-
1
-
-
0020956787
-
Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
-
Pan, B. T., and Johnstone, R. M. (1983) Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33, 967-978
-
(1983)
Cell
, vol.33
, pp. 967-978
-
-
Pan, B.T.1
Johnstone, R.M.2
-
2
-
-
0020804037
-
Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
-
Harding, C., Heuser, J., and Stahl, P. (1983) Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97, 329-339
-
(1983)
J. Cell Biol.
, vol.97
, pp. 329-339
-
-
Harding, C.1
Heuser, J.2
Stahl, P.3
-
3
-
-
84874377202
-
Extracellular vesicles: Exosomes, microvesicles, and friends
-
Raposo, G., and Stoorvogel, W. (2013) Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200, 373-383
-
(2013)
J. Cell Biol.
, vol.200
, pp. 373-383
-
-
Raposo, G.1
Stoorvogel, W.2
-
4
-
-
0031863853
-
Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
-
Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi-Castagnoli, P., Raposo, G., and Amigorena, S. (1998) Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. 4, 594-600
-
(1998)
Nat. Med.
, vol.4
, pp. 594-600
-
-
Zitvogel, L.1
Regnault, A.2
Lozier, A.3
Wolfers, J.4
Flament, C.5
Tenza, D.6
Ricciardi-Castagnoli, P.7
Raposo, G.8
Amigorena, S.9
-
5
-
-
84904704297
-
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
-
Colombo, M., Raposo, G., and Thery, C. (2014) Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255-289
-
(2014)
Annu. Rev. Cell Dev. Biol.
, vol.30
, pp. 255-289
-
-
Colombo, M.1
Raposo, G.2
Thery, C.3
-
6
-
-
84938581025
-
Extracellular vesicles shuffling intercellular messages: For good or for bad
-
Lo Cicero, A., Stahl, P. D., and Raposo, G. (2015) Extracellular vesicles shuffling intercellular messages: for good or for bad. Curr. Opin. Cell Biol. 35, 69-77
-
(2015)
Curr. Opin. Cell Biol.
, vol.35
, pp. 69-77
-
-
Lo Cicero, A.1
Stahl, P.D.2
Raposo, G.3
-
7
-
-
79957879331
-
Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
-
Hood, J. L., San, R. S., and Wickline, S. A. (2011) Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 71, 3792-3801
-
(2011)
Cancer Res.
, vol.71
, pp. 3792-3801
-
-
Hood, J.L.1
San, R.S.2
Wickline, S.A.3
-
8
-
-
84862007577
-
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
-
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., Garcia-Santos, G., Ghajar, C., Nitadori-Hoshino, A., Hoffman, C., Badal, K., Garcia, B. A., Callahan, M. K., et al. (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883-891
-
(2012)
Nat. Med.
, vol.18
, pp. 883-891
-
-
Peinado, H.1
Alečković, M.2
Lavotshkin, S.3
Matei, I.4
Costa-Silva, B.5
Moreno-Bueno, G.6
Hergueta-Redondo, M.7
Williams, C.8
Garcia-Santos, G.9
Ghajar, C.10
Nitadori-Hoshino, A.11
Hoffman, C.12
Badal, K.13
Garcia, B.A.14
Callahan, M.K.15
-
9
-
-
84930170395
-
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
-
Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., Xiang, J., Zhang, T., Theilen, T. M., Garcia-Santos, G., Williams, C., et al. (2015) Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17, 816-826
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 816-826
-
-
Costa-Silva, B.1
Aiello, N.M.2
Ocean, A.J.3
Singh, S.4
Zhang, H.5
Thakur, B.K.6
Becker, A.7
Hoshino, A.8
Mark, M.T.9
Molina, H.10
Xiang, J.11
Zhang, T.12
Theilen, T.M.13
Garcia-Santos, G.14
Williams, C.15
-
10
-
-
84947723880
-
Tumour exosome integrins determine organotropic metastasis
-
Hoshino, A., Costa-Silva, B., Shen, T. L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., Singh, S., Williams, C., Soplop, N., Uryu, K., et al. (2015) Tumour exosome integrins determine organotropic metastasis. Nature 527, 329-335
-
(2015)
Nature
, vol.527
, pp. 329-335
-
-
Hoshino, A.1
Costa-Silva, B.2
Shen, T.L.3
Rodrigues, G.4
Hashimoto, A.5
Tesic Mark, M.6
Molina, H.7
Kohsaka, S.8
Di Giannatale, A.9
Ceder, S.10
Singh, S.11
Williams, C.12
Soplop, N.13
Uryu, K.14
-
11
-
-
0038748401
-
Idiopathic Parkinson's disease: Possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
-
Braak, H., Rub, U., Gai, W. P., and Del Tredici, K. (2003) Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J. Neural Transm. (Vienna) 110, 517-536
-
(2003)
J. Neural Transm. (Vienna)
, vol.110
, pp. 517-536
-
-
Braak, H.1
Rub, U.2
Gai, W.P.3
Del Tredici, K.4
-
12
-
-
84926513913
-
Spreading of pathology in neurodegenerative diseases: A focus on human studies
-
Brettschneider, J., Del Tredici, K., Lee, V. M., and Trojanowski, J. Q. (2015) Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat. Rev. Neurosci. 16, 109-120
-
(2015)
Nat. Rev. Neurosci.
, vol.16
, pp. 109-120
-
-
Brettschneider, J.1
Del Tredici, K.2
Lee, V.M.3
Trojanowski, J.Q.4
-
13
-
-
0020321767
-
Novel proteinaceous infectious particles cause scrapie
-
Prusiner, S. B. (1982) Novel proteinaceous infectious particles cause scrapie. Science 216, 136-144
-
(1982)
Science
, vol.216
, pp. 136-144
-
-
Prusiner, S.B.1
-
14
-
-
84942860108
-
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
-
Prusiner, S. B., Woerman, A. L., Mordes, D. A., Watts, J. C., Rampersaud, R., Berry, D. B., Patel, S., Oehler, A., Lowe, J. K., Kravitz, S. N., Geschwind, D. H., Glidden, D. V., Halliday, G. M., Middleton, L. T., Gentleman, S. M., Grinberg, L. T., and Giles, K. (2015) Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc. Natl. Acad. Sci. U.S.A. 112, E5308-E5317
-
(2015)
Proc. Natl. Acad. Sci. U.S.A.
