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Volumn 54, Issue , 2017, Pages 78-88

Epigenetics in non-alcoholic fatty liver disease

Author keywords

DNA methylation; Epigenetics; Histone modifications; microRNA; Non alcoholic fatty liver disease (NAFLD); Non alcoholic steatohepatitis (NASH)

Indexed keywords

BIOLOGICAL MARKER; MICRORNA; MICRORNA 10B; MICRORNA 122; MICRORNA 155; MICRORNA 16; MICRORNA 181; MICRORNA 21; MICRORNA 33A; MICRORNA 33B; MICRORNA 34A; MICRORNA 451; SIRTUIN 1; SIRTUIN 3; UNCLASSIFIED DRUG; HISTONE;

EID: 85007294669     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2016.11.008     Document Type: Review
Times cited : (109)

References (140)
  • 2
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies
    • Adams, L.A., Sanderson, S., Lindor, K.D., Angulo, P., The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J. Hepatol. 42:1 (2005), 132–138.
    • (2005) J. Hepatol. , vol.42 , Issue.1 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3    Angulo, P.4
  • 3
    • 85048814308 scopus 로고    scopus 로고
    • Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma
    • Afonso, M.B., Rodrigues, P.M., Simao, A.L., Castro, R.E., Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma. J. Clin. Med., 5(3), 2016.
    • (2016) J. Clin. Med. , vol.5 , Issue.3
    • Afonso, M.B.1    Rodrigues, P.M.2    Simao, A.L.3    Castro, R.E.4
  • 4
    • 0035966319 scopus 로고    scopus 로고
    • microRNAs: tiny regulators with great potential
    • Ambros, V., microRNAs: tiny regulators with great potential. Cell 107:7 (2001), 823–826.
    • (2001) Cell , vol.107 , Issue.7 , pp. 823-826
    • Ambros, V.1
  • 6
    • 84878930738 scopus 로고    scopus 로고
    • Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
    • Anstee, Q.M., Targher, G., Day, C.P., Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat. Rev. Gastroenterol. Hepatol. 10:6 (2013), 330–344.
    • (2013) Nat. Rev. Gastroenterol. Hepatol. , vol.10 , Issue.6 , pp. 330-344
    • Anstee, Q.M.1    Targher, G.2    Day, C.P.3
  • 7
    • 84928538090 scopus 로고    scopus 로고
    • Circulating microRNAs: emerging biomarkers of liver disease
    • Arrese, M., Eguchi, A., Feldstein, A.E., Circulating microRNAs: emerging biomarkers of liver disease. Semin. Liver Dis. 35:1 (2015), 43–54.
    • (2015) Semin. Liver Dis. , vol.35 , Issue.1 , pp. 43-54
    • Arrese, M.1    Eguchi, A.2    Feldstein, A.E.3
  • 8
    • 84959248478 scopus 로고    scopus 로고
    • MicroRNAs in nonalcoholic fatty liver disease
    • Baffy, G., MicroRNAs in nonalcoholic fatty liver disease. J. Clin. Med. 4:12 (2015), 1977–1988.
    • (2015) J. Clin. Med. , vol.4 , Issue.12 , pp. 1977-1988
    • Baffy, G.1
  • 9
    • 77956173286 scopus 로고    scopus 로고
    • SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
    • Bao, J., Scott, I., Lu, Z., Pang, L., Dimond, C.C., Gius, D., Sack, M.N., SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity. Free Radic. Biol. Med. 49:7 (2010), 1230–1237.
    • (2010) Free Radic. Biol. Med. , vol.49 , Issue.7 , pp. 1230-1237
    • Bao, J.1    Scott, I.2    Lu, Z.3    Pang, L.4    Dimond, C.C.5    Gius, D.6    Sack, M.N.7
  • 10
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel, D.P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:2 (2004), 281–297.
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 11
    • 84925371744 scopus 로고    scopus 로고
    • Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats
    • Baselga-Escudero, L., Pascual-Serrano, A., Ribas-Latre, A., Casanova, E., Salvado, M.J., Arola, L., Arola-Arnal, A., Blade, C., Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats. Nutr. Res. 35:4 (2015), 337–345.
    • (2015) Nutr. Res. , vol.35 , Issue.4 , pp. 337-345
    • Baselga-Escudero, L.1    Pascual-Serrano, A.2    Ribas-Latre, A.3    Casanova, E.4    Salvado, M.J.5    Arola, L.6    Arola-Arnal, A.7    Blade, C.8
  • 12
    • 77952576769 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease
    • Bellentani, S., Scaglioni, F., Marino, M., Bedogni, G., Epidemiology of non-alcoholic fatty liver disease. Dig. Dis. 28:1 (2010), 155–161.
    • (2010) Dig. Dis. , vol.28 , Issue.1 , pp. 155-161
    • Bellentani, S.1    Scaglioni, F.2    Marino, M.3    Bedogni, G.4
  • 13
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander, G., Guarente, L., The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73 (2004), 417–435.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 14
    • 78649855297 scopus 로고    scopus 로고
    • Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice
    • Bricambert, J., Miranda, J., Benhamed, F., Girard, J., Postic, C., Dentin, R., Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J. Clin. Investig. 120:12 (2010), 4316–4331.
