Zhang H, Chen Y, Wadham C, McCaughan GW, Keane FM and Gorrell MD: Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochim Biophys Acta 1853: 470-480, 2015.
29. Babbin BA, Koch S, Bachar M, Conti MA, Parkos CA, Adelstein RS, Nusrat A and Ivanov AI: Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion. Am J Pathol 174: 436-448, 2009.