Folate intake, Mthfr genotype, and sex modulate choline metabolism in mice

Journal of Nutrition

Volumn 141, Issue 8, 2011, Pages 1475-1481

  Chew, Tina W ^a   Jiang, Xinyin ^b   Yan, Jian ^b   Wang, Wei ^a   Lusa, Amanda L ^b   Carrier, Bradley J ^b   West, Allyson A ^b   Malysheva, Olga V ^b   Brenna, J Thomas ^b   Gregory, Jesse F ^c   Caudill, Marie A ^b  

^a CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BETAINE; CHOLINE; CHOLINE DEHYDROGENASE; DEUTERIUM; DRINKING WATER; FOLIC ACID; GLYCEROPHOSPHORYLCHOLINE; METHYL GROUP; PHOSPHATIDYLCHOLINE;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BRAIN LEVEL; CONTROLLED STUDY; FOLATE METABOLISM; FOLIC ACID DEFICIENCY; GENE DELETION; GENOTYPE; HETEROZYGOSITY; HOMEOSTASIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; SEX; WILD TYPE;

ANIMALS; CHOLINE; FEMALE; FOLIC ACID; GENOTYPE; LIVER; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX FACTORS;

MUS;

EID: 79961116632     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.138859     Document Type: Article

References (30)

1. Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. J Lipid Res. 2008;49:1187-94.
2. Nozawa Y. A thematic series on lipid signaling: prologue. J Biochem. 2002;131:283-4.
3. Sunden SL, Renduchintala MS, Park EI, Miklasz SD, Garrow TA. Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys. 1997;345:171-4.
4. Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. Am J Pharmacogenomics. 2001; 1:189-201.
5. Vance DE, Walkey CJ, Cui Z. Phosphatidylethanolamine N-methyl-transferase from liver. Biochim Biophys Acta. 1997;1348:142-50.
6. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr. 2006;83: 5-10.
7. Caudill MA. Folate and choline interrelationships: metabolic and potential health implications. In: Bailey LB, editor. Folate in health and disease. Boca Raton (FL): CRC Press; 2009. p. 449-65.
8. Schwahn BC, Chen Z, Laryea MD, Wendel U, Lussier-Cacan S, Genest J Jr, Mar MH, Zeisel SH, Castro C, et al. Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J. 2003;17:512-4.
9. Veenema K, Solis C, Li R, Wang W, Maletz CV, Abratte CM, Caudill MA. Adequate intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load. Am J Clin Nutr. 2008;88:685-92.
10. Troen AM, Chao WH, Crivello NA, D'Anci KE, Shukitt-Hale B, Smith DE, Selhub J, Rosenberg IH. Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine. J Nutr. 2008;138:2502-9.
11. Hung J, Abratte CM, Wang W, Li R, Moriarty DJ, Caudill MA. Ethnicity and folate influence choline status in young women consuming controlled nutrient intakes. J Am Coll Nutr. 2008;27:253-9.
12. Abratte CM, Wang W, Li R, Moriarty DJ, Caudill MA. Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women. J Nutr Biochem. 2008;19:158-65.
13. Christensen KE, Wu Q, Wang X, Deng L, Caudill MA, Rozen R. Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. J Nutr. 2010;140:1736-41.
14. Institute of Medicine, National Academy of Sciences USA. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline. Washington, DC: National Academy Press; 1998.
15. Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, et al. Mice deficient in methylenetetrahy-drofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet. 2001;10:433-43.
16. Reeves PG. Components of the AIN-93 diets as improvements in the AIN 76-A diet. J Nutr. 1997;127:S838-41.
17. Bachmanov AA, Reed DR, Beauchamp GK, Tordoff MG. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet. 2002;32:435-43.
18. Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem. 2003;49:286-94.
19. Koc H, Mar MH, Ranasinghe A, Swenberg JA, Zeisel SH. Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem. 2002;74:4734-40.
20. Yan J, Wang W, Gregory JF, Malysheva O, Brenna JT, Stabler SP, Allen RH, Caudill MA. MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. Am J Clin Nutr. 2011;93:348-55.
21. Tamura T. Microbiological assay of folates. In: Picciano M, Stokstad ELR, Gregory JF, editors. Folic acid metabolism in health and disease. New York: John Wiley & Sons; 1990. p. 121-37.
22. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402-8.
23. Li Z, Agellon LB, Vance DE. Choline redistribution during adaptation to choline deprivation. J Biol Chem. 2007;282:10283-9.
24. Yao ZM, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem. 1988;263:2998-3004.
25. Li Z, Agellon LB, Vance DE. Phosphatidylcholine homeostasis and liver failure. J Biol Chem. 2005;280:37798-802.
26. DeLong CJ, Shen YJ, Thomas MJ, Cui Z. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J Biol Chem. 1999; 274:29683-8.
27. da Costa KA, Rai KS, Craciunescu CN, Parikh K, Mehedint MG, Sanders LM, McLean-Pottinger A, Zeisel SH. Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- mouse. J Biol Chem. 2010;285:1008-15.
28. Brenna JT, Lapillonne A. Background paper on fat and fatty acid require-ments during pregnancy and lactation. Ann Nutr Metab. 2009;55:97-122.
29. Noga AA, Zhao Y, Vance DE. An unexpected requirement for phos-phatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem. 2002;277:42358-65.
30. Watkins SM, Zhu X, Zeisel SH. Phosphatidylethanolamine N-methyl-transferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice. J Nutr. 2003;133:3386-91.