, vol.112
, pp. E5308-E5317
-
-
Prusiner, S.B.1
Woerman, A.L.2
Mordes, D.A.3
Watts, J.C.4
Rampersaud, R.5
Berry, D.B.6
Patel, S.7
Oehler, A.8
Lowe, J.K.9
Kravitz, S.N.10
Geschwind, D.H.11
Glidden, D.V.12
Halliday, G.M.13
Middleton, L.T.14
Gentleman, S.M.15
Grinberg, L.T.16
Giles, K.17
-
15
-
-
72149125838
-
The transcellular spread of cytosolic amyloids, prions, and prionoids
-
Aguzzi, A., and Rajendran, L. (2009) The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron 64, 783-790
-
(2009)
Neuron
, vol.64
, pp. 783-790
-
-
Aguzzi, A.1
Rajendran, L.2
-
16
-
-
0000930795
-
Histochemical study of senile plaques
-
Divry, P. (1927) Histochemical study of senile plaques. J. Belge Neurol. Psychiatr. 27, 643-657
-
(1927)
J. Belge Neurol. Psychiatr.
, vol.27
, pp. 643-657
-
-
Divry, P.1
-
17
-
-
0001509014
-
Paralysis agitans. I. Pathological anatomy
-
(Lewandowsky, M., ed), Springer, Berlin
-
Lewy, F. H. (1912) Paralysis Agitans. I. Pathological Anatomy. In Lewandowsky's Manual of Neurology, III (Lewandowsky, M., ed), pp. 920-933, Springer, Berlin
-
(1912)
Lewandowsky's Manual of Neurology, III
, pp. 920-933
-
-
Lewy, F.H.1
-
18
-
-
67649286622
-
Cell biology: Beyond the prion principle
-
Aguzzi, A. (2009) Cell biology: Beyond the prion principle. Nature 459, 924-925
-
(2009)
Nature
, vol.459
, pp. 924-925
-
-
Aguzzi, A.1
-
19
-
-
84888594143
-
Biology and genetics of prions causing neurodegeneration
-
Prusiner, S. B. (2013) Biology and genetics of prions causing neurodegeneration. Annu. Rev. Genet. 47, 601-623
-
(2013)
Annu. Rev. Genet.
, vol.47
, pp. 601-623
-
-
Prusiner, S.B.1
-
20
-
-
77957939093
-
Are synucleinopathies prion-like disorders?
-
Angot, E., Steiner, J. A., Hansen, C., Li, J. Y., and Brundin, P. (2010) Are synucleinopathies prion-like disorders? Lancet Neurol. 9, 1128-1138
-
(2010)
Lancet Neurol.
, vol.9
, pp. 1128-1138
-
-
Angot, E.1
Steiner, J.A.2
Hansen, C.3
Li, J.Y.4
Brundin, P.5
-
21
-
-
84941198850
-
Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy
-
Jaunmuktane, Z., Mead, S., Ellis, M., Wadsworth, J. D., Nicoll, A. J., Kenny, J., Launchbury, F., Linehan, J., Richard-Loendt, A., Walker, A. S., Rudge, P., Collinge, J., and Brandner, S. (2015) Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy. Nature 525, 247-250
-
(2015)
Nature
, vol.525
, pp. 247-250
-
-
Jaunmuktane, Z.1
Mead, S.2
Ellis, M.3
Wadsworth, J.D.4
Nicoll, A.J.5
Kenny, J.6
Launchbury, F.7
Linehan, J.8
Richard-Loendt, A.9
Walker, A.S.10
Rudge, P.11
Collinge, J.12
Brandner, S.13
-
22
-
-
0014190760
-
Self-replication and scrapie
-
Griffith, J. S. (1967) Self-replication and scrapie. Nature 215, 1043-1044
-
(1967)
Nature
, vol.215
, pp. 1043-1044
-
-
Griffith, J.S.1
-
23
-
-
0037006804
-
Transfer of scrapie prion infectivity by cell contact in culture
-
Kanu, N., Imokawa, Y., Drechsel, D. N., Williamson, R. A., Birkett, C. R., Bostock, C. J., and Brockes, J. P. (2002) Transfer of scrapie prion infectivity by cell contact in culture. Curr. Biol. 12, 523-530
-
(2002)
Curr. Biol.
, vol.12
, pp. 523-530
-
-
Kanu, N.1
Imokawa, Y.2
Drechsel, D.N.3
Williamson, R.A.4
Birkett, C.R.5
Bostock, C.J.6
Brockes, J.P.7
-
24
-
-
61849178720
-
Prions hijack tunnelling nanotubes for intercellular spread
-
Gousset, K., Schiff, E., Langevin, C., Marijanovic, Z., Caputo, A., Browman, D. T., Chenouard, N., de Chaumont, F., Martino, A., Enninga, J., Olivo-Marin, J. C., Mannel, D., and Zurzolo, C. (2009) Prions hijack tunnelling nanotubes for intercellular spread. Nat. Cell Biol. 11, 328-336
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 328-336
-
-
Gousset, K.1
Schiff, E.2
Langevin, C.3
Marijanovic, Z.4
Caputo, A.5
Browman, D.T.6
Chenouard, N.7
De Chaumont, F.8
Martino, A.9
Enninga, J.10
Olivo-Marin, J.C.11
Mannel, D.12
Zurzolo, C.13
-
25
-
-
0024828497
-
Organ distribution of proteinase-resistant prion protein in humans and mice with Creutzfeldt-Jakob disease
-
Kitamoto, T., Mohri, S., and Tateishi, J. (1989) Organ distribution of proteinase-resistant prion protein in humans and mice with Creutzfeldt-Jakob disease. J. Gen. Virol. 70, 3371-3379
-
(1989)
J. Gen. Virol.
, vol.70
, pp. 3371-3379
-
-
Kitamoto, T.1
Mohri, S.2
Tateishi, J.3
-
26
-
-
0033573778
-
Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples
-
Hill, A. F., Butterworth, R. J., Joiner, S., Jackson, G., Rossor, M. N., Thomas, D. J., Frosh, A., Tolley, N., Bell, J. E., Spencer, M., King, A., Al-Sarraj, S., Ironside, J. W., Lantos, P. L., and Collinge, J. (1999) Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet 353, 183-189
-
(1999)
Lancet
, vol.353
, pp. 183-189
-
-
Hill, A.F.1
Butterworth, R.J.2
Joiner, S.3
Jackson, G.4
Rossor, M.N.5
Thomas, D.J.6
Frosh, A.7
Tolley, N.8
Bell, J.E.9
Spencer, M.10
King, A.11
Al-Sarraj, S.12
Ironside, J.W.13
Lantos, P.L.14
Collinge, J.15
-
27
-
-
3042788972
-
Cells release prions in association with exosomes
-
Fevrier, B., Vilette, D., Archer, F., Loew, D., Faigle, W., Vidal, M., Laude, H., and Raposo, G. (2004) Cells release prions in association with exosomes. Proc. Natl. Acad. Sci. U.S.A. 101, 9683-9688
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 9683-9688
-
-
Fevrier, B.1
Vilette, D.2
Archer, F.3
Loew, D.4
Faigle, W.5
Vidal, M.6
Laude, H.7
Raposo, G.8
-
28
-
-
33947709328
-
Packaging of prions into exosomes is associated with a novel pathway of PrP processing
-
Vella, L. J., Sharples, R. A., Lawson, V. A., Masters, C. L., Cappai, R., and Hill, A. F. (2007) Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J. Pathol. 211, 582-590
-
(2007)
J. Pathol.
, vol.211
, pp. 582-590
-
-
Vella, L.J.1
Sharples, R.A.2
Lawson, V.A.3
Masters, C.L.4
Cappai, R.5
Hill, A.F.6
-
29
-
-
84868149990
-
Prioninfected cells regulate the release of exosomes with distinct ultrastructural features
-
Coleman, B. M., Hanssen, E., Lawson, V. A., and Hill, A. F. (2012) Prioninfected cells regulate the release of exosomes with distinct ultrastructural features. FASEB J. 26, 4160-4173
-
(2012)
FASEB J.