    • (2010) J. Clin. Investig. , vol.120 , Issue.12 , pp. 4316-4331
    • Bricambert, J.1    Miranda, J.2    Benhamed, F.3    Girard, J.4    Postic, C.5    Dentin, R.6
  • 18
    • 78649618722 scopus 로고    scopus 로고
    • High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia
    • Carabelli, J., Burgueno, A.L., Rosselli, M.S., Gianotti, T.F., Lago, N.R., Pirola, C.J., Sookoian, S., High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia. J. Cell Mol. Med. 15:6 (2011), 1329–1338.
    • (2011) J. Cell Mol. Med. , vol.15 , Issue.6 , pp. 1329-1338
    • Carabelli, J.1    Burgueno, A.L.2    Rosselli, M.S.3    Gianotti, T.F.4    Lago, N.R.5    Pirola, C.J.6    Sookoian, S.7
  • 19
    • 84871221881 scopus 로고    scopus 로고
    • miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    • Castro, R.E., Ferreira, D.M., Afonso, M.B., Borralho, P.M., Machado, M.V., Cortez-Pinto, H., Rodrigues, C.M., miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J. Hepatol. 58:1 (2013), 119–125.
    • (2013) J. Hepatol. , vol.58 , Issue.1 , pp. 119-125
    • Castro, R.E.1    Ferreira, D.M.2    Afonso, M.B.3    Borralho, P.M.4    Machado, M.V.5    Cortez-Pinto, H.6    Rodrigues, C.M.7
  • 21
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • Cermelli, S., Ruggieri, A., Marrero, J.A., Ioannou, G.N., Beretta, L., Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One, 6(8), 2011, e23937.
    • (2011) PLoS One , vol.6 , Issue.8 , pp. e23937
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3    Ioannou, G.N.4    Beretta, L.5
  • 22
    • 0034916613 scopus 로고    scopus 로고
    • p300/CBP proteins: HATs for transcriptional bridges and scaffolds
    • Chan, H.M., La Thangue, N.B., p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci. 114:Pt 13 (2001), 2363–2373.
    • (2001) J. Cell Sci. , vol.114 , pp. 2363-2373
    • Chan, H.M.1    La Thangue, N.B.2
  • 23
    • 77956864571 scopus 로고    scopus 로고
    • Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats
    • Chang, X., Yan, H., Fei, J., Jiang, M., Zhu, H., Lu, D., Gao, X., Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. J. Lipid Res. 51:9 (2010), 2504–2515.
    • (2010) J. Lipid Res. , vol.51 , Issue.9 , pp. 2504-2515
    • Chang, X.1    Yan, H.2    Fei, J.3    Jiang, M.4    Zhu, H.5    Lu, D.6    Gao, X.7
  • 24
    • 0030799238 scopus 로고    scopus 로고
    • Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance
    • Chen, Z.J., Pikaard, C.S., Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance. Genes Dev. 11:16 (1997), 2124–2136.
    • (1997) Genes Dev. , vol.11 , Issue.16 , pp. 2124-2136
    • Chen, Z.J.1    Pikaard, C.S.2
  • 27
    • 79960144827 scopus 로고    scopus 로고
    • Epigenetics: a new bridge between nutrition and health
    • Choi, S.W., Friso, S., Epigenetics: a new bridge between nutrition and health. Adv. Nutr. 1:1 (2010), 8–16.
    • (2010) Adv. Nutr. , vol.1 , Issue.1 , pp. 8-16
    • Choi, S.W.1    Friso, S.2
  • 29
    • 84885431822 scopus 로고    scopus 로고
    • Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation
    • Cordero, P., Campion, J., Milagro, F.I., Martinez, J.A., Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation. Mol. Genet. Metab. 110:3 (2013), 388–395.
    • (2013) Mol. Genet. Metab. , vol.110 , Issue.3 , pp. 388-395
    • Cordero, P.1    Campion, J.2    Milagro, F.I.3    Martinez, J.A.4
  • 31
    • 84921596898 scopus 로고    scopus 로고
    • microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis
    • Csak, T., Bala, S., Lippai, D., Satishchandran, A., Catalano, D., Kodys, K., Szabo, G., microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis. Liver Int. 35:2 (2015), 532–541.
    • (2015) Liver Int. , vol.35 , Issue.2 , pp. 532-541
    • Csak, T.1    Bala, S.2    Lippai, D.3    Satishchandran, A.4    Catalano, D.5    Kodys, K.6    Szabo, G.7
  • 32
    • 84902544544 scopus 로고    scopus 로고
    • Novel insights on interactions between folate and lipid metabolism
    • da Silva, R.P., Kelly, K.B., Al Rajabi, A., Jacobs, R.L., Novel insights on interactions between folate and lipid metabolism. Biofactors 40:3 (2014), 277–283.
    • (2014) Biofactors , vol.40 , Issue.3 , pp. 277-283
    • da Silva, R.P.1    Kelly, K.B.2    Al Rajabi, A.3    Jacobs, R.L.4
  • 35
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two “hits”?
    • Day, C.P., James, O.F., Steatohepatitis: a tale of two “hits”?. Gastroenterology 114:4 (1998), 842–845.
