메뉴 건너뛰기




Volumn 35, Issue 19, 2016, Pages 2120-2138

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes

Author keywords

intercellular transfer; synucleinopathies; TNTs; synuclein

Indexed keywords

ALPHA SYNUCLEIN; NANOTUBE; TUNNELING NANOTUBE; UNCLASSIFIED DRUG;

EID: 84989908457     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201593411     Document Type: Article
Times cited : (287)

References (71)
  • 1
    • 84861361400 scopus 로고    scopus 로고
    • Wiring through tunneling nanotubes–from electrical signals to organelle transfer
    • Abounit S, Zurzolo C (2012) Wiring through tunneling nanotubes–from electrical signals to organelle transfer. J Cell Sci 125: 1089–1098
    • (2012) J Cell Sci , vol.125 , pp. 1089-1098
    • Abounit, S.1    Zurzolo, C.2
  • 6
  • 8
    • 84884250340 scopus 로고    scopus 로고
    • The function of α-synuclein
    • Bendor J, Logan T, Edwards R (2013) The function of α-synuclein. Neuron 79: 1044–1066
    • (2013) Neuron , vol.79 , pp. 1044-1066
    • Bendor, J.1    Logan, T.2    Edwards, R.3
  • 9
    • 84930757862 scopus 로고    scopus 로고
    • Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death
    • Bourdenx M, Bezard E, Dehay B (2014) Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death. Front Neuroanat 8: 83
    • (2014) Front Neuroanat , vol.8 , pp. 83
    • Bourdenx, M.1    Bezard, E.2    Dehay, B.3
  • 12
    • 0038748401 scopus 로고    scopus 로고
    • Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
    • Braak H, Rüb U, Gai WP, Del Tredici K (2003a) Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 110: 517–536
    • (2003) J Neural Transm , vol.110 , pp. 517-536
    • Braak, H.1    Rüb, U.2    Gai, W.P.3    Del Tredici, K.4
  • 13
    • 84961135800 scopus 로고    scopus 로고
    • Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
    • Brahic M, Bousset L, Bieri G, Melki R, Gitler AD (2016) Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1. Acta Neuropathol 131: 539–548
    • (2016) Acta Neuropathol , vol.131 , pp. 539-548
    • Brahic, M.1    Bousset, L.2    Bieri, G.3    Melki, R.4    Gitler, A.D.5
  • 15
    • 44449108230 scopus 로고    scopus 로고
    • Cutting edge: membrane nanotubes in vivo: a feature of MHC class II+ cells in the mouse cornea
    • Chinnery HR, Pearlman E, McMenamin PG (2008) Cutting edge: membrane nanotubes in vivo: a feature of MHC class II+ cells in the mouse cornea. J Immunol 180: 5779–5783
    • (2008) J Immunol , vol.180 , pp. 5779-5783
    • Chinnery, H.R.1    Pearlman, E.2    McMenamin, P.G.3
  • 16
    • 68149123529 scopus 로고    scopus 로고
    • Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions
    • Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH (2009) Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 35: 385–398
    • (2009) Neurobiol Dis , vol.35 , pp. 385-398
    • Chu, Y.1    Dodiya, H.2    Aebischer, P.3    Olanow, C.W.4    Kordower, J.H.5
  • 18
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292–1295
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 19
    • 79251565507 scopus 로고    scopus 로고
    • Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
    • Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ (2011) Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J 25: 326–336
    • (2011) FASEB J , vol.25 , pp. 326-336
    • Danzer, K.M.1    Ruf, W.P.2    Putcha, P.3    Joyner, D.4    Hashimoto, T.5    Glabe, C.6    Hyman, B.T.7    McLean, P.J.8
  • 22
    • 84943414298 scopus 로고    scopus 로고
    • Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure
    • Ding X, Ma M, Teng J, Teng RKF, Zhou S, Yin J, Fonkem E, Huang JH, Wu E, Wang X (2015) Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure. Oncotarget 6: 24178–24191
    • (2015) Oncotarget , vol.6 , pp. 24178-24191
    • Ding, X.1    Ma, M.2    Teng, J.3    Teng, R.K.F.4    Zhou, S.5    Yin, J.6    Fonkem, E.7    Huang, J.H.8    Wu, E.9    Wang, X.10
  • 25
    • 23844531539 scopus 로고    scopus 로고
    • PA700, the regulatory complex of the 26S proteasome, interferes with alpha-synuclein assembly
    • Ghee M, Melki R, Michot N, Mallet J (2005) PA700, the regulatory complex of the 26S proteasome, interferes with alpha-synuclein assembly. FEBS J 272: 4023–4033