, vol.26
, pp. 4160-4173
-
-
Coleman, B.M.1
Hanssen, E.2
Lawson, V.A.3
Hill, A.F.4
-
30
-
-
84923532203
-
Prion strains are differentially released through the exosomal pathway
-
Arellano-Anaya, Z. E., Huor, A., Leblanc, P., Lehmann, S., Provansal, M., Raposo, G., Andreoletti, O., and Vilette, D. (2015) Prion strains are differentially released through the exosomal pathway. Cell. Mol. Life Sci. 72, 1185-1196
-
(2015)
Cell. Mol. Life Sci.
, vol.72
, pp. 1185-1196
-
-
Arellano-Anaya, Z.E.1
Huor, A.2
Leblanc, P.3
Lehmann, S.4
Provansal, M.5
Raposo, G.6
Andreoletti, O.7
Vilette, D.8
-
31
-
-
84977123370
-
Induction ofα-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies
-
Stuendl, A., Kunadt, M., Kruse, N., Bartels, C., Moebius, W., Danzer, K. M., Mollenhauer, B., and Schneider, A. (2016) Induction ofα-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies. Brain 139, 481-494
-
(2016)
Brain
, vol.139
, pp. 481-494
-
-
Stuendl, A.1
Kunadt, M.2
Kruse, N.3
Bartels, C.4
Moebius, W.5
Danzer, K.M.6
Mollenhauer, B.7
Schneider, A.8
-
32
-
-
0025800143
-
A 'unified theory' of prion propagation
-
Weissmann, C. (1991) A 'unified theory' of prion propagation. Nature 352, 679-683
-
(1991)
Nature
, vol.352
, pp. 679-683
-
-
Weissmann, C.1
-
33
-
-
0029831213
-
Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
-
Collinge, J., Sidle, K. C., Meads, J., Ironside, J., and Hill, A. F. (1996) Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 383, 685-690
-
(1996)
Nature
, vol.383
, pp. 685-690
-
-
Collinge, J.1
Sidle, K.C.2
Meads, J.3
Ironside, J.4
Hill, A.F.5
-
34
-
-
12244249201
-
Self-propagating, molecular-level polymorphism in Alzheimer's β-amyloid fibrils
-
Petkova, A. T., Leapman, R. D., Guo, Z., Yau, W. M., Mattson, M. P., and Tycko, R. (2005) Self-propagating, molecular-level polymorphism in Alzheimer's β-amyloid fibrils. Science 307, 262-265
-
(2005)
Science
, vol.307
, pp. 262-265
-
-
Petkova, A.T.1
Leapman, R.D.2
Guo, Z.3
Yau, W.M.4
Mattson, M.P.5
Tycko, R.6
-
35
-
-
84879895467
-
Distinct α-synuclein strains differentially promote tau inclusions in neurons
-
Guo, J. L., Covell, D. J., Daniels, J. P., Iba, M., Stieber, A., Zhang, B., Riddle, D. M., Kwong, L. K., Xu, Y., Trojanowski, J. Q., and Lee, V. M. (2013) Distinct α-synuclein strains differentially promote tau inclusions in neurons. Cell 154, 103-117
-
(2013)
Cell
, vol.154
, pp. 103-117
-
-
Guo, J.L.1
Covell, D.J.2
Daniels, J.P.3
Iba, M.4
Stieber, A.5
Zhang, B.6
Riddle, D.M.7
Kwong, L.K.8
Xu, Y.9
Trojanowski, J.Q.10
Lee, V.M.11
-
36
-
-
85109083933
-
α-Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
-
El-Agnaf, O. M., Salem, S. A., Paleologou, K. E., Cooper, L. J., Fullwood, N. J., Gibson, M. J., Curran, M. D., Court, J. A., Mann, D. M., Ikeda, S., Cookson, M. R., Hardy, J., and Allsop, D. (2003) α-Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J. 17, 1945-1947
-
(2003)
FASEB J.
, vol.17
, pp. 1945-1947
-
-
El-Agnaf, O.M.1
Salem, S.A.2
Paleologou, K.E.3
Cooper, L.J.4
Fullwood, N.J.5
Gibson, M.J.6
Curran, M.D.7
Court, J.A.8
Mann, D.M.9
Ikeda, S.10
Cookson, M.R.11
Hardy, J.12
Allsop, D.13
-
37
-
-
79960308070
-
Assessment of α-synuclein secretion in mouse and human brain parenchyma
-
Emmanouilidou, E., Elenis, D., Papasilekas, T., Stranjalis, G., Gerozissis, K., Ioannou, P. C., and Vekrellis, K. (2011) Assessment of α-synuclein secretion in mouse and human brain parenchyma. PLoS One 6, e22225
-
(2011)
PLoS One
, vol.6
-
-
Emmanouilidou, E.1
Elenis, D.2
Papasilekas, T.3
Stranjalis, G.4
Gerozissis, K.5
Ioannou, P.C.6
Vekrellis, K.7
-
38
-
-
21344456506
-
Intravesicular localization and exocytosis of α-synuclein and its aggregates
-
Lee, H. J., Patel, S., and Lee, S. J. (2005) Intravesicular localization and exocytosis of α-synuclein and its aggregates. J. Neurosci. 25, 6016-6024
-
(2005)
J. Neurosci.
, vol.25
, pp. 6016-6024
-
-
Lee, H.J.1
Patel, S.2
Lee, S.J.3
-
39
-
-
77952648551
-
Cellproduced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
-
Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., and Vekrellis, K. (2010) Cellproduced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J. Neurosci. 30, 6838-6851
-
(2010)
J. Neurosci.
, vol.30
, pp. 6838-6851
-
-
Emmanouilidou, E.1
Melachroinou, K.2
Roumeliotis, T.3
Garbis, S.D.4
Ntzouni, M.5
Margaritis, L.H.6
Stefanis, L.7
Vekrellis, K.8
-
40
-
-
84917736593
-
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease
-
Shi, M., Liu, C., Cook, T. J., Bullock, K. M., Zhao, Y., Ginghina, C., Li, Y., Aro, P., Dator, R., He, C., Hipp, M. J., Zabetian, C. P., Peskind, E. R., Hu, S. C., Quinn, J. F., Galasko, D. R., Banks, W. A., and Zhang, J. (2014) Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol. 128, 639-650
-
(2014)
Acta Neuropathol.