    • (1998) Gastroenterology , vol.114 , Issue.4 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 36
    • 37349081571 scopus 로고    scopus 로고
    • Role of ChREBP in hepatic steatosis and insulin resistance
    • Denechaud, P.D., Dentin, R., Girard, J., Postic, C., Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett. 582:1 (2008), 68–73.
    • (2008) FEBS Lett. , vol.582 , Issue.1 , pp. 68-73
    • Denechaud, P.D.1    Dentin, R.2    Girard, J.3    Postic, C.4
  • 37
    • 84880925312 scopus 로고    scopus 로고
    • Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease
    • Derdak, Z., Villegas, K.A., Harb, R., Wu, A.M., Sousa, A., Wands, J.R., Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J. Hepatol. 58:4 (2013), 785–791.
    • (2013) J. Hepatol. , vol.58 , Issue.4 , pp. 785-791
    • Derdak, Z.1    Villegas, K.A.2    Harb, R.3    Wu, A.M.4    Sousa, A.5    Wands, J.R.6
  • 38
    • 84940849475 scopus 로고    scopus 로고
    • Effect of miR-34a in regulating steatosis by targeting PPARalpha expression in nonalcoholic fatty liver disease
    • Ding, J., Li, M., Wan, X., Jin, X., Chen, S., Yu, C., Li, Y., Effect of miR-34a in regulating steatosis by targeting PPARalpha expression in nonalcoholic fatty liver disease. Sci. Rep., 5, 2015, 13729.
    • (2015) Sci. Rep. , vol.5 , pp. 13729
    • Ding, J.1    Li, M.2    Wan, X.3    Jin, X.4    Chen, S.5    Yu, C.6    Li, Y.7
  • 42
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies
    • Fassio, E., Alvarez, E., Dominguez, N., Landeira, G., Longo, C., Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 40:4 (2004), 820–826.
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 43
    • 79952529158 scopus 로고    scopus 로고
    • A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
    • Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S.E., Alenghat, T., Liu, X.S., Lazar, M.A., A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331:6022 (2011), 1315–1319.
    • (2011) Science , vol.331 , Issue.6022 , pp. 1315-1319
    • Feng, D.1    Liu, T.2    Sun, Z.3    Bugge, A.4    Mullican, S.E.5    Alenghat, T.6    Liu, X.S.7    Lazar, M.A.8
  • 45
    • 84901944989 scopus 로고    scopus 로고
    • Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease
    • Ferreira, D.M., Simao, A.L., Rodrigues, C.M., Castro, R.E., Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. FEBS J. 281:11 (2014), 2503–2524.
    • (2014) FEBS J. , vol.281 , Issue.11 , pp. 2503-2524
    • Ferreira, D.M.1    Simao, A.L.2    Rodrigues, C.M.3    Castro, R.E.4
  • 46
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman, R.C., Farh, K.K., Burge, C.B., Bartel, D.P., Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:1 (2009), 92–105.
    • (2009) Genome Res. , vol.19 , Issue.1 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 47
    • 84945944367 scopus 로고    scopus 로고
    • Epigenetic mechanisms in non-alcoholic fatty liver disease: an emerging field
    • Gallego-Duran, R., Romero-Gomez, M., Epigenetic mechanisms in non-alcoholic fatty liver disease: an emerging field. World J. Hepatol. 7:24 (2015), 2497–2502.
    • (2015) World J. Hepatol. , vol.7 , Issue.24 , pp. 2497-2502
    • Gallego-Duran, R.1    Romero-Gomez, M.2
  • 48
    • 84896445385 scopus 로고    scopus 로고
    • Expression of serum miR-16, let-7f, and miR-21 in patients with hepatocellular carcinoma and their clinical significances
    • Ge, W., Yu, D.C., Li, Q.G., Chen, X., Zhang, C.Y., Ding, Y.T., Expression of serum miR-16, let-7f, and miR-21 in patients with hepatocellular carcinoma and their clinical significances. Clin. Lab. 60:3 (2014), 427–434.
    • (2014) Clin. Lab. , vol.60 , Issue.3 , pp. 427-434
    • Ge, W.1    Yu, D.C.2    Li, Q.G.3    Chen, X.4    Zhang, C.Y.5    Ding, Y.T.6
  • 50
    • 84897505627 scopus 로고    scopus 로고
    • MicroRNAs in nonalcoholic fatty liver disease: novel biomarkers and prognostic tools during the transition from steatosis to hepatocarcinoma
    • Gori, M., Arciello, M., Balsano, C., MicroRNAs in nonalcoholic fatty liver disease: novel biomarkers and prognostic tools during the transition from steatosis to hepatocarcinoma. Biomed. Res. Int., 2014, 2014, 741465.
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 741465
    • Gori, M.1    Arciello, M.2    Balsano, C.3
  • 53
    • 61849096150 scopus 로고    scopus 로고
    • miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis
    • Guo, C.J., Pan, Q., Li, D.G., Sun, H., Liu, B.W., miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis. J. Hepatol. 50:4 (2009), 766–778.