    • (2005) FEBS J , vol.272 , pp. 4023-4033
    • Ghee, M.1    Melki, R.2    Michot, N.3    Mallet, J.4
  • 26
    • 67649371158 scopus 로고    scopus 로고
    • Tunnelling nanotubes: a highway for prion spreading?
    • Gousset K, Zurzolo C (2009) Tunnelling nanotubes: a highway for prion spreading? Prion 3: 94–98
    • (2009) Prion , vol.3 , pp. 94-98
    • Gousset, K.1    Zurzolo, C.2
  • 28
    • 84885448134 scopus 로고    scopus 로고
    • Myo10 is a key regulator of TNT formation in neuronal cells
    • Gousset K, Marzo L, Commere P-H, Zurzolo C (2013) Myo10 is a key regulator of TNT formation in neuronal cells. J Cell Sci 126: 4424–4435
    • (2013) J Cell Sci , vol.126 , pp. 4424-4435
    • Gousset, K.1    Marzo, L.2    Commere, P.-H.3    Zurzolo, C.4
  • 32
    • 79960334171 scopus 로고    scopus 로고
    • α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells
    • Kondo K, Obitsu S, Teshima R (2011) α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells. Biol Pharm Bull 34: 1078–1083
    • (2011) Biol Pharm Bull , vol.34 , pp. 1078-1083
    • Kondo, K.1    Obitsu, S.2    Teshima, R.3
  • 34
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14: 504–506
    • (2008) Nat Med , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 37
    • 77950571596 scopus 로고    scopus 로고
    • Direct transfer of Alpha -synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
    • Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, Hwang D, Masliah E, Lee SJ (2010) Direct transfer of Alpha -synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 285: 9262–9272
    • (2010) J Biol Chem , vol.285 , pp. 9262-9272
    • Lee, H.J.1    Suk, J.E.2    Patrick, C.3    Bae, E.J.4    Cho, J.H.5    Rho, S.6    Hwang, D.7    Masliah, E.8    Lee, S.J.9
  • 38
    • 84881147729 scopus 로고    scopus 로고
    • Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein
    • Lee H-J, Cho E-D, Lee KW, Kim J-H, Cho S-G, Lee S-J (2013) Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med 45: e22
    • (2013) Exp Mol Med , vol.45
    • Lee, H.-J.1    Cho, E.-D.2    Lee, K.W.3    Kim, J.-H.4    Cho, S.-G.5    Lee, S.-J.6
  • 42
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM-Y (2012b) Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338: 949–953
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.-Y.7
  • 43
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
    • Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VMY (2012a) Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med 209: 975–986
    • (2012) J Exp Med , vol.209 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3    O'Brien, P.4    Trojanowski, J.Q.5    Lee, V.M.Y.6
  • 45
    • 84866327994 scopus 로고    scopus 로고
    • Multifaceted roles of tunneling nanotubes in intercellular communication
    • Marzo L, Gousset K, Zurzolo C (2012) Multifaceted roles of tunneling nanotubes in intercellular communication. Front Physiol 3: 1–14
    • (2012) Front Physiol , vol.3 , pp. 1-14
    • Marzo, L.1    Gousset, K.2    Zurzolo, C.3
  • 51
    • 84882254367 scopus 로고    scopus 로고
    • The role of autophagy in neurodegenerative disease
    • Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19: 983–997
    • (2013) Nat Med , vol.19 , pp. 983-997
    • Nixon, R.A.1
  • 52
    • 3242767507 scopus 로고    scopus 로고
    • Cutting edge: membrane nanotubes connect immune cells
    • Onfelt B, Nedvetzki S, Yanagi K, Davis DM (2004) Cutting edge: membrane nanotubes connect immune cells. J Immunol 173: 1511–1513
    • (2004) J Immunol , vol.173 , pp. 1511-1513
    • Onfelt, B.1    Nedvetzki, S.2    Yanagi, K.3    Davis, D.M.4
  • 54
    • 84857746017 scopus 로고    scopus 로고
    • Different modalities of intercellular membrane exchanges mediate cell-to-cell P-glycoprotein transfers in MCF-7 breast cancer cells
    • Pasquier J, Galas L, Boulangé-Lecomte C, Rioult D, Bultelle F, Magal P, Webb G, Le Foll F (2012) Different modalities of intercellular membrane exchanges mediate cell-to-cell P-glycoprotein transfers in MCF-7 breast cancer cells. J Biol Chem 287: 7374–7387
    • (2012) J Biol Chem , vol.287 , pp. 7374-7387