, vol.128
, pp. 639-650
-
-
Shi, M.1
Liu, C.2
Cook, T.J.3
Bullock, K.M.4
Zhao, Y.5
Ginghina, C.6
Li, Y.7
Aro, P.8
Dator, R.9
He, C.10
Hipp, M.J.11
Zabetian, C.P.12
Peskind, E.R.13
Hu, S.C.14
Quinn, J.F.15
Galasko, D.R.16
Banks, W.A.17
Zhang, J.18
-
41
-
-
84865307818
-
Exosomal cell-to-cell transmission of α synuclein oligomers
-
Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal-Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R., and McLean, P. J. (2012) Exosomal cell-to-cell transmission of α synuclein oligomers. Mol. Neurodegener. 7, 42
-
(2012)
Mol. Neurodegener.
, vol.7
, pp. 42
-
-
Danzer, K.M.1
Kranich, L.R.2
Ruf, W.P.3
Cagsal-Getkin, O.4
Winslow, A.R.5
Zhu, L.6
Vanderburg, C.R.7
McLean, P.J.8
-
42
-
-
84921915868
-
Acceleration of α-synuclein aggregation by exosomes
-
Grey, M., Dunning, C. J., Gaspar, R., Grey, C., Brundin, P., Sparr, E., and Linse, S. (2015) Acceleration of α-synuclein aggregation by exosomes. J. Biol. Chem. 290, 2969-2982
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 2969-2982
-
-
Grey, M.1
Dunning, C.J.2
Gaspar, R.3
Grey, C.4
Brundin, P.5
Sparr, E.6
Linse, S.7
-
43
-
-
84881147729
-
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein
-
Lee, H. J., Cho, E. D., Lee, K. W., Kim, J. H., Cho, S. G., and Lee, S. J. (2013) Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp. Mol. Med. 45, e22
-
(2013)
Exp. Mol. Med.
, vol.45
, pp. e22
-
-
Lee, H.J.1
Cho, E.D.2
Lee, K.W.3
Kim, J.H.4
Cho, S.G.5
Lee, S.J.6
-
44
-
-
84055207529
-
The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein
-
Hasegawa, T., Konno, M., Baba, T., Sugeno, N., Kikuchi, A., Kobayashi, M., Miura, E., Tanaka, N., Tamai, K., Furukawa, K., Arai, H., Mori, F., Wakabayashi, K., Aoki, M., Itoyama, Y., and Takeda, A. (2011) The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein. PLoS One 6, e29460
-
(2011)
PLoS One
, vol.6
-
-
Hasegawa, T.1
Konno, M.2
Baba, T.3
Sugeno, N.4
Kikuchi, A.5
Kobayashi, M.6
Miura, E.7
Tanaka, N.8
Tamai, K.9
Furukawa, K.10
Arai, H.11
Mori, F.12
Wakabayashi, K.13
Aoki, M.14
Itoyama, Y.15
Takeda, A.16
-
45
-
-
79954631518
-
Lysosomal dysfunction increases exosome-mediated α-synuclein release and transmission
-
Alvarez-Erviti, L., Seow, Y., Schapira, A. H., Gardiner, C., Sargent, I. L., Wood, M. J., and Cooper, J. M. (2011) Lysosomal dysfunction increases exosome-mediated α-synuclein release and transmission. Neurobiol. Dis. 42, 360-367
-
(2011)
Neurobiol. Dis.
, vol.42
, pp. 360-367
-
-
Alvarez-Erviti, L.1
Seow, Y.2
Schapira, A.H.3
Gardiner, C.4
Sargent, I.L.5
Wood, M.J.6
Cooper, J.M.7
-
46
-
-
38149044992
-
Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in K562 cells
-
Fader, C. M., Sanchez, D., Furlan, M., and Colombo, M. I. (2008) Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in K562 cells. Traffic 9, 230-250
-
(2008)
Traffic
, vol.9
, pp. 230-250
-
-
Fader, C.M.1
Sanchez, D.2
Furlan, M.3
Colombo, M.I.4
-
47
-
-
84922364789
-
Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment
-
Poehler, A. M., Xiang, W., Spitzer, P., May, V. E., Meixner, H., Rockenstein, E., Chutna, O., Outeiro, T. F., Winkler, J., Masliah, E., and Klucken, J. (2014) Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment. Autophagy 10, 2171-2192
-
(2014)
Autophagy
, vol.10
, pp. 2171-2192
-
-
Poehler, A.M.1
Xiang, W.2
Spitzer, P.3
May, V.E.4
Meixner, H.5
Rockenstein, E.6
Chutna, O.7
Outeiro, T.F.8
Winkler, J.9
Masliah, E.10
Klucken, J.11
-
48
-
-
84922431034
-
Rab11 modulates α-synuclein-me-diated defects in synaptic transmission and behaviour
-
Breda, C., Nugent, M. L., Estranero, J. G., Kyriacou, C. P., Outeiro, T. F., Steinert, J. R., and Giorgini, F. (2015) Rab11 modulates α-synuclein-me-diated defects in synaptic transmission and behaviour. Hum. Mol. Genet. 24, 1077-1091
-
(2015)
Hum. Mol. Genet.
, vol.24
, pp. 1077-1091
-
-
Breda, C.1
Nugent, M.L.2
Estranero, J.G.3
Kyriacou, C.P.4
Outeiro, T.F.5
Steinert, J.R.6
Giorgini, F.7
-
49
-
-
33749133430
-
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
-
Ramirez, A., Heimbach, A., Grundemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A. L., Roeper, J., Al-Din, A., Hillmer, A. M., Karsak, M., Liss, B., Woods, C. G., Behrens, M. I., and Kubisch, C. (2006) Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat. Genet. 38, 1184-1191
-
(2006)
Nat. Genet.