    • (2009) J. Hepatol. , vol.50 , Issue.4 , pp. 766-778
    • Guo, C.J.1    Pan, Q.2    Li, D.G.3    Sun, H.4    Liu, B.W.5
  • 54
    • 84904985459 scopus 로고    scopus 로고
    • Regulation of microRNA biogenesis
    • Ha, M., Kim, V.N., Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell Biol. 15:8 (2014), 509–524.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , Issue.8 , pp. 509-524
    • Ha, M.1    Kim, V.N.2
  • 56
    • 78649482634 scopus 로고    scopus 로고
    • SIRT1: recent lessons from mouse models
    • Herranz, D., Serrano, M., SIRT1: recent lessons from mouse models. Nat. Rev. Cancer 10:12 (2010), 819–823.
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.12 , pp. 819-823
    • Herranz, D.1    Serrano, M.2
  • 57
    • 81055127044 scopus 로고    scopus 로고
    • SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2
    • Hirschey, M.D., Shimazu, T., Capra, J.A., Pollard, K.S., Verdin, E., SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY) 3:6 (2011), 635–642.
    • (2011) Aging (Albany NY) , vol.3 , Issue.6 , pp. 635-642
    • Hirschey, M.D.1    Shimazu, T.2    Capra, J.A.3    Pollard, K.S.4    Verdin, E.5
  • 60
    • 84929308803 scopus 로고    scopus 로고
    • Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway
    • Hur, W., Lee, J.H., Kim, S.W., Kim, J.H., Bae, S.H., Kim, M., Hwang, D., Kim, Y.S., Park, T., Um, S.J., Song, B.J., Yoon, S.K., Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway. Int. J. Biochem. Cell Biol. 64 (2015), 265–276.
    • (2015) Int. J. Biochem. Cell Biol. , vol.64 , pp. 265-276
    • Hur, W.1    Lee, J.H.2    Kim, S.W.3    Kim, J.H.4    Bae, S.H.5    Kim, M.6    Hwang, D.7    Kim, Y.S.8    Park, T.9    Um, S.J.10    Song, B.J.11    Yoon, S.K.12
  • 61
    • 38349092277 scopus 로고    scopus 로고
    • Hepatic CTP: phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein
    • Jacobs, R.L., Lingrell, S., Zhao, Y., Francis, G.A., Vance, D.E., Hepatic CTP: phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. J. Biol. Chem. 283:4 (2008), 2147–2155.
    • (2008) J. Biol. Chem. , vol.283 , Issue.4 , pp. 2147-2155
    • Jacobs, R.L.1    Lingrell, S.2    Zhao, Y.3    Francis, G.A.4    Vance, D.E.5
  • 62
    • 84929031531 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers in hepatocellular carcinoma screening: a validation set from China
    • Jiang, L., Cheng, Q., Zhang, B.H., Zhang, M.Z., Circulating microRNAs as biomarkers in hepatocellular carcinoma screening: a validation set from China. Med. Baltim., 94(10), 2015, e603.
    • (2015) Med. Baltim. , vol.94 , Issue.10 , pp. e603
    • Jiang, L.1    Cheng, Q.2    Zhang, B.H.3    Zhang, M.Z.4
  • 63
    • 62049083189 scopus 로고    scopus 로고
    • MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease
    • Jin, X., Ye, Y.F., Chen, S.H., Yu, C.H., Liu, J., Li, Y.M., MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease. Dig. Liver Dis. 41:4 (2009), 289–297.
    • (2009) Dig. Liver Dis. , vol.41 , Issue.4 , pp. 289-297
    • Jin, X.1    Ye, Y.F.2    Chen, S.H.3    Yu, C.H.4    Liu, J.5    Li, Y.M.6
  • 64
    • 77952567958 scopus 로고    scopus 로고
    • Environmental and genetic determinants of fatty liver in humans
    • Kantartzis, K., Schick, F., Haring, H.U., Stefan, N., Environmental and genetic determinants of fatty liver in humans. Dig. Dis. 28:1 (2010), 169–178.
    • (2010) Dig. Dis. , vol.28 , Issue.1 , pp. 169-178
    • Kantartzis, K.1    Schick, F.2    Haring, H.U.3    Stefan, N.4
  • 67
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: the mark and its mediators
    • Klose, R.J., Bird, A.P., Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 31:2 (2006), 89–97.
    • (2006) Trends Biochem. Sci. , vol.31 , Issue.2 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 69
    • 84899744572 scopus 로고    scopus 로고
    • KASL clinical practice guidelines: management of nonalcoholic fatty liver disease
    • Korean Association for the Study of the, L., KASL clinical practice guidelines: management of nonalcoholic fatty liver disease. Clin. Mol. Hepatol. 19:4 (2013), 325–348.
    • (2013) Clin. Mol. Hepatol. , vol.19 , Issue.4 , pp. 325-348
    • Korean Association for the Study of the, L.,1
  • 73
    • 84925867973 scopus 로고    scopus 로고
    • Epigenetic mechanisms underlying the link between non-alcoholic fatty liver diseases and nutrition
    • Lee, J.H., Friso, S., Choi, S.W., Epigenetic mechanisms underlying the link between non-alcoholic fatty liver diseases and nutrition. Nutrients 6:8 (2014), 3303–3325.