    • Pasquier, J.1    Galas, L.2    Boulangé-Lecomte, C.3    Rioult, D.4    Bultelle, F.5    Magal, P.6    Webb, G.7    Le Foll, F.8
  • 56
    • 84862701723 scopus 로고    scopus 로고
    • Fibrillar α -synuclein and huntingtin exon 1 assemblies are toxic to the cells
    • Pieri L, Madiona K, Bousset L, Melki R (2012) Fibrillar α -synuclein and huntingtin exon 1 assemblies are toxic to the cells. Biophys J 102: 2894–2905
    • (2012) Biophys J , vol.102 , pp. 2894-2905
    • Pieri, L.1    Madiona, K.2    Bousset, L.3    Melki, R.4
  • 58
    • 84885470591 scopus 로고    scopus 로고
    • Transfer of human alpha-synuclein from the olfactory bulb to interconnected brain regions in mice
    • Rey NL, Petit GH, Bousset L, Melki R, Brundin P (2013) Transfer of human alpha-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol 126: 555–573
    • (2013) Acta Neuropathol , vol.126 , pp. 555-573
    • Rey, N.L.1    Petit, G.H.2    Bousset, L.3    Melki, R.4    Brundin, P.5
  • 61
    • 84872137228 scopus 로고    scopus 로고
    • Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction
    • Seyed-Razavi Y, Hickey MJ, Kuffova L, McMenamin PG, Chinnery HR (2013) Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction. Immunol Cell Biol 91: 89–95
    • (2013) Immunol Cell Biol , vol.91 , pp. 89-95
    • Seyed-Razavi, Y.1    Hickey, M.J.2    Kuffova, L.3    McMenamin, P.G.4    Chinnery, H.R.5
  • 63
    • 70350550208 scopus 로고    scopus 로고
    • Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
    • Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E (2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 29: 13578–13588
    • (2009) J Neurosci , vol.29 , pp. 13578-13588
    • Spencer, B.1    Potkar, R.2    Trejo, M.3    Rockenstein, E.4    Patrick, C.5    Gindi, R.6    Adame, A.7    Wyss-Coray, T.8    Masliah, E.9
  • 64
    • 0035920226 scopus 로고    scopus 로고
    • Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein
    • Sung JY, Kim J, Paik SR, Park JH, Ahn YS, Chung KC (2001) Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. J Biol Chem 276: 27441–27448
    • (2001) J Biol Chem , vol.276 , pp. 27441-27448
    • Sung, J.Y.1    Kim, J.2    Paik, S.R.3    Park, J.H.4    Ahn, Y.S.5    Chung, K.C.6
  • 67
    • 84907033533 scopus 로고    scopus 로고
    • Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates
    • Volpicelli-Daley LA, Luk KC, Lee VM (2014) Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nat Protoc 9: 2135–2146
    • (2014) Nat Protoc , vol.9 , pp. 2135-2146
    • Volpicelli-Daley, L.A.1    Luk, K.C.2    Lee, V.M.3
  • 68
    • 79952619322 scopus 로고    scopus 로고
    • Tunneling-nanotube development in astrocytes depends on p53 activation
    • Wang Y, Cui J, Sun X, Zhang Y (2011) Tunneling-nanotube development in astrocytes depends on p53 activation. Cell Death Differ 18: 732–742
    • (2011) Cell Death Differ , vol.18 , pp. 732-742
    • Wang, Y.1    Cui, J.2    Sun, X.3    Zhang, Y.4
  • 69
    • 81055149523 scopus 로고    scopus 로고
    • Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool
    • Yasuda K, Khandare A, Burianovskyy L, Maruyama S, Zhang F, Nasjletti A, Goligorsky MS (2011) Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool. Aging 3: 597–608
    • (2011) Aging , vol.3 , pp. 597-608
    • Yasuda, K.1    Khandare, A.2    Burianovskyy, L.3    Maruyama, S.4    Zhang, F.5    Nasjletti, A.6    Goligorsky, M.S.7
  • 70
    • 68549111280 scopus 로고    scopus 로고
    • The lysosome and neurodegenerative diseases structure and function of lysosomes
    • Zhang L, Sheng R, Qin Z (2009) The lysosome and neurodegenerative diseases structure and function of lysosomes. Acta Biochim Biophys Sin 41: 437–445
    • (2009) Acta Biochim Biophys Sin , vol.41 , pp. 437-445
    • Zhang, L.1    Sheng, R.2    Qin, Z.3
  • 71
    • 84939440707 scopus 로고    scopus 로고
    • Prion aggregates transfer through tunneling nanotubes in endocytic vesicles
    • Zhu S, Victoria GS, Marzo L, Ghosh R, Zurzolo C (2015) Prion aggregates transfer through tunneling nanotubes in endocytic vesicles. Prion 9: 125–135
    • (2015) Prion , vol.9 , pp. 125-135
    • Zhu, S.1    Victoria, G.S.2    Marzo, L.3    Ghosh, R.4    Zurzolo, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.