, vol.38
, pp. 1184-1191
-
-
Ramirez, A.1
Heimbach, A.2
Grundemann, J.3
Stiller, B.4
Hampshire, D.5
Cid, L.P.6
Goebel, I.7
Mubaidin, A.F.8
Wriekat, A.L.9
Roeper, J.10
Al-Din, A.11
Hillmer, A.M.12
Karsak, M.13
Liss, B.14
Woods, C.G.15
Behrens, M.I.16
Kubisch, C.17
-
50
-
-
61349147706
-
α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
-
Gitler, A. D., Chesi, A., Geddie, M. L., Strathearn, K. E., Hamamichi, S., Hill, K. J., Caldwell, K. A., Caldwell, G. A., Cooper, A. A., Rochet, J. C., and Lindquist, S. (2009) α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat. Genet. 41, 308-315
-
(2009)
Nat. Genet.
, vol.41
, pp. 308-315
-
-
Gitler, A.D.1
Chesi, A.2
Geddie, M.L.3
Strathearn, K.E.4
Hamamichi, S.5
Hill, K.J.6
Caldwell, K.A.7
Caldwell, G.A.8
Cooper, A.A.9
Rochet, J.C.10
Lindquist, S.11
-
51
-
-
84909952796
-
ATP13A2/PARK9 regulates secretion of exosomes andα-synuclein
-
Tsunemi, T., Hamada, K., and Krainc, D. (2014) ATP13A2/PARK9 regulates secretion of exosomes andα-synuclein. J. Neurosci. 34, 15281-15287
-
(2014)
J. Neurosci.
, vol.34
, pp. 15281-15287
-
-
Tsunemi, T.1
Hamada, K.2
Krainc, D.3
-
52
-
-
84899964982
-
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
-
Kong, S. M., Chan, B. K., Park, J. S., Hill, K. J., Aitken, J. B., Cottle, L., Farghaian, H., Cole, A. R., Lay, P. A., Sue, C. M., and Cooper, A. A. (2014) Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes. Hum. Mol. Genet. 23, 2816-2833
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 2816-2833
-
-
Kong, S.M.1
Chan, B.K.2
Park, J.S.3
Hill, K.J.4
Aitken, J.B.5
Cottle, L.6
Farghaian, H.7
Cole, A.R.8
Lay, P.A.9
Sue, C.M.10
Cooper, A.A.11
-
53
-
-
84939939990
-
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
-
Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kugler, S., Falomir Lockhart, L., Schwalbe, M., Krumova, P., Oliveira, L. M., Bahr, M., Mobius, W., Levin, J., et al. (2015) Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathol. 129, 695-713
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 695-713
-
-
Kunadt, M.1
Eckermann, K.2
Stuendl, A.3
Gong, J.4
Russo, B.5
Strauss, K.6
Rai, S.7
Kugler, S.8
Falomir Lockhart, L.9
Schwalbe, M.10
Krumova, P.11
Oliveira, L.M.12
Bahr, M.13
Mobius, W.14
Levin, J.15
-
54
-
-
84870769168
-
Environmental toxins trigger PD-like progression via increased α-synuclein release from enteric neurons in mice
-
Pan-Montojo, F., Schwarz, M., Winkler, C., Arnhold, M., O'Sullivan, G. A., Pal, A., Said, J., Marsico, G., Verbavatz, J. M., Rodrigo-Angulo, M., Gille, G., Funk, R. H., and Reichmann, H. (2012) Environmental toxins trigger PD-like progression via increased α-synuclein release from enteric neurons in mice. Sci. Rep. 2, 898
-
(2012)
Sci. Rep.
, vol.2
, pp. 898
-
-
Pan-Montojo, F.1
Schwarz, M.2
Winkler, C.3
Arnhold, M.4
O'Sullivan, G.A.5
Pal, A.6
Said, J.7
Marsico, G.8
Verbavatz, J.M.9
Rodrigo-Angulo, M.10
Gille, G.11
Funk, R.H.12
Reichmann, H.13
-
55
-
-
84959186182
-
Review: Sporadic Parkinson's disease: Development and distribution of α-synuclein pathology
-
Del Tredici, K., and Braak, H. (2016) Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology. Neuropathol. Appl. Neurobiol. 42, 33-50
-
(2016)
Neuropathol. Appl. Neurobiol.
, vol.42
, pp. 33-50
-
-
Del Tredici, K.1
Braak, H.2
-
56
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li, J. Y., Englund, E., Holton, J. L., Soulet, D., Hagell, P., Lees, A. J., Lashley, T., Quinn, N. P., Rehncrona, S., Bjorklund, A., Widner, H., Revesz, T., Lindvall, O., and Brundin, P. (2008) Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat. Med. 14, 501-503
-
(2008)
Nat. Med.
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
Englund, E.2
Holton, J.L.3
Soulet, D.4
Hagell, P.5
Lees, A.J.6
Lashley, T.7
Quinn, N.P.8
Rehncrona, S.9
Bjorklund, A.10
Widner, H.11
Revesz, T.12
Lindvall, O.13
Brundin, P.14
-
57
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., and Olanow, C. W. (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 14, 504-506
-
(2008)
Nat. Med.
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
58
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
-
Desplats, P., Lee, H. J., Bae, E. J., Patrick, C., Rockenstein, E., Crews, L., Spencer, B., Masliah, E., and Lee, S. J. (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein. Proc. Natl. Acad. Sci. U.S.A. 106, 13010-13015
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
Spencer, B.7
Masliah, E.8
Lee, S.J.9
-
59
-
-
84897977607
-
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
-
Recasens, A., Dehay, B., Bove, J., Carballo-Carbajal, I., Dovero, S., Perez-Villalba, A., Fernagut, P. O., Blesa, J., Parent, A., Perier, C., Farinas, I., Obeso, J. A., Bezard, E., and Vila, M. (2014) Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys. Ann. Neurol. 75, 351-362
-
(2014)
Ann. Neurol.
, vol.75
, pp. 351-362
-
-
Recasens, A.1
Dehay, B.2
Bove, J.3
Carballo-Carbajal, I.4
Dovero, S.5
Perez-Villalba, A.6
Fernagut, P.O.7
Blesa, J.8
Parent, A.9
Perier, C.10
Farinas, I.11
Obeso, J.A.12
Bezard, E.13
Vila, M.14
-
60
-
-
72149119358
-
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
-
Luk, K. C., Song, C., O'Brien, P., Stieber, A., Branch, J. R., Brunden, K. R., Trojanowski, J. Q., and Lee, V. M. (2009) Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc. Natl. Acad. Sci. U.S.A. 106, 20051-20056
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 20051-20056
-
-
Luk, K.C.1
Song, C.2
O'Brien, P.3
Stieber, A.4
Branch, J.R.5
Brunden, K.R.6
Trojanowski, J.Q.7
Lee, V.M.8
-
61
-
-
84869109864
-
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O'Brien, P., Trojanowski, J. Q., and Lee, V. M. (2012) Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338, 949-953
-
(2012)
Science
, vol.338
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
Zhang, B.4
O'Brien, P.5
Trojanowski, J.Q.6
Lee, V.M.7
-
62
-
-
84907015989
-
Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker
-
Sacino, A. N., Brooks, M., McKinney, A. B., Thomas, M. A., Shaw, G., Golde, T. E., and Giasson, B. I. (2014) Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. J. Neurosci. 34, 12368-12378
-
(2014)
J. Neurosci.
, vol.34
, pp. 12368-12378
-
-
Sacino, A.N.1
Brooks, M.2
McKinney, A.B.3
Thomas, M.A.4
Shaw, G.5
Golde, T.E.6
Giasson, B.I.7
-
63
-
-
85005777549
-
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
-
Sacino, A. N., Brooks, M., McGarvey, N. H., McKinney, A. B., Thomas, M. A., Levites, Y., Ran, Y., Golde, T. E., and Giasson, B. I. (2013) Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein. Acta Neuropathol. Commun. 1, 38
-
(2013)
Acta Neuropathol. Commun.