    • (2014) Nutrients , vol.6 , Issue.8 , pp. 3303-3325
    • Lee, J.H.1    Friso, S.2    Choi, S.W.3
  • 74
    • 78649752499 scopus 로고    scopus 로고
    • Regulation and biological function of the liver-specific miR-122
    • Lewis, A.P., Jopling, C.L., Regulation and biological function of the liver-specific miR-122. Biochem. Soc. Trans. 38:6 (2010), 1553–1557.
    • (2010) Biochem. Soc. Trans. , vol.38 , Issue.6 , pp. 1553-1557
    • Lewis, A.P.1    Jopling, C.L.2
  • 75
    • 84874109529 scopus 로고    scopus 로고
    • miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression
    • Li, J., Ghazwani, M., Zhang, Y., Lu, J., Li, J., Fan, J., Gandhi, C.R., Li, S., miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. J. Hepatol. 58:3 (2013), 522–528.
    • (2013) J. Hepatol. , vol.58 , Issue.3 , pp. 522-528
    • Li, J.1    Ghazwani, M.2    Zhang, Y.3    Lu, J.4    Li, J.5    Fan, J.6    Gandhi, C.R.7    Li, S.8
  • 76
    • 84873909398 scopus 로고    scopus 로고
    • Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease
    • Li, Y.Y., Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease. World J. Gastroenterol. 18:45 (2012), 6546–6551.
    • (2012) World J. Gastroenterol. , vol.18 , Issue.45 , pp. 6546-6551
    • Li, Y.Y.1
  • 77
    • 84887187262 scopus 로고    scopus 로고
    • Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells
    • Li, Z.J., Ou-Yang, P.H., Han, X.P., Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells. Cell Signal 26:1 (2014), 141–148.
    • (2014) Cell Signal , vol.26 , Issue.1 , pp. 141-148
    • Li, Z.J.1    Ou-Yang, P.H.2    Han, X.P.3
  • 78
    • 84907945370 scopus 로고    scopus 로고
    • miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs
    • Liao, C.G., Kong, L.M., Zhou, P., Yang, X.L., Huang, J.G., Zhang, H.L., Lu, N., miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs. J. Transl. Med., 12, 2014, 234.
    • (2014) J. Transl. Med. , vol.12 , pp. 234
    • Liao, C.G.1    Kong, L.M.2    Zhou, P.3    Yang, X.L.4    Huang, J.G.5    Zhang, H.L.6    Lu, N.7
  • 80
    • 73249133400 scopus 로고    scopus 로고
    • Epigenetics: a molecular link between environmental factors and type 2 diabetes
    • Ling, C., Groop, L., Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 58:12 (2009), 2718–2725.
    • (2009) Diabetes , vol.58 , Issue.12 , pp. 2718-2725
    • Ling, C.1    Groop, L.2
  • 82
    • 0035826898 scopus 로고    scopus 로고
    • Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation
    • Lu, S.C., Alvarez, L., Huang, Z.Z., Chen, L., An, W., Corrales, F.J., Avila, M.A., Kanel, G., Mato, J.M., Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc. Natl. Acad. Sci. U. S. A. 98:10 (2001), 5560–5565.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , Issue.10 , pp. 5560-5565
    • Lu, S.C.1    Alvarez, L.2    Huang, Z.Z.3    Chen, L.4    An, W.5    Corrales, F.J.6    Avila, M.A.7    Kanel, G.8    Mato, J.M.9
  • 83
    • 84867706295 scopus 로고    scopus 로고
    • S-adenosylmethionine in liver health, injury, and cancer
    • Lu, S.C., Mato, J.M., S-adenosylmethionine in liver health, injury, and cancer. Physiol. Rev. 92:4 (2012), 1515–1542.
    • (2012) Physiol. Rev. , vol.92 , Issue.4 , pp. 1515-1542
    • Lu, S.C.1    Mato, J.M.2
  • 86
    • 34248653254 scopus 로고    scopus 로고
    • Role of S-adenosyl-L-methionine in liver health and injury
    • Mato, J.M., Lu, S.C., Role of S-adenosyl-L-methionine in liver health and injury. Hepatology 45:5 (2007), 1306–1312.
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1306-1312
    • Mato, J.M.1    Lu, S.C.2
  • 87
    • 84905724839 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity
    • Mazzoccoli, G., Vinciguerra, M., Oben, J., Tarquini, R., De Cosmo, S., Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity. Liver Int. 34:8 (2014), 1133–1152.
    • (2014) Liver Int. , vol.34 , Issue.8 , pp. 1133-1152
    • Mazzoccoli, G.1    Vinciguerra, M.2    Oben, J.3    Tarquini, R.4    De Cosmo, S.5
  • 88
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • (viii)
    • McCullough, A.J., The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin. Liver Dis. 8:3 (2004), 521–533 (viii).
    • (2004) Clin. Liver Dis. , vol.8 , Issue.3 , pp. 521-533
    • McCullough, A.J.1
  • 89
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng, F., Henson, R., Wehbe-Janek, H., Ghoshal, K., Jacob, S.T., Patel, T., MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133:2 (2007), 647–658.
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 90
    • 0029011539 scopus 로고
    • 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J.G., Mao, L., Lee, D.J., Gabrielson, E., Burger, P.C., Baylin, S.B., Sidransky, D., 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1:7 (1995), 686–692.