, vol.1
, pp. 38
-
-
Sacino, A.N.1
Brooks, M.2
McGarvey, N.H.3
McKinney, A.B.4
Thomas, M.A.5
Levites, Y.6
Ran, Y.7
Golde, T.E.8
Giasson, B.I.9
-
64
-
-
84862609075
-
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerativeα-synucleinopathy in mice
-
Luk, K. C., Kehm, V. M., Zhang, B., O'Brien, P., Trojanowski, J. Q., and Lee, V. M. (2012) Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerativeα-synucleinopathy in mice. J. Exp. Med. 209, 975-986
-
(2012)
J. Exp. Med.
, vol.209
, pp. 975-986
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
O'Brien, P.4
Trojanowski, J.Q.5
Lee, V.M.6
-
65
-
-
84963520567
-
The amyloid hypothesis of Alzheimer's disease at 25 years
-
Selkoe, D. J., and Hardy, J. (2016) The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol. Med. 8, 595-608
-
(2016)
EMBO Mol. Med.
, vol.8
, pp. 595-608
-
-
Selkoe, D.J.1
Hardy, J.2
-
66
-
-
78649573450
-
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
-
Jones, L., Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. S., Jones, N., Stretton, A., Morgan, A. R., et al. (2010) Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One 5, e13950
-
(2010)
PLoS One
, vol.5
-
-
Jones, L.1
Holmans, P.A.2
Hamshere, M.L.3
Harold, D.4
Moskvina, V.5
Ivanov, D.6
Pocklington, A.7
Abraham, R.8
Hollingworth, P.9
Sims, R.10
Gerrish, A.11
Pahwa, J.S.12
Jones, N.13
Stretton, A.14
Morgan, A.R.15
-
67
-
-
33846613222
-
The neuronal sortilinrelated receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., Chen, F., Shibata, N., Lunetta, K. L., Pardossi-Piquard, R., Bohm, C., et al. (2007) The neuronal sortilinrelated receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 39, 168-177
-
(2007)
Nat. Genet.
, vol.39
, pp. 168-177
-
-
Rogaeva, E.1
Meng, Y.2
Lee, J.H.3
Gu, Y.4
Kawarai, T.5
Zou, F.6
Katayama, T.7
Baldwin, C.T.8
Cheng, R.9
Hasegawa, H.10
Chen, F.11
Shibata, N.12
Lunetta, K.L.13
Pardossi-Piquard, R.14
Bohm, C.15
-
68
-
-
84888317489
-
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
-
Lambert, J. C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., DeStafano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thorton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., et al. (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet. 45, 1452-1458
-
(2013)
Nat. Genet.
, vol.45
, pp. 1452-1458
-
-
Lambert, J.C.1
Ibrahim-Verbaas, C.A.2
Harold, D.3
Naj, A.C.4
Sims, R.5
Bellenguez, C.6
DeStafano, A.L.7
Bis, J.C.8
Beecham, G.W.9
Grenier-Boley, B.10
Russo, G.11
Thorton-Wells, T.A.12
Jones, N.13
Smith, A.V.14
Chouraki, V.15
-
69
-
-
84933277693
-
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
-
Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., Owens, N. C., Rege, S. V., Si, G., Ahuja, A., Zhu, D., et al. (2015) Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat. Neurosci. 18, 978-987
-
(2015)
Nat. Neurosci.
, vol.18
, pp. 978-987
-
-
Zhao, Z.1
Sagare, A.P.2
Ma, Q.3
Halliday, M.R.4
Kong, P.5
Kisler, K.6
Winkler, E.A.7
Ramanathan, A.8
Kanekiyo, T.9
Bu, G.10
Owens, N.C.11
Rege, S.V.12
Si, G.13
Ahuja, A.14
Zhu, D.15
-
70
-
-
0024560146
-
Characterization of an amyloid β precursor protein that binds heparin and contains tyrosine sulfate
-
Schubert, D., LaCorbiere, M., Saitoh, T., and Cole, G. (1989) Characterization of an amyloid β precursor protein that binds heparin and contains tyrosine sulfate. Proc. Natl. Acad. Sci. U.S.A. 86, 2066-2069
-
(1989)
Proc. Natl. Acad. Sci. U.S.A.
, vol.86
, pp. 2066-2069
-
-
Schubert, D.1
LaCorbiere, M.2
Saitoh, T.3
Cole, G.4
-
71
-
-
33746593662
-
Alzheimer's disease β-amyloid peptides are released in association with exosomes
-
Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., and Simons, K. (2006) Alzheimer's disease β-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. U.S.A. 103, 11172-11177
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 11172-11177
-
-
Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
Verkade, P.6
Simons, K.7
-
72
-
-
43249087541
-
Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
-
Sharples, R. A., Vella, L. J., Nisbet, R. M., Naylor, R., Perez, K., Barnham, K. J., Masters, C. L., and Hill, A. F. (2008) Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. FASEB J. 22, 1469-1478
-
(2008)
FASEB J.
, vol.22
, pp. 1469-1478
-
-
Sharples, R.A.1
Vella, L.J.2
Nisbet, R.M.3
Naylor, R.4
Perez, K.5
Barnham, K.J.6
Masters, C.L.7
Hill, A.F.8
-
73
-
-
84859499570
-
Sphingolipidmodulated exosome secretion promotes clearance of amyloid-β by microglia
-
Yuyama, K., Sun, H., Mitsutake, S., and Igarashi, Y. (2012) Sphingolipidmodulated exosome secretion promotes clearance of amyloid-β by microglia. J. Biol. Chem. 287, 10977-10989
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 10977-10989
-
-
Yuyama, K.1
Sun, H.2
Mitsutake, S.3
Igarashi, Y.4
-
74
-
-
75149166216
-
Insulin-degrading enzyme sorting in exosomes: A secretory pathway for a key brain amyloid-β degrading protease
-
Bulloj, A., Leal, M. C., Xu, H., Castano, E. M., and Morelli, L. (2010) Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-β degrading protease. J. Alzheimers Dis. 19, 79-95
-
(2010)
J. Alzheimers Dis.
, vol.19
, pp. 79-95
-
-
Bulloj, A.1
Leal, M.C.2
Xu, H.3
Castano, E.M.4
Morelli, L.5
-
75
-
-
78549284024
-
Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
-
Tamboli, I. Y., Barth, E., Christian, L., Siepmann, M., Kumar, S., Singh, S., Tolksdorf, K., Heneka, M. T., Lutjohann, D., Wunderlich, P., and Walter, J. (2010) Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. J. Biol. Chem. 285, 37405-37414
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37405-37414
-
-
Tamboli, I.Y.1
Barth, E.2
Christian, L.3
Siepmann, M.4
Kumar, S.5
Singh, S.6
Tolksdorf, K.7
Heneka, M.T.8
Lutjohann, D.9
Wunderlich, P.10
Walter, J.11
-
76
-
-
41149088714
-
Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: Another putative pathway for GM1-induced amyloid fibril formation
-
Yuyama, K., Yamamoto, N., and Yanagisawa, K. (2008) Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation. J. Neurochem. 105, 217-224
-
(2008)
J. Neurochem.
, vol.105
, pp. 217-224
-
-
Yuyama, K.1
Yamamoto, N.2
Yanagisawa, K.3
-
77
-
-
84865576825
-
Amyloid-β secretion, generation, and lysosomal sequestration in response to proteasome inhibition: Involvement of autophagy
-
Agholme, L., Hallbeck, M., Benedikz, E., Marcusson, J., and Kagedal, K. (2012) Amyloid-β secretion, generation, and lysosomal sequestration in response to proteasome inhibition: involvement of autophagy. J. Alzheimers Dis. 31, 343-358
-
(2012)
J. Alzheimers Dis.
, vol.31
, pp. 343-358
-
-
Agholme, L.1
Hallbeck, M.2
Benedikz, E.3
Marcusson, J.4
Kagedal, K.5
-
78
-
-
84870213683
-
Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway
-
Son, S. M., Song, H., Byun, J., Park, K. S., Jang, H. C., Park, Y. J., and Mook-Jung, I. (2012) Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway. Diabetes 61, 3126-3138
-
(2012)
Diabetes
, vol.61
, pp. 3126-3138
-
-
Son, S.M.1
Song, H.2
Byun, J.3
Park, K.S.4
Jang, H.C.5
Park, Y.J.6
Mook-Jung, I.7
-
79
-
-
84899968840
-
Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
-
Dinkins, M. B., Dasgupta, S., Wang, G., Zhu, G., and Bieberich, E. (2014) Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease. Neurobiol. Aging 35, 1792-1800
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 1792-1800
-
-
Dinkins, M.B.1
Dasgupta, S.2
Wang, G.3
Zhu, G.4
Bieberich, E.5
-
80
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ42 fibrils
-
Gotz, J., Chen, F., van Dorpe, J., and Nitsch, R. M. (2001) Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ42 fibrils. Science 293, 1491-1495
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
81
-
-
77955322042
-
Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models
-
Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wolfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., Eckert, A., Staufenbiel, M., Hardeman, E., and Gotz, J. (2010) Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell 142, 387-397
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
Van Eersel, J.6
Wolfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
Eckert, A.11
Staufenbiel, M.12
Hardeman, E.13
Gotz, J.14
-
82
-
-
0027374233
-
Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzymelinked immunosorbent assay
-
Vandermeeren, M., Mercken, M., Vanmechelen, E., Six, J., van de Voorde, A., Martin, J. J., and Cras, P. (1993) Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzymelinked immunosorbent assay. J. Neurochem. 61, 1828-1834
-
(1993)
J. Neurochem.
, vol.61
, pp. 1828-1834
-
-
Vandermeeren, M.1
Mercken, M.2
Vanmechelen, E.3
Six, J.4
Van De Voorde, A.5
Martin, J.J.6
Cras, P.7
-
83
-
-
67650077008
-
Transmission and spreading of tauopathy in transgenic mouse brain
-
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., Jucker, M., Goedert, M., and Tolnay, M. (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat. Cell Biol. 11, 909-913
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 909-913
-
-
Clavaguera, F.1
Bolmont, T.2
Crowther, R.A.3
Abramowski, D.4
Frank, S.5
Probst, A.6
Fraser, G.7
Stalder, A.K.8
Beibel, M.9
Staufenbiel, M.10
Jucker, M.11
Goedert, M.12
Tolnay, M.13
-
84
-
-
84872346089
-
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy
-
Iba, M., Guo, J. L., McBride, J. D., Zhang, B., Trojanowski, J. Q., and Lee, V. M. (2013) Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J. Neurosci. 33, 1024-1037
-
(2013)
J. Neurosci.
, vol.33
, pp. 1024-1037
-
-
Iba, M.1
Guo, J.L.2
McBride, J.D.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.6
-
85
-
-
84899944338
-
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: The pattern of spread is determined by connectivity, not proximity
-
Ahmed, Z., Cooper, J., Murray, T. K., Garn, K., McNaughton, E., Clarke, H., Parhizkar, S., Ward, M. A., Cavallini, A., Jackson, S., Bose, S., Clavaguera, F., Tolnay, M., Lavenir, I., Goedert, M., Hutton, M. L., and O'Neill, M. J. (2014) A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta Neuropathol. 127, 667-683
-
(2014)
Acta Neuropathol.
, vol.127
, pp. 667-683
-
-
Ahmed, Z.1
Cooper, J.2
Murray, T.K.3
Garn, K.4
McNaughton, E.5
Clarke, H.6
Parhizkar, S.7
Ward, M.A.8
Cavallini, A.9
Jackson, S.10
Bose, S.11
Clavaguera, F.12
Tolnay, M.13
Lavenir, I.14
Goedert, M.15
Hutton, M.L.16
O'Neill, M.J.17
-
86
-
-
84929709813
-
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains
-
Boluda, S., Iba, M., Zhang, B., Raible, K. M., Lee, V. M., and Trojanowski, J. Q. (2015) Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathol. 129, 221-237
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 221-237
-
-
Boluda, S.1
Iba, M.2
Zhang, B.3
Raible, K.M.4
Lee, V.M.5
Trojanowski, J.Q.6
-
87
-
-
84868269943
-
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
-
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R., and Kayed, R. (2012) Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci. Rep. 2, 700
-
(2012)
Sci. Rep.