    • (1995) Nat. Med. , vol.1 , Issue.7 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 91
    • 2342423022 scopus 로고    scopus 로고
    • In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions
    • Miao, F., Gonzalo, I.G., Lanting, L., Natarajan, R., In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. J. Biol. Chem. 279:17 (2004), 18091–18097.
    • (2004) J. Biol. Chem. , vol.279 , Issue.17 , pp. 18091-18097
    • Miao, F.1    Gonzalo, I.G.2    Lanting, L.3    Natarajan, R.4
  • 94
    • 84928553627 scopus 로고    scopus 로고
    • Overview of microRNA biology
    • Mohr, A.M., Mott, J.L., Overview of microRNA biology. Semin. Liver Dis. 35:1 (2015), 3–11.
    • (2015) Semin. Liver Dis. , vol.35 , Issue.1 , pp. 3-11
    • Mohr, A.M.1    Mott, J.L.2
  • 97
    • 84867002762 scopus 로고    scopus 로고
    • MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
    • Ogawa, T., Enomoto, M., Fujii, H., Sekiya, Y., Yoshizato, K., Ikeda, K., Kawada, N., MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. Gut 61:11 (2012), 1600–1609.
    • (2012) Gut , vol.61 , Issue.11 , pp. 1600-1609
    • Ogawa, T.1    Enomoto, M.2    Fujii, H.3    Sekiya, Y.4    Yoshizato, K.5    Ikeda, K.6    Kawada, N.7
  • 98
    • 78650747994 scopus 로고    scopus 로고
    • SIRT1 contributes to telomere maintenance and augments global homologous recombination
    • Palacios, J.A., Herranz, D., De Bonis, M.L., Velasco, S., Serrano, M., Blasco, M.A., SIRT1 contributes to telomere maintenance and augments global homologous recombination. J. Cell Biol. 191:7 (2010), 1299–1313.
    • (2010) J. Cell Biol. , vol.191 , Issue.7 , pp. 1299-1313
    • Palacios, J.A.1    Herranz, D.2    De Bonis, M.L.3    Velasco, S.4    Serrano, M.5    Blasco, M.A.6
  • 99
    • 84912118983 scopus 로고    scopus 로고
    • MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease
    • Panera, N., Gnani, D., Crudele, A., Ceccarelli, S., Nobili, V., Alisi, A., MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease. World J. Gastroenterol. 20:41 (2014), 15079–15086.
    • (2014) World J. Gastroenterol. , vol.20 , Issue.41 , pp. 15079-15086
    • Panera, N.1    Gnani, D.2    Crudele, A.3    Ceccarelli, S.4    Nobili, V.5    Alisi, A.6
  • 100
    • 84863011800 scopus 로고    scopus 로고
    • Nutritional influences on epigenetics and age-related disease
    • Park, L.K., Friso, S., Choi, S.W., Nutritional influences on epigenetics and age-related disease. Proc. Nutr. Soc. 71:1 (2012), 75–83.
    • (2012) Proc. Nutr. Soc. , vol.71 , Issue.1 , pp. 75-83
    • Park, L.K.1    Friso, S.2    Choi, S.W.3
  • 104
    • 84881546730 scopus 로고    scopus 로고
    • Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease
    • Pirola, C.J., Gianotti, T.F., Burgueno, A.L., Rey-Funes, M., Loidl, C.F., Mallardi, P., Martino, J.S., Castano, G.O., Sookoian, S., Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut 62:9 (2013), 1356–1363.
    • (2013) Gut , vol.62 , Issue.9 , pp. 1356-1363
    • Pirola, C.J.1    Gianotti, T.F.2    Burgueno, A.L.3    Rey-Funes, M.4    Loidl, C.F.5    Mallardi, P.6    Martino, J.S.7    Castano, G.O.8    Sookoian, S.9
  • 107
    • 63449112017 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    • Purushotham, A., Schug, T.T., Xu, Q., Surapureddi, S., Guo, X., Li, X., Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9:4 (2009), 327–338.
    • (2009) Cell Metab. , vol.9 , Issue.4 , pp. 327-338
    • Purushotham, A.1    Schug, T.T.2    Xu, Q.3    Surapureddi, S.4    Guo, X.5    Li, X.6
  • 108
    • 79952813995 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers for hepatocellular carcinoma
    • Qu, K.Z., Zhang, K., Li, H., Afdhal, N.H., Albitar, M., Circulating microRNAs as biomarkers for hepatocellular carcinoma. J. Clin. Gastroenterol. 45:4 (2011), 355–360.
    • (2011) J. Clin. Gastroenterol. , vol.45 , Issue.4 , pp. 355-360
    • Qu, K.Z.1    Zhang, K.2    Li, H.3    Afdhal, N.H.4    Albitar, M.5
  • 112
    • 38649123072 scopus 로고    scopus 로고
    • Conserved metabolic regulatory functions of sirtuins
    • Schwer, B., Verdin, E., Conserved metabolic regulatory functions of sirtuins. Cell Metab. 7:2 (2008), 104–112.
    • (2008) Cell Metab. , vol.7 , Issue.2 , pp. 104-112
    • Schwer, B.1    Verdin, E.2
  • 113
    • 80052356803 scopus 로고    scopus 로고
    • Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet
    • Serviddio, G., Giudetti, A.M., Bellanti, F., Priore, P., Rollo, T., Tamborra, R., Siculella, L., Vendemiale, G., Altomare, E., Gnoni, G.V., Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet. PloS One, 6(9), 2011, e24084.
    • (2011) PloS One , vol.6 , Issue.9 , pp. e24084
    • Serviddio, G.1    Giudetti, A.M.2    Bellanti, F.3    Priore, P.4    Rollo, T.5    Tamborra, R.6    Siculella, L.7    Vendemiale, G.8    Altomare, E.9    Gnoni, G.V.10
  • 115
    • 85015316415 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis is Associated with a State of Betaine-insufficiency
    • Liver International
    • Sookoian, S., Puri, P., Castaño, G.O., Scian, R., Mirshahi, F., Sanyal, A.J., Pirola, C.J., Nonalcoholic Steatohepatitis is Associated with a State of Betaine-insufficiency. 2016, Liver International.
    • (2016)
    • Sookoian, S.1    Puri, P.2    Castaño, G.O.3    Scian, R.4    Mirshahi, F.5    Sanyal, A.J.6    Pirola, C.J.7
  • 116
    • 78649568544 scopus 로고    scopus 로고
    • Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor gamma coactivator 1alpha promoter
    • Sookoian, S., Rosselli, M.S., Gemma, C., Burgueno, A.L., Fernandez Gianotti, T., Castano, G.O., Pirola, C.J., Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor gamma coactivator 1alpha promoter. Hepatology 52:6 (2010), 1992–2000.
    • (2010) Hepatology , vol.52 , Issue.6 , pp. 1992-2000
    • Sookoian, S.1    Rosselli, M.S.2    Gemma, C.3    Burgueno, A.L.4    Fernandez Gianotti, T.5    Castano, G.O.6    Pirola, C.J.7
  • 117
    • 84925851270 scopus 로고    scopus 로고
    • Potential epigenetic mechanism in non-alcoholic Fatty liver disease
    • Sun, C., Fan, J.G., Qiao, L., Potential epigenetic mechanism in non-alcoholic Fatty liver disease. Int. J. Mol. Sci. 16:3 (2015), 5161–5179.
    • (2015) Int. J. Mol. Sci. , vol.16 , Issue.3 , pp. 5161-5179
    • Sun, C.1    Fan, J.G.2    Qiao, L.3
  • 118
    • 84921718665 scopus 로고    scopus 로고
    • miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR
    • Sun, C., Huang, F., Liu, X., Xiao, X., Yang, M., Hu, G., Liu, H., Liao, L., miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR. Int. J. Mol. Med. 35:3 (2015), 847–853.
    • (2015) Int. J. Mol. Med. , vol.35 , Issue.3 , pp. 847-853
    • Sun, C.1    Huang, F.2    Liu, X.3    Xiao, X.4    Yang, M.5    Hu, G.6    Liu, H.7    Liao, L.8
  • 119
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
    • Sun, C., Zhang, F., Ge, X., Yan, T., Chen, X., Shi, X., Zhai, Q., SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6:4 (2007), 307–319.
    • (2007) Cell Metab. , vol.6 , Issue.4 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3    Yan, T.4    Chen, X.5    Shi, X.6    Zhai, Q.7
  • 120
    • 61949261267 scopus 로고    scopus 로고
    • Inflammatory pathways in liver homeostasis and liver injury
    • Tacke, F., Luedde, T., Trautwein, C., Inflammatory pathways in liver homeostasis and liver injury. Clin. Rev. Allergy Immunol. 36:1 (2009), 4–12.
    • (2009) Clin. Rev. Allergy Immunol. , vol.36 , Issue.1 , pp. 4-12
    • Tacke, F.1    Luedde, T.2    Trautwein, C.3
  • 121
    • 84887613357 scopus 로고    scopus 로고
    • Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease
    • Tian, Y., Wong, V.W., Chan, H.L., Cheng, A.S., Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease. Semin. Cancer Biol. 23:6 Pt B (2013), 471–482.
    • (2013) Semin. Cancer Biol. , vol.23 , Issue.6 , pp. 471-482
    • Tian, Y.1    Wong, V.W.2    Chan, H.L.3    Cheng, A.S.4
  • 123
    • 79952123300 scopus 로고    scopus 로고
    • Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet
    • Tryndyak, V.P., Han, T., Muskhelishvili, L., Fuscoe, J.C., Ross, S.A., Beland, F.A., Pogribny, I.P., Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet. Mol. Nutr. Food Res. 55:3 (2011), 411–418.
    • (2011) Mol. Nutr. Food Res. , vol.55 , Issue.3 , pp. 411-418
    • Tryndyak, V.P.1    Han, T.2    Muskhelishvili, L.3    Fuscoe, J.C.4    Ross, S.A.5    Beland, F.A.6    Pogribny, I.P.7
  • 125
    • 84901934284 scopus 로고    scopus 로고
    • Early life nutrition, epigenetics and programming of later life disease
    • Vickers, M.H., Early life nutrition, epigenetics and programming of later life disease. Nutrients 6:6 (2014), 2165–2178.