, vol.2
, pp. 700
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Sengupta, U.3
Guerrero-Munoz, M.J.4
Kiritoshi, T.5
Neugebauer, V.6
Jackson, G.R.7
Kayed, R.8
-
88
-
-
84856707794
-
Exosomeassociated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
-
Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C., and Hall, G. F. (2012) Exosomeassociated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J. Biol. Chem. 287, 3842-3849
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 3842-3849
-
-
Saman, S.1
Kim, W.2
Raya, M.3
Visnick, Y.4
Miro, S.5
Saman, S.6
Jackson, B.7
McKee, A.C.8
Alvarez, V.E.9
Lee, N.C.10
Hall, G.F.11
-
89
-
-
84864935106
-
Constitutive secretion of tau protein by an unconventional mechanism
-
Chai, X., Dage, J. L., and Citron, M. (2012) Constitutive secretion of tau protein by an unconventional mechanism. Neurobiol. Dis. 48, 356-366
-
(2012)
Neurobiol. Dis.
, vol.48
, pp. 356-366
-
-
Chai, X.1
Dage, J.L.2
Citron, M.3
-
90
-
-
85007360121
-
Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
-
Tardivel, M., Begard, S., Bousset, L., Dujardin, S., Coens, A., Melki, R., Buee, L., and Colin, M. (2016) Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies. Acta Neuropathol. Commun. 4, 117
-
(2016)
Acta Neuropathol. Commun.
, vol.4
, pp. 117
-
-
Tardivel, M.1
Begard, S.2
Bousset, L.3
Dujardin, S.4
Coens, A.5
Melki, R.6
Buee, L.7
Colin, M.8
-
91
-
-
84945474523
-
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
-
Asai, H., Ikezu, S., Tsunoda, S., Medalla, M., Luebke, J., Haydar, T., Wolozin, B., Butovsky, O., Kugler, S., and Ikezu, T. (2015) Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat. Neurosci. 18, 1584-1593
-
(2015)
Nat. Neurosci.
, vol.18
, pp. 1584-1593
-
-
Asai, H.1
Ikezu, S.2
Tsunoda, S.3
Medalla, M.4
Luebke, J.5
Haydar, T.6
Wolozin, B.7
Butovsky, O.8
Kugler, S.9
Ikezu, T.10
-
92
-
-
84930225521
-
In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior
-
Zomer, A., Maynard, C., Verweij, F. J., Kamermans, A., Schafer, R., Beerling, E., Schiffelers, R. M., de Wit, E., Berenguer, J., Ellenbroek, S. I., Wurdinger, T., Pegtel, D. M., and van Rheenen, J. (2015) In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior. Cell 161, 1046-1057
-
(2015)
Cell
, vol.161
, pp. 1046-1057
-
-
Zomer, A.1
Maynard, C.2
Verweij, F.J.3
Kamermans, A.4
Schafer, R.5
Beerling, E.6
Schiffelers, R.M.7
De Wit, E.8
Berenguer, J.9
Ellenbroek, S.I.10
Wurdinger, T.11
Pegtel, D.M.12
Van Rheenen, J.13
-
93
-
-
84974530686
-
Extracellular vesicles isolated from the brains of rTg4510 mice seed Tau protein aggregation in a threshold-dependent manner
-
Polanco, J. C., Scicluna, B. J., Hill, A. F., and Gotz, J. (2016) Extracellular vesicles isolated from the brains of rTg4510 mice seed Tau protein aggregation in a threshold-dependent manner. J. Biol. Chem. 291, 12445-12466
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 12445-12466
-
-
Polanco, J.C.1
Scicluna, B.J.2
Hill, A.F.3
Gotz, J.4
-
94
-
-
84920768238
-
Exosome-dependent and independent mechanisms are involved in prionlike transmission of propagated Cu/Zn superoxide dismutase misfolding
-
Grad, L. I., Pokrishevsky, E., Silverman, J. M., and Cashman, N. R. (2014) Exosome-dependent and independent mechanisms are involved in prionlike transmission of propagated Cu/Zn superoxide dismutase misfolding. Prion 8, 331-335
-
(2014)
Prion
, vol.8
, pp. 331-335
-
-
Grad, L.I.1
Pokrishevsky, E.2
Silverman, J.M.3
Cashman, N.R.4
-
95
-
-
84885484356
-
Prion-like properties of pathological TDP-43 aggregates from diseased brains
-
Nonaka, T., Masuda-Suzukake, M., Arai, T., Hasegawa, Y., Akatsu, H., Obi, T., Yoshida, M., Murayama, S., Mann, D. M., Akiyama, H., and Hasegawa, M. (2013) Prion-like properties of pathological TDP-43 aggregates from diseased brains. Cell Rep. 4, 124-134
-
(2013)
Cell Rep.
, vol.4
, pp. 124-134
-
-
Nonaka, T.1
Masuda-Suzukake, M.2
Arai, T.3
Hasegawa, Y.4
Akatsu, H.5
Obi, T.6
Yoshida, M.7
Murayama, S.8
Mann, D.M.9
Akiyama, H.10
Hasegawa, M.11
-
96
-
-
84927949614
-
Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain
-
Pearce, M. M., Spartz, E. J., Hong, W., Luo, L., and Kopito, R. R. (2015) Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain. Nat. Commun. 6, 6768
-
(2015)
Nat. Commun.
, vol.6
, pp. 6768
-
-
Pearce, M.M.1
Spartz, E.J.2
Hong, W.3
Luo, L.4
Kopito, R.R.5
-
97
-
-
84883348572
-
Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes
-
Costanzo, M., Abounit, S., Marzo, L., Danckaert, A., Chamoun, Z., Roux, P., and Zurzolo, C. (2013) Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes. J. Cell Sci. 126, 3678-3685
-
(2013)
J. Cell Sci.
, vol.126
, pp. 3678-3685
-
-
Costanzo, M.1
Abounit, S.2
Marzo, L.3
Danckaert, A.4
Chamoun, Z.5
Roux, P.6
Zurzolo, C.7
-
98
-
-
84989908457
-
Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes
-
Abounit, S., Bousset, L., Loria, F., Zhu, S., de Chaumont, F., Pieri, L., Olivo-Marin, J. C., Melki, R., and Zurzolo, C. (2016) Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes. EMBO J. 35, 2120-2138
-
(2016)
EMBO J.
, vol.35
, pp. 2120-2138
-
-
Abounit, S.1
Bousset, L.2
Loria, F.3
Zhu, S.4
De Chaumont, F.5
Pieri, L.6
Olivo-Marin, J.C.7
Melki, R.8
Zurzolo, C.9
-
99
-
-
84922340030
-
The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes
-
Guo, B. B., Bellingham, S. A., and Hill, A. F. (2015) The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. J. Biol. Chem. 290, 3455-3467
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 3455-3467
-
-
Guo, B.B.1
Bellingham, S.A.2
Hill, A.F.3
|