    • (2014) Nutrients , vol.6 , Issue.6 , pp. 2165-2178
    • Vickers, M.H.1
  • 126
    • 65449119905 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes
    • Vinciguerra, M., Sgroi, A., Veyrat-Durebex, C., Rubbia-Brandt, L., Buhler, L.H., Foti, M., Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. Hepatology 49:4 (2009), 1176–1184.
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1176-1184
    • Vinciguerra, M.1    Sgroi, A.2    Veyrat-Durebex, C.3    Rubbia-Brandt, L.4    Buhler, L.H.5    Foti, M.6
  • 127
    • 84860329438 scopus 로고    scopus 로고
    • miR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients
    • Wang, B., Li, W., Guo, K., Xiao, Y., Wang, Y., Fan, J., miR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients. Biochem. Biophys. Res. Commun. 421:1 (2012), 4–8.
    • (2012) Biochem. Biophys. Res. Commun. , vol.421 , Issue.1 , pp. 4-8
    • Wang, B.1    Li, W.2    Guo, K.3    Xiao, Y.4    Wang, Y.5    Fan, J.6
  • 128
    • 84902176122 scopus 로고    scopus 로고
    • Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma
    • Wang, H., Hou, L., Li, A., Duan, Y., Gao, H., Song, X., Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. Biomed. Res. Int., 2014, 2014, 864894.
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 864894
    • Wang, H.1    Hou, L.2    Li, A.3    Duan, Y.4    Gao, H.5    Song, X.6
  • 129
    • 84893798702 scopus 로고    scopus 로고
    • Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet
    • Wang, L.J., Zhang, H.W., Zhou, J.Y., Liu, Y., Yang, Y., Chen, X.L., Zhu, C.H., Zheng, R.D., Ling, W.H., Zhu, H.L., Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. J. Nutr. Biochem. 25:3 (2014), 329–336.
    • (2014) J. Nutr. Biochem. , vol.25 , Issue.3 , pp. 329-336
    • Wang, L.J.1    Zhang, H.W.2    Zhou, J.Y.3    Liu, Y.4    Yang, Y.5    Chen, X.L.6    Zhu, C.H.7    Zheng, R.D.8    Ling, W.H.9    Zhu, H.L.10
  • 130
    • 39849091969 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and mitochondrial dysfunction
    • Wei, Y., Rector, R.S., Thyfault, J.P., Ibdah, J.A., Nonalcoholic fatty liver disease and mitochondrial dysfunction. World J. Gastroenterol., 14(2), 2008, 193.
    • (2008) World J. Gastroenterol. , vol.14 , Issue.2 , pp. 193
    • Wei, Y.1    Rector, R.S.2    Thyfault, J.P.3    Ibdah, J.A.4
  • 131
    • 84864984120 scopus 로고    scopus 로고
    • MicroRNAs in insulin resistance and obesity
    • Williams, M.D., Mitchell, G.M., MicroRNAs in insulin resistance and obesity. Exp. Diabetes Res., 2012, 2012, 484696.
    • (2012) Exp. Diabetes Res. , vol.2012 , pp. 484696
    • Williams, M.D.1    Mitchell, G.M.2
  • 132
    • 84995342296 scopus 로고    scopus 로고
    • MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway
    • Wu, H., Ng, R., Chen, X., Steer, C.J., Song, G., MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway. Gut, 2015.
    • (2015) Gut
    • Wu, H.1    Ng, R.2    Chen, X.3    Steer, C.J.4    Song, G.5
  • 136
    • 85015268297 scopus 로고    scopus 로고
    • MicroRNA expression relating to dietary-induced liver steatosis and NASH
    • Zarfeshani, A., Ngo, S., Sheppard, A.M., MicroRNA expression relating to dietary-induced liver steatosis and NASH. J. Clin. Med. 4:11 (2015), 1938–1950.
    • (2015) J. Clin. Med. , vol.4 , Issue.11 , pp. 1938-1950
    • Zarfeshani, A.1    Ngo, S.2    Sheppard, A.M.3
  • 138
    • 73449136157 scopus 로고    scopus 로고
    • Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD
    • Zheng, L., Lv, G.C., Sheng, J., Yang, Y.D., Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD. J. Gastroenterol. Hepatol. 25:1 (2010), 156–163.
    • (2010) J. Gastroenterol. Hepatol. , vol.25 , Issue.1 , pp. 156-163
    • Zheng, L.1    Lv, G.C.2    Sheng, J.3    Yang, Y.D.4
  • 139
    • 37249026814 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation patterns
    • Zilberman, D., Henikoff, S., Genome-wide analysis of DNA methylation patterns. Development 134:22 (2007), 3959–3965.
    • (2007) Development , vol.134 , Issue.22 , pp. 3959-3965
    • Zilberman, D.1    Henikoff, S.2
  • 140
    • 79954452677 scopus 로고    scopus 로고
    • Genetics and epigenetics in the fibrogenic evolution of chronic liver diseases
    • Zimmer, V., Lammert, F., Genetics and epigenetics in the fibrogenic evolution of chronic liver diseases. Best. Pract. Res. Clin. Gastroenterol. 25:2 (2011), 269–280.
    • (2011) Best. Pract. Res. Clin. Gastroenterol. , vol.25 , Issue.2 , pp. 269-280
    • Zimmer, V.1    Lammert